Article
Neurosciences
Ye Yang, Yujun Long, Dongyu Kang, Chenchen Liu, Jingmei Xiao, Renrong Wu, Jingping Zhao
Summary: The study suggests that probiotics may reduce olanzapine-induced weight gain at the early stage of treatment and delay olanzapine-induced appetite increase. However, this difference disappears at 8 and 12 weeks of treatment.
PSYCHOPHARMACOLOGY
(2021)
Article
Psychiatry
Jinling Zhang, Shu Chen, Jia Chen, Handi Zhang, Wen-Wang Rao
Summary: This study aimed to investigate the differences in the efficacy of topiramate (TPM) and vitamin C (VC) in reducing olanzapine (OLZ)-induced weight gain and metabolic abnormalities. The results showed that TPM was more effective in reducing OLZ-induced increase in triglyceride levels, and there were also differences in the trajectories of change in metabolic indexes between the two groups.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Manit Srisurapanont, Sirijit Suttajit, Surinporn Likhitsathian, Benchalak Maneeton, Narong Maneeton
Summary: This study compared weight and cardiometabolic changes after short-term treatment of olanzapine/samidorphan and olanzapine, finding no significant differences in weight changes and all-cause dropout rates between the two treatments.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Junfa Gao, Junsheng Li, Xiuhua Lu, Junyi Yang
Summary: Combining samidorphan (SAM) with olanzapine (OLZ) can mitigate OLZ-associated weight gain while maintaining its antipsychotic efficacy. Clinical trials have shown that OLZ/SAM significantly improves psychotic symptoms and results in less weight gain.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Georgios Schoretsanitis, Celine Dubath, Claire Grosu, Marianna Piras, Nermine Laaboub, Setareh Ranjbar, Nicolas Ansermot, Severine Crettol, Frederik Vandenberghe, Franziska Gamma, Armin Gunten, Kerstin Jessica Plessen, Erich Seifritz, Philippe Conus, Chin B. Eap
Summary: This study assessed the effects of olanzapine on metabolic parameters, and found that high-dose olanzapine treatment may lead to early weight gain, while low-dose treatment is associated with increases in blood lipids and blood pressure. Treatment duration and co-prescription of other medications were also found to be related to weight gain.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ghulam Md Ashraf, Badrah S. Alghamdi, Fahad S. Alshehri, Mohammad Zubair Alam, Haythum O. Tayeb, Frank Tarazi
Summary: The study found that the antidiabetic drug EMPA effectively attenuated the body weight gain induced by the atypical antipsychotic drug Ola in female Wistar rats. The impact of Ola on female Wistar rats was significantly different from male rats, indicating a potential gender difference in body weight gain caused by antipsychotic drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Health Care Sciences & Services
Gesche Jurgens, Benjamin Skov Kaas-Hansen, Merete Nordentoft, Thomas Werge, Stig Ejdrup Andersen
Summary: This study found an association between genetically predicted CYP2D6 metabolic capacity and antipsychotic-induced weight gain. The results showed significant weight gain in both CYP2D6 poor metabolizers and ultrarapid metabolizers after taking antipsychotic drugs.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Psychiatry
Jia Hong Liu, Nan Chen, Yan Hong Guo, Xiao Ni Guan, Jun Wang, Dong Wang, Mei Hong Xiu
Summary: Studies have shown that patients with schizophrenia have a higher rate of metabolic disorder compared to the general population, possibly due to the use of atypical antipsychotics. Olanzapine, a commonly used antipsychotic, is known to increase weight in schizophrenia patients, with potential metabolic implications. Metabolomics may help identify biomarkers related to antipsychotic-induced metabolic disorder in schizophrenia patients.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychiatry
Yuying Qiu, Meijuan Li, Yonghui Zhang, Ying Liu, Yongping Zhao, Jing Zhang, Qiong Jia, Jie Li
Summary: Berberine could reduce weight gain in schizophrenia patients, with significant weight loss observed in the berberine group compared to placebo. The effect may be related to the regulation of leptin levels.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Psychiatry
Wei Chou Tseng, Veronica Reinhart, Thomas A. Lanz, Mark L. Weber, Jincheng Pang, Kevin Xuong Vinh Le, Robert D. Bell, Patricio O'Donnell, Derek L. Buhl
