Article
Clinical Neurology
Carter E. Bedford, Norman B. Schmidt
Summary: This study evaluated the effect of a brief computer-based intervention (SBETS) on posttraumatic stress symptoms (PTSS). The results showed that SBETS had a significant impact on PTSS and could be considered as an accessible and acceptable treatment option for trauma survivors.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Jennifer M. Mitchell, G. Marcela Ot'alora, Bessel van der Kolk, Scott Shannon, Michael Bogenschutz, Yevgeniy Gelfand, Casey Paleos, Christopher R. Nicholas, Sylvestre Quevedo, Brooke Balliett, Scott Hamilton, Michael Mithoefer, Sarah Kleiman, Kelly Parker-Guilbert, Keren Tzarfaty, Charlotte Harrison, Alberdina de Boer, Rick Doblin, Berra Yazar-Klosinski
Summary: This study evaluated the efficacy and safety of MDMA-AT in participants with moderate to severe PTSD. The results showed that MDMA-AT significantly reduced the severity of symptoms and functional impairment, and was well tolerated by a diverse population.
Article
Medicine, Research & Experimental
Lei Yi, Yunling Lian, Ning Ma, Ni Duan
Summary: This study found that yoga intervention can alleviate anxiety and depression, and improve symptoms for women with PTSD who are survivors of motor vehicle accidents.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Psychology, Clinical
Yaron Alon, Omer Azriel, Daniel S. Pine, Yair Bar-Haim
Summary: This study examined remotely-delivered attention bias modification (ABM) and attention control training (ACT) for PTSD treatment. Results showed that both ACT and ABM led to significant symptom reduction, with ACT showing advantages in non-depressed patients and patients whose trauma occurred more recently. Further refinements in remote ABM/ACT treatments may be necessary.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Austeja Dumarkaite, Inga Truskauskaite-Kuneviciene, Gerhard Andersson, Evaldas Kazlauskas
Summary: This study investigated the effects of an online mindfulness-based intervention on ICD-11 posttraumatic stress disorder (PTSD) and complex PTSD (CPTSD) symptoms at a 3-month follow-up. Results showed that the intervention was effective for reducing CPTSD symptoms, specifically in self-organization and relationship disturbances.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Junfeng Zhong, Yan Li, Lichao Fang, Dan Han, Chuhao Gong, Shuangyan Hu, Rongguo Wang, Liwei Wang, Rui Yao, Beiping Li, Yangzi Zhu, Youjia Yu
Summary: The early use of propofol general anesthesia in emergency surgery for trauma patients may increase the risk of PTSD.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Tanya C. Saraiya, Amber M. Jarnecke, Alex O. Rothbaum, Bethany Wangelin, Lisa M. McTeague, Ron Acierno, Delisa G. Brown, Emily Bristol, Hayley Feigl, Mclain Reese, Adam R. Cobb, Bill Harley, Robert J. Adams, Sudie E. Back
Summary: This study assessed the use of wearable technology in Prolonged Exposure therapy for PTSD. The findings suggest that using this technology for virtual, clinician-guided exposures can enhance treatment outcomes and reduce symptoms.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Neurosciences
Sarah K. Fineberg, Esther Y. Choi, Rosa Shapiro-Thompson, Khushwant Dhaliwal, Eli Neustadter, Madison Sakheim, Kaylee Null, Daniel Trujillo-Diaz, Jocelyne Rondeau, Giana F. Pittaro, Jessica R. Peters, Philip R. Corlett, John H. Krystal
Summary: This study is the first randomized controlled trial to assess the effects of ketamine in Borderline Personality Disorder (BPD). The results showed that ketamine infusion was well tolerated but did not significantly reduce suicidal ideation, depression, anxiety, or BPD symptoms. However, there was an improvement in socio-occupational functioning in the ketamine group compared to the midazolam group at Day 14. Overall, this pilot study provides evidence that antidepressant-dosed ketamine may benefit BPD patients in terms of mood symptoms and related impairments.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jennifer M. Mitchell, Michael Bogenschutz, Alia Lilienstein, Charlotte Harrison, Sarah Kleiman, Kelly Parker-Guilbert, Marcela G. Ot'alora, Wael Garas, Casey Paleos, Ingmar Gorman, Christopher Nicholas, Michael Mithoefer, Shannon Carlin, Bruce Poulter, Ann Mithoefer, Sylvestre Quevedo, Gregory Wells, Sukhpreet S. Klaire, Bessel van der Kolk, Keren Tzarfaty, Revital Amiaz, Ray Worthy, Scott Shannon, Joshua D. Woolley, Cole Marta, Yevgeniy Gelfand, Emma Hapke, Simon Amar, Yair Wallach, Randall Brown, Scott Hamilton, Julie B. Wang, Allison Coker, Rebecca Matthews, Alberdina de Boer, Berra Yazar-Klosinski, Amy Emerson, Rick Doblin
Summary: The results demonstrate that MDMA-assisted therapy is safe and effective in treating severe post-traumatic stress disorder. Compared with placebo, MDMA significantly reduces CAPS-5 scores and improves functional impairment.
