Review
Biology
Masataka Taniuchi, Tetsuya Terada, Ryo Kawata
Summary: Fine-needle aspiration cytology is widely used for preoperative evaluation of parotid tumors, with core needle biopsy and liquid-based cytology improving reliability of immunostaining and molecular testing.
Article
Gastroenterology & Hepatology
Silvia Carrara, Daoud Rahal, Kareem Khalaf, Tommy Rizkala, Glenn Koleth, Cristiana Bonifacio, Marta Andreozzi, Benedetto Mangiavillano, Francesco Auriemma, Paola Bossi, Monica Balzarotti, Antonio Facciorusso, Teresa Staiano, Elena Maldi, Marco Spadaccini, Matteo Colombo, Alessandro Fugazza, Roberta Maselli, Cesare Hassan, Alessandro Repici
Summary: This study aimed to evaluate the diagnostic accuracy and adverse event rate of EUS-guided fine-needle biopsy sampling (EUS-FNB) in diagnosing lymphadenopathies (LAs). The results showed that EUS-FNB with new end-cutting needles is a valuable and safe method for diagnosing LAs.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Dermatology
E. E. Siddig, O. El Had Bakhait, M. El Nour Hussein Bahar, E. Siddig Ahmed, S. M. Bakhiet, M. Motasim Ali, O. Babekir Abdallah, R. Ahmed Hassan, A. Verbon, W. W. J. van de Sande, A. H. Fahal
Summary: Ultrasound-guided fine-needle aspiration cytology (US-FNAC) has higher diagnostic accuracy than conventional FNAC for the diagnosis of mycetoma, allowing for rapid differentiation between the two types of mycetoma.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Oncology
Isabela Panzeri Carlotti Buzatto, Francisco Jose Candido dos Reis, Jurandyr Moreira de Andrade, Tamara Cristina Gomes Ferraz Rodrigues, Jessica Maria Camargo Borba, Amanda Homse Netto, Marina Sconzo Polydoro, Daniel Guimaraes Tiezzi
Summary: The study demonstrated that axillary ultrasound coupled with fine-needle aspiration cytology is effective in evaluating axillary involvement in breast cancer patients. Ultrasound combined with FNAC showed high specificity in accurately predicting clinically relevant node metastasis in patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jeeyong Lee, Hwa Jeong Ha, Da Yeon Kim, Jae Soo Koh, Eun Ju Kim
Summary: Fine needle aspiration cytology (FNAC) is a valuable tool for evaluating lymphadenopathy and diagnosing malignant tumors. However, some tumor diagnoses may still be unclear. In this study, we used mRNA sequencing technology to re-analyze misinterpreted patient samples and identified under-diagnosed characteristics of non-Hodgkin's lymphoma. Through bioinformatic and biological analysis, we identified genes and pathways potentially involved in this type of tumor. FOS, ENDOG, and PRKAR2B were identified as hub genes, and their association with lymphoma was confirmed by the cBioPortal database. These findings suggest the potential use of these candidate genes as biomarkers to improve the accuracy of FNAC diagnosis in lymphadenopathy, ultimately leading to better prognosis for patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Hwa Jeong Ha, Jeeyong Lee, Da Yeon Kim, Jung-Soon Kim, Myung-Soon Shin, Insup Noh, Jae Soo Koh, Eun Ju Kim, Seung-Sook Lee
Summary: This study assessed the reliability and effectiveness of fine needle aspiration cytology (FNAC) in the diagnosis of lymphadenopathy. The results showed that FNAC was safe, practical, and effective in the early diagnosis of lymphadenopathy. However, it had limitations in some diagnoses, suggesting the need for additional attempts according to the clinical situation.
Article
Health Care Sciences & Services
Carolla El Chamieh, Philippe Vielh, Sylvie Chevret
Summary: Statistical issues in evaluating the diagnostic accuracy of fine needle aspiration cytology for breast cancer, such as suspect test results and verification bias, were addressed using various methods including conditional estimates, Begg and Greenes method, multivariate imputation by chained equations, and a Bayesian approach. The FNAC test demonstrated high specificity, always above 94%, and performed better as a rule-in test for breast cancer diagnosis.