Summary: The A391T missense mutation in ZIP8 results in reduced zinc transport, altered glutamate signaling, and an exacerbated immune and inflammatory response. Re-expression of wild-type ZIP8 or application of the zinc chelator ZX1 can rescue the observed phenotypes. These findings provide novel therapeutic targets relevant to schizophrenia.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biology
Shivprakash Nagaraj Kanagali, B. M. Patil, Pukar Khanal, Banappa S. Unger
Summary: This study predicted the interactions of bioactives from Cyperus rotundus against obesity using network pharmacology and evaluated the efficacy of Cyperus rotundus hydroalcoholic extract in treating olanzapine-induced weight gain and metabolic disturbances in experimental animals.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Julia Paik
Summary: Samidorphan, developed by Alkermes, is an opioid receptor antagonist co-formulated with olanzapine into a single-dose oral tablet to reduce weight gain risk while maintaining the therapeutic effect of olanzapine. Recently approved in the USA for the treatment of schizophrenia and bipolar I disorder, olanzapine/samidorphan represents a milestone in the development of samidorphan.
Article
Pharmacology & Pharmacy
Vera S. Dobrodeeva, Natalia A. Shnayder, Maxim A. Novitsky, Azat R. Asadullin, Elena E. Vaiman, Marina M. Petrova, Oleg V. Limankin, Nikolay G. Neznanov, Natalia P. Garganeeva, Regina F. Nasyrova
Summary: This study revealed a significant association between the major allele C of SNP rs11100494 of the NPY5R gene and AP-induced weight gain in Russian patients with SSDs, suggesting its predictive role in the development of weight gain. Additionally, first-generation APs were more likely to increase serum transaminase levels, while second-generation APs were more likely to cause weight gain and changes in serum glucose levels.
Article
Psychiatry
Tianhang Zhou, Chengcheng Pu, Zetao Huang, Tianqi Gao, Enpeng Zhou, Yue Zheng, Dan Zhang, Bingjie Huang, Zhang Cheng, Chuan Shi, Xin Yu
Summary: This study assessed weight changes following antipsychotic treatment in first-episode schizophrenia patients and compared the effects of aripiprazole, risperidone, and olanzapine. The results showed that body weight increased at an average rate of 0.93% per month, with the highest growth rate in the first 3 months. Clinically relevant weight gain (CRW) was observed in 79% of patients. Olanzapine was associated with significantly higher weight gain compared to risperidone and aripiprazole. Predictors for first-year CRW included smaller baseline BMI, family history of mental disorder, receiving olanzapine, and CRW in the first month. Aripiprazole may not be the ideal choice for long-term metabolic side effects.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Review
Psychiatry
Kenn Lee, Seri Abraham, Robert Cleaver
Summary: This study evaluated the efficacy of licensed weight loss medications (WLMs) for treating antipsychotic-induced weight gain (AIWG) and obesity in schizophrenia and psychosis. The findings showed that liraglutide had the strongest evidence compared to other licensed WLMs in improving weight, BMI, waist circumference, HbA1c, cholesterol, and LDL readings. This evidence supports the use of liraglutide in treating AIWG and OSP.
GENERAL HOSPITAL PSYCHIATRY
(2022)
Editorial Material
Endocrinology & Metabolism
Seung-Hoi Koo
ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Clinical Neurology
Michael J. McCarthy, John F. Gottlieb, Robert Gonzalez, Colleen A. McClung, Lauren B. Alloy, Sean Cain, Davide Dulcis, Bruno Etain, Benicio N. Frey, Corrado Garbazza, Kyle D. Ketchesin, Dominic Landgraf, Heon-Jeong Lee, Cynthia Marie-Claire, Robin Nusslock, Alessandra Porcu, Richard Porter, Philipp Ritter, Jan Scott, Daniel Smith, Holly A. Swartz, Greg Murray
Summary: Symptoms of bipolar disorder include changes in mood, activity, energy, sleep, and appetite, with circadian rhythm disturbance considered a biological feature underlying BD. Research has found associations between the circadian system and mood regulation, but circadian disruption is not specific to BD and is present across various psychiatric disorders. Future studies on circadian rhythms and its role in BD should carefully define associations and integrate across levels of analysis for more comprehensive insights.
