Review
Anesthesiology
Alexander Schnabel, Stephanie Weibel, Sylvia U. Reichl, Michael Meissner, Peter Kranke, Peter K. Zahn, Esther M. Pogatzki-Zahn, Christine H. Meyer-Friessem
Summary: SSNRI may effectively reduce postoperative pain between 24 and 48 hours after surgery, but may increase the risk of dizziness. Further research is needed to confirm its applicability in different individuals and types of surgeries.
JOURNAL OF CLINICAL ANESTHESIA
(2021)
Article
Integrative & Complementary Medicine
Ali Sabbagh Gol, Amir Rezaei Ardani, Seyed Kazem Farahmand, Malihe Dadgarmoghaddam, Vahideh Ghorani, Shima Rezaei, Ali Khorsand
Summary: The study found that the additive effect of acupuncture combined with SSRIs for treating anxiety disorders was significantly better than using SSRIs alone for anti-anxiety therapy. The acupuncture group showed greater improvements in STAI score changes and cortisol level decreases compared to the other groups.
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2021)
Review
Andrology
Niranjan J. Sathianathen, Eu Chang Hwang, Ruma Mian, Joshua A. Bodie, Ayman Soubra, Jennifer A. Lyon, Shahnaz Sultan, Philipp Dahm
Summary: The study found that SSRI treatment significantly improves symptoms of premature ejaculation, satisfaction with intercourse, and perceived control over ejaculation compared to placebo. However, treatment cessations may increase due to adverse events.
WORLD JOURNAL OF MENS HEALTH
(2022)
Article
Clinical Neurology
Irene Visos-Varela, Maruxa Zapata-Cachafeiro, Maria Pineiro-Lamas, Eduardo Carracedo-Martinez, Marc Saez, Maria Teresa Herdeiro, Adolfo Figueiras, Angel Salgado-Barreira
Summary: The World Health Organization suggests finding alternatives to vaccines for COVID-19 prevention and treatment, such as selective serotonin reuptake inhibitors (SSRIs). This study assesses the effect of previous treatment with SSRIs on the severity of COVID-19 and susceptibility to SARS-CoV-2.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Gabriele Giuseppe Distefano, Roberta Zangrando, Marco Basso, Lucio Panzarin, Andrea Gambaro, Annamaria Volpi Ghirardini, Marco Picone
Summary: Exposure to pharmaceuticals poses a growing threat to wildlife, with waterbirds showing high concentrations of NSAIDs and SSRIs in their feathers. The prevalence of diclofenac in particular raises concerns due to its documented toxicity towards certain bird species and its widespread use, highlighting the need for further monitoring and regulation in wastewater treatment processes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Dentistry, Oral Surgery & Medicine
Abeer Essam Hakam, Gabriela Vila, Poliana Mendes Duarte, Marcia Phemba Mbadu, Dannia Sulaiman Ai Angary, Ikramuddin Aukhil, Rodrigo Neiva, Helio Doyle Pereira da Silva, Jia Chang
Summary: This study found that patients taking antidepressants are at higher risk of dental implant failure, with users of SNRI and TCA having the highest risk of implant loss. However, conclusions about TCA are based on a limited number of cases.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Elli Anna Kotsailidi, Catherine Gagnon, Lucy Johnson, Abdul Barmak Basir, Alexandra Tsigarida
Summary: This retrospective study evaluated the association between the use of selective serotonin reuptake inhibitors (SSRIs) and changes in peri-implant marginal bone levels. The results showed a significant correlation between SSRI use and marginal bone loss around dental implants.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Abeer Essam Hakam, Poliana Mendes Duarte, Marcia Phemba Mbadu, Ikramuddin Aukhil, Helio Doyle Pereira da Silva, Jia Chang
Summary: This study found that the use of antidepressant medications was associated with higher alveolar bone levels and less clinical attachment loss in patients with periodontitis. Specifically, only SSRI class users and multiple-class users showed significantly less periodontal breakdown.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Akhil Sood, Yong-Fang Kuo, Jordan Westra, Gulshan Sharma, Mukaila A. Raji
Summary: This study found that the combination of opioids with GABA and SSRI/SNRI is associated with a lower risk of acute respiratory events in COPD patients with co-occurring chronic pain and anxiety. The findings highlight the importance of multimodal management in this vulnerable population.
