Article
Cell Biology
Tongzhou Liang, Taiqiu Chen, Jincheng Qiu, Wenjie Gao, Xianjian Qiu, Yuanxin Zhu, Xudong Wang, Yanbo Chen, Hang Zhou, Zhihuai Deng, Pengfei Li, Caixia Xu, Yan Peng, Anjing Liang, Peiqiang Su, Bo Gao, Dongsheng Huang
Summary: Evidence suggests that ROR alpha plays a crucial role in cartilage development and OA pathogenesis by regulating the expression of cartilage matrix components. Blocking ROR alpha can reverse cartilage damage and elevate the expression of cartilage matrix components. Additionally, ROR alpha affects the IL-6/STAT3 signaling pathway, highlighting its potential as a treatment target in OA therapy.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Sasi Kumar Jagadeesan, Mustafa Al-gafari, Jiashu Wang, Sarah Takallou, Danielle Allard, Maryam Hajikarimlou, Thomas David Daniel Kazmirchuk, Houman Moteshareie, Kamaledin B. Said, Reza Nokhbeh, Myron Smith, Bahram Samanfar, Ashkan Golshani
Summary: Lithium chloride (LiCl) is widely studied and used as a therapeutic option for bipolar disorder (BD). It negatively regulates the expression and activity of PGM2, a phosphoglucomutase that influences sugar metabolism in yeast. Our study shows that yeast mutant strains DBP7 increment and YRF1-6 increment exhibit increased LiCl sensitivity on galactose-containing media, and that DBP7 and YRF1-6 modulate the translational level of PGM2 mRNA, potentially through the 5'-UTR region.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Fumio Matsumura, Robin Polz, Sukhwinder Singh, Aya Matsumura, Juergen Scheller, Shigeko Yamashiro
Summary: Research shows that IL-6 signaling is essential for the chemotaxis of mature dendritic cells (DCs), as it affects the internalization and recycling of CCR7, thereby regulating DC migration. This study identifies IL-6 signaling as a new regulatory pathway for CCR7/CCL19-mediated chemotaxis, highlighting the importance of inflammation-associated IL-6 signaling in the rapid migration of mature DCs to lymph nodes.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Developmental Biology
Fang Guo, Yongpei He, Yixian Fan, Zhenzhen Du, Huanhuan Sun, Zuohua Feng, Guimei Zhang, Ting Xiong
Summary: Evidence suggests that neutrophils modulated by G-CSF and IL-6 through the STAT3 pathway may promote the establishment of early endometriosis by altering the expression levels of angiogenesis-related genes such as Mmp9, Bv8, and Trail.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Endocrinology & Metabolism
Chi Wang, Ming Guan, Shuang Zhang, Can Cui
Summary: This article reports a rare case of paraganglioma that only secretes interleukin-6 (IL-6). Through genomic sequencing, a mutation in the KIF1B gene was found in the patient. In terms of treatment, the patient's symptoms rapidly disappeared, body temperature and heart rate returned to normal after taking doxazosin, and blood indexes gradually improved.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Genetics & Heredity
Ali Azmi, Maziyar Rismani, Hossein Pourmontaseri, Ebrahim Mirzaii, Sedigheh Niknia, Behnoosh Miladpour
Summary: This study examined the changes in vitamin D receptor (VDR) expression and interleukin 6 levels in COVID-19 patients. The results showed lower expression of VDR and higher levels of interleukin 6 in COVID-19 patients. Further research is needed to determine the factors affecting VDR expression levels, especially in patients with diabetes, hypertension, and cardiovascular disease.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2023)
Article
Immunology
Akihiro Hoshino, David Boutboul, Yuan Zhang, Hye Sun Kuehn, Jerome Hadjadj, Nihal Ozdemir, Tiraje Celkan, Christoph Walz, Capucine Picard, Christelle Lenoir, Nizar Mahlaoui, Christoph Klein, Xiao Peng, Antoine Azar, Erin Reigh, Morgane Cheminant, Alain Fischer, Frederic Rieux-Laucat, Isabelle Callebaut, Fabian Hauck, Joshua Milner, Sergio D. Rosenzweig, Sylvain Latour
Summary: This study identified IKZF1 variants in the DNA binding domain that cause inflammatory, autoimmune, allergic symptoms, and abnormal plasma cell proliferation. These variants act as gain-of-function alleles, leading to increased gene expression associated with T(H)2 and plasma cell differentiation. Treatment with Lenalidomide can correct these abnormalities.
