Article
Cell Biology
Colby E. Witt, Sergio Mena, Lauren E. Honan, Lauren Batey, Victoria Salem, Yangguang Ou, Parastoo Hashemi
Summary: This study used fast-scan controlled-adsorption voltammetry (FSCAV) to measure low-periodicity fluctuations in serotonin levels in mouse hippocampi. Correlation analyses revealed that these oscillations were present in vivo but not in vitro, and were not significantly different under different conditions (sex and stress paradigm). The administration of a selective serotonin reuptake inhibitor resulted in a shift in the frequency of the oscillations, suggesting regulation by transporter proteins. Additionally, the experimental parameters of FSCAV were optimized for higher temporal resolution, leading to more pronounced shifts in oscillation frequency and decreased amplitude.
Article
Neurosciences
Nikita Deo, Gregory Redpath
Summary: This article examines the important role of endocytosis in the cellular basis of depression and anxiety. It provides a detailed explanation of the endocytic regulation of 5-HT receptors and SERT, and explores how SSRIs and hallucinogenic compounds modulate serotonin signaling through endocytosis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Gael Villanueva-Charbonneau, Stephane Potvin, Serge Marchand, Alexander McIntyre, Diane McIntosh, Alain Bissonnette, Alain Gendron, Charles-edouard Giguere, Marie-eve Koue, Edouard Kouassi
Summary: This study found that mRNA expression of serotonin transporter (SERT) on the surface of peripheral blood mononuclear cells (PBMCs) was significantly reduced in subjects with major depression disorder (MDD), but not in those with fibromyalgia (FM) or FM + MDD. Although drug treatment improved symptoms, it had no significant effect on SERT mRNA expression.
Article
Cell Biology
Melodi A. Bowman, Jorge A. Gomez, Nathan C. Mitchell, Anne M. Wells, Melissa Vitela, Kyra M. Clarke, Rebecca E. Horton, Wouter Koek, Lynette C. Daws
Summary: Selective serotonin reuptake inhibitors (SSRIs) are less effective in treating depression in children than in adults. This may be due to the upregulation of organic cation transporter 3 (OCT3) and plasma membrane monoamine transporter (PMAT) in juveniles, leading to faster serotonin clearance and specific blocker's antidepressant-like effects.
Article
Psychiatry
Enrique Becerril-Villanueva, Maria Irma Olvera-Alvarez, Samantha Alvarez-Herrera, Jose Luis Maldonado-Garcia, Adolfo Lopez-Torres, Oscar Abelardo Ramirez-Marroquin, Octavio Gonzalez-Ruiz, Jose Manuel Nogueira-Fernandez, Jose Manuel Mendoza-Contreras, Hector Omar Sanchez-Garcia, Jose Antonio Jose-Alfallo, Atenodoro Valencia Banos, Ana Berta Torres-Serrano, Janeth Jimenez-Genchi, Danelia Mendieta-Cabrera, Gilberto Perez-Sanchez, Lenin Pavon
Summary: Airline pilots are susceptible to psychiatric disorders due to their high-stress work environment. This study found that the genes SLC6A4 and S100A10, which are associated with stress and depression, were overexpressed in the mononuclear cells of both pilots and depressed patients. These findings suggest that the alterations in these genes could be related to the professional stress experienced by pilots and may affect their long-term mental health.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Andrology
Yuanyuan Huang, Jingjing Gao, Pan Gao, Dangwei Peng, Yutian Dai, Hui Jiang, Xiansheng Zhang
Summary: This study found that Chinese premature ejaculation patients with the S'S' genotype have a significantly different response to dapoxetine treatment compared to those with the L' genotype, in terms of treatment response, clinical global impression, adverse effects, etc.
