Article
Nutrition & Dietetics
Mingluan Xing, Simeng Gu, Xiaofeng Wang, Guangming Mao, Zhe Mo, Xiaoming Lou, Xueqing Li, Xuemin Huang, Yuanyang Wang, Zhifang Wang
Summary: Salt iodization is a cost-effective strategy to eliminate iodine deficiency disorders, but the dismantling of salt monopoly in China has reduced access to iodized salt for pregnant women, potentially causing adverse health effects. The study found that iodine deficiency significantly impacted fecundity in pregnant women, highlighting the importance of ongoing monitoring of iodine nutrition in women of reproductive age. Maintaining an optimal level of iodine nutrition during pregnancy is crucial for maternal and child health.
Review
Endocrinology & Metabolism
Ines Bucci, Cesidio Giuliani, Giulia Di Dalmazi, Gloria Formoso, Giorgio Napolitano
Summary: The regulation of the female reproductive system by thyroid hormones is crucial for normal menstrual function, fertility, and successful pregnancy. Thyroid autoimmunity (TAI) is prevalent among women and is associated with infertility and negative reproductive outcomes. The role of TAI, especially in the absence of thyroid dysfunction, in assisted reproductive technology (ART) is still controversial.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Anna Joud, Emma Nilsson-Condori, Lone Schmidt, Soren Ziebe, Ditte Vassard, Kristina Mattsson
Summary: Women with asthma have comparable chances of giving birth compared to women without asthma, but they have a higher risk of infertility, pregnancy loss, and the need for medically assisted reproduction.
HUMAN REPRODUCTION
(2022)
Review
Obstetrics & Gynecology
Xuening Li, Xiugui Li, Yanhua Sun, Jie Han, Huagang Ma, Yanli Sun
Summary: Y chromosome microdeletions are associated with a decreased fertilization rate in assisted reproductive technology, but do not significantly affect the good embryo rate, clinical pregnancy rate, early miscarriage rate, miscarriage rate, live birth rate, or baby boy rate.
REPRODUCTIVE SCIENCES
(2021)
Review
Plant Sciences
Kannan Maharajan, Qing Xia, Xiuying Duan, Pengfei Tu, Yun Zhang, Kechun Liu
Summary: Zishen Yutai Pill (ZYP) is a widely used Traditional Chinese Medicine in Assisted Reproductive Technology (ART) medications, and has shown potential therapeutic effects in improving fertility and pregnancy rates. Clinical studies have demonstrated its curative effects on various reproductive disorders by regulating reproductive functions such as ovulation, follicle development, and hormonal balance.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Obstetrics & Gynecology
Eva L. Siegel, Akhgar Ghassabian, Alison E. Hipwell, Pam Factor-Litvak, Yeyi Zhu, Hannah G. Steinthal, Carolina Focella, Lindsey Battaglia, Christina A. Porucznik, Scott C. Collingwood, Michele Klein-Fedyshin, Linda G. Kahn
Summary: This article provides a systematic review of the association between air pollution and fecundability. The results indicate that outdoor air pollution, secondhand smoke, and occupational exposure to inhaled pollutants may reduce fecundability. However, there are differences in exposure windows and assessment methods among studies, which need further research to determine their specific effects.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Medicine, General & Internal
Annacandida Villani, Andrea Fontana, Stefano Barone, Silvia de Stefani, Mariangela Primiterra, Massimiliano Copetti, Concetta Panebianco, Cristiana Parri, Natale Scianname, Pasqua Anna Quitadamo, Alessandra Tiezzi, Liliana Santana, Annamaria Maglione, Federica D'Amato, Francesco Perri, Simone Palini, Valerio Pazienza
Summary: This study aimed to analyze the microbiota of human cervical swab and its correlation with Assisted Reproductive Technologies (ART) outcomes. The results showed that different microorganisms were predictive of women's pregnancy outcomes, with significant differences found at the species level, including Lactobacillus salivarius and Lactobacillus rhamnosus. The abundance of Lactobacillus crispatus increased and Lactobacillus iners decreased in the favorable group compared to the unfavorable group, indicating their association with positive ART outcomes. Furthermore, the presence of Bifidobacterium, along with other lactobacilli, was more abundant in the favorable group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Johanna Lumme, Laure Morin-Papunen, Paula Pesonen, Sylvain Sebert, Elina Hypponen, Marjo-Riitta Jarvelin, Karl-Heinz Herzig, Marja Ojaniemi, Maarit Niinimaki
Summary: A population-based study showed that previous infertility and decreased fecundability were associated with lower 25(OH)D concentrations.
