Article
Obstetrics & Gynecology
Yu-Han Chiu, Jennifer J. Yland, Paolo Rinaudo, John Hsu, Sean McGrath, Sonia Hernandez-Diaz, Miguel A. Hernan
Summary: This study compared the effectiveness and safety of one cycle of assisted reproductive technology (ART) with three cycles of intrauterine insemination (IUI). The results showed that one cycle of ART had a similar probability of live birth as three cycles of IUI, but slightly higher risks of multiple gestations, preterm births, and neonatal intensive care unit (NICU) admissions.
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
Julie Lyngso, Ulrik S. Kesmodel, Bjorn Bay, Hans J. Ingerslev, Charlotta H. Pisinger, Cecilia H. Ramlau-Hansen
Summary: In a cohort study analyzing data from 1708 women undergoing medically assisted reproduction treatments, it was found that female occasional/daily cigarette smoking was not associated with the chance of achieving a clinical pregnancy or a live birth.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Medicine, General & Internal
Yumei Luo, Shunhong Wu, Jingru Yuan, Hua Zhou, Yufang Zhong, Mimi Zhang, Qing Li, Xia Xu, Xiaofang Sun, Detu Zhu
Summary: The study analyzed 3,015 AIH cycles in infertile Chinese couples to identify independent prognostic factors for successful pregnancy. Factors such as treatment options, female age, and sperm parameters like straight-line velocity and normal form rate were found to predict successful pregnancy following AIH. A multivariate logistic regression equation was developed to improve prognostic classification compared to individual predictors.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Laura Catalini, Jens Fedder, Bente Mertz Norgard, Line Riis Jolving
Summary: This nationwide cohort study examined the outcomes of assisted reproductive technology treatments in women using donor or partner sperm in Denmark from 2007 to 2017. The study found that the use of donor sperm was associated with higher odds of live birth after IUI treatments in women with male partners (aOR 1.48), single women (aOR 1.20), and women with female partners (aOR 1.46). However, there was no significant difference in live birth rates between women using donor and partner sperm after IVF treatments. The study highlights the importance of healthcare professionals attending to the individual needs and fertility issues of women seeking fertility treatments.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Maryam Asgharnia, Marzieh Mehrafza, Azadeh Raoufi, Tahereh Zare Yousefi, Elmira Hosseinzadeh, Sajedeh Samadnia, Ziba Zahiri, Amirhossein Tamimi, Ahmad Hosseini
Summary: This multicenter study found that combination therapy with letrozole and clomiphene citrate was more effective than using either drug alone in patients undergoing ovarian induction plus intrauterine insemination, leading to higher rates of pregnancy success.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Genetics & Heredity
Stephen A. Roberts, Jack Wilkinson, Andy Vail, Daniel R. Brison
Summary: The purpose of this study is to investigate how naive analyses of UK ART Register data can lead to misleading estimates of the effects of PGT-A and to propose a more credible analysis method. By utilizing logistic regression models and adjusting for confounding factors, the study suggests that PGT-A may have a detrimental effect on live birth events. However, due to limitations in the available dataset, this cannot be considered a definitive estimation. Further research is needed to explore the impact of PGT-A when used as a treatment add-on.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Review
Obstetrics & Gynecology
Stuart Spencer, Alexandros Lazaridis, Alexandros Grammatis, Martin Hirsch
Summary: The treatment of infertility in patients with endometriosis remains challenging, with surgery playing a role in enhancing assisted conception for those with deep rectovaginal endometriosis. The use of the endometriosis fertility index is validated in predicting reproductive outcomes after surgery and can be used in counseling patients on their likelihood of spontaneous conception prior to surgery. Further research is needed to establish the role of surgery in treating superficial and deep endometriosis and its impact on both spontaneous and assisted conception outcomes. Counseling patients with endometriosis regarding their fertility prospects continues to be challenging.
CURRENT OPINION IN OBSTETRICS & GYNECOLOGY
(2022)
Review
Information Science & Library Science
Gloria Puliga, Akhatjon Nasullaev, Flavio Bono, Eugenio Gutierrez, Fernanda Strozzi
Summary: The authors analyzed the impact of European funding research programmes on Ambient Assisted Living technology through a systematic literature review. They found that the funding programs led to increased scientific production and identified three main research directions: activity and vital sign recognition, human-computer interaction, and technology acceptance.
