Review
Biochemistry & Molecular Biology
Nathalie di Clemente, Chrystele Racine, Rodolfo A. Rey
Summary: This article reviews the main findings on anti-Mullerian hormone (AMH) and its involvement in the pathogenesis of polycystic ovary syndrome (PCOS) and its male equivalent. AMH has important roles in ovarian reserve, follicular development, and the differentiation of the genital tract. It is also used to assess Sertoli cell function in children and has potential implications for male fertility.
Article
Obstetrics & Gynecology
Kiper Aslan, Ozge Albayrak, Aylin Orhaner, Isil Kasapoglu, Gurkan Uncu
Summary: This study found that the frequency of uterine cavity abnormalities is significantly higher in PCOS patients compared to the healthy population.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Mojgan Javedani Masroor, Hossein Sheybani, Shiva Sheybani, Nastaran Abolghasem
Summary: After laparoscopic ovarian drilling (LOD) in patients with PCOS, the mean AMH level decreases significantly and the menstrual cycle distribution changes significantly, but these variables do not affect the pregnancy rate.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Fisun Vural, Birol Vural, Eyupcan Kardas, Ayse Deniz Erturk Coskun, Irem Yildirim
Summary: This study investigated the utilization of Anti-Mullerian hormone (AMH) alone or replacing polycystic ovarian morphology (PCOM) in the PCOS diagnostic criteria. The results showed that AMH can be used with high diagnostic accuracy instead of PCOM in Rotterdam criteria, especially for phenotype A and D.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Endocrinology & Metabolism
Klara Beitl, Didier Dewailly, Rudolf Seemann, Marlene Hager, Jakob Buenker, Daniel Mayrhofer, Iris Holzer, Johannes Ott
Summary: Polycystic ovary syndrome (PCOS) and functional hypothalamic amenorrhea (FHA) are the two most frequent causes of secondary amenorrhea, and distinguishing between them remains challenging. A retrospective case-control study found significant differences in hormone levels and protein binding globulin between PCOS-D patients and FHA-PCOM patients. The authors proposed a model including serological parameters as a reliable tool to distinguish between the two conditions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Alexandra Dietz de Loos, Martin Hund, Katharina Buck, Cindy Meun, Johanna Sillman, Joop S. E. Laven
Summary: The study aimed to determine a cutoff for the Elecsys AMH Plus immunoassay to aid in PCOM diagnosis. The results showed that a cutoff of 3.2 ng/mL (23 pmol/L) demonstrated high sensitivity and specificity for PCOM diagnosis, with consistent performance across different ages and PCOS phenotypes.
FERTILITY AND STERILITY
(2021)
Article
Reproductive Biology
Yijie Chen, Miao Deng, Zhaojing Chen, Shuyang Han, Jun Chen, Hongyan Zhang, Qianwen Wang, Xuejing Jin, Wenhua Liu, Zhifen Zhang
Summary: This study found a significant positive correlation between serum INSL5 levels and AMH levels in women with PCOS. After adjusting for other factors, AMH levels remained significantly associated with INSL5 levels. The diagnostic value of AMH was better than that of INSL5.
JOURNAL OF OVARIAN RESEARCH
(2022)
Review
Medicine, General & Internal
Mala S. Sivanandy, Sierra K. Ha
Summary: Polycystic ovary syndrome (PCOS) is an endocrinological disorder with significant implications for women's reproductive, metabolic, and psychological health. The lack of a specific diagnostic test poses challenges in diagnosing PCOS, resulting in underdiagnosis and undertreatment. Anti-Mullerian hormone (AMH) appears to be a promising diagnostic marker for PCOS, with elevated levels correlating highly with PCOS features such as polycystic ovarian morphology, hyperandrogenism, and oligo/amenorrhea.
