Article
Oncology
Li Zhang, Liping Luo, Qiaoyun Zheng, Wenfeng Wang, Zhongyang Huang, Jianda Hu, Yingyu Chen
Summary: The study found that E35 has the potential to inhibit the proliferation of AML cells and induce autophagy and apoptosis. The combination of E35 with an autophagy inhibitor showed enhanced efficacy in AML treatment.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Chemistry, Medicinal
Hongxia Ma, Yang Liu, Zhen Miao, Shijia Cheng, Yunan Zhu, Yifan Wu, Xinxin Fan, Jing Yang, Xingang Li, Liyin Guo
Summary: Neratinib is able to suppress the progression of AML by promoting cell ferroptosis and autophagy, inhibiting cell proliferation, and promoting apoptosis.
DRUG DEVELOPMENT RESEARCH
(2022)
Review
Cell Biology
Wenxin Du, Aixiao Xu, Yunpeng Huang, Ji Cao, Hong Zhu, Bo Yang, Xuejing Shao, Qiaojun He, Meidan Ying
Summary: Autophagy plays a crucial role in the development of AML, with studies indicating the potential of modulating autophagy to enhance targeted therapy for AML.
Article
Cell Biology
Marc Garcia-Montolio, Cecilia Ballare, Enrique Blanco, Arantxa Gutierrez, Sergi Aranda, Antonio Gomez, Chung H. Kok, David T. Yeung, Timothy P. Hughes, Pedro Vizan, Luciano Di Croce
Summary: Polycomb group proteins, including PHF19, play important roles in regulating cell fate determination and could be potential therapeutic targets for myeloid leukemia treatment. PHF19 depletion reduces cell proliferation and promotes leukemia cell differentiation, with its homolog MTF2 partially compensating for its effects in specific gene targets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Wonhyoung Seo, Prashanta Silwal, Ik-Chan Song, Eun-Kyeong Jo
Summary: In this review, the multifaceted functions of autophagy in AML were discussed, including its link to genetic alterations, potential prognostic predictors, and drivers of AML tumorigenesis. The crosstalk between autophagy and tumor cell metabolism and its impact on AML progression and treatment were also examined. Additionally, the potential therapeutics for AML, such as autophagy regulators, were described, along with their translation into clinical practice.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Kyu-Won Cho, Mark Andrade, Seongho Bae, Sangsung Kim, Jin Eyun Kim, Er Yearn Jang, Sangho Lee, Ahsan Husain, Roy L. Sutliff, John W. Calvert, Changwon Park, Young-sup Yoon
Summary: The study reveals that CBX7 plays a crucial role in regulating cardiomyocyte proliferation and cardiac regeneration, suggesting that CBX7 could be a potential target for cardiac regeneration.
Article
Oncology
Shuming Chen, He Li, Siyu Chen, Bing Wang, Kaixiang Zhang
Summary: This study found that COPZ1 is upregulated in breast cancer and is associated with poor prognosis. BMI1 can activate COPZ1 and promote proliferation while inhibiting autophagy in breast cancer cells. These findings provide a preliminary theoretical basis for the role of COPZ1 in autophagy in breast cancer cells.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yang-Liu Song, Ming-Hui Yang, Si Zhang, Hao Wang, Kun-Lun Kai, Chun-Xia Yao, Fei-Fei Dai, Meng-Jiao Zhou, Jin-Biao Li, Zhi-Ru Wei, Zhongnan Yin, Wei-Guo Zhu, Lixiang Xue, Ming-Xi Zang
Summary: This study reveals that GATA-4 acts as a molecular switch for the regulation of miR-29a expression. It recruits polycomb group proteins like EZH2 to negatively regulate miR-29a in undifferentiated C2C12 myoblast cells. In poorly differentiated rhabdomyosarcoma cells, EZH2 still binds to the miR-29a promoter with GATA-4 to mediate transcriptional repression of miR-29a. However, during re-differentiation of rhabdomyosarcoma cells, EZH2 is displaced from the miR-29a promoter, leading to the activation of miR-29a and promoting myogenic differentiation.
Article
Cell Biology
Adrien Grenier, Laury Poulain, Johanna Mondesir, Arnaud Jacquel, Claudie Bosc, Lucille Stuani, Sarah Mouche, Clement Larrue, Ambrine Sahal, Rudy Birsen, Victoria Ghesquier, Justine Decroocq, Fetta Mazed, Mireille Lambert, Mamy Andrianteranagna, Benoit Viollet, Patrick Auberger, Andrew A. Lane, Pierre Sujobert, Didier Bouscary, Jean-Emmanuel Sarry, Jerome Tamburini
Summary: AMPK activation in AML cells triggers the unfolded protein response, leading to repression of oxidative phosphorylation, TCA cycle, and pyrimidine biosynthesis, as well as enhanced mitochondrial apoptotic signaling. Combination therapy with the AMPK activator GSK621 and the Bcl-2 inhibitor venetoclax shows synergistic effects, suggesting therapeutic potential in AML.