SCIENCE IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Lorenzo Piemonti, Valeria Sordi, Silvia Pellegrini, Giulia Maria Scotti, Marina Scavini, Viviana Sioli, Andrea Gianelli Castiglione, Massimo Cardillo
Summary: The study found that circulating CXCL10 and IL-6 levels in donor after brain death can predict graft outcomes. Several factors affect the concentrations of IL-6 and CXCL10 in donors, and these cytokines act as independent predictors of Immediate Graft Function. Serum IL-6 and CXCL10 in donors can provide additional incremental prediction of graft outcomes for recipients.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Sandra Ampuero, Guillermo Bahamonde, Fabian Tempio, Maria Luisa Garmendia, Mauricio Ruiz, Rolando Pizarro, Patricio Rossi, Lucia Huenchur, Luis Lizama, Mercedes Lopez, Luis F. Avendano, Vivian Luchsinger
Summary: Community-acquired pneumonia (CAP) is a leading cause of death worldwide. This study explores the involvement of the IL-7/IL7R alpha axis in the severity of adult CAP for the first time. Specific genotypes and levels of IL7R gene are associated with the prognosis of CAP. Increased plasmatic sIL7R could help identify CAP cases at risk of death.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Maria Segarra-Queralt, Michael Neidlin, Laura Tio, Jordi Monfort, Joan Carles Monllau, Miguel A. Gonzalez Ballester, Leonidas G. Alexopoulos, Gemma Piella, Jerome Noailly
Summary: This study proposes a network-based model at the chondrocyte level to explain the complex mechanisms of osteoarthritis progression. By analyzing literature and enriching the network, we obtained a molecular interaction network that represents chondrocyte activity and accurately predicts the outcomes of OA treatment based on experimental data.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Elizabeta Georgieva, Stefan L. Leber, Cora Wex, Christoph Garbers
Summary: The study reveals that perturbation of the actin cytoskeleton is not sufficient to induce NF-kappa B activation and IL-6 secretion, but it reduces IL-6-induced activation of STAT3 in Hep3B cells. Additionally, IL-6 receptor proteolysis by ADAM10 is not dependent on the integrity of the actin cytoskeleton.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Yu Nakanishi, Yasushi Horimasu, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Takeshi Masuda, Taku Nakashima, Shintaro Miyamoto, Hiroshi Iwamoto, Shinichiro Ohshimo, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
Summary: The study indicates that interleukin-18 binding protein can serve as a diagnostic and prognostic biomarker for idiopathic pulmonary fibrosis. Serum interleukin-18 binding protein levels are independently associated with the disease and can predict the prognosis of idiopathic pulmonary fibrosis, showing a positive correlation with the extent of fibrosis.
Article
Biochemistry & Molecular Biology
Maha Maqsood, Saima Sharif, Shagufta Naz, Tasnim Farasat, Farkhanda Manzoor, Maqsood Cheema, Muhammad Saqib
Summary: This case-control study aimed to determine the role of IL-6 and IL-18 in the development of diabetic nephropathy in the Pakistani population. The findings showed that increased expression of IL-6 and decreased expression of IL-18 were associated with the development of DN.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Immunology
Bo-Ran Choi, Kory R. Johnson, Dragan Maric, Dorian B. McGavern
Summary: This study investigates how infiltrating monocytes in the central nervous system program resident microglia to mediate angiogenesis and cerebrovascular repair after intracerebral hemorrhage. The researchers identified a subpopulation of microglia, termed 'repair-associated microglia' (RAMs), that express vascular endothelial growth factor A and interleukin-6Ra in stroke brain lesions. Faulty RAM programming was observed without IL-6 signaling, and infiltrating CCR2(+) monocytes were found to be the primary source of IL-6 and necessary for microglia proliferation and proangiogenic properties. Defective RAM programming resulted in poor cerebrovascular repair, neuronal destruction, and sustained neurological deficits, which were all restored with exogenous IL-6 administration.
Review
Cardiac & Cardiovascular Systems
Paul M. Ridker, Manas Rane
Summary: IL-6 is a pivotal cytokine in innate immunity with a proatherogenic role in cardiovascular disease. Research has explored mechanisms of IL-6 signaling, murine models, and human epidemiological data regarding its utility as a biomarker of vascular risk.
