Article
Psychiatry
Fang Chen, Weizheng Yan, Vince D. Calhoun, Linzhen Yu, Lili Chen, Xiaoyi Hao, Leilei Zheng
Summary: A new self-assessment Fast Screen Questionnaire for Mental Illness Symptoms (FSQ-MIS) was developed to quickly identify mental illness symptoms, showing high reliability and validity. The questionnaire demonstrated advantages in predicting anxiety and depression prevalence during COVID-19.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Chemistry, Multidisciplinary
Anamika Gupta, Yogesh Kumar, Mohd Rehan Zaheer, Roohi, Safia Iqbal, Jawaid Iqbal
Summary: Quetiapine (QTP), a photosensitive psychotropic agent, undergoes photoinduced electron transfer-mediated transformation to produce different photoproducts under different conditions, demonstrating the relevance of its molecular structure in photophysics and photochemistry.
Article
Psychiatry
Arti Gandhi, Jasmine Mote, Daniel Fulford
Summary: The research found that individuals with Major Depressive Disorder (MDD) and Schizophrenia Spectrum Disorder (SSDs) experience higher levels of physical and social anhedonia compared to controls. Depressive symptom severity influences the differences in physical anhedonia, while age moderates the differences between social and physical anhedonia in the SSD group.
PSYCHIATRY RESEARCH
(2022)
Article
Polymer Science
Mullaicharam Bhupathyraaj, K. Reeta Vijaya Rani, Sathvik B. Sridhar, Javed Shareef, Sabin Thomas, Nirmala Halligudi, Anbazhagan Sockalingam, Kiruba Mohandoss, Shyam Sundar
Summary: With the help of permeation enhancers, Quetiapine Fumarate can be easily delivered across the skin, and the prepared transdermal patches exhibited desirable characteristics in physicochemical evaluations and release studies. Among them, the F2 formulation was selected as the optimized formulation and showed good results in skin irritation test and stability study.
Article
Psychiatry
Raymond W. C. Au, Helen N. W. Sezto, Vera W. M. Lam, Y. T. Wan, L. T. Poon, P. F. Pang, Jackson K. K. Wong
Summary: Individuals with schizophrenia or depression often experience deficits in prospective memory (PM) which can significantly impact their daily functioning. A study was conducted to investigate the effects of a Chinese version of Cognitive Compensatory Training (CCT-C-PM) on PM performance in these populations. Results showed that CCT-C-PM improved PM, especially event-based PM, suggesting it as a viable training method for enhancing PM abilities in individuals with these mental health conditions. Further research is needed to clarify the effects on time-based PM.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
Daniel Braun, Jens Schlossmann, Ekkehard Haen
Summary: In patients with various psychiatric diseases, elevated serum concentrations of ADMA were found, suggesting its involvement in the pathophysiology of these disorders.
PSYCHIATRY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Ying Zhao, Shi Wu Wen, Mengzhe Li, Zhongyu Sun, Xiang Yuan, Ravi Retnakaran, Ruiling Zhang, Desheng Zhai
Summary: Acute phase treatment with quetiapine for schizophrenia patients is strongly associated with an increased risk of developing new-onset hypothyroidism, with a clear dose-response relationship.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Clinical Neurology
Chuanjun Zhuo, Hongjun Tian, Jingjing Zhu, Tao Fang, Jing Ping, Lina Wang, Yun Sun, Langlang Cheng, Chunmian Chen, Guangdong Chen
Summary: Low-dose lithium (LD-Li) has been shown to improve cognitive impairment in mouse models, but its effects on MK801-induced long-term cognitive impairment have not been fully studied. This study used in vivo Ca2+ imaging and cognitive function assessments to investigate the long-term effects of LD-Li on cognitive performance in mice exposed to MK801. The results suggest that LD-Li + QTP combination therapy is more effective in improving long-term cognitive impairments compared to QTP monotherapy.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Anniina Kananen, Guro Pauck Bernhardsen, Soili Marianne Lehto, Pasi Huuskonen, Hannu Kokki, Leea Keski-Nisula
Summary: This study surveyed the usage trends of antipsychotic medications during pregnancy and explored the associations between the use of quetiapine or any antipsychotic and adverse obstetric and neonatal outcomes. The results showed that pregnant women using quetiapine or any antipsychotic had a higher risk of adverse outcomes, such as increased postpartum bleeding, prolonged neonatal hospitalization, and higher placental to birth weight ratio.
NORDIC JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
G. Fond, M. Faugere, R. Richieri, M. Cermolacce, T. Korchia, J. A. Micoulaud-Franchi, P. L. Sunhary de Verville, L. Boyer, C. Lancon
Summary: This study found that depressive symptoms and chronic peripheral inflammation are associated with impaired functional remission in patients with schizophrenia, independent of psychotic remission. These findings emphasize the potential of improving depressive symptoms and chronic peripheral inflammation to help patients achieve functional remission.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Public, Environmental & Occupational Health
Yuzhu Hao, Qiuxia Wu, Xuyi Wang, Yuejiao Ma, Yunfei Wang, Pu Peng, Xin Wang, Qian Yang, Yueheng Liu, Manyun Li, Li He, Qianjin Wang, Yanan Zhou, Tieqiao Liu, Shubao Chen
Summary: This study explored the stigmatizing attitudes towards depression, schizophrenia, and general anxiety disorder (GAD) among caregivers in China. Data on caregivers’ attitudes and willingness to interact with individuals with mental disorders were collected using vignettes. The results showed that despite the stigma and desire for social distance, caregivers often expected positive outcomes and more positive attitudes towards mental disorders. It is important to improve caregivers’ knowledge about mental health and reduce stigma.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Hannah M. Sallis, Robyn E. Wootton, George Davey Smith, Marcus R. Munafo
Summary: This study used a proxy gene-by-environment Mendelian randomization approach to investigate the causal effect of maternal smoking during pregnancy on offspring mental health. The results suggest that the effect of maternal smoking on offspring schizophrenia is dependent on offspring smoking status. However, there is no clear evidence of an association between maternal smoking heaviness and offspring depression.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Medicine, General & Internal
Brona Nic Giolla Easpaig, Jianxia Zhai, Richard Gray, Ellie Brown, Daniel Bressington
Summary: The aim of this systematic review is to evaluate the recruitment rate, study attrition rates, and intervention completion of psychosocial intervention randomized controlled trial studies involving people with early and emerging psychosis. The findings will inform the design and planning of future research and support the development of high-quality evidence in this field.
Article
Neurosciences
Chiara Fabbri, Oliver Pain, Saskia P. Hagenaars, Cathryn M. Lewis, Alessandro Serretti
Summary: Major depressive disorder (MDD) is a major global disability, with up to 20-30% of patients being treatment-resistant. This study performed a drug repurposing analysis using imputed gene expression in treatment-resistant depression (TRD). Subtypes of MDD such as anxious MDD and MDD with weight gain were found to be associated with TRD, with potential pharmacological approaches identified.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Randa Mohammed Zaki, Munerah M. Alfadhel, Manal A. Alossaimi, Lara Ayman Elsawaf, Vidya Devanathadesikan Seshadri, Alanood S. Almurshedi, Rehab Mohammad Yusif, Mayada Said
Summary: This study aimed to enhance the oral bioavailability and brain delivery of Quetiapine fumarate through the formulation and optimization of glycerosomal formulations. The optimized formula showed improved vesicle characteristics, enhanced drug release, and increased bioavailability in the brain and plasma.