Article
Obstetrics & Gynecology
Vivienne Moore, Alice Rumbold, Renae Fernandez, Heather McElroy, Lynette Moore, Lynne Giles, Luke Grzeskowiak, Elizabeth Roughead, Michael Stark, Michael Davies
Summary: A study in South Australia found that 1.6% of pregnancies of at least 20 weeks' gestation were conceived with the use of clomiphene citrate (CC), with 5.7% resulting in multiple births. This increases the proportion of women who achieved an ongoing pregnancy with medical assistance from 4.4% to 6%.
FERTILITY AND STERILITY
(2022)
Article
Medicine, General & Internal
Marta Ciaffaglione, Marco Reschini, Martina Balli, Cristina Guarneri, Maria Carla Palermo, Monica Pinna, Valerio Pisaturo, Edgardo Somigliana, Alessio Paffoni, Paola Vigano
Summary: This study demonstrates that different post-thaw embryo culture timings do not negatively affect pregnancy outcomes. These findings are important in organizing the workflow in embryological laboratories.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
A. Karaer, B. Dogan, S. Gunal, G. Tuncay, S. Arda Duz, T. Unver, N. Tecellioglu
Summary: This study aimed to evaluate the impact of vaginal microbiota on pregnancy outcomes in women undergoing assisted reproduction. The findings suggest that a relatively high abundance of Streptococcus in the vaginal microbiota may be associated with a lower ART success rate.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Reproductive Biology
Simona Iodice, Luca Pagliardini, Laura Cantone, Elisa Giacomini, Massimo Candiani, Paola Vigano, Valentina Bollati
Summary: The study examined the association between short-term PM10 exposure and ART outcomes in patients undergoing fresh or frozen ART cycles in Lombardy, Italy. The results showed negative associations between PM10 exposure and the number of retrieved oocytes, percentage of metaphase II oocytes, as well as clinical and ongoing pregnancy rates. This study adds suggestive evidence of a potential harmful effect of PM10 exposure on ART outcomes in a highly polluted area.
REPRODUCTIVE TOXICOLOGY
(2021)
Review
Microbiology
Giovanna Cocomazzi, Silvia De Stefani, Lino Del Pup, Simone Palini, Matteo Buccheri, Mariangela Primiterra, Natale Scianname, Raffaele Faioli, Annamaria Maglione, Giorgio Maria Baldini, Domenico Baldini, Valerio Pazienza
Summary: The vaginal microbiota is crucial for the health of the female genital tract and is associated with gynecological disorders and infertility. Lactobacilli, the dominant species in the female genital tract, prevent the growth of pathogenic microorganisms through the production of lactic acid, hydrogen peroxide, and bacteriocins. Imbalance and dysbiosis of the vaginal microbiota can be caused by factors such as hormonal changes, age of reproduction, sexual practices, menstrual cycle, pregnancy, and antimicrobial drug use.
Article
Materials Science, Multidisciplinary
Farin Yazdan Parast, Moira K. O'Bryan, Reza Nosrati
Summary: Selection of high-quality sperm is crucial for assisted reproduction. This article introduces a scalable technology called 'sperm syringe' that mimics the 3D selection process in vivo to select high-quality sperm. Experimental results show that the sperm syringe significantly improves selected sperm morphology and DNA integrity, making it a promising assisted reproductive technology.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Acoustics
C. J. Valdera Simbron, C. Hernandez Rodriguez, L. Llanos Jimenez, L. Perez Garcia, J. Plaza Arranz, M. Albi Gonzalez
Summary: The use of the M4 model in pregnancies conceived by ART with low beta-hCG concentration in early gestation showed limited capacity in classifying them as being at low or high risk for EP, therefore, its use in pregnancies of this type is not recommended. No serious adverse events or complications related to the use of the model were observed.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Infectious Diseases
Josiane Warszawski, Anne-Lise Beaumont, Remonie Seng, Xavier de Lamballerie, Delphine Rahib, Nathalie Lydie, Remy Slama, Sylvain Durrleman, Philippe Raynaud, Patrick Sillard, Francois Beck, Laurence Meyer, Nathalie Bajos
Summary: This study estimated the seroprevalence of SARS-CoV-2 infection during the first epidemic wave in France, revealing that high-density residences, larger household size, healthcare workers, middle-aged individuals, and non-daily smokers were more likely to be infected. The study emphasizes the significant role of contextual living conditions in the initial spread of COVID-19.