ANNALS OF PHARMACOTHERAPY
(2023)
Article
Neurosciences
Kazumi Yoshizawa, Yukina Suzuki, Toka Nakamura, Yukino Takahashi, Kosho Makino, Hideyo Takahashi
Summary: The study found that duloxetine and venlafaxine produce antinociceptive effects via sodium channel blockade, while milnacipran does not. Additionally, some antidepressants and tramadol can reduce pain sensation.
Article
Pharmacology & Pharmacy
Ethan A. Poweleit, Margaret A. Cinibulk, Sarah A. Novotny, Melissa Wagner-Schuman, Laura B. Ramsey, Jeffrey R. Strawn
Summary: Pregnancy can affect the pharmacokinetics of selective serotonin reuptake inhibitors (SSRIs), which are commonly used for treating depressive and anxiety disorders. The activity of cytochrome P450 (CYP) enzymes, which metabolize SSRIs, changes significantly during pregnancy, leading to pharmacokinetic variability that may impact the tolerability and efficacy of these medications. This perspective examines the impact of pharmacokinetic genes related to CYP activity on SSRI pharmacokinetics during pregnancy and discusses the implications for dosing and future research.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Neurosciences
Mathilde Baudat, Anne R. de Kort, Daniel L. A. van den Hove, Elbert A. Joosten
Summary: Early-life exposure to selective serotonin reuptake inhibitor has long-term consequences on offspring's pain and affective disorders, altering neuronal network formation. This exposure affects the development of the prefrontal cortex and amygdala, leading to changes in nociceptive effects and behavior, as well as impacting neurotransmitter levels and connectivity within these brain regions.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Psychiatry
Or Burstein, Noam Simon, Yaarit Simchon-Tenenbaum, Moshe Rehavi, Motty Franko, Alon Shamir, Ravid Doron
Summary: Maternal stress can have negative effects on both mother and child, with the current COVID-19 pandemic exacerbating this situation. Animal models suggest that SSRIs may help alleviate anxiety, but further research is needed to understand their impact on offspring.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Jakob Christensen, Betina B. Trabjerg, Yuelian Sun, Julie Werenberg Dreier
Summary: This study examined the association between maternal antidepressant prescription during pregnancy and standardized test scores among Danish schoolchildren. Results showed that children born to mothers filling antidepressant prescriptions during pregnancy had significantly lower math test scores but no significant difference in language test scores compared to children whose mothers did not fill antidepressant prescriptions. The difference in math scores was small and of uncertain clinical importance, suggesting the need to balance the findings against the benefits of treating maternal depression during pregnancy.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Oncology
Naiqi Zhang, Jan Sundquist, Kristina Sundquist, Jianguang Ji
Summary: This population-based cohort study suggests that the use of SSRIs is associated with a reduced risk of CRC among individuals with a family history of CRC. The decreased risk of CRC showed a non-linear, dose-dependent pattern. Furthermore, the use of SSRIs was strongly associated with advanced-stage CRC rather than early-stage CRC.
Review
Psychiatry
Maria Rosaria Anna Muscatello, Giovanna Torre, Laura Celebre, Bernardo Dell'Osso, Carmela Mento, Rocco Antonio Zoccali, Antonio Bruno
Summary: Night eating syndrome, characterized by excessive nocturnal eating and frequent comorbidities with obesity and other disorders, has unclear etiology and treatment methods. Further research and clinical attention are needed to better understand and address this complex disorder.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
Maria Antonietta Barbieri, Emanuela Elisa Sorbara, Giuseppe Cicala, Vincenza Santoro, Paola Maria Cutroneo, Tindara Franchina, Edoardo Spina
Summary: This study analyzed adverse drug reactions related to HER2-positive breast cancer treatments through a spontaneous reporting system database. The majority of reports were related to trastuzumab in female patients aged 18-65 years, showing general disorders, gastrointestinal disorders, skin diseases, and blood disorders as common side effects. Serious ADR reports in Sicily mainly involved thrombocytopenia, diarrhea, and cardiac failure. Future analyses are needed to further understand the safety profile of these target therapies.