Article
Psychiatry
Huiling Yuan, Bin Liu, Fengzhan Li, Yinchuan Jin, Shi Zheng, Zhujing Ma, Zhongying Wu, Chen Chen, Liang Zhang, Yanan Gu, Xing Gao, Qun Yang
Summary: This study compared the effectiveness of two forms of transcranial magnetic stimulation (TMS), 10 Hz rTMS and intermittent theta burst stimulation (iTBS), in treating post-traumatic stress disorder (PTSD). The results showed that both iTBS and rTMS significantly improved symptoms compared to a sham-controlled group, with no significant difference between the two active treatment groups. iTBS offers the advantage of shorter treatment sessions compared to 10 Hz rTMS.
PSYCHIATRY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Kelly H. M. Cooijmans, Roseriet Beijers, Bonnie E. Brett, Carolina de Weerth
Summary: Mother-infant skin-to-skin contact during the early postpartum period may reduce anxiety and fatigue symptoms for mothers, but not depressive, stress, and pain symptoms. Replication studies are recommended.
SCIENTIFIC REPORTS
(2022)
Article
Psychology, Clinical
Nithya Ramakrishnan, Marijn Lijffijt, Charles E. Green, Nicholas L. Balderston, Nicholas Murphy, Christian Grillon, Tabish Iqbal, Brittany Vo-Le, Brittany O'Brien, James W. Murrough, Alan C. Swann, Sanjay J. Mathew
Summary: The study demonstrated successful occupancy of lanicemine on NMDAR and effects on arousal symptoms. While lanicemine strongly attenuated APS following a single infusion, differential changes from placebo after three infusions may have been obscured by habituation effects. This research supports selective NMDAR antagonism as a viable pharmacological strategy for treating salient aspects of PTSD.
DEPRESSION AND ANXIETY
(2021)
Article
Psychology, Clinical
Austeja Dumarkaite, Inga Truskauskaite-Kuneviciene, Gerhard Andersson, Julija Mingaudaite, Evaldas Kazlauskas
Summary: The study showed that mindfulness-based internet intervention can reduce symptoms of CPTSD, particularly disturbances in self-organization like negative self-concept and relationship issues. It also decreased PTSD symptoms related to sense of threat and improved positive mental health. High user satisfaction and good usability of the intervention were reported.
Article
Psychology, Clinical
Kathryn Trottier, Candice M. Monson, Stephen A. Wonderlich, Ross D. Crosby
Summary: This study shows that integrating cognitive-behavioral therapy for PTSD and ED after intensive ED treatment is safe, desirable, and effective in improving PTSD symptoms. Both treatments significantly improved PTSD, anxiety, and depression symptoms.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Medicine, General & Internal
David J. Kearney, Carol A. Malte, Meghan Storms, Tracy L. Simpson
Summary: This study compared the effectiveness of group loving-kindness meditation and group cognitive processing therapy for treating PTSD among veterans. The results showed that loving-kindness meditation was noninferior to cognitive processing therapy in reducing PTSD symptoms, with modest improvements observed in both interventions. Additionally, loving-kindness meditation showed greater reduction in depressive symptoms compared to cognitive processing therapy over time.