BMC INFECTIOUS DISEASES
(2022)
Article
Environmental Sciences
Helene Bouscasse, Stephan Gabet, Glen Kerneis, Ariane Provent, Camille Rieux, Nabil Ben Salem, Harry Dupont, Florence Troude, Sandrine Mathy, Remy Slama
Summary: By combining backward and forward methods, this study identified urban policies that significantly reduce air pollution-related mortality by starting from health objectives set by urban decision-makers, estimating reductions in PM2.5 exposure and emissions to achieve these objectives, and finding policies that lead to these reductions.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Public, Environmental & Occupational Health
Ian Hough, Matthieu Rolland, Ariane Guilbert, Emie Seyve, Barbara Heude, Remy Slama, Sarah Lyon-Caen, Isabelle Pin, Cecile Chevrier, Itai Kloog, Johanna Lepeule
Summary: This study aimed to evaluate the association between ambient temperature and preterm delivery. The results showed that night-time heat and cold exposure were associated with an increased risk of preterm birth in a temperate climate.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Environmental Sciences
Dorothy Nakiwala, Pamela D. Noyes, Patrice Faure, Benoit Chovelon, Christelle Corne, Anne Sophie Gauchez, Dorra Guergour, Sarah Lyon-Caen, Amrit K. Sakhi, Azemira Sabaredzovic, Cathrine Thomsen, Isabelle Pin, Remy Slama, Claire Philippat
Summary: This study evaluated associations between phenol/phthalate exposures and serum thyroid hormones using a two-tiered approach. The results showed negative or positive associations between phenol/phthalate exposures and thyroid hormones, which were influenced by iodine status.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Environmental Sciences
Deepika Deepika, Raju Prasad Sharma, Marta Schuhmacher, Amrit Kaur Sakhi, Cathrine Thomsen, Leda Chatzi, Marina Vafeiadi, Joane Quentin, Remy Slama, Regina Grazuleviciene, Sandra Andrusaityte, Dagmar Waiblinger, John Wright, Tiffany C. Yang, Jose Urquiza, Martine Vrijheid, Maribel Casas, Jose L. Domingo, Vikas Kumar
Summary: This study aimed to develop a sex-specific pediatric physiologically based pharmacokinetic model for BPA and compare toxicokinetic differences. The results showed that children's exposure to BPA was estimated to be 1500 times higher than the tolerable daily intake set by European Food Safety Authority.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Lucille Joanna S. Borlaza, Gaelle Uzu, Marion Ouidir, Sarah Lyon-Caen, Anouk Marsal, Samuel Weber, Valerie Siroux, Johanna Lepeule, Anne Boudier, Jean-Luc Jaffrezo, Remy Slama
Summary: This study investigated the association between oxidative potential (OP) and birth outcomes in relation to personal exposure to fine particulate matter (PM2.5). The results showed that personal OP exposure was associated with fetal growth restrictions, specifically decreased weight and height at birth, possibly to a larger extent than PM2.5 mass concentration alone.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
Lea Maitre, Mariona Bustamante, Carles Hernandez-Ferrer, Denise Thiel, Chung-Ho E. Lau, Alexandros Siskos, Marta Vives-Usano, Carlos Ruiz-Arenas, Dolors Pelegri-Siso, Oliver Robinson, Dan Mason, John Wright, Solene Cadiou, Remy Slama, Barbara Heude, Maribel Casas, Jordi Sunyer, Eleni Z. Papadopoulou, Kristine B. Gutzkow, Sandra Andrusaityte, Regina Grazuleviciene, Marina Vafeiadi, Leda Chatzi, Amrit K. Sakhi, Cathrine Thomsen, Ibon Tamayo, Mark Nieuwenhuijsen, Jose Urquiza, Eva Borras, Eduard Sabido, Ines Quintela, Angel Carracedo, Xavier Estivill, Muireann Coen, Juan R. Gonzalez, Hector C. Keun, Martine Vrijheid
Summary: Environmental exposures during early life have a significant impact on lifelong health, but the molecular effects underlying these exposures are poorly understood. In the HELIX project, researchers investigate the associations between individual exposomes and multi-omics profiles in a cohort of 1301 mother-child pairs. The findings reveal potential biological responses and sources of exposure, with pregnancy exposures primarily affecting child DNA methylation changes and childhood exposures affecting features across multiple omics layers, such as the serum metabolome.