CIRCULATION RESEARCH
(2021)
Article
Psychiatry
Hisashi Yamada, Mikuni Motoyama, Naomi Hasegawa, Kenichiro Miura, Junya Matsumoto, Kazutaka Ohi, Norio Yasui-Furukori, Shusuke Numata, Masahiro Takeshima, Nobuhiro Sugiyama, Tatsuya Nagasawa, Chika Kubota, Kiyokazu Atake, Takashi Tsuboi, Kayo Ichihashi, Naoki Hashimoto, Takahiko Inagaki, Yoshikazu Takaesu, Jun-ichi Iga, Hikaru Hori, Toshiaki Onitsuka, Hiroshi Komatsu, Akitoyo Hishimoto, Kentaro Fukumoto, Michiko Fujimoto, Toshinori Nakamura, Kiyotaka Nemoto, Ryuji Furihata, Satoshi Yamamura, Hirotaka Yamagata, Kazuyoshi Ogasawara, Eiichi Katsumoto, Atsunobu Murata, Hitoshi Iida, Shinichiro Ochi, Manabu Makinodan, Mikio Kido, Taishiro Kishimoto, Yuka Yasuda, Masahide Usami, Taro Suwa, Ken Inada, Koichiro Watanabe, Ryota Hashimoto
Summary: This study aimed to assess the effectiveness of the EGUIDE project on the clinical behavior of psychiatrists in accordance with clinical practice guidelines. The results showed that the EGUIDE program significantly improved the clinical behaviors of psychiatrists in accordance with guidelines, and these improvements were sustained for at least 2 years.
Article
Psychiatry
Yu Funahashi, Yuta Yoshino, Jun-ichi Iga, Shu-ichi Ueno
Summary: This study investigated the global expression changes of miRNA in plasma exosomes derived from treatment-resistant schizophrenia patients. The results showed significant upregulation of miR-675-3p expression after clozapine treatment.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Takashi Tsuboi, Yoshikazu Takaesu, Naomi Hasegawa, Shinichiro Ochi, Kentaro Fukumoto, Kazutaka Ohi, Hiroyuki Muraoka, Tsuyoshi Okada, Funitoshi Kodaka, Shun Igarashi, Hitoshi Iida, Hiroko Kashiwagi, Hikaru Hori, Kayo Ichihashi, Kazuyoshi Ogasawara, Naoki Hashimoto, Jun-Ichi Iga, Toshinori Nakamura, Masahide Usami, Tatsuya Nagasawa, Mikio Kido, Hiroshi Komatsu, Hirotaka Yamagata, Kiyokazu Atake, Ryuji Furihata, Saya Kikuchi, Tadasu Horai, Masahiro Takeshima, Yoji Hirano, Manabu Makinodan, Junya Matsumoto, Kenichiro Miura, Akitoyo Hishimoto, Shusuke Numata, Hisashi Yamada, Norio Yasui-Furukori, Ken Inada, Koichiro Watanabe, Ryota Hashimoto
Summary: The use of electroconvulsive therapy (ECT) may reduce the need for anxiolytic and sleep medication in patients with major depressive disorder (MDD). However, there was no significant difference in anxiolytic and sleep medication use between the ECT and non-ECT groups in patients with schizophrenia (SZ).
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Neurosciences
Rie Hosokawa, Yuta Yoshino, Yu Funahashi, Fumie Horiuchi, Jun-ichi Iga, Shu-ichi Ueno
Summary: This study investigates the expression of miRNA and mRNA in peripheral blood to explore a diagnostic biomarker for autism spectrum disorder (ASD). The results suggest that upregulated expression of miR-15b-5p may serve as a useful diagnostic marker for ASD and it may regulate the expression of TGFBR3 mRNA.
Article
Multidisciplinary Sciences
Hirotaka Yamagata, Ryouichi Tsunedomi, Toshiharu Kamishikiryo, Ayumi Kobayashi, Tomoe Seki, Masaaki Kobayashi, Kosuke Hagiwara, Norihiro Yamada, Chong Chen, Shusaku Uchida, Hiroyuki Ogihara, Yoshihiko Hamamoto, Go Okada, Manabu Fuchikami, Jun-ichi Iga, Shusuke Numata, Makoto Kinoshita, Takahiro A. Kato, Ryota Hashimoto, Hiroaki Nagano, Shuichi Ueno, Yasumasa Okamoto, Tetsuro Ohmori, Shin Nakagawa
Summary: By studying biomarkers for predicting antidepressant responses, we identified genes associated with antidepressant responsiveness and confirmed their differential expression through molecular biology experiments. Further research indicated an association between antidepressant responses and inflammation, which could be valuable for future treatment strategies for depression.