INFORMATION TECHNOLOGY & PEOPLE
(2021)
Article
Obstetrics & Gynecology
Yumei Luo, Mingxing Liu, Shunhong Wu, Mimi Zhang, Jingru Yuan, Yufang Zhong, Qing Li, Xiaofang Sun, Xia Xu, Detu Zhu
Summary: The study found that sperm parameters pre- and post-processing have predictive value for clinical pregnancy rates following artificial insemination in infertile couples. Sperm parameters in the male factor and both-factor groups were more effective in predictive classification compared to other groups.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
Michael Kitlinski, Aleksander Giwercman, Angel Elenkov
Summary: This study found that fathers with a history of cancer, particularly those with testicular, prostate, and hematological and lymphatic malignancies, were more likely to use assisted reproduction to achieve paternity. These findings highlight the importance of fertility care for male cancer survivors.
HUMAN REPRODUCTION
(2023)
Article
Medicine, General & Internal
Fanchao Meng, Sheng Deng, Lu Wang, Yumei Zhou, Mengjie Zhao, Haibin Li, Dong Liu, Guojing Gao, Xiaoxing Liao, Jisheng Wang
Summary: This study analyzed the quantity and quality of publications in the field of assisted reproductive technology (ART) and profiled the publishing groups, including countries, institutions, journals, and authors. The results showed that research on ART has been steadily increasing, with academic institutions in Europe and the United States leading the research. The main research topics and hotspots in ART are frozen embryo transfer, intracytoplasmic sperm injection, and in vitro fertilization.
FRONTIERS IN MEDICINE
(2022)
Article
Obstetrics & Gynecology
Sara E. Arian, Hadi Erfani, Ghanshyam S. Yadav, Steven Clark, William E. Gibbons, Alireza A. Shamshirsaz
Summary: This study compared neonatal and maternal outcomes between twin pregnancies conceived through different fertility treatments and spontaneously conceived twin pregnancies. The risk of adverse maternal outcomes and medical complications was higher in the fertility treatment group, while the risk of adverse neonatal outcomes was slightly lower in the spontaneously conceived twin group after adjusting for potential confounders. The study concluded that despite a slight increase in morbidity rates, overall reassurance regarding maternal and neonatal outcomes can be provided to patients undergoing fertility treatments.
FERTILITY AND STERILITY
(2021)
Article
Medicine, General & Internal
Annacandida Villani, Andrea Fontana, Stefano Barone, Silvia de Stefani, Mariangela Primiterra, Massimiliano Copetti, Concetta Panebianco, Cristiana Parri, Natale Scianname, Pasqua Anna Quitadamo, Alessandra Tiezzi, Liliana Santana, Annamaria Maglione, Federica D'Amato, Francesco Perri, Simone Palini, Valerio Pazienza
Summary: This study aimed to analyze the microbiota of human cervical swab and its correlation with Assisted Reproductive Technologies (ART) outcomes. The results showed that different microorganisms were predictive of women's pregnancy outcomes, with significant differences found at the species level, including Lactobacillus salivarius and Lactobacillus rhamnosus. The abundance of Lactobacillus crispatus increased and Lactobacillus iners decreased in the favorable group compared to the unfavorable group, indicating their association with positive ART outcomes. Furthermore, the presence of Bifidobacterium, along with other lactobacilli, was more abundant in the favorable group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Line Riis Jolving, Karin Erb, Bente Mertz Norgard, Jens Fedder, Michael Due Larsen
Summary: The Danish National Register of assisted reproductive technology (ART) provides comprehensive information on all ART procedures in Denmark since 2013, making it a valuable tool for monitoring and researching infertility treatment and reproductive topics. Researchers can access aggregated data on ART treatments annually through the Danish Health Data Authority's website and obtain individual pseudonomized data via secure servers for further analysis.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Tong Wu, Yangyang Wu, Jinfeng Yan, Jinjin Zhang, Shixuan Wang
Summary: Assisted reproductive technology aims to select high-quality reproductive cells and embryos for successful pregnancy. Microfluidic chips provide a powerful tool for functional evaluation, offering reduced size, precise control, and flexible extension.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Medicine, General & Internal
Miriam Cervan-Martin, Jose A. Castilla, Rogelio J. Palomino-Morales, F. David Carmona
JOURNAL OF CLINICAL MEDICINE
(2020)
Editorial Material
Obstetrics & Gynecology
