Article
Oncology
Leslie K. Dennis
Summary: This study examined the relationship between cumulative sun exposure and melanoma and found that there was no association before the age of 60. However, among individuals with fair skin color, there was no association between hours of sun exposure and melanoma, while among medium- or darker-skinned individuals, higher hours of sun exposure were associated with an increased risk of melanoma. This finding has implications for melanoma prevention efforts, particularly for darker-skinned individuals.
Article
Nutrition & Dietetics
Sakine Ghasemisedaghat, Ghazaleh Eslamian, Seyyedeh Neda Kazemi, Bahram Rashidkhani, Robabeh Taheripanah
Summary: The study found that following a fertility diet may decrease the odds of endometriosis in Iranian women. Consuming vegetable proteins and multivitamins were associated with lower odds of endometriosis, while consuming animal proteins, heme iron, and having a high glycemic load were associated with significantly higher odds of endometriosis. These findings should be verified through extensive, prospective studies.
FRONTIERS IN NUTRITION
(2023)
Article
Obstetrics & Gynecology
Laura Buggio, Edgardo Somigliana, Greta Sergenti, Federica Ottolini, Dhouha Dridi, Paolo Vercellini
Summary: Our study failed to find an association between AGD and the presence of endometriosis. Therefore, AGD does not seem to be a reliable indicator of the presence of endometriosis in clinical practice.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Leslie Farland, William J. Degnan, Holly R. Harris, Jiali Han, Eunyoung Cho, Trang VoPham, Marina Kvaskoff, Stacey A. Missmer
Summary: The study found that tanning bed use in early adulthood, sunscreen use, and history of sunburns were associated with a higher risk of endometriosis, while higher residential UV exposure was associated with a lower risk of endometriosis.
HUMAN REPRODUCTION
(2021)
Article
Immunology
Marta Barretta, Federica Savasta, Giuliana Pietropaolo, Allegra Barbasetti, Valeria Barbera, Michele Vignali
Summary: This study found that patients with endometriosis have a higher risk of contracting COVID-19 infection and may experience more severe symptoms. Regardless of the stage of the disease, women with endometriosis are susceptible to SARS-CoV-2 infection.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Oncology
Carolina Bonilla, Bernardo Bertoni, Josine L. Min, Gibran Hemani, Hannah R. Elliott
Summary: Polymorphisms in pigmentation genes have been found to be associated with DNA methylation sites in European populations. Some DNA methylation sites are related to traits such as red hair, hair color, melanoma, and basal cell carcinoma.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Arash Rahafar, Lisa Sophie Kalbacher, Christoph Randler
Summary: This study explores the association between sleep/wake habits and the Dark Triad traits. The results show a positive relationship between the Dark Triad and eveningness, and a negative relationship with circadian distinctness. Psychopathy is the most sleep-related DT trait, while narcissism is the least sleep-related. The study suggests that higher DT traits influence both sleep timing and stability.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Giovanni Delli Carpini, Luca Giannella, Jacopo Di Giuseppe, Nina Montik, Michele Montanari, Mariasole Fichera, Daniele Crescenzi, Carolina Marzocchini, Maria Liberata Meccariello, Donato Di Biase, Arianna Vignini, Andrea Ciavattini
Summary: This study suggests that the MTHFR C677T homozygous polymorphism may be a risk factor for endometriosis, potentially explaining the association through altered DNA methylation and reduced activity of antioxidant systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Khadija Kacem-Berjeb, Marouen Braham, Cyrine Ben Massoud, Hela Hannachi, Manel Hamdoun, Sana Chtourou, Linda Debbabi, Maha Bouyahia, Anis Fadhlaoui, Fethi Zhioua, Anis Feki, Nozha Chakroun, Olfa Bahri
Summary: The aim of this study was to compare follicular liquid levels of IL6 and AMH in women with and without endometriosis and evaluate their impact on ICSI outcomes. The IL-6 levels were higher in the endometriosis group, but there was no statistical difference in AMH levels between the two groups. There was no significant correlation between IL6 and AMH levels in the follicular fluid.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Christian M. Page, Therese H. Nost, Vera Djordjilovic, Magne Thoresen, Arnoldo Frigessi, Torkjel M. Sandanger, Marit B. Veierod
Summary: This study aimed to identify DNA methylation sites conferring melanoma risk by studying pre-diagnostic blood samples of melanoma cases and controls, but no genome-wide significant CpG sites were identified in future melanoma cases and controls.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Xavier Farre, Natalia Blay, Beatriz Cortes, Anna Carreras, Susana Iraola-Guzman, Rafael de Cid
Summary: Human pigmentation is genetically determined and has been associated with disease prevalence. This study analyzed pigmentary traits using GWAS and PRS in a South European cohort. The results showed associations between fair phototype and non-melanoma skin cancer, as well as shared genetic basis with melanoma, basal cell carcinoma, vitiligo, and cataracts. Multiple genes and risk loci were identified, including both well-known and novel candidate genes. This highlights the importance of considering phototype as a genetic proxy for skin functionality and disease in diverse populations.
