Review
Biochemistry & Molecular Biology
Samuel Gebremedhn, Asghar Ali, Munir Hossain, Michael Hoelker, Dessie Salilew-Wondim, Russell V. Anthony, Dawit Tesfaye
Summary: Mammalian reproductive health is crucial for the entire reproductive cycle, with various factors contributing to reproductive health problems. Studies have shown that miRNAs play a significant role in gene regulation and are associated with pathophysiological conditions, either intracellularly or extracellularly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Christopher Arkfeld, Eric Han, Reshef Tal, David B. Seifer
Summary: This study investigated the association between AMH levels and miscarriage rates in ART cycles. The results showed that AMH levels were not associated with increased miscarriage rates overall, but there was a significant difference in non-PCOS patients with AMH < 1 ng/ml. The findings suggest that AMH < 1 ng/mL can be an independent predictor of increased miscarriage rate in non-PCOS infertility patients.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mauro S. B. Silva, Paolo Giacobini
Summary: Research on the physiological actions of anti-Mullerian hormone (AMH) has expanded beyond its classical role in male sexual differentiation to include regulation of ovarian function, clinical use in reproductive health, and its potential as a biomarker for polycystic ovary syndrome (PCOS). Recent studies have shown that AMH can have effects throughout the Hypothalamic-Pituitary-Gonadal (HPG) axis, providing new insights into reproductive disorders and potentially contributing to the pathophysiology of diseases such as PCOS.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Endocrinology & Metabolism
Zhuoyao Mai, Manlin Liu, Ping Pan, Lin Li, Jia Huang, Xiaoli Chen, Dongzi Yang
Summary: This study found that women with PCOS aged 35 years and older had a higher cumulative live birth rate over two years of IVF/ICSI cycles compared with age- and BMI-matched controls. Factors such as the number of transferable embryos and antral follicle counts were significant predictors of cumulative live birth.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Medicine, General & Internal
Honghao Sun, Jiao Jiao, Feng Tian, Qing Liu, Jiansu Bian, Rongmin Xu, Da Li, Xiuxia Wang, Hong Shu
Summary: This study found that inflammatory bowel disease (IBD) may reduce ovarian reserve in reproductive age women, and in vitro fertilization (IVF) treatment may improve pregnancy outcomes in IBD patients with impaired fertility.
Review
Biochemical Research Methods
Vasiliki Kanaka, Petros Drakakis, Dimitrios Loutradis, George Th. Tsangaris
Summary: Proteomics plays a significant role in studying female fertility and infertility, providing insights for diagnosis, prognosis, and prediction of infertility. By studying the proteins in oocytes, endometrial environment, and fertility biomarkers following IVF, success rates of IVF can be improved.
EXPERT REVIEW OF PROTEOMICS
(2023)
Review
Oncology
Giulia Sgueglia, Salvatore Longobardi, Domenico Valerio, Maria Rosaria Campitiello, Nicola Colacurci, Cinzia Di Pietro, Rosalia Battaglia, Thomas D'Hooghe, Lucia Altucci, Carmela Dell'Aversana
Summary: The decline in fertility rates and increasing age of reproductive individuals are contributing factors to low clinical pregnancy rates in industrialized countries. Epigenetic modifications play a crucial role in embryonic development during in vitro fertilization (IVF) protocols in women. This article discusses the main epigenetic mechanisms that can impact female reproduction and potentially affect the success of IVF.