DRUGS-REAL WORLD OUTCOMES
(2022)
Review
Neurosciences
Maria Antonietta Barbieri, Emilio Perucca, Edoardo Spina, Paola Rota, Valentina Franco
Summary: Cenobamate is a new antiseizure medication used for the treatment of focal seizures in adults. Its mechanisms of action include enhancing the inactivated state of sodium channels and positive modulation of GABA(A) receptors. It has high oral bioavailability and a long half-life, allowing for once-daily dosing. However, it can cause drug-drug interactions due to its effects on various liver enzymes.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Clinical Neurology
Borwin Bandelow, Antonia M. Werner, Ina Kopp, Sebastian Rudolf, Joerg Wiltink, Manfred E. Beutel
Summary: The 2014 German Guidelines for Anxiety Disorders have been revised by a consensus group in 2019, with the addition of 92 new RCTs. The guideline recommends the use of CBT as the primary psychological treatment, and SSRIs and SNRIs as first-line drugs for anxiety disorders. Alternative strategies should be considered for patients non-responsive to standard treatments.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Amelia Rizzo, Antonio Bruno, Giovanna Torre, Carmela Mento, Gianluca Pandolfo, Clemente Cedro, Antonio Simone Lagana, Roberta Granese, Rocco Antonio Zoccali, Maria Rosaria Anna Muscatello
Summary: The study found that subthreshold mental disorders are associated with postpartum depression, and early identification of these symptoms is crucial for preventing mood problems in mothers.
HEALTH CARE FOR WOMEN INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Ian McGrane, Edoardo Spina, Christoph Hiemke, Jose de Leon
Summary: This article systematically reviews the pharmacokinetic drug-drug interactions of oral haloperidol and summarizes recommendations for clinicians based on current knowledge.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2022)
Article
Environmental Sciences
Clemente Cedro, Carmela Mento, Maria Cristina Piccolo, Fiammetta Iannuzzo, Amelia Rizzo, Maria Rosaria Anna Muscatello, Gianluca Pandolfo
Summary: Recent research has shown that women's body image, sexual arousability, and sexual anxiety were affected during the COVID-19 lockdown. Women scored lower than men in terms of body image, sexual arousability, and sexual anxiety. During the lockdown, there were significant correlations between women's sexual arousal function and parameters related to body image alteration.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Psychiatry
Borwin Bandelow, Dirk Wedekind
Summary: This study reviewed and conducted a meta-analysis on internet-delivered psychotherapeutic interventions during the COVID-19 pandemic. The results showed that these interventions were as effective as face-to-face therapy and superior to waitlist controls for treating anxiety disorders. However, the effect sizes of these interventions may be overestimated and there were limitations in the study, such as the lack of blinding and limitations in participant backgrounds.