Article
Medicine, General & Internal
Zheng-Yun Chen, Li-Feng Zhang, Yong-Qing Zhang, Yong Zhou, Xiao-Yong Li, Xiu-Feng Huang
Summary: This study evaluated the role of blood hemostatic parameters and inflammatory indices in predicting deep endometriosis (DE) and found that the combination of plasma fibrinogen and hemoglobin was a reliable predictor of DE, with improved sensitivity and specificity. Further large-scale studies are needed to confirm these findings.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Dermatology
F. Flament, D. G. Mercurio, B. Muller, J. Li, C. Tricaud, F. Bernerd, A. Roudot, D. Candau, T. Passeron
Summary: Under outdoor summer conditions, the SPF50/MCE sunscreen offers better protection against UVA1 radiation, resulting in reduced pigmentation and signs of aging.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Astronomy & Astrophysics
E. Philishvili, B. M. Shergelashvili, S. Buitendag, J. Raes, S. Poedts, M. L. Khodachenko
Summary: The study proposed a novel methodology to identify flows in the solar atmosphere and classify their velocities as supersonic, subsonic, or sonic. The results show that the methodology provides an automatic and scalable solution to identify small-scale flows and classify their velocities. It can be used to characterize the physical properties of the solar atmosphere.
ASTRONOMY & ASTROPHYSICS
(2021)
Article
Obstetrics & Gynecology
Federica Facchin, Laura Buggio, Elena Roncella, Edgardo Somigliana, Federica Ottolini, Dhouha Dridi, Anna Roberto, Paolo Vercellini
Summary: For patients with endometriosis, pelvic pain symptoms are associated with increased fatigue, poor sleep quality, and more severe sleep disturbances. Poor sleep quality is linked to greater fatigue, poorer psychological health, and lower quality of life for endometriosis patients.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Obstetrics & Gynecology
Massimo Candiani, Paolo Vercellini, Francesco Fedele, Marta Parma, Stefano Salvatore, Luigi Fedele
Summary: This study described the surgical technique and long-term results of laparoscopically assisted uterovestibular anastomosis in patients with cervical atresia and complete absence of the vagina. All patients underwent the surgery without perioperative complications. Follow-up assessments showed that the length of the neovagina was satisfactory and iodine-positive epithelium was present in all patients. The continuity of the neovagina, neocervix, and uterine body was maintained without further interventions in most patients, and some patients were able to engage in sexual activity and achieve pregnancy.
JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Ida Pino, Gaia Maria Belloni, Valeria Barbera, Eugenio Solima, Davide Radice, Stefano Angioni, Saverio Arena, Valentino Bergamini, Massimo Candiani, Antonio Maiorana, Alberto Mattei, Ludovico Muzii, Luca Pagliardini, Maria Grazia Porpora, Valentino Remorgida, Renato Seracchioli, Paolo Vercellini, Fulvio Zullo, Errico Zupi, Michele Vignali
Summary: The mean diagnostic delay of symptomatic endometriosis in Italy is about 11 years, with patients under the age of 20 experiencing a delay of up to 4 years. There is no significant association between a delayed diagnosis and clinically relevant factors such as the severity of symptoms or the method of diagnosis.
EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE
(2023)
Article
Obstetrics & Gynecology
Luca Giannella, Giovanni Delli Carpini, Jacopo Di Giuseppe, Barbara Gardella, Giorgio Bogani, Ermelinda Monti, Carlo Antonio Liverani, Elena Roncella, Francesco Raspagliesi, Arsenio Spinillo, Paolo Vercellini, Andrea Ciavattini
Summary: This study aimed to evaluate the independent variables associated with positive endocervical margin (EM) in women with high-grade cervical intraepithelial neoplasia (CIN) and fully visible transformation zone (TZ). The study found that TZ type and lesion extension were positively associated with positive EM, while cone depth was inversely related to positive EM. In women with TZ type 2 and lesion extension ≥2 cervical quadrants, an 8-mm cone depth provided a good cutoff value.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Oncology
Joy Shi, Peter Kraft, Bernard A. Rosner, Yolanda Benavente, Amanda Black, Louise A. Brinton, Chu Chen, Megan A. Clarke, Linda S. Cook, Laura Costas, Luigino Dal Maso, Jo L. Freudenheim, Jon Frias-Gomez, Christine M. Friedenreich, Montserrat Garcia-Closas, Marc T. Goodman, Lisa Johnson, Carlo La Vecchia, Fabio Levi, Jolanta Lissowska, Lingeng Lu, Susan E. McCann, Kirsten B. Moysich, Eva Negri, Kelli O'Connell, Fabio Parazzini, Stacey Petruzella, Jerry Polesel, Jeanette Ponte, Timothy R. Rebbeck, Peggy Reynolds, Fulvio Ricceri, Harvey A. Risch, Carlotta Sacerdote, Veronica W. Setiawan, Xiao-Ou Shu, Amanda B. Spurdle, Britton Trabert, Penelope M. Webb, Nicolas Wentzensen, Lynne R. Wilkens, Wang Hong Xu, Hannah P. Yang, Herbert Yu, Mengmeng Du, Immaculata De Vivo
Summary: To mitigate the burden of endometrial cancer, risk stratification can help target interventions. The study developed risk prediction models using data from postmenopausal White women aged 45-85 years. The models based on epidemiologic factors alone successfully identified women at high risk of endometrial cancer, with limited improvements from genetic factors.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Review
Andrology
Sonia Cipriani, Elena Ricci, Francesca Chiaffarino, Giovanna Esposito, Michela Dalmartello, Carlo La Vecchia, Eva Negri, Fabio Parazzini
Summary: This study aims to evaluate the continuing trend of decreasing sperm count in Western European countries and USA. The results show no significant trends in sperm concentration in these regions.
Article
Oncology
Luca Giannella, Giovanni Delli Carpini, Jacopo Di Giuseppe, Giorgio Bogani, Francesco Sopracordevole, Nicolo Clemente, Giorgio Giorda, Rosa Pasqualina De Vincenzo, Maria Teresa Evangelista, Barbara Gardella, Mattia Dominoni, Ermelinda Monti, Chiara Alessi, Lara Alessandrini, Alessio Pagan, Marta Caretto, Alessandro Ghelardi, Andrea Amadori, Massimo Origoni, Maggiorino Barbero, Francesco Raspagliesi, Tommaso Simoncini, Paolo Vercellini, Giovanni Scambia, Andrea Ciavattini
Summary: This study examined the impact of HPV status on the prognosis of early stage cervical glandular lesions. The results showed that HPV status did not affect the recurrence rate, but most adenocarcinomas were positive for high-risk HPV.