Article
Cell Biology
Angela Ianniciello, G. Vignir Helgason
Summary: Minimal residual disease (MRD) is the main cause of relapse in solid cancers and leukemias. In chronic myeloid leukemia (CML), autophagy plays a crucial role in maintaining the survival of drug resistant leukemic stem cells. Inhibition of autophagy-initiating kinase ULK1 could lead to stress-induced differentiation of leukemic stem cells, making them sensitive to drug treatment, providing a promising strategy for selective eradication of leukemic stem cells in CML patients.
Article
Immunology
Huabin Zhu, John D. Klement, Chunwan Lu, Priscilla S. Redd, Dafeng Yang, Alyssa D. Smith, Dakota B. Poschel, Juan Zou, Ding Liu, Peng George Wang, David Ostrov, Nicolas Coant, Yusuf A. Hannun, Aaron H. Colby, Mark W. Grinstaff, Kebin Liu
Summary: MDSCs are immune suppressive cells that accumulate in pathological conditions to suppress T cell immune response. ASAH2 is highly expressed in tumor-infiltrating MDSCs and acts as a survival factor, targeting ASAH2 can induce MDSC ferroptosis to suppress MDSC accumulation in cancer immunotherapy.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Oncology
You Jiang, Shui-Yan Wu, Yan-Ling Chen, Zi-Mu Zhang, Yan-Fang Tao, Yi Xie, Xin-Mei Liao, Xiao-Lu Li, Gen Li, Di Wu, Hai-Rong Wang, Ran Zuo, Hai-Bo Cao, Jing-Jing Pan, Juan-Juan Yu, Si-Qi Jia, Zheng Zhang, Xin-Ran Chu, Yong-Ping Zhang, Chen-xi Feng, Jian-Wei Wang, Shao-Yan Hu, Zhi-Heng Li, Jian Pan, Fang Fang, Jun Lu
Summary: This study systematically explored the molecular characteristics of CEBPG in AML and identified CEBPG as a potential therapeutic target for AML patients. It was found that CEBPG promotes AML cell proliferation by activating EIF4EBP1, thus contributing to the progression of AML.
CANCER CELL INTERNATIONAL
(2021)
Article
Chemistry, Physical
Wei Guo, Xing Liu, Lianjie Ye, Jie Liu, Kollie Larwubah, Ge Meng, Weiqiang Shen, Xiangxian Ying, Jun Zhu, Shengjie Yang, Jianjun Guo, Yanrong Jia, Meilan Yu
Summary: Hydroxylated fullerene C-60(OH)(n) (n = 18-22) has both growth-promoting and inhibitory effects on leukemia cells, with high concentrations leading to cell death.
Article
Cell Biology
Youping Wang, Chi Pan, Xia Zhang, Aiqi Zhao, Ying Dong
Summary: RASGRP3 is identified as a proto-oncogene in NPM1-mutated acute myeloid leukemia and may serve as a promising therapeutic target for NPM1 mutation-driven acute myeloid leukemia.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Review
Oncology
Sreoshee Rafiq, Sharon L. McKenna, Sylviane Muller, Mario P. Tschan, Magali Humbert
Summary: Lysosomes, traditionally known for degrading cellular macromolecules, have emerged as crucial regulators of cell homeostasis. Their involvement in cellular trafficking, nutrient signaling, energy metabolism, and immune regulation has sparked interest in targeting lysosomes for novel disease treatments, particularly cancer. This review highlights the diverse functions of lysosomes and their importance in malignant disease, with a focus on potential targeting strategies in acute myeloid leukemia (AML).
Review
Biochemistry & Molecular Biology
Jennifer E. Adair, Lindsay Androski, Lois Bayigga, Deus Bazira, Eugene Brandon, Lynda Dee, Steven Deeks, Mohammed Draz, Karine Dube, Mark Dybul, Umut Gurkan, Evelyn Harlow, Cissy Kityo, Michael Louella, Punam Malik, Vikram Mathews, Adrian McKemey, Henry Mugerwa, Daniel Muyanja, Olabimpe Olayiwola, Rimas J. Orentas, Alex Popovski, Jeff Sheehy, Francis Ssali, Moses Supercharger Nsubuga, John F. Tisdale, Els Verhoeyen, Boro Dropulic
Summary: The gene and cell therapy field has seen significant growth, but there is a geographical exclusion of low- and middle-income countries. To address this, the Global Gene Therapy Initiative aims to introduce clinical trials in Uganda and India.