Review
Endocrinology & Metabolism
Begum Aydogan Mathyk, Esra Cetin, Bulent O. Yildiz
Summary: This review focuses on the role of anti-Mullerian hormone in ovulatory dysfunction in polycystic ovarian syndrome, highlighting the impact of AMH levels on PCOS and the significance of standardizing serum AMH measurements.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
(2022)
Article
Endocrinology & Metabolism
Josefin Kataoka, Ingrid Larsson, Eva Lindgren, Li Oskarson Kindstrand, Johanna Schmidt, Elisabet Stener-Victorin
Summary: The study investigated the circulating AMH levels in women with severe obesity and PCOS, as well as the effect of a one-year VLED weight loss program on AMH levels. The results showed that women with PCOS had higher AMH levels, but it couldn't accurately differentiate between women with PCOS and severe obesity. Additionally, significant weight loss did not impact AMH levels.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yu Ran, Qiang Yi, Cong Li
Summary: The study found that AMH levels were higher in PCOS patients compared to controls, with no difference in subgroups of PCOS patients under 30 years old. AMH levels in the PCOM subgroup were significantly higher than those in the HA subgroup, suggesting a strong relationship between AMH and PCOM but not with HA.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Environmental Sciences
Richelle Bjorvang, Jasmin Hassan, Maria Stefopoulou, Kristina Gemzell-Danielsson, Matteo Pedrelli, Hannu Kiviranta, Panu Rantakokko, Paivi Ruokojarvi, Christian H. Lindh, Ganesh Acharya, Pauliina Damdimopoulou
Summary: Chemical exposure among pregnant women may impact the size of ovarian reserve. Serum AMH levels, as a surrogate marker of ovarian reserve, correlates with follicular density, while certain chemicals are associated with decreased non-growing follicle densities.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Aysegul Mut, Cemal Tamer Erel, Deniz Inan, Yahya Ozgun Oner
Summary: Serum kisspeptin levels were similar in women with and without PCOS, but positively correlated with AMH levels in PCOS women. Additionally, serum LH, AMH, DHEA-S, total testosterone, glucose, insulin levels, and HOMA-IR values were significantly higher in women with PCOS compared to controls.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Mirte R. Caanen, Henrike E. Peters, Peter M. van de Ven, Anne M. F. M. Juttner, Joop S. E. Laven, Marcel H. A. van Hooff, Cornelis B. Lambalk
Summary: The study found that higher AMH levels in adolescence were associated with a higher risk of developing PCOS in adulthood for girls with oligomenorrhea. However, adolescent AMH levels alone or in combination with menstrual irregularities were not effective in predicting adult PCOS, and therefore routine use in clinical practice is not recommended.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Kai-Lun Hu, Kwanghann Gan, Yue Ying, Junyan Zheng, Ruixue Chen, Jinglei Xue, Yiqing Wu, Yifeng Liu, Yimin Zhu, Lanfeng Xing, Dan Zhang
Summary: The study found a close association between menstrual cycle length and anti-Mullerian hormone (AMH) levels and ovarian response. In women without polycystic ovary syndrome (PCOS), those with short cycles and oligo/amenorrhea showed different levels of antral follicle count and serum AMH levels. This association differed in women with PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fateme Binayi, Mehdi Moslemi, Fariba Khodagholi, Mehdi Hedayati, Homeira Zardooz
Summary: This study investigated the effects of long-term high-fat diet on plasma lipid profile and inflammation probability in adult rats. The results showed that high-fat diet increased body weight, food intake, intra-abdominal fat, and plasma leptin level. Additionally, it increased plasma concentrations of triglycerides, LDL, cholesterol, and IL 1-beta, while decreasing HDL level. Injection of an ER stress inhibitor reversed these changes. It suggests that long-term high-fat diet can disrupt lipid metabolism and induce inflammation through ER stress.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Psychology, Developmental
Sara Jalali-Farahani, Parisa Amiri, Fariba Zarani, Fereidoun Azizi
Summary: This study used qualitative methods to explore the perceptions of Iranian adolescents regarding their bodies, focusing on the psychological aspects that contribute to their body image perceptions. The findings revealed various beliefs, body evaluations, emotions, and behaviors among the participants.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2023)
Article
Medicine, General & Internal
Parvin Mirmiran, Marjan Ramezan, Hossein Farhadnejad, Golaleh Asghari, Zhaleh Tahmasebinejad, Fereidoun Azizi
Summary: This study aimed to investigate the association between dietary diabetes risk reduction score (DDRRS) and chronic kidney disease (CKD) in an Iranian adult population. The findings suggest that adherence to a dietary pattern with a higher score of DDRRS may be associated with a lower risk of CKD incident.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Article
Public, Environmental & Occupational Health
Maryam Barzin, Shayan Aryannezhad, Mohammad Bagheri, Maryam Mahdavi, Majid Valizadeh, Fereidoun Azizi, Farhad Hosseinpanah
Summary: This study examined the association between age, period, and birth cohort with body mass index (BMI) and waist circumference (WC) changes in participants of the Tehran Lipid and Glucose Study from 1999 to 2015. The results showed that BMI and WC increased with age in both men and women, and younger men from recent birth cohorts and older women from earlier birth cohorts had the most concerning BMI and WC trends. These findings highlight the importance of implementing obesity prevention policies, especially targeting younger men.
Article
Endocrinology & Metabolism
Fatemeh Ahmadian, Elham Razmpoosh, Hanieh-Sadat Ejtahed, Maryam Javadi, Parvin Mirmiran, Fereidoun Azizi
Summary: This study evaluated the effects of probiotic supplementation on cardiovascular disease (CVD)-related parameters in patients with type-2 diabetes. The results showed that probiotic supplementation significantly improved blood pressure, atherogenic index, and CVD risk score, but had no significant impact on antioxidant markers.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Endocrinology & Metabolism
Farzaneh Eskandari, Mina Salimi, Fateme Binayi, Mohammad-Amin Abdollahifar, Mohamad Eftekhary, Mehdi Hedayati, Hossein Ghanbarian, Homeira Zardooz
Summary: This study aimed to explore the communication between glucose metabolism and HPA axis dysregulations under chronic social defeat stress (CSDS) in the context of maternal separation (MS). The study found that MS exacerbated HPA axis overactivity and endocrine pancreas dysfunctions under CSDS, which may be related to increased corticosterone secretion and decreased content of specific receptor protein in the pancreas.
NEUROENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Nazanin Moslehi, Sheida Zeraattalab-Motlagh, Fatemeh Rahimi Sakak, Sakineh Shab-Bidar, Fahimeh Ramezani Tehrani, Parvin Mirmiran
Summary: There is no high-certainty evidence that diets alone improve health or reproductive outcomes in women with PCOS. However, supplementation with vitamin D, probiotics/synbiotics, omega-3, inositol, and curcumin has favorable effects on some metabolic outcomes.
Review
Dermatology
Mina Amiri, Leila Mahmoudieh, Ali Sheidaei, Fahimeh Ramezani Tehrani
Summary: This study aimed to evaluate the lipid profiles in women with idiopathic hirsutism (IH) compared to those of polycystic ovary syndrome (PCOS) and healthy controls. The meta-analysis results showed that the levels of total cholesterol were slightly higher and high-density lipoprotein cholesterol were slightly lower in women with IH compared to healthy controls. There were no significant differences in the levels of triglyceride and low-density lipoprotein cholesterol between the study groups. The levels of lipid profiles were also not significantly different between women with IH and PCOS patients, except for triglyceride levels.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Review
Endocrinology & Metabolism
S. Nazarpour, F. Ramezani Tehrani, R. Valizadeh, M. Amiri
Summary: This systematic review and meta-analysis found that exposure to air pollutants, especially PM2.5, PM10, O3, and SO2, increases the risk of gestational diabetes mellitus (GDM).
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Public, Environmental & Occupational Health
Maryam Farahmand, Parisa Amiri, Fahimeh Ramezani Tehrani, Leila Cheraghi, Fereidoun Azizi
Summary: This study explores the relationship between spiritual health and health-related quality of life in different stages of life in healthy women. The study found that higher spiritual health is associated with higher mental health and overall quality of life. These findings can be used to develop programs aimed at improving psychological health in women.
Article
Endocrinology & Metabolism
Mahbanoo Farhadi-Azar, Marzieh Saei Ghare Naz, Mehrdad Ghahremani, Maryam Mousavi, Fereidoun Azizi, Fahimeh Ramezani Tehrani
Summary: This study aimed to examine the prevalence of self-reported male infertility and related metabolic disturbances. It was found that the total prevalence of self-reported male infertility was 6.42%. Male infertility was positively associated with total cholesterol and hip circumference, indicating the importance of addressing these risk factors.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Veterinary Sciences
M. R. Rezaei Ahvanooei, M. A. Norouzian, M. Hedayati, M. H. Ghaffari
Summary: Heat stress and growing demand for dairy products in tropical regions can cause metabolic diseases and economic losses in dairy cows. However, the use of resveratrol (RSV) can help prevent these problems by providing antioxidant, anti-inflammatory, anti-obesity, and antimicrobial effects. RSV also improves reproductive performance and reduces methane emissions. It is important to note that the dosage of RSV is crucial, as high doses can have adverse effects. Overall, RSV polyphenol at optimal doses shows promise for preventing and treating metabolic abnormalities in dairy cows.
VETERINARY RESEARCH COMMUNICATIONS
(2023)
Article
Obstetrics & Gynecology
Mahsa Noroozzadeh, Maryam Rahmati, Mahbanoo Farhadi-Azar, Marzieh Saei Ghare Naz, Fereidoun Azizi, Fahimeh Ramezani Tehrani
Summary: The study aimed to determine the impact of maternal hyperandrogenism (MHA) on the risk of metabolic syndrome (MetS) in female offspring in their later life. The results showed that female offspring with MHA had a higher risk of developing MetS compared to controls. Therefore, screening for MetS in these female offspring may be recommended.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Maryam Asltoghiri, Lida Moghaddam-Banaem, Samira Behboudi-Gandevani, Abbas Rahimi Froushani, Fahimeh Ramezani Tehrani
Summary: This study aimed to identify the optimal cutoff values of each component of metabolic syndrome (MetS) in the first trimester of pregnancy for predicting adverse pregnancy outcomes. Receiver operating characteristic (ROC) curve analysis using the Youden's index was used to obtain the cutoff values for each MetS component.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Sima Nazarpour, Fahimeh Ramezani Tehrani, Firoozeh Sajedi, Maryam Rahmati, Razieh Bidhendi Yarandi, Fereidoun Azizi
Summary: This study aimed to evaluate the effects of levothyroxine therapy on the neurodevelopment of infants born to pregnant women with subclinical hypothyroidism. The results showed that levothyroxine therapy had no significant beneficial effect on the neurodevelopment of children in the first three years of life.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)