Article
Psychology, Clinical
Alan E. Kazdin, Chi-Shin Wu, Irving Hwang, Victor Puac-Polanco, Nancy A. Sampson, Ali Al-Hamzawi, Jordi Alonso, Laura Helena Andrade, Corina Benjet, Jose-Miguel Caldas-de-Almeida, Giovanni de Girolamo, Peter de Jonge, Silvia Florescu, Oye Gureje, Josep M. Haro, Meredith G. Harris, Elie G. Karam, Georges Karam, Viviane Kovess-Masfety, Sing Lee, John J. McGrath, Fernando Navarro-Mateu, Daisuke Nishi, Bibilola D. Oladeji, Jose Posada-Villa, Dan J. Stein, T. Bedirhan Ustun, Daniel V. Vigo, Zahari Zarkov, Alan M. Zaslavsky, Ronald C. Kessler
Summary: Antidepressant medications (ADMs) are widely used for a variety of conditions, not only depression and anxiety. The usage rate of ADMs is higher in high-income countries compared to low- and middle-income countries, and newer ADMs are more frequently used in high-income countries. Among users, 58.8% perceive ADMs to be very effective and 28.3% perceive them to be somewhat effective, with these proportions being higher in low- and middle-income countries than in high-income countries.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Glenn Kiekens, Penelope Hasking, Ronny Bruffaerts, Jordi Alonso, Randy P. Auerbach, Jason Bantjes, Corina Benjet, Mark Boyes, Wai Tat Chiu, Laurence Claes, Pim Cuijpers, David D. Ebert, Arthur Mak, Philippe Mortier, Siobhan O'Neill, Nancy A. Sampson, Dan J. Stein, Gemma Vilagut, Matthew K. Nock, Ronald C. Kessler
Summary: Non-suicidal self-injury (NSSI) is common among college students and is a behavioral marker of various common mental disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Neurosciences
Ann M. Alex, Claudia Buss, Elysia Poggi Davis, Gustavo de los Campos, Kirsten A. Donald, Damien A. Fair, Nadine Gaab, Wei Gao, John H. Gilmore, Jessica B. Girault, Karen Grewen, Nynke A. Groenewold, Benjamin L. Hankin, Jonathan Ipser, Shreya Kapoor, Pilyoung Kim, Weili Lin, Shan Luo, Elizabeth S. Norton, Thomas G. O'Connor, Joseph Piven, Anqi Qiu, Jerod M. Rasmussen, Michael A. Skeide, Dan J. Stein, Martin A. Styner, Paul M. Thompson, Laurie Wakschlag, Rebecca Knickmeyer
Summary: Imaging genetics studies have primarily focused on adults and adolescents, with very few studies examining brain development in infancy and early childhood. However, understanding the genetic influences on early brain development is crucial for predicting risk of psychiatric illness and neurodevelopmental disabilities. This review summarizes findings from imaging genetics studies in infants and young children, and introduces a working group established to facilitate large-scale studies in this population.
BIOLOGICAL PSYCHIATRY
(2023)
Review
Psychiatry
Kimberly Blake, Ziphozihle Ntwatwa, Tobias Kaufmann, Dan J. Stein, Jonathan C. Ipser, Nynke A. Groenewold
Summary: The study suggests that psychopathology is related to an advanced brain aging process, and machine learning models can predict an individual's age based on brain imaging data. The meta-analysis found that there is a larger brain age difference in psychotic disorders and a smaller difference in mood disorders. Clinical factors, such as symptom severity, may be associated with a larger brain age difference in psychopathology.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychology, Developmental
Sara Bertolin, Pino Alonso, Ignacio Martinez-Zalacain, Jose M. Menchon, Susana Jimenez-Murcia, Justin T. Baker, Nuria Bargallo, Marcelo Camargo Batistuzzo, Premika S. W. Boedhoe, Brian P. Brennan, Jamie D. Feusner, Kate D. Fitzgerald, Martine Fontaine, Bjarne Hansen, Yoshiyuki Hirano, Marcelo Q. Hoexter, Chaim Huyser, Neda Jahanshad, Fern Jaspers-Fayer, Masaru Kuno, Gerd Kvale, Luisa Lazaro, Mafalda Machado-Sousa, Rachel Marsh, Pedro Morgado, Akiko Nakagawa, Luke Norman, Erika L. Nurmi, Joseph O'Neill, Ana E. Ortiz, Chris Perriello, John Piacentini, Maria Pico-Perez, Roseli G. Shavitt, Eiji Shimizu, Helen Blair Simpson, S. Evelyn Stewart, Sophia I. Thomopoulos, Anders Lillevik Thorsen, Susanne Walitza, Lidewij H. Wolters, Paul M. Thompson, Odile A. van den Heuvel, Dan J. Stein, Carles Soriano-Mas
Summary: The results of the study suggest that higher cortical thickness in specific right prefrontal cortex regions may play an important role in the response to cognitive-behavioral therapy in children with OCD.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Pediatrics
Carlyle McCready, Sadia Haider, Francesca Little, Mark P. Nicol, Lesley Workman, Diane M. Gray, Raquel Granell, Dan J. Stein, Adnan Custovic, Heather J. Zar
Summary: This study aimed to describe the developmental trajectories of childhood wheezing in South Africa and the UK. Four wheeze phenotypes were identified in the South African cohort: never, early transient, late onset, and recurrent. All-cause lower respiratory tract infection and respiratory syncytial virus infection were associated with recurrent wheeze.