Article
Hematology
Kensuke Sasaki, Takuji Yamauchi, Yuichiro Semba, Jumpei Nogami, Hiroshi Imanaga, Tatsuya Terasaki, Fumihiko Nakao, Koshi Akahane, Takeshi Inukai, Els Verhoeyen, Koichi Akashi, Takahiro Maeda
Summary: This study identified molecules/pathways relevant for IgH-CRLF2-r ALL pathogenesis and found that CRKL and RAS signaling are critical for cell fitness and ruxolitinib sensitivity. The pan-tyrosine kinase inhibitor gilteritinib effectively killed RAS wild-type IgH-CRLF2-r ALL cells, either alone or combined with ruxolitinib. Combining gilteritinib with the MEK1/2 inhibitor trametinib is an effective means to target IgH-CRLF2-r ALL cells regardless of RAS mutational status.
Correction
Biochemistry & Molecular Biology
Jennifer E. Adair, Lindsay Androski, Lois Bayigga, Deus Bazira, Eugene Brandon, Lynda Dee, Steven Deeks, Mohamed Draz, Karine Dube, Mark Dybul, Umut Gurkan, Evelyn Harlow, Cissy Kityo, Michael Louella, Punam Malik, Vikram Mathews, Adrian McKemey, Henry Mugerwa, Daniel Muyanja, Olabimpe Olayiwola, Rimas J. Orentas, Alex Popovski, Jeff Sheehy, Francis Ssali, Moses Supercharger Nsubuga, John F. Tisdale, Els Verhoeyen, Boro Dropulic
Article
Dermatology
Laura Sormani, Henri Montaudie, Lauriane Blot, Marjorie Heim, Nathalie Cardot Leccia, Rana Mhaidly, Els Verhoeyen, Claire Regazzetti, Nicolas Nottet, Yann Cheli, Gian Marco De Donatis, Anne Sophie Dabert Gay, Delphine Debayle, Helene Taquin Martin, Franck Gesbert, Stephane Rocchi, Meri K. Tulic, Thierry Passeron
Summary: Pigmentation of human skin is regulated by multiple genes, and this study reveals the importance of CLEC12B gene in melanocytes and its regulatory mechanism. CLEC12B activates SHP1 and SHP2 proteins, leading to the degradation of CRE-binding protein, ultimately controlling melanin production and pigmentation.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Friederike Knipping, Gregory A. Newby, Cindy R. Eide, Amber N. McElroy, Sarah C. Nielsen, Kyle Smith, Yongxing Fang, Tatjana Cornu, Caroline Costa, Alejandra Gutierrez-Guerrero, Samuel P. Bingea, Colby J. Feser, Benjamin Steinbeck, Keli L. Hippen, Bruce R. Blazar, Anton McCaffrey, Claudio Mussolino, Els Verhoeyen, Jakub Tolar, David R. Liu, Mark J. Osborn
Summary: The disruption of CCR5 and CXCR4 co-receptors using base editing techniques has been shown to protect CD4(+) T cells from HIV-1 infection. The base editing strategies effectively introduce targeted mutations to inactivate the genes without causing double stranded DNA breaks. This study demonstrates the potential of base-editing strategies in preventing viral transduction and maintaining cellular functionality.
Article
Multidisciplinary Sciences
Raphael Bonnet, Lee Mariault, Jean-Francois Peyron
Summary: Drug repurposing is an interesting strategy for addressing the COVID-19 pandemic. Using a bioinformatic resource, we identified several drugs whose gene expression profiles negatively correlated with SARS-COV-2, suggesting their potential to counteract the virus's harmful effects. These findings provide a first step in developing repositioning strategies for treating SARS-COV-2.
Article
Oncology
Sylvain Garciaz, Andrew A. Guirguis, Sebastian Muller, Fiona C. Brown, Yih-Chih Chan, Ali Motazediani, Caitlin L. Rowe, James A. Kuzich, Kah Lok Chan, Kevin Tran, Lorey Smith, Laura MacPherson, Brian Liddicoat, Enid Y. N. Lam, Tatiana Caneque, Marian L. Burr, Veronique Litalien, Giovanna Pomilio, Mathilde Poplineau, Estelle Duprez, Sarah-Jane Dawson, Georg Ramm, Andrew G. Cox, Kristin K. Brown, David C. S. Huang, Andrew H. Wei, Kate McArthur, Raphael Rodriguez, Mark A. Dawson
Summary: Ironomycin is a drug that disrupts mitochondrial metabolism and induces cell death in cancer cells by reducing mitochondrial iron load and activating BAX/BAK. It exhibits synergy with BH3 mimetics and overcomes venetoclax resistance in cancers such as acute myeloid leukemia.