Editorial Material
Biochemistry & Molecular Biology
Paola Vigano, Maira Casalechi, Paolo Vercellini, Edgardo Somigliana
Article
Obstetrics & Gynecology
Alba Nicolas-Boluda, Enora Le Roux, Arounie Tavenet, Jerome Bouaziz, Paolo Vercellini, Pamela Stratton, Arnaud Fauconnier
Summary: This study aims to identify a set of patient-centered outcomes for routine endometriosis care that are relevant to all patient profiles. The final set of outcomes includes six patient-reported outcome measures (PROMs) and ten clinician-reported outcome measures (CROMs) that capture the common features for all endometriosis patients.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Editorial Material
Obstetrics & Gynecology
Paolo Vercellini, Giovanna Esposito, Claudia Santucci, Fabio Parazzini, Carlo La Vecchia
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Giulia Emily Cetera, Camilla Erminia Maria Merli, Federica Facchin, Paola Vigano, Elisa Pesce, Francesca Caprara, Paolo Vercellini
Summary: Approximately 25-33% of women with endometriosis do not have an adequate response to first-line hormonal treatment for resolution of painful symptoms. The concept of progesterone resistance has been proposed but is controversial. A broader perspective of endometriosis is emerging, questioning whether the lack of response is due to altered signaling pathways or other pain contributors.
Article
Obstetrics & Gynecology
Alessandra Chine, Marco Reschini, Gianfranco Fornelli, Ludovica Basili, Andrea Busnelli, Paola Vigano, Ludovico Muzii, Edgardo Somigliana
Summary: Low ovarian reserve, indicated by anti-Mullerian hormone (AMH) or antral follicle count (AFC), does not increase the risk of miscarriage in young women conceiving with ART.
HUMAN REPRODUCTION OPEN
(2023)
Review
Obstetrics & Gynecology
Paolo Vercellini, Veronica Bandini, Laura Buggio, Giussy Barbara, Nicola Berlanda, Dhouha Dridi, Maria Pina Frattaruolo, Edgardo Somigliana
Summary: This study aimed to investigate a cost-saving measure for the treatment of endometriosis by using a non-standard dosing regimen of a 3.75 mg depot formulation of triptorelin. The extended-interval dosing regimen, with injections every 6 weeks instead of every 4 weeks, reduced the cost by one-third without compromising pain relief.
HUMAN REPRODUCTION OPEN
(2023)
Article
Obstetrics & Gynecology
Paolo Vercellini, Veronica Bandini, Paola Vigano, Giorgia Di Stefano, Camilla Erminia Maria Merli, Edgardo Somigliana
Summary: Repetitive ovulation and menstruation provided an advantage in the Palaeolithic era, but societal changes have created a mismatch between genetic adaptation and environment, leading to an increased risk of estrogen-related diseases.
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
Paolo Vercellini, Veronica Bandini, Paola Vigano, Deborah Ambruoso, Giulia Emily Cetera, Edgardo Somigliana
Summary: According to epidemiological data, the incidence of endometriosis increases rapidly around the age of 25. The delay in diagnosis is usually between 5 and 8 years in adult women and over 10 years in adolescents. Ovulation and menstruation, which are inflammatory events, may contribute to the early development of endometriosis and adenomyosis. Therefore, secondary prevention targeting severely symptomatic adolescents is crucial for reducing suffering, limiting lesion progression, and preserving future reproductive potential.
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
Francesco Fedele, Fabio Parazzini, Paolo Vercellini, Valentino Bergamini, Luigi Fedele
Summary: The authors discuss the incidence, embryological development, classification, presentation, and treatment options of a rare reproductive tract abnormality. In the past, hysterectomy and subsequent neovagina construction were almost unanimously proposed as the treatment. However, recent experiences with conservative therapies have shown potential for restoring menstrual function and achieving pregnancy. This review emphasizes the importance of conservative surgery as the first-line treatment option, but highlights the lack of conclusive evidence regarding the superiority of one technique over another.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)