Article
Neurosciences
Hitoshi Iida, Tsuyoshi Okada, Kiyotaka Nemoto, Naomi Hasegawa, Shusuke Numata, Kazuyoshi Ogasawara, Kenichiro Miura, Junya Matsumoto, Hikaru Hori, Jun-ichi Iga, Kayo Ichihashi, Naoki Hashimoto, Hisashi Yamada, Kazutaka Ohi, Norio Yasui-Furukori, Kentaro Fukumoto, Takashi Tsuboi, Masahide Usami, Ryuji Furihata, Yoshikazu Takaesu, Akitoyo Hishimoto, Hiroyuki Muraoka, Eiichi Katsumoto, Tatsuya Nagasawa, Shinichiro Ochi, Hiroshi Komatsu, Saya Kikuchi, Masahiro Takeshima, Toshiaki Onitsuka, Shinichiro Tamai, Chika Kubota, Ken Inada, Koichiro Watanabe, Hiroaki Kawasaki, Ryota Hashimoto
Summary: The EGUIDE project was launched in 2016 to disseminate, educate, and validate psychiatric clinical practice guidelines. This study compared the effectiveness of web-based courses and face-to-face courses offered by the project. The results showed that web-based courses were rated as more satisfying than expected and there were no significant differences in satisfaction and clinical knowledge between the two formats. This suggests that web-based courses could be widely adopted alongside face-to-face courses after the COVID-19 pandemic.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2023)
Article
Urology & Nephrology
Kenji Maki, Tomoyuki Ohara, Jun Hata, Mao Shibata, Naoki Hirabayashi, Takanori Honda, Satoko Sakata, Yoshihiko Furuta, Masato Akiyama, Keisuke Yamasaki, Yasuko Tatewaki, Yasuyuki Taki, Takanari Kitazono, Tatsuya Mikami, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya
Summary: This study aimed to examine the associations between urinary albumin-creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) levels with brain atrophy and white matter lesion volume (WMLV) in a large-scale community-dwelling older population of Japanese. The results showed that higher UACR levels were significantly associated with lower total brain volume-to-intracranial volume ratio (TBV/ICV) and higher WMLV-to-ICV ratio. Lower eGFR levels were associated with lower TBV/ICV, but not clearly associated with WMLV/ICV. Higher UACR levels were also associated with lower regional brain volume-to-TBV ratio and lower hippocampal volume-to-TBV ratio.
Article
Neurosciences
Hiroaki Mori, Yuta Yoshino, Jun-ichi Iga, Shinichiro Ochi, Yu Funahashi, Kiyohiro Yamazaki, Hiroshi Kumon, Yuki Ozaki, Shu-ichi Ueno
Summary: In this study, the gene expression levels in the brain of 3xTg-AD model mice were explored to understand the molecular pathological changes of Alzheimer's disease (AD) from early to late stages. The study found changes in immune response and GABAergic neurotransmission in the brain of the mice from early to late stages of AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Pharmacology & Pharmacy
Toshiaki Onitsuka, Tsuyoshi Okada, Naomi Hasegawa, Takashi Tsuboi, Jun-ichi Iga, Norio Yasui-Furukori, Naoki Yamada, Hikaru Hori, Hiroyuki Muraoka, Kazutaka Ohi, Kazuyoshi Ogasawara, Shinichiro Ochi, Masahiro Takeshima, Kayo Ichihashi, Kentaro Fukumoto, Hitoshi Iida, Hisashi Yamada, Ryuji Furihata, Manabu Makinodan, Yoshikazu Takaesu, Shusuke Numata, Hiroshi Komatsu, Akitoyo Hishimoto, Mikio Kido, Kiyokazu Atake, Hirotaka Yamagata, Saya Kikuchi, Naoki Hashimoto, Masahide Usami, Eiichi Katsumoto, Takeshi Asami, Chika Kubota, Junya Matsumoto, Kenichiro Miura, Yoji Hirano, Koichiro Watanabe, Ken Inada, Ryota Hashimoto
Summary: This study investigated the use of psychotropic medications among schizophrenia patients in Japan who received long-acting injectable antipsychotics (LAIs) or oral antipsychotics (OAPs). The results showed that the LAI group had higher rates of polypharmacy antipsychotics, number of antipsychotics, and chlorpromazine equivalents compared to the non-LAI group. However, the LAI group had a lower rate of concomitant use of hypnotic and/or antianxiety medication than the non-LAI group. The study concluded that clinicians should consider monotherapy for the treatment of schizophrenia, especially by reducing concomitant use of antipsychotics in the LAI group and reducing hypnotic and/or antianxiety medication in the non-LAI group.