NATURE COMMUNICATIONS
(2022)
Article
Environmental Sciences
Ophelie Coiffier, Dorothy Nakiwala, Matthieu Rolland, Andres Malatesta, Sarah Lyon-Caen, Benoit Chovelon, Patrice Faure, Anne Sophie Gauchez, Dorra Guergour, Amrit K. Sakhi, Azemira Sabaredzovic, Cathrine Thomsen, Isabelle Pin, Remy Slama, Christelle Corne, Claire Philippat
Summary: This study aimed to assess the effects of non-persistent environmental chemicals on neonatal thyroid hormones and found that prenatal exposure to certain phenols and phthalates can disrupt thyroid hormone homeostasis at birth. Additionally, the effects of these chemicals on thyroid hormones were found to be modified by the child's sex.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Lorenzo Fabbri, Ronan Garlantezec, Karine Audouze, Mariona Bustamante, Angel Carracedo, Leda Chatzi, Juan Ramon Gonzalez, Regina Grazuleviciene, Hector Keun, Chung-Ho E. Lau, Eduard Sabido, Alexandros P. Siskos, Remy Slama, Cathrine Thomsen, John Wright, Wen Lun Yuan, Maribel Casas, Martin Vrijheid, Lea Maitre
Summary: This study aimed to identify multi-omic signatures associated with childhood exposure to non-persistent endocrine disrupting chemicals (EDCs). By using a repeated sampling strategy and integrating multiple omics data, a total of 950 reproducible associations were found, including 23 direct associations between EDCs and omics. These associations can help us understand the effects of EDCs on neurological and metabolic outcomes.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Matthieu Rolland, Sarah Lyon-Caen, Cathrine Thomsen, Amrit K. Sakhi, Azemira Sabaredzovic, Sam Bayat, Remy Slama, David Meary, Claire Philippat
Summary: This study investigated the neurodevelopmental effects of phthalate exposure during pregnancy and infancy. Using objective measures such as questionnaires and eye tracking tasks, the researchers found that prenatal exposure to monobenzyl phthalate was associated with shorter fixation durations, while postnatal exposure to di(2-ethylhexyl) phthalate was associated with increased time spent looking at a novel face and eyes. Increased postnatal exposure to monoethyl, mono-iso-butyl, and mono-n-butyl phthalates was also linked to faster reaction times and decreased time spent looking at the eyes in a face recognition task. These findings highlight the importance of phthalate exposure in early life on neurodevelopment.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Johanna Lepeule, Isabelle Pin, Anne Boudier, Joane Quentin, Sarah Lyon-Caen, Karine Supernant, Emie Seyve, Ryan Chartier, Remy Slama, Valerie Siroux, SEPAGES Study Grp
Summary: This study found that exposure of pregnant women to fine particulate matter (PM2.5) air pollution is associated with lower lung volumes in female newborns, but not in males. These results suggest that the effects of air pollution on fetal lung health can occur in utero.
ENVIRONMENTAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Remy Slama
Summary: The limitations in the laws governing environmental health issues may result in public decisions that are out of step with scientific knowledge. These limitations could be related to the scope of the laws and their approach to risk management. The fragmented decisions and weak risk management logics impede the protection of public health.
ENVIRONNEMENT RISQUES & SANTE
(2022)
Meeting Abstract
Clinical Neurology
M. Kim, S. Lyon-Caen, I. Pin, R. Slama, C. Philippat, S. Plancoulaine
JOURNAL OF SLEEP RESEARCH
(2022)
Review
Public, Environmental & Occupational Health
Basile Chaix, Remy Slama
Summary: Climate change has both direct and indirect effects on health, with high temperatures, extreme climatic events, and changes in disease distribution being some of the key impacts. It also affects agricultural yields, water availability, and can amplify the occurrence of respiratory problems and natural disasters. Measures to fight against climate change can have a positive impact on health, making it important to incorporate public health issues into climate change research.
ENVIRONNEMENT RISQUES & SANTE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Georgia Escaramis, Marta Vives-Usano, Carles Hernandez-Ferrer, Lea Maitre, Sandra Andrusaityte, Angel Carracedo, Maribel Casas, Leda Chatzi, Regina Grazuleviciene, Kristine B. Gutzkow, Solene Cadiou, Johanna Lepeule, Dan Mason, Gillian Santorelli, Remy Slama, Marina Vafeiadi, Xavier Estivill, Juan R. Gonzalez, Eulalia Marti, Martine Vrihjeid, Mariona Bustamante
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)