Article
Psychiatry
Maja Kesic, Gordana Mokrovic, Ante Tvrdeic, Branko Mise, Jasminka Stefulj, Lipa Cicin-Sain
Summary: Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed medications for treating mood disorders, but individual response to SSRIs varies. Individual serotonin levels may play a role in influencing the biological actions of SSRIs.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Mithula Sivasaravanaparan, Louise Orum Olesen, Maurizio Severino, Christian Ulrich von Linstow, Kate Lykke Lambertsen, Jan Bert Gramsbergen, Jorgen Hasselstrom, Athanasios Metaxas, Ove Wiborg, Bente Finsen
Summary: Chronic treatment with the SSRI paroxetine does not mitigate A beta pathology and A beta plaque-induced microgliosis in the hippocampus of APP(swe)/PS1(Delta E9) mice.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Cell Biology
Huangfei Yu, Tianyin Qu, Jinlan Yang, Qing Dai
Summary: In this study, it is reported that serotonin transporter (SERT) transports serotonin into colorectal cancer cells, enhancing Yes-associated protein (YAP) expression and promoting colon cancer cell growth. The transglutaminase 2 (TG2) mediates RhoA serotonylation and activates RhoA-ROCK1/2 signaling to upregulate YAP expression. Blocking SERT with citalopram reverses serotonin-induced YAP expression and cell proliferation. In addition, SERT expression is correlated with YAP in human colorectal cancer samples and the levels of serotonin are significant in patients with colorectal cancer. Therefore, targeting the serotonin-SERT-YAP axis may be a potential therapeutic strategy for colorectal cancer.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Clinical Neurology
Linda Garvert, Kevin Kirchner, Hans J. Grabe, Sandra Van der Auwera
Summary: Recent GWAS have found many single nucleotide polymorphisms that affect depressive disorders, suggesting that depression is a heterogeneous disorder influenced by numerous genetic variants with small effect sizes. However, there is limited understanding of the interaction between different genetic risk factors. This study used a genome-wide gene-gene interaction approach and identified a significant interaction effect between the DPF1 gene and the 5-HTTLPR gene on lifetime depression. DPF1, previously not associated with depressive disorders, is expressed exclusively in the brain and plays a major role in neuronal development and neuroplasticity.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Review
Psychiatry
David E. Nichols
Summary: At first glance, the molecular structures of MDMA and MDA seem similar, but their activity stereochemistry differs. MDMA is distinct from classical hallucinogenic phenethylamines in structure and psychopharmacology. It promotes affiliative social behavior, has acute anxiolytic effects, and induces introspection and personal reflection. Its mechanism of action involves the transport and release of neuronal serotonin.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Patryk Rodek, Malgorzata Kowalczyk, Jan Kowalski, Aleksander Owczarek, Piotr Choreza, Krzysztof Kucia
Summary: This study found an association between the SCL1A2 gene rs4354668 polymorphism and depression occurrence. However, no similar results were observed for the SLC6A5 and SLC6A9 polymorphisms. Further research is needed to validate these findings.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychiatry
Claudia Delli Colli, Marta Borgi, Silvia Poggini, Flavia Chiarotti, Francesca Cirulli, Brenda W. J. H. Penninx, Francesco Benedetti, Benedetta Vai, Igor Branchi
Summary: The study elucidated the dynamic interaction of 5-HTTLPR gene with stress at different time points, highlighting the importance of time in influencing depression susceptibility.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Neurosciences
Gwenn S. Smith, Hiroto Kuwabara, Neda F. Gould, Najilla Nassery, Alena Savonenko, Jin Hui Joo, Kristin L. Bigos, Michael Kraut, James Brasic, Daniel P. Holt, Andrew W. Hall, William B. Mathews, Robert F. Dannals, Ayon Nandi, Clifford I. Workman
Summary: Late-life depression (LLD) patients have lower cortical and limbic serotonin transporter (5-HTT) availability compared to controls and show less 5-HTT occupancy by antidepressant medications. Greater regional 5-HTT occupancy by antidepressants is associated with greater improvement in depressive symptoms and visual-spatial memory performance in LLD patients, supporting the hypothesis that serotonin degeneration and variability in 5-HTT occupancy may contribute to heterogeneity in treatment response.