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Naoki Hashimoto, Norio Yasui-Furukori, Naomi Hasegawa, Shuhei Ishikawa, Hikaru Hori, Hitoshi Iida, Kayo Ichihashi, Kenichiro Miura, Junya Matsumoto, Shusuke Numata, Fumitoshi Kodaka, Ryuji Furihata, Kazutaka Ohi, Kazuyoshi Ogasawara, Jun-ichi Iga, Hiroyuki Muraoka, Hiroshi Komatsu, Masahiro Takeshima, Kiyokazu Atake, Mikio Kido, Toshinori Nakamura, Taishiro Kishimoto, Akitoyo Hishimoto, Toshiaki Onitsuka, Tsuyoshi Okada, Shinichiro Ochi, Tatsuya Nagasawa, Manabu Makinodan, Hiroki Yamada, Takashi Tsuboi, Hisashi Yamada, Ken Inada, Koichiro Watanabe, Ryota Hashimoto
Summary: The study aimed to compare psychotropic prescriptions in Japan between hospital admission and discharge, aligning them with international standards and reducing facility differences. Patients who received monotherapy with the main drug at admission were likely to continue with monotherapy at discharge. Polypharmacy was more common in patients who switched from monotherapy to polypharmacy. Over 10% of patients had no changes in prescription throughout their hospital stay.
Article
Neurosciences
Hiroshi Kumon, Yuta Yoshino, Tomoki Ozaki, Yu Funahashi, Hiroaki Mori, Mariko Ueno, Yuki Ozaki, Kiyohiro Yamazaki, Shinichiro Ochi, Jun-ichi Iga, Shu-ichi Ueno
Summary: This study aimed to replicate previous research and focused on apoptotic-related gene expression changes in fetal brains exposed to haloperidol during pregnancy. Using RNA sequencing and qPCR methods, the up-regulation of Cdkn1a and Apaf1 mRNA expression in the hippocampus of offspring was successfully validated, and the dose-dependent upregulation of both mRNA expressions by haloperidol and aripiprazole was confirmed in in vitro experiments.
BRAIN RESEARCH BULLETIN
(2023)
Article
Geriatrics & Gerontology
Ayumi Tachibana, Jun-ichi Iga, Yasuko Tatewaki, Benjamin Thyreau, Hongkun Chen, Tomoki Ozaki, Taku Yoshida, Yuta Yoshino, Hideaki Shimizu, Takaaki Mori, Yoshihiko Furuta, Mao Shibata, Tomoyuki Ohara, Jun Hata, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Minoru Takebayashi, Toshiharu Ninomiya, Shu-ichi Ueno
Summary: The aim of this study was to determine the association between blood pressure (BP) and enlarged perivascular spaces (EPVS) volumes, and to examine the interactions of relevant factors. The study found a significant association between higher blood pressure levels and greater EPVS volumes in cognitively normal older people, and this association persisted even after excluding subjects with dementia.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2023)
Article
Clinical Neurology
Naoki Hirabayashi, Takanori Honda, Jun Hata, Yoshihiko Furuta, Mao Shibata, Tomoyuki Ohara, Yasuko Tatewaki, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya
Summary: Low frequency of social contact is associated with brain atrophy, and depressive symptoms play a role in this relationship.
Article
Geriatrics & Gerontology
Taku Yoshida, Takaaki Mori, Hideaki Shimizu, Ayumi Tachibana, Yuta Yoshino, Shinichiro Ochi, Kiyohiro Yamazaki, Yuki Ozaki, Kentaro Kawabe, Fumie Horiuchi, Kenjiro Komori, Jun-ichi Iga, Shu-ichi Ueno
Summary: This study aimed to identify risk and protective factors for cognitive disorders and found that diabetes mellitus, low activities of daily living, and living alone are risk factors for cognitive decline, while exercise and drinking habits are protective factors.
Article
Geriatrics & Gerontology
Shogyoku Bun, Kouta Suzuki, Hidehito Niimura, Ryo Shikimoto, Hisashi Kida, Mao Shibata, Takanori Honda, Tomoyuki Ohara, Jun Hata, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Kenji Nakashima, Jun-ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya, Masaru Mimura, JPSC-AD Study Grp
Summary: The association between decreased gait speed and impaired cognitive function was examined, with a focus on the influence of age and gender in the older population. Results showed that reduced gait speed was associated with increased odds of mild cognitive impairment (MCI), and this association may vary according to gender and age.