Silke Dyer, Georgina M. Chambers, G. David Adamson, Manish Banker, Jacques De Mouzon, Osamu Ishihara, Markus Kupka, Ragaa Mansour, Fernando Zegers-Hochschild
REPRODUCTIVE BIOMEDICINE ONLINE
(2020)
Article
Obstetrics & Gynecology
Marta Molina, Alberto Yoldi, Purificacion Navas, Miguel Ganan, Angel Vaquero, Jose L. del Pico, Juan P. Ramirez, Jose A. Castilla
FERTILITY AND STERILITY
(2020)
Article
Obstetrics & Gynecology
Miriam Cervan-Martin, M. Irene Suazo-Sanchez, Rocio Rivera-Egea, Nicolas Garrido, Saturnino Lujan, Gema Romeu, Samuel Santos-Ribeiro, Jose A. Castilla, M. Carmen Gonzalvo, Ana Clavero, F. Javier Vicente, Vicente Maldonado, Miguel Burgos, Francisco J. Barrionuevo, Rafael Jimenez, Josvany Sanchez-Curbelo, Olga Lopez-Rodrigo, M. Fernanda Peraza, Iris Pereira-Caetano, Patricia I. Marques, Filipa Carvalho, Alberto Barros, Lluis Bassas, Susana Seixas, Joao Goncalves, Sara Larriba, Alexandra M. Lopes, Rogelio J. Palomino-Morales, F. David Carmona
FERTILITY AND STERILITY
(2020)
Article
Health Care Sciences & Services
Miriam Cervan-Martin, Lara Bossini-Castillo, Rocio Rivera-Egea, Nicolas Garrido, Saturnino Lujan, Gema Romeu, Samuel Santos-Ribeiro, Jose A. Castilla, M. Carmen Gonzalvo, Ana Clavero, F. Javier Vicente, Andrea Guzman-Jimenez, Claudia Costa, Ines Llinares-Burguet, Chiranan Khantham, Miguel Burgos, Francisco J. Barrionuevo, Rafael Jimenez, Josvany Sanchez-Curbelo, Olga Lopez-Rodrigo, M. Fernanda Peraza, Iris Pereira-Caetano, Patricia I. Marques, Filipa Carvalho, Alberto Barros, Lluis Bassas, Susana Seixas, Joao Goncalves, Sara Larriba, Alexandra M. Lopes, Rogelio J. Palomino-Morales, F. David Carmona
Summary: The study identified a significant difference in allele frequencies of USP8-rs7174015 between the NOA group, the control group, and the SO group, suggesting a possible association of this gene with male infertility. Other genetic associations were found for EPSTI1-rs12870438 and PSAT1-rs7867029 with SO, as well as TUSC1-rs10966811 with TESE success in the context of non-obstructive azoospermia.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Obstetrics & Gynecology
Nerea M. Molina, Alberto Sola-Leyva, Thor Haahr, Lusine Aghajanova, Piotr Laudanski, Jose Antonio Castilla, Signe Altmae
Summary: There is increasing evidence that the upper female genital tract is not sterile and has its own microbial communities. However, the role of endometrial microorganisms in reproductive functions is still not fully understood. Studying the endometrial microbiome presents challenges due to the low biomass, requiring well-designed experiments to avoid contamination risks from the lower genital tract. Recommendations for future studies include methodological considerations and good practice guidelines.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Manish Banker, Silke Dyer, Georgina M. Chambers, Osamu Ishihara, Markus Kupka, Jacques de Mouzon, Fernando Zegers-Hochschild, G. David Adamson
Summary: The report provides data on the utilization, effectiveness, and safety of assisted reproductive technology (ART) globally in 2013, showing an increase in ART cycles and changes in trends such as a rise in the proportion of older women undergoing non-donor ART. Further efforts are needed to improve the quality and consistency of reporting ART data by registries.
FERTILITY AND STERILITY
(2021)
Article
Andrology
Miriam Cervan-Martin, Lara Bossini-Castillo, Rocio Rivera-Egea, Nicolas Garrido, Saturnino Lujan, Gema Romeu, Samuel Santos-Ribeiro, Jose A. Castilla, Maria del Carmen Gonzalvo, Ana Clavero, Francisco Javier Vicente, Andrea Guzman-Jimenez, Miguel Burgos, Francisco Javier Barrionuevo, Rafael Jimenez, Josvany Sanchez-Curbelo, Olga Lopez-Rodrigo, Maria Fernanda Peraza, Iris Pereira-Caetano, Patricia Isabel Marques, Filipa Carvalho, Alberto Barros, Lluis Bassas, Susana Seixas, Joao Goncalves, Sara Larriba, Alexandra Manuel Lopes, Francisco David Carmona, Rogelio Jesus Palomino-Morales
Summary: The study analyzed the impact of 6 single-nucleotide polymorphisms associated with NOA in the Iberian population, and found three variants linked to different manifestations of SpF. These variations may influence the development of spermatogenic failure by affecting gene expression and lincRNA deregulation.
Article
Obstetrics & Gynecology
Georgina M. Chambers, Silke Dyer, Fernando Zegers-Hochschild, Jacques de Mouzon, Osamu Ishihara, Manish Banker, Ragaa Mansour, Markus S. Kupka, G. David Adamson
Summary: In 2014, 1.93 million ART cycles were performed in 76 countries, with trends showing increased success rates, frozen embryo transfer cycles, single embryo transfer, and preimplantation genetic testing. Utilization rates and effectiveness of ART continue to improve globally.