Article
Immunology
Johannes Hoch, Niklas Burkhard, Shanshan Zhang, Marina Rieder, Timoteo Marchini, Vincent Geest, Krystin Krauel, Timm Zahn, Nicolas Schommer, Muataz Ali Hamad, Carolina Bauer, Nadine Gauchel, Daniela Stallmann, Claus Normann, Dennis Wolf, Ruediger Eberhard Scharf, Daniel Duerschmied, Nancy Schanze
Summary: This study found that deficiency of the serotonin transporter (SERT) is associated with metabolic derangements in mice. High-fat diet feeding in SERT-deficient mice resulted in enhanced insulin resistance, liver steatosis, and adipose tissue inflammation. These findings suggest that SERT deficiency may contribute to altered inflammatory processes.
FRONTIERS IN IMMUNOLOGY
(2023)
Letter
Psychiatry
Reiji Yoshimura, Naomichi Okamoto, Atsuko Ikenouchi
EUROPEAN JOURNAL OF PSYCHIATRY
(2023)
Article
Neurosciences
Naomichi Okamoto, Takashi Hoshikawa, Atsuko Ikenouchi, Tomoya Natsuyama, Rintaro Fujii, Ryohei Igata, Hirofumi Tesen, Yuki Konishi, Yuichi Honma, Masaru Harada, Reiji Yoshimura
Summary: This study compared the metabolomic profiles of patients with major depressive disorder (MDD) with and without type 2 diabetes mellitus. The results showed that there may be differences in serum metabolite patterns among different groups and that type 2 diabetes mellitus could affect metabolic pathways and alter the distribution of serum metabolites in patients with MDD.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Shogo Kitagawa, Naomichi Okamoto, Atsuko Ikenouchi, Ryohei Igata, Reia Hashimoto, Yuki Konishi, Hirofumi Tesen, Reiji Yoshimura
Article
Psychiatry
Tomoya Natsuyama, Naomichi Okamoto, Keita Watanabe, Enkhmurun Chibaatar, Hirofumi Tesen, Gaku Hayasaki, Atsuko Ikenouchi, Shingo Kakeda, Reiji Yoshimura
Summary: In this study, differences in gyrification patterns between major depressive disorder (MDD) patients and healthy controls (HCs) were investigated, and the association of these patterns with plasma brain-derived neurotrophic factor (BDNF) levels and depressive symptoms was explored. The results suggest that abnormal early cortical neurodevelopment may mediate vulnerability to MDD, independent of plasma BDNF levels and depressive symptoms.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Naomichi Okamoto, Atsuko Ikenouchi, Tatsuro Hirashima, Hirofumi Tesen, Satoru Ide, Reiji Yoshimura
Article
Rheumatology
Yuya Fujita, Shigeru Iwata, Shinsuke Hidese, Sayuri Ishiwata, Satoru Ide, Hiroaki Tanaka, Koshiro Sonomoto, Yusuke Miyazaki, Shingo Nakayamada, Atsuko Ikenouchi, Kotaro Hattori, Hiroshi Kunugi, Reiji Yoshimura, Yoshiya Tanaka
Summary: The study aimed to find a new method of evaluation and surrogate markers for diffuse neuropsychiatric SLE (NPSLE). Retrospective evaluation revealed that many patients with active SLE have subclinical depression, and MADRS evaluation is useful in detecting them. Additionally, the decrease in CSF levels of HVA, SDF-1 alpha, and SCGF-1 beta reflects the same pathology, and these may serve as surrogate markers.
Article
Psychiatry
Enkhmurun Chibaatar, Keita Watanabe, Naomichi Okamoto, Nasanbadrakh Orkhonselenge, Tomoya Natsuyama, Gaku Hayakawa, Atsuko Ikenouchi, Shingo Kakeda, Reiji Yoshimura
Summary: This study investigated the volumetric changes of thalamic subregions and their nuclei in drug-naive, first-episode MDD patients, as well as the association between thalamic nuclei volumes and HAM-D scores. The results revealed significant volume reductions in the left whole thalamus and several thalamic nuclei in the MDD group compared to healthy controls, and weak negative correlations between thalamic nuclei volumes and HAM-D scores. These findings provide preliminary insights into the thalamic structural changes in drug-naive, first-episode MDD patients.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Reiji Yoshimura, Naomichi Okamoto, Enkmurun Chibaatar, Tomoya Natsuyama, Atsuko Ikenouchi
Summary: This study compared the changes in serum BDNF concentrations in first-episode, drug-naive patients with major depression treated with antidepressants between treatment-response and treatment-nonresponse groups. The results showed that the serum BDNF levels changed significantly in the responder group but not in the non-responder group. The measurement of serum BDNF has the potential to be a useful predictor of pharmacotherapy in patients with first-episode, drug-naive major depression.
