期刊
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
卷 27, 期 4, 页码 411-418出版社
WILEY-BLACKWELL
DOI: 10.1002/hup.2242
关键词
attention-deficit; hyperactivity disorder; bupropion; methylphenidate; children; adolescent
资金
- Tehran University of Medical Sciences [9745]
Objective To compare the safety and efficacy of bupropion with methylphenidate in children and adolescents with attention-deficit/hyperactivity disorder (ADHD). Methods In a 6-week randomized double-blind study, 44 patients with a DSM-IV-TR diagnosis of ADHD were randomly assigned to receive bupropion 100150?mg/day (100?mg/day for <30?kg and 150?mg/day for >30?kg) or methylphenidate 2030?mg/day. Symptoms were assessed using Teacher and Parent Attention-Deficit/Hyperactivity Disorder Rating Scale-IV (ADHD-RS-IV) at baseline and weeks 3 and 6. Results Forty patients had at least one post-baseline measurement, and 38 patients completed the trial. No significant difference was found between the two groups on the Parent and Teacher ADHD-RS-IV scores ([F(1, 38)?=?0.266, p?=?0.609] and [F(1, 38)?=?0.001, p?=?0.972], respectively). By week 6, 18 patients (90%) in each group achieved response on the Parent scale (Fisher's exact test p-value?=?1.0). With the Teacher ADHD-RS-IV used, eight (40%) patients in the bupropion group and 12 (60%) patients in the methylphenidate group achieved response by week 6 (?2(1)?=?1.600, p?=?0.206). Headache was observed more frequently in the methylphenidate group. Frequency of other side effects was not significantly different between the two groups. Conclusions Bupropion has a comparable safety and efficacy profile with methylphenidate in children and adolescents with ADHD. Copyright (C) 2012 John Wiley & Sons, Ltd.
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