LANCET CHILD & ADOLESCENT HEALTH
(2023)
Review
Neurosciences
A. Prag, K. A. Donald, E. Weldon, S. L. Halligan, D. J. Stein, S. Malcolm-Smith
Summary: Child development is influenced by maternal characteristics, but there is limited research on this topic in Sub-Saharan Africa. This scoping review aims to assess the nature and extent of observational assessments of dyadic interactions and explore the risks and outcomes associated with maternal sensitivity in this context. The research findings highlight the need for more culturally sensitive and rigorous studies in this field.
ACTA NEUROPSYCHIATRICA
(2023)
Article
Neurosciences
Olivia Wootton, Shareefa Dalvie, Rae MacGinty, Linda Ngqengelele, Ezra S. Susser, Ruben C. Gur, Dan J. Stein
Summary: This study examined the relationship between within-individual variability (WIV) and clinical and demographic variables in people with schizophrenia in South Africa. The results showed that increased WIV in performance speed was associated with a diagnosis of schizophrenia, older age, lower education level, and lower overall functioning. Increased WIV in accuracy was associated with younger age. Therefore, studying WIV can provide additional insights into cognitive dysfunction in schizophrenia in resource-limited settings.
ACTA NEUROPSYCHIATRICA
(2023)
Article
Biochemistry & Molecular Biology
Anna Kotsakis Ruehlmann, Sara Sammallahti, Andrea P. Cortes Hidalgo, Kelly M. Bakulski, Elisabeth B. Binder, Megan Loraine Campbell, Doretta Caramaschi, Charlotte A. M. Cecil, Elena Colicino, Cristiana Cruceanu, Darina Czamara, Linda Dieckmann, John Dou, Janine F. Felix, Josef Frank, Siri E. Haberg, Gunda Herberth, Thanh T. Hoang, Lotte C. Houtepen, Anke Huls, Nastassja Koen, Stephanie J. London, Maria C. Magnus, Giulia Mancano, Rosa H. Mulder, Christian M. Page, Katri Raikkonen, Stefan Roeder, Rebecca J. Schmidt, Tabea S. Send, Gemma Sharp, Dan J. Stein, Fabian Streit, Johanna Tuhkanen, Stephanie H. Witt, Heather J. Zar, Ana C. Zenclussen, Yining Zhang, Lea Zillich, Rosalind Wright, Jari Lahti, Kelly J. Brunst
Summary: Prenatal maternal stressful life events are associated with adverse neurodevelopmental outcomes in offspring. This meta-analysis examined the association between maternal stressful life events during pregnancy and DNA methylation in cord blood. Children whose mothers reported higher levels of cumulative maternal stressful life events during pregnancy exhibited differential methylation of specific genes implicated in neurodevelopment, neurodegeneration, immune and cellular functions, regulation of global methylation levels, metabolism, and schizophrenia risk. These findings provide novel insights into potential mechanisms of neurodevelopment in offspring.
MOLECULAR PSYCHIATRY
(2023)
Article
Anthropology
Olivia P. Matshabane, Paul S. Appelbaum, Marlyn C. Faure, Patricia A. Marshall, Dan J. Stein, Jantina de Vries, Megan M. Campbell
Summary: Internalised stigma among people with mental illness is common and has negative consequences. However, there is no validated tool to measure internalised stigma in the Xhosa language. This study aimed to translate and validate the ISMI scale in isiXhosa. The results showed that the ISMI-X scale demonstrated good psychometric utility and validity, providing valuable insights into the translation design.