Article
Materials Science, Biomaterials
Thibault Voeltzel, Gaelle Fossard, Michael Degaud, Kevin Geistlich, Nicolas Gadot, Sandrine Jeanpierre, Ivan Mikaelian, Marie Brevet, Adrienne Anginot, Marie-Caroline Le Bousse-Kerdiles, Valerie Trichet, Sylvain Lefort, Veronique Maguer-Satta
Summary: We have developed a simple and highly reproducible three-dimensional model that accurately mimics the structure and function of human bone marrow, allowing histological analysis and functional assays on collected cells.
BIOMATERIALS SCIENCE
(2022)
Article
Endocrinology & Metabolism
Anne Trinh, Raeeka Khamari, Quentin Fovez, Francois-Xavier Mahon, Beatrice Turcq, Didier Bouscary, Patrice Maboudou, Marie Joncquel, Valerie Coiteux, Nicolas Germain, William Laine, Salim Dekiouk, Sandrine Jean-Pierre, Veronique Maguer-Satta, Bart Ghesquiere, Thierry Idziorek, Bruno Quesnel, Jerome Kluza, Philippe Marchetti
Summary: The study revealed that despite the suppression of glycolysis by TKI, glutamine-dependent mitochondrial oxidation supported the survival of CML cells. Inhibiting glutamine metabolism with L-Asparaginases made CML cells more susceptible to TKI and induced apoptosis, improving efficacy. Targeting glutamine metabolism with Kidrolase in combination with glycolysis-suppressing TKI is an effective therapeutic strategy for eradicating stem-like CML cells.
MOLECULAR METABOLISM
(2022)
Review
Cell Biology
Leonard Herault, Mathilde Poplineau, Elisabeth Remy, Estelle Duprez
Summary: Single-cell transcriptomic technologies are crucial in uncovering cellular heterogeneity and understanding the deregulation of hematopoietic stem cells (HSC) during aging. This review highlights the importance of bioinformatics tools and mathematical modeling in analyzing complex datasets and predicting HSC behavior in interconnected networks.
Article
Oncology
Fabien Muselli, Lucas Mourgues, Nathalie Rochet, Marielle Nebout, Agnes Guerci, Els Verhoeyen, Adrien Krug, Laurence Legros, Jean-Francois Peyron, Didier Mary
Summary: Over the past two decades, three generations of Tyrosine Kinase Inhibitors (TKIs) have been developed to target the BCR::ABL1 oncoprotein to successfully treat chronic myeloid leukemia (CML). However, the daily administration of TKIs cannot be stopped to maintain a definitive remission state, resulting in unwanted side effects in the long term. New pharmacological approaches, such as the combination of bis-biguanides and TKIs, have been proposed to improve the sensitivity of TKI-insensitive leukemic stem cells (LSCs).
Article
Oncology
Emmanuel Griessinger, Diego Pereira-Martins, Marielle Nebout, Claudie Bosc, Estelle Saland, Emiline Boet, Ambrine Sahal, Johanna Chiche, Delphine Debayle, Lucile Fleuriot, Maurien Pruis, Veronique De Mas, Francois Vergez, Christian Recher, Gerwin Huls, Jean-Emmanuel Sarry, Jan Jacob Schuringa, Jean-Francois Peyron
Summary: Dependency on mitochondrial oxidative phosphorylation (OxPhos) is a potential weakness for leukemic stem cells (LSC) that can be exploited for therapeutic purposes. Fatty acid oxidation (FAO) is a crucial OxPhos-fueling catabolic pathway for some acute myeloid leukemia (AML) cells, particularly chemotherapy-resistant AML cells. Cold sensitivity at 4℃ can selectively kill AML LSCs with active FAO supported OxPhos while sparing normal hematopoietic stem cells.
Review
Biochemistry & Molecular Biology
Irene Barguilla, Veronique Maguer-Satta, Boris Guyot, Susana Pastor, Ricard Marcos, Alba Hernandez
Summary: One important environmental/health challenge is to determine the potential carcinogenic risk associated with environmental agents/exposures. Long-term trials with rodents are inefficient when testing thousands of agents, so a battery of assays covering most of the hallmarks of the carcinogenesis process is proposed. This structured battery could be useful for in vitro studies using human cell lines to detect potential carcinogenic risks of environmental agents/exposures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Biotechnology & Applied Microbiology
Denise Klatt, Adele Mucci, Chi Y. Zhang, Kayla E. Wright, Susanne Wolf, Axel Schambach, Els Verhoeyen, David A. Williams, Christian Brendel