Article
Psychiatry
Seulki Lee, Heon-Jeong Lee, Chul-Hyun Cho
Summary: This study aimed to examine the impact of stress on quality of life and the mediating role of insomnia symptoms in the relationship between stress and quality of life. The results showed a positive association between stress and insomnia symptoms, with insomnia symptoms predicting quality of life. Notably, the mediating effect of insomnia symptoms was more significant in females.
PSYCHIATRY INVESTIGATION
(2022)
Article
Neurosciences
Hyun Jung Kim, Hyeijung Yoo, Ji Yeon Kim, Soo Hyun Yang, Hyun Woo Lee, Heon-Jeong Lee, Gi Hoon Son, Hyun Kim
Summary: Through postmortem gene expression analysis, 251 differentially expressed genes (DEGs) were identified in the Hb tissue of suicides compared to Hb tissues from neurotypical individuals. Subsequent bioinformatic analyses using single-cell transcriptome data from the mouse Hb revealed that a subset of endothelial cell-enriched genes and their putative upstream transcriptional regulators were significantly affected in suicides. Despite being based on a limited number of samples, the study suggests a potential association of endothelial dysfunction in the Hb with depression and suicidal behavior.
Article
Environmental Sciences
Mi-Nam Bae, Seo-Eun Cho, Ju-Hyeon Ryu, Mi-Hwa Kim, Hye-Jin Jeon, Eun-Ji Shin, Seon-A Lee, Tae-Yeon Hwang, Seung-Gul Kang
Summary: This study used psychological autopsies to investigate factors related to suicide in Incheon, South Korea. The findings showed that 87% of suicide victims had mental health conditions before their death, but only 15.2% received treatment or counseling. Warning signs were present in most individuals who died by suicide, but only 19.6% of survivors noticed them. Mental health concerns were also identified in over half of the families of the deceased. Intensive and continuous treatment for psychiatric conditions, prompt recognition of suicide warning signs, and care for the mental health of family members are crucial for suicide prevention.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Neurosciences
Jeonggeun Moon, Jae Hyoung Park, Seo-Eun Cho, Kwang-Pil Ko, Seung-Heon Shin, Ji-Eun Kim, Jae Kean Ryu, Seung-Gul Kang
Summary: This study compared the mean PR and mean BP between OSA and SS patients during a 24-hour period and investigated the correlation between AHI, PR, and BP in SRBD patients with and without hypertension, DM, and CVDs. The results showed significantly higher mean PRs in the OSA group compared to the SS group, but no significant difference in mean BP. Correlation analysis showed a significant correlation between AHI and PR in participants without hypertension, DM, or CVDs but not in participants with these conditions.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Kyoung Jin Kim, Jung-Been Lee, Jimi Choi, Ju Yeon Seo, Ji Won Yeom, Chul-Hyun Cho, Jae Hyun Bae, Sin Gon Kim, Heon-Jeong Lee, Nam Hoon Kim
Summary: Factors related to regular sleep patterns may determine lifestyle clustering in patients with type 2 diabetes. Patients with a healthy lifestyle have higher daily step count, lower resting heart rate, and longer sleep duration compared to others.
ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Clinical Neurology
Ju Yeon Seo, Ji Won Yeom, Chul-Hyun Cho, Serhim Son, Yong-Min Ahn, Se Joo Kim, Tae Hyon Ha, Boseok Cha, Eunsoo Moon, Dong Yeon Park, Ji Hyun Baek, Hee-Ju Kang, Hyonggin An, Heon-Jeong Lee
Summary: The study found that morningness is associated with depressive symptoms and quality of life. Individuals with morningness have milder depressive symptoms and better quality of life.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Clinical
Heon-Jeong Lee, Chul-Hyun Cho, Taek Lee, Jaegwon Jeong, Ji Won Yeom, Sojeong Kim, Sehyun Jeon, Ju Yeon Seo, Eunsoo Moon, Ji Hyun Baek, Dong Yeon Park, Se Joo Kim, Tae Hyon Ha, Boseok Cha, Hee-Ju Kang, Yong-Min Ahn, Yujin Lee, Jung-Been Lee, Leen Kim
Summary: This study aims to predict impending mood episode recurrences using digital phenotypes related to circadian rhythm obtained from wearable devices and smartphones. The results show that using digital phenotypes can accurately predict the occurrence of mood episodes, with circadian rhythm misalignment being the most important predictor. This finding suggests that monitoring circadian rhythm using digital devices can be useful in preventing and treating mood disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Joo Young Chun, Hyun-Jin Kim, Ji-Won Hur, Dooyoung Jung, Heon-Jeong Lee, Seung Pil Pack, Sungkil Lee, Gerard Kim, Chung-Yean Cho, Seung-Moo Lee, Hyeri Lee, Seungmoon Choi, Taesu Cheong, Chul-Hyun Cho
Summary: This study used machine learning techniques to predict the severity of specific anxiety symptoms and VR sickness in patients with SAD based on autonomic physiological signals. The results show that machine learning models can accurately predict the severity of these symptoms in real time during VR interventions.
JMIR SERIOUS GAMES
(2022)
Article
Clinical Neurology
Jae Myeong Kang, Seong-Jin Cho, Seo-Eun Cho, Taemo Bang, Byung Do Chae, Eojin Yi, Seung Min Bae, Kyoung-Sae Na, Jaehun Jung, Seung-Gul Kang
Summary: This study investigated the mental health status of Korean crew members dispatched to Antarctica, revealing significant increases in mental illness and depressive symptoms, as well as worsening sleep status during the long-term stay, especially in early winter.
NATURE AND SCIENCE OF SLEEP
(2022)
Article
Medicine, General & Internal
Won-Pyo Kim, Hyun-Jin Kim, Seung Pil Pack, Jae-Hyun Lim, Chul-Hyun Cho, Heon-Jeong Lee
Summary: This study evaluated the predictive performance of machine learning models in detecting attention-deficit/hyperactivity disorder (ADHD) and sleep problems using data obtained from personal digital devices. The results showed that the machine learning models had reasonable predictive performance for ADHD and sleep problems. The study developed a machine learning method for early detection or screening using digital phenotypes in children's daily lives.
Article
Chemistry, Analytical
Taek Lee, Heon-Jeong Lee, Jung-Been Lee, Jeong-Dong Kim
Summary: Managing mood disorders can be challenging, but daily monitoring and episode prediction tools can aid in self-management. In this study, lifelog sequence data was analyzed using various models to predict depressive episodes, resulting in high accuracy and performance. The findings contribute to understanding and managing depressive episodes in individuals with depression.
Article
Psychiatry
Tai Hui Sun, Ji Won Yeom, Kwang-Yeon Choi, Jeong-Lan Kim, Heon-Jeong Lee, Hyun-Jin Kim, Chul-Hyun Cho
Summary: This study aimed to investigate the efficacy of digital therapeutics (DTx) in managing ADHD symptoms. The results showed significant improvement in clinical symptoms after using a specific DTx program. This study suggests that DTx holds potential as an adjunctive treatment for children with ADHD, especially in subjective clinical symptoms. Future research with larger sample sizes and targeted clinical domains is needed.
FRONTIERS IN PSYCHIATRY
(2023)
Letter
Psychiatry
Chul-Hyun Cho, Jin Yong Jun, Heon-Jeong Lee
ASIAN JOURNAL OF PSYCHIATRY
(2023)