BMC MEDICAL RESEARCH METHODOLOGY
(2022)
Review
Medicine, General & Internal
Georgios D. Koimtzis, Christopher G. Chalklin, Eliot Carrington-Windo, Mark Ramsden, Leandros Stefanopoulos, Christoforos S. Kosmidis
Summary: Gallbladder cancer is the most common malignancy of the biliary tract, and early diagnosis and assessment are crucial for improving survival rates. Fine needle aspiration cytology has high sensitivity and specificity in the management of gallbladder cancer, suggesting that suspicious masses should be further evaluated with FNAC for appropriate management.
Article
Oncology
Luai Sallout, Mohamed Tashkandi, Amani Moqnas, Hebah AlMajed, Abdulrhman Al-Naeem, Yazeed Alwelaie
Summary: The study found that axillary lymph node fine-needle aspiration biopsy could be a potential alternative to SLNB in newly diagnosed breast cancer patients. When axillary lymph node FNAB results are negative, a standard SLNB should be considered, especially in nodes with abnormal imaging findings.
CANCER CYTOPATHOLOGY
(2023)
Article
Medical Laboratory Technology
Zaibo Li, Rhona Souers, Sana O. Tabbara, Kristen E. Natale, Lananh N. Nguyen, Christine N. Booth
Summary: The survey revealed significant differences in breast FNA practice among different types of institutions and between domestic and international laboratories, including the frequency of concurrent FNA and core needle biopsy for the same lesion, primary personnel who performed the FNA, etc. This survey provides a baseline for future breast FNA studies in a variety of practice settings.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Endocrinology & Metabolism
Ilenia Pirola, Elena Di Lodovico, Claudio Casella, Letizia Pezzaioli, Paolo Facondo, Alberto Ferlin, Davide Lombardi, Carlo Cappelli
Summary: This study aimed to evaluate the impact of thyroid scintigraphy on the clinical management of patients referred for FNA. The results showed that in patients with TSH levels <= 1.5 mIU/L, using thyroid scintigraphy can help identify hyperfunctioning nodules and avoid unnecessary FNAs.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Gastroenterology & Hepatology
Munish Ashat, Jagpal S. Klair, Sydney L. Rooney, Sagar J. Vishal, Chris Jensen, Nadav Sahar, Arvind R. Murali, Rami El-Abiad, Henning Gerke
Summary: This study compared two commonly used EUS-FNB needles in their ability to provide histologic tissue samples and reach an accurate diagnosis, and found no significant difference in performance between the Franseen needle and the Fork-tip needle. Both needles achieved high yield of histologic tissue samples and high diagnostic accuracy.
GASTROINTESTINAL ENDOSCOPY
(2021)
Review
Pathology
Richard L. Cantley
Summary: Fine needle aspiration cytology plays an important role in distinguishing primary and metastatic adrenal neoplasms, but there is variability. Immunohistochemistry can aid in the diagnosis of adrenal neoplasms.
ADVANCES IN ANATOMIC PATHOLOGY
(2022)
Article
Oncology
Huang Chen, Aiping Song, Ye Wang, Yifan He, Jie Tong, Jinxi Di, Chun Li, Zhongren Zhou, Xiaopin Cai, Dingrong Zhong, Jiping Da
Summary: The study demonstrated that combining fine-needle aspiration cytology with BRAF(V600E) mutation testing can improve the accuracy of papillary thyroid cancer diagnosis, especially for thyroid nodules with indeterminate or nondiagnostic cytology.
Article
Infectious Diseases
Wenting Li, Wei Sha
Summary: This study retrospectively studied patients with suspected chest wall tuberculosis who underwent FNA for diagnosis and reported the diagnostic efficacy of various tests. The results showed that GeneXpert had higher sensitivity compared to conventional tests. Therefore, the implementation of GeneXpert can increase the accuracy of FNA in the diagnosis of chest wall tuberculosis.
INFECTION AND DRUG RESISTANCE
(2023)