HUMAN REPRODUCTION
(2021)
Article
Health Care Sciences & Services
Miriam Cervan-Martin, Lara Bossini-Castillo, Andrea Guzman-Jimenez, Rocio Rivera-Egea, Nicolas Garrido, Saturnino Lujan, Gema Romeu, Samuel Santos-Ribeiro, Jose A. Castilla, M. Carmen Gonzalvo, Ana Clavero, F. Javier Vicente, Vicente Maldonado, Sara Gonzalez-Munoz, Inmaculada Rodriguez-Martin, Miguel Burgos, Rafael Jimenez, Maria Graca Pinto, Isabel Pereira, Joaquim Nunes, Josvany Sanchez-Curbelo, Olga Lopez-Rodrigo, Iris Pereira-Caetano, Patricia Isabel Marques, Filipa Carvalho, Alberto Barros, Lluis Bassas, Susana Seixas, Joao Goncalves, Sara Larriba, Alexandra M. Lopes, F. David Carmona, Rogelio J. Palomino-Morales
Summary: This study aimed to analyze the role of common genetic variants in the PIN1 gene locus in the genetic risk of male infertility. The study found that certain non-coding single-nucleotide polymorphisms in PIN1 were associated with the Sertoli cell-only syndrome in male infertility patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biology
Miriam Cervan-Martin, Frank Tuettelmann, Alexandra M. Lopes, Lara Bossini-Castillo, Rocio Rivera-Egea, Nicolas Garrido, Saturnino Lujan, Gema Romeu, Samuel Santos-Ribeiro, Jose A. Castilla, M. Carmen Gonzalvo, Ana Clavero, Vicente Maldonado, F. Javier Vicente, Sara Gonzalez-Munoz, Andrea Guzman-Jimenez, Miguel Burgos, Rafael Jimenez, Alberto Pacheco, Cristina Gonzalez, Susana Gomez, David Amoros, Jesus Aguilar, Fernando Quintana, Carlos Calhaz-Jorge, Ana Aguiar, Joaquim Nunes, Sandra Sousa, Isabel Pereira, Maria Graca Pinto, Sonia Correia, Josvany Sanchez-Curbelo, Olga Lopez-Rodrigo, Javier Martin, Iris Pereira-Caetano, Patricia I. Marques, Filipa Carvalho, Alberto Barros, Joerg Gromoll, Lluis Bassas, Susana Seixas, Joao Goncalves, Sara Larriba, Sabine Kliesch, Rogelio J. Palomino-Morales, F. David Carmona
Summary: This study identified two genomic regions associated with the most severe phenotype of spermatogenic failure through genome-wide association analysis. The findings suggest that unexplained spermatogenic failure may be influenced by common genetic variations in the genome and have an immune-mediated component.
COMMUNICATIONS BIOLOGY
(2022)
Meeting Abstract
Obstetrics & Gynecology
M. Cervan Martin, F. Tuttelmann, A. M. Lopes, L. Bossini-Castillo, N. Garrido, S. Lujan, J. A. Castilla, S. G. Azoonomic, J. Gromoll, S. Seixas, J. Goncalves, S. Larriba, S. Kliesch, R. J. Palomino-Morales, F. D. Carmona
HUMAN REPRODUCTION
(2021)
Meeting Abstract
Obstetrics & Gynecology
D. Mataro, I. Cuevas-Saiz, J. A. Castilla, J. A. Dominguez, N. Prados, B. Buch, B. Gonzalez Lopez de Bustamante, F. J. Prados, M. Ruiz-Jorro, J. L. Gomez, L. De la Fuente, M. Devesa, M. Munoz-Cantero, C. Pardos, L. Martinez
HUMAN REPRODUCTION
(2021)
Meeting Abstract
Obstetrics & Gynecology
M. Molin Romero, A. Yoldi, M. Ganan, P. Navas, J. L. De Pico, A. Vaquero, P. D. L. Fuente, J. P. Ramirez, J. A. Castilla
HUMAN REPRODUCTION
(2021)
Meeting Abstract
Obstetrics & Gynecology
N. M. Molina, A. Sola-Leyva, I. Perez-Prieto, E. Vargas, M. Molina, A. Yoldi, A. Vaquero, P. Navas, A. Clavero-Gilabert, M. C. Gonzalvo-Lopez, N. Morales, J. P. Ramirez, J. A. Castilla, C. M. Aguilera, S. Altmae
HUMAN REPRODUCTION
(2021)