Article
Psychiatry
Borwin Bandelow, Christer Allgulander, David S. Baldwin, Daniel Lucas da Conceicao Costa, Damiaan Denys, Nesrin Dilbaz, Katharina Domschke, Eric Hollander, Siegfried Kasper, Hans-Juergen Moeller, Elias Eriksson, Naomi A. Fineberg, Josef Haettenschwiler, Hisanobu Kaiya, Tatiana Karavaeva, Martin A. Katzman, Yong-Ku Kim, Takeshi Inoue, Leslie Lim, Vasilios Masdrakis, Jose M. Menchon, Euripedes C. Miguel, Antonio E. Nardi, Stefano Pallanti, Giampaolo Perna, Dan Rujescu, Vladan Starcevic, Dan J. Stein, Shih-Jen Tsai, Michael Van Ameringen, Anna Vasileva, Zhen Wang, Joseph Zohar
Summary: According to the guideline by the World Federation of Societies of Biological Psychiatry, OCD and PTSD can be effectively treated with medications and CBT. SSRIs and CBT are first-line treatments for OCD, while SSRIs and venlafaxine are first-line treatments for PTSD.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychiatry
Borwin Bandelow, Christer Allgulander, David S. Baldwin, Daniel Lucas da Conceicao Costa, Damiaan Denys, Nesrin Dilbaz, Katharina Domschke, Elias Eriksson, Naomi A. Fineberg, Josef Hattenschwiler, Eric Hollander, Hisanobu Kaiya, Tatiana Karavaeva, Siegfried Kasper, Martin Katzman, Yong-Ku Kim, Takeshi Inoue, Leslie Lim, Vasilios Masdrakis, Jose M. Menchon, Euripedes C. Miguel, Hans-Jurgen Moller, Antonio E. Nardi, Stefano Pallanti, Giampaolo Perna, Dan Rujescu, Vladan Starcevic, Dan J. Stein, Shih-Jen Tsai, Michael Van Ameringen, Anna Vasileva, Zhen Wang, Joseph Zohar
Summary: This study presents the third version of the guideline for the pharmacological treatment of anxiety, obsessive-compulsive, and posttraumatic stress disorders. It provides recommendations based on efficacy and acceptability of available treatments, evaluated through rigorous methods. The study highlights the importance of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) as first-line medications, and cognitive behavioral therapy (CBT) as the first-line psychotherapy for anxiety disorders.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Maria Antonietta Barbieri, Anna Viola, Giuseppe Cicala, Edoardo Spina, Walter Fries
Summary: This study investigated the persistence and safety profiles of biologic therapies in patients with inflammatory bowel disease. The results showed varying levels of persistence and the occurrence of adverse drug reactions with different biologic therapies. Further research is needed to study undetected safety concerns and the risk of malignancy.
Article
Oncology
Maria Antonietta Barbieri, Emanuela Elisa Sorbara, Giulia Russo, Giuseppe Cicala, Tindara Franchina, Mariacarmela Santarpia, Nicola Silvestris, Edoardo Spina
Summary: Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms primarily occurring in the stomach. Most cases of GISTs are associated with activating mutations in the KIT and PDGFRA genes. The approval of tyrosine kinase inhibitors (TKIs) has significantly improved the treatment of GISTs, and the analysis of adverse drug reactions (ADRs) through spontaneous reporting systems is important for understanding the safety profile of these drugs.
Article
Chemistry, Medicinal
Cosimo Galletti, Maria Antonietta Barbieri, Francesco Ciodaro, Francesco Freni, Francesco Galletti, Edoardo Spina, Bruno Galletti
Summary: This study aimed to evaluate the effectiveness and safety profile of Dupilumab in patients with chronic rhinosinusitis with nasal polyps. The results showed a significant reduction in SNOT-22 and NPS scores at 6 and 12 months compared to baseline values. Adverse effects such as injection site reactions and transient hypereosinophilia were observed in a small number of patients. In conclusion, Dupilumab is considered a safe and effective treatment option.
Article
Biochemistry & Molecular Biology
Giulia Russo, Maria Antonietta Barbieri, Emanuela Elisa Sorbara, Giuseppe Cicala, Tindara Franchina, Mariacarmela Santarpia, Nicola Silvestris, Edoardo Spina
Summary: This study evaluated the nephrotoxicity of REG and ENC in mCRC patients by analyzing reports from the FAERS database. The results indicated a significant association between REG and renal ADRs, highlighting the need for further investigation into the safety profiles of REG and ENC.
Review
Psychiatry
Carmela Mento, Maria Catena Silvestri, Maria Rosaria Anna Muscatello, Amelia Rizzo, Laura Celebre, Clemente Cedro, Rocco Antonio Zoccali, Giuseppe Navarra, Antonio Bruno
Summary: The findings suggest that body image typically does not change after bariatric surgery for obese patients, potentially due to difficulties in adapting to the new body and persistent obese self-view. Additionally, patients may experience dissatisfaction with excessive skin post-surgery.
EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
(2022)