CLINICAL EPIGENETICS
(2023)
Article
Obstetrics & Gynecology
Marlise N. Gunning, Jacob P. Christ, Bas B. van Rijn, Maria P. H. Koster, Gouke J. Bonsel, Joop S. E. Laven, Marinus J. C. Eijkemans, Bart C. J. M. Fauser
Summary: This prospective cohort follow-up study aimed to identify patient features that predict the time to pregnancy leading to term live birth in infertile women diagnosed with polycystic ovary syndrome (PCOS). The results showed that race, smoking, BMI, insulin, total testosterone, and SHBG concentrations were associated with the chance of pregnancy.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Biochemistry & Molecular Biology
Dawood Khan, Opeolu O. Ojo, Orla R. M. Woodward, Jo Edward Lewis, Ananyaa Sridhar, Fiona M. Gribble, Frank Reimann, Peter R. Flatt, R. Charlotte Moffett
Summary: This study evaluated the role of glucose-dependent-insulinotropic-polypeptide (GIP) and glucagon-like-peptide-1 (GLP-1) in reproductive function. The results showed that deletion of GIPR and GLP-1R genes led to reproductive dysfunction and reduced fertility in mice.
Article
Obstetrics & Gynecology
E. Elenis, E. Desroziers, S. Persson, I. Sundstrom Poromaa, R. E. Campbell
Summary: Early initiation of anti-androgen treatment is associated with an increased probability of childbirth after spontaneous conception among women with PCOS.
HUMAN REPRODUCTION
(2021)
Article
Nutrition & Dietetics
Caterina Meneghini, Claudia Bianco, Francesco Galanti, Valentina Tamburelli, Alessandro Dal Lago, Emanuele Licata, Mariagrazia Gallo, Cristina Fabiani, Roberta Corno, Donatella Miriello, Rocco Rago
Summary: Polycystic ovary syndrome (PCOS) patients can improve weight, hormonal, and metabolic parameters by adopting a very-low-calorie ketogenic diet (VLCKD) or Mediterranean diet (MD). VLCKD has better effects on BMI, body circumference, and hormone index compared to MD, and can reduce the risk of ovarian hyperstimulation syndrome (OHSS).
Article
Cell Biology
Siva Prasad Panda, Adarsh Kesharwani, Gaurav Deep Singh, D. S. N. B. K. Prasanth, Bhaskara Raju Vatchavai, P. V. Kamala Kumari, Sunil Kumar Panda, Sarada Prasanna Mallick
Summary: The interaction of KISS1/KISS1R in the hypothalamus plays a regulatory role in the reproductive stage, and its decrease with ageing may lead to dysfunction. KNDy neurons are crucial for the release of GnRH and neuroendocrine function.
AGEING RESEARCH REVIEWS
(2023)
Editorial Material
Obstetrics & Gynecology
Mykola Gryshchenko, Valentyn Parashchuk, Christophe Blockeel
Summary: The Russian attack on Ukraine and the subsequent war have had a significant impact on reproductive medicine, leading to changes in service availability and quality and posing challenges for healthcare providers and patients. IVF clinics are facing challenges in safeguarding cryopreserved embryos and reproductive cells, necessitating measures to ensure facility safety, continuity of operations, and ethical and legal dilemmas related to patients' reproductive material.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Endocrinology & Metabolism
Haroon Latif Khan, Shahzad Bhatti, Sana Abbas, Celal Kaloglu, Ahmed M. Isa, Hooria Younas, Rachel Ziders, Yousaf Latif Khan, Zahira Hassan, Bilgun Ozturk Turhan, Aysegul Yildiz, Hikmet Hakan Aydin, Ender Yalcinkaya Kalyan
Summary: The study demonstrated the differential expression of miR-7-5p, miR-378-3p, miR-224, and miR-212-3p in normo-androgenic PCOS patients compared to NOR patients, while miRNA-320a showed significance in predicting embryo quality.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Stephanie C. Bohaczuk, Varykina G. Thackray, Jia Shen, Dorota Skowronska-Krawczyk, Pamela L. Mellon
Summary: This study identified a novel upstream regulator of FSHB transcription and indicated that rs11031006 can modulate FSH levels.