Article
Psychology, Multidisciplinary
Naomichi Okamoto, Atsuko Ikenouchi, Enkhmurun Chibaatar, Keita Watanabe, Ryohei Igata, Issei Seki, Reiji Yoshimura
Summary: This study examined 101 Japanese drug overdose patients who attempted suicide and identified depressive state, social support lacking, and no spouse as major risk factors. Additionally, several close associations of suicide risk were identified, such as previous suicide attempts and substance abuse, which intensify with simultaneous social support lacking.
OMEGA-JOURNAL OF DEATH AND DYING
(2023)
Article
Medicine, General & Internal
Tomoya Natsuyama, Naomichi Okamoto, Haruka Akaji, Kaori Hoshino, Atsuko Ikenouchi, Reiji Yoshimura
Summary: This article reports a case of prolonged delirium in a patient with schizoaffective disorder who had been on long-term lithium treatment. The patient had recently been diagnosed with stage IVB endometrial cancer and had a deteriorating general condition. Toxic levels of lithium were detected in the serum. After hemodialysis, lithium levels gradually decreased and the symptoms disappeared completely.
CLINICAL CASE REPORTS
(2023)
Article
Medicine, General & Internal
Mako Yanaga, Naomichi Okamoto, Reia Hashimoto, Ryohei Igata, Yuki Konishi, Atsuko Ikenouchi, Naoki Isomoto, Takahiro Shinkai, Masaru Harada, Reiji Yoshimura
Summary: This article presents a case of VPA-induced pancreatitis in a patient with vascular dementia. The patient did not have typical abdominal symptoms, but blood tests showed an inflammatory response and elevated amylase levels. Acute pancreatitis resolved after treatment initiation.
JOURNAL OF MEDICAL CASE REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Issei Seki, Hiroto Izumi, Naomichi Okamoto, Atsuko Ikenouchi, Yasuo Morimoto, Seichi Horie, Reiji Yoshimura
Summary: This study examined the association between miRNA levels in extracellular vesicles (EVs) from serum and the severity of Major Depression (MD). The expression levels of hsa-miR-6813-3p and hsa-miR-2277-3p were found to be significantly downregulated with increasing depression severity of MD. These miRNAs could serve as novel biomarkers for MD and contribute to understanding its pathophysiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Atsuko Ikenouchi, Naomichi Okamoto, Shinsuke Hamada, Enkhmurun Chibaatar, Rintaro Fujii, Yuki Konishi, Ryohei Igata, Hirofumi Tesen, Reiji Yoshimura
Summary: This study aimed to explore the reliability of salivary mBDNF as a biomarker for psychological distress in healthcare workers and the relationship between salivary and plasma mBDNF levels as well as their correlation with age, sex, BMI, and exercise habits. The findings indicate that salivary mBDNF can be accurately measured noninvasively in healthcare workers, but did not show correlation with K6 and plasma mBDNF. Future studies with a larger sample size and diverse populations are needed to further investigate these relationships.
BRAIN AND BEHAVIOR
(2023)
Article
Public, Environmental & Occupational Health
Atsuko Ikenouchi, Yoshihisa Fujino, Ryutaro Matsugaki, Kosuke Mafune, Hajime Ando, Tomohisa Nagata, Seiichiro Tateishi, Reiji Yoshimura, Mayumi Tsuji
Summary: This study collected data from 33,302 workers in Japan through an Internet survey and found that the impact of telecommuting on psychological distress during the COVID-19 pandemic varied depending on the cohabitation status of workers' family members.
JOURNAL OF OCCUPATIONAL HEALTH
(2023)
Article
Geriatrics & Gerontology
Arisa Fujii, Atsuko Ikenouchi, Naomichi Okamoto, Rintaro Fujii, Satoru Ide, Reiji Yoshimura