TRANSCULTURAL PSYCHIATRY
(2023)
Article
Psychiatry
Zsolt Horvath, Lena Nagy, Monika Koos, Shane W. Kraus, Zsolt Demetrovics, Marc N. Potenza, Rafael Ballester-Arnal, Dominik Batthyany, Sophie Bergeron, Joel Billieux, Peer Briken, Julius Burkauskas, Georgina Cardenas-Lopez, Joana Carvalho, Jesus Castro-Calvo, Lijun Chen, Giacomo Ciocca, Ornella Corazza, Rita Csako, David P. Fernandez, Hironobu Fujiwara, Elaine F. Fernandez, Johannes Fuss, Roman Gabrhelik, Ateret Gewirtz-Meydan, Biljana Gjoneska, Mateusz Gola, Joshua B. Grubbs, Hashim T. Hashim, Md. Saiful Islam, Mustafa Ismail, C. Martha Jimenez-Martinez, Tanja Jurin, Ondrej Kalina, Verena Klein, Andras Kolto, Sang-Kyu Lee, Karol Lewczuk, Chung-Ying Lin, Christine Lochner, Silvia Lopez-Alvarado, Katerina Lukavska, Percy Mayta-Tristan, Dan J. Miller, Olga Orosova, Gabor Orosz, Mami Sungkyunkwan Univ res team, Fernando P. Ponce, Gonzalo R. Quintana, Gabriel C. Quintero Garzola, Jano Ramos-Diaz, Kevin Rigaud, Ann Rousseau, Marco De Tubino Scanavino, Marion K. Schulmeyer, Pratap Sharan, Mami Shibata, Sheikh Shoib, Vera Sigre-Leiros, Luke Sniewski, Ognen Spasovski, Vesta Steibliene, Dan J. Stein, Julian Strizek, Meng-Che Tsai, Berk C. Unsal, Marie-Pier Vaillancourt-Morel, Marie Claire Van Hout, Beata Bothej
Summary: This study examined different measurement models for the Alcohol Use Disorders Identification Test (AUDIT) and its measurement invariance across various subgroups. The results showed that a two-factor model with factors of 'alcohol use' and 'alcohol problems' had the best fit across countries, languages, genders, and sexual orientations. The study also found high levels of measurement invariance for the AUDIT, supporting its use in cross-cultural research and comparisons among genders and sexual orientations.
COMPREHENSIVE PSYCHIATRY
(2023)
Article
Psychiatry
Sheri-Michelle Koopowitz, Karen Thea Mare, Marilyn Lake, Christopher du Plooy, Nadia Hoffman, Kirsten A. Donald, Susan Malcolm-Smith, Lynne Murray, Heather J. Zar, Peter Cooper, Dan J. Stein
Summary: This study investigated the effects of dialogic book-sharing on language development, neurocognitive function, and socio-emotional domains in 3.5-year-old children from low-income South African communities. The results showed no significant differences between the intervention and control groups after 4 months post-intervention.
COMPREHENSIVE PSYCHIATRY
(2024)
Article
Psychology, Clinical
Debra Kaminer, Candice Simmons, Soraya Seedat, Stephanie Skavenski, Laura Murray, Martin Kidd, Judith A. A. Cohen
Summary: This study evaluated the efficacy of an abbreviated eight-session version of Trauma-Focused Cognitive Behavioural Therapy (TF-CBT) for reducing posttraumatic stress disorder (PTSD) and depression symptoms in South African adolescents. The results showed significant improvements in PTSD and depression symptoms in the TF-CBT group compared to the control group at post-treatment and three-month follow-up. This suggests that the abbreviated TF-CBT has potential efficacy in LMIC settings for adolescents with multiple trauma exposure.
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2023)
Article
Psychiatry
Gondah Lekpeh, Muneeb Salie, Leigh L. van den Heuvel, Soraya Seedat
Summary: This study describes the neurological and/or neuropsychiatric manifestations in hospitalized COVID-19 patients and compares patients with and without such symptoms in terms of demographic and clinical characteristics, treatment, and outcomes. The results suggest that while COVID-19 patients with neurological and/or neuropsychiatric manifestations may have less respiratory symptoms, they still have similar mortality rates as patients without such symptoms.
SOUTH AFRICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Jason Bantjes, Molly J. Kessler, Xanthe Hunt, Dan J. Stein, Ronald C. Kessler
Summary: Mental health problems are common among South African university students, yet treatment rates are low. Identifying barriers to treatment is crucial for increasing the treatment rates.
INTERNATIONAL JOURNAL OF MENTAL HEALTH SYSTEMS
(2023)