Letter
Obstetrics & Gynecology
Heidi Tiller, Peter Fedorcsak, Bjorn R. Skogen
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2016)
Article
Obstetrics & Gynecology
Miriam Landfors, Sigve Nakken, Markus Fusser, John-Arne Dahl, Arne Klungland, Peter Fedorcsak
FERTILITY AND STERILITY
(2016)
Article
Obstetrics & Gynecology
Inger Sundstrom Poromaa, Jan Roar Mellembakken, Laure Morin Papunen, Terhi Piltonen, Johanna Puurunen, Juha S. Tapanainen, Elisabet Stener-Victorin, Angelica Linden Hirschberg, Eszter Vanky, Pernille Ravn, Dorte Glintborg, Marianne Andersen
HUMAN REPRODUCTION
(2016)
Article
Obstetrics & Gynecology
Hilde Jorgensen, Abby S. Hill, Michael T. Beste, Manu P. Kumar, Evan Chiswick, Peter Fedorcsak, Keith B. Isaacson, Douglas A. Lauffenburger, Linda G. Griffith, Erik Qvigstad
FERTILITY AND STERILITY
(2017)
Article
Obstetrics & Gynecology
Pekka Pinola, Katri Puukka, Terhi T. Piltonen, Johanna Puurunen, Eszter Vanky, Inger Sundstrom-Poromaa, Elisabet Stener-Victorin, Angelica Linden Hirschberg, Pernille Ravn, Marianne Skovsager Andersen, Dorte Glintborg, Jan Roar Mellembakken, Aimo Ruokonen, Juha S. Tapanainen, Laure C. Morin-Papunen
FERTILITY AND STERILITY
(2017)
Correction
Obstetrics & Gynecology
Inger Sundstrom Poromaa, Jan Roar Mellembakken, Laure Morin-Papunen, Terhi Piltonen, Johanna Puurenen, Juha Tapanainen, Elisabet Stener-Victorin, Angelica Lindn Hirschberg, Eszter Vanky, Pernille Ravn, Dorte Glintborg, Marianne Andersen
HUMAN REPRODUCTION
(2017)
Article
Obstetrics & Gynecology
Rasa Pelanis, Jan Roar Mellembakken, Inger Sundstr MPoromaa, Pernille Ravn, Laure Morin-Papunen, Juha S. Tapanainen, Terhi Piltonen, Johanna Puurunen, Angelica Linden Hirschberg, Peter Fedorcsak, Marianne Andersen, Dorte Glintborg
HUMAN REPRODUCTION
(2017)
Article
Biochemical Research Methods
Arne Klungland, John Arne Dahl, Gareth Greggains, Peter Fedorcsak, Adam Filipczyk
Article
Cell Biology
Miriam Landfors, Jostein Johansen, Jan Magnus Aronsen, Cathrine Broberg Vagbo, Louis C. Dore, Chuan He, Ivar Sjaastad, Pal Saetrom, Peter Fedorcsak, John Arne Dahl, Havard Aanes, Markus Fusser, Arne Klungland
Review
Obstetrics & Gynecology
Tom Tanbo, Jan Mellembakken, Sverre Bjercke, Eva Ring, Thomas Abyholm, Peter Fedorcsak
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2018)
Letter
Obstetrics & Gynecology
Tom Tanbo, Jan Mellembakken, Sverre Bjercke, Eva Ring, Thomas Abyholm, Peter Fedorcsak
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2019)
Review
Obstetrics & Gynecology
Tom G. Tanbo, Peter Z. Fedorcsak
Summary: Despite the increase in mean menopausal age over the last century, there is significant individual variation in natural menopause age. Women are now able to choose when to have children due to efficient contraception methods, leading to a significant increase in age at first birth. Fertility declines long before menopause, making it important but difficult to predict when a woman will enter menopause.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Obstetrics & Gynecology
Jessica L. Chan, Sujata Kar, Eszter Vanky, Laure Morin-Papunen, Terhi Piltonen, Johanna Puurunen, Juha S. Tapanainen, Gustavo Arantes Rosa Maciel, Sylvia Asaka Yamashita Hayashida, Jose Maria Soares, Edmund Chada Baracat, Jan Roar Mellembakken, Anuja Dokras
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2017)
Review
Obstetrics & Gynecology
Tom Tanbo, Peter Fedorcsak
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2017)