Article
Psychiatry
Jurriaan M. J. L. Brouwer, Erien Olde Hengel, Arne J. Risselada, Eric N. van Roon, Hans Mulder
Summary: This study assessed the consistency and applicability of somatic monitoring instructions recommended by CPGs for adult and (frail) elderly populations treated with antipsychotic drugs. The majority of monitoring instructions were applicable, but critical values and response methods for aberrant values were lacking. Only one CPG specifically addressed (frail) elderly populations, highlighting the need for more comprehensive guidelines in this population.
Article
Nursing
Bayan Abdulhaq, Latefa A. Dardas, Omar Sami
Summary: The study aimed to explore the knowledge, attitudes, practices, and adherence of psychiatrists in Jordan regarding metabolic monitoring guidelines for patients taking SGAs, as well as their perceived barriers. Findings showed that while most psychiatrists were aware of the guidelines, there were challenges in their implementation, with financial burden and lack of compliance from families and patients being major barriers identified.
PERSPECTIVES IN PSYCHIATRIC CARE
(2021)
Article
Psychiatry
Swarnava Sanyal, Chadi A. Calarge, Paul J. Rowan, Rajender R. Aparasu, Susan Abughosh, Hua Chen
Summary: The objective of this study was to evaluate the impact of the publication of AACAP practice parameters on SGA metabolic monitoring in pediatric SGA recipients. A retrospective study was conducted using a national Electronic Medical Records database. The results showed that the publication of AACAP practice parameters was associated with a significant improvement in BMI monitoring, but no changes were observed for BG and CHL monitoring.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Health Policy & Services
Sorabh Singhal, Joseph Billian, Casey Kloosterman, Teresa Bailey, Neelkamal Soares
Summary: This study found that in the United States, adherence to established pediatric SGA monitoring guidelines in community practice is low, with some patients not receiving any monitoring orders. Patients who interacted more frequently with the healthcare system were more likely to be monitored.
COMMUNITY MENTAL HEALTH JOURNAL
(2022)
Review
Chemistry, Medicinal
Nicole Moschny, Gudrun Hefner, Renate Grohmann, Gabriel Eckermann, Hannah B. Maier, Johanna Seifert, Johannes Heck, Flverly Francis, Stefan Bleich, Sermin Toto, Catharina Meissner
Summary: Inflammation and smoking can impact drug metabolism and alter treatment responses, requiring close clinical monitoring. Antipsychotic drugs should be carefully monitored due to various factors, such as narrow therapeutic windows, chronic mental illnesses, and common polypharmacotherapy in psychiatry. Therapeutic drug monitoring (TDM), particularly for drugs like clozapine and olanzapine, is crucial for optimizing drug safety and providing personalized treatment.
Article
Medicine, General & Internal
Jennifer Fontaine, Evelyn Chin, Jean-Francois Provencher, Anthony Rainone, Dana Wazzan, Carmella Roy, Soham Rej, Marie Lordkipanidze, Vincent Dagenais-Beaule
Summary: This study reveals suboptimal baseline cardiometabolic monitoring of patients taking antipsychotic drugs in a Canadian hospital. Improving collaboration within a multidisciplinary team may enhance cardiometabolic monitoring.
Article
Endocrinology & Metabolism
Ana B. Alves-Wagner, Joji Kusuyama, Pasquale Nigro, Krithika Ramachandran, Nathan Makarewicz, Michael F. Hirshman, Laurie J. Goodyear
Summary: Recent pre-clinical studies have found that exercise before and during pregnancy can improve the risk of metabolic diseases transmitted from obese mothers to offspring. This study further demonstrates that exercise by grandmothers can have beneficial effects on the metabolic health of their grandoffspring, including improvements in glucose tolerance, reduction in fat mass, and improved liver metabolic function.
MOLECULAR METABOLISM
(2022)
Review
Pharmacology & Pharmacy
Pedro Novais, Patricia M. A. Silva, Isabel Amorim, Hassan Bousbaa
Summary: Mitosis is a promising target for inhibiting cancer cell proliferation, with traditional antimitotics facing limitations such as resistance and toxicity. Second-generation antimitotics, targeting mitotic and SAC components, have attracted interest for overcoming these limitations. While many inhibitors have entered clinical trials, their efficacy as monotherapy is limited, leading to emerging interest in combination therapies.
Article
Nursing
Julie Henshaw Roebuck
Summary: This study aimed to improve metabolic monitoring and follow-up recommendations for pediatric patients prescribed second-generation antipsychotic medication. Before implementation, metabolic monitoring adherence was low, but after implementation, it significantly improved. Written recommendations for follow-up monitoring also improved significantly.
JOURNAL OF CHILD AND ADOLESCENT PSYCHIATRIC NURSING
(2023)
Article
Nursing
Julie-Kathryn Graham, Emily R. Nasser, Danisha Jenkins, Molly Quillin-Mcewan, Christina Kelley
Summary: This study provides further evidence of the usefulness of metabolic monitoring in early recognition of sepsis.
JOURNAL OF ADVANCED NURSING
(2023)
Review
Health Care Sciences & Services
Giuliana Giacobbe, Vincenza Granata, Piero Trovato, Roberta Fusco, Igino Simonetti, Federica De Muzio, Carmen Cutolo, Pierpaolo Palumbo, Alessandra Borgheresi, Federica Flammia, Diletta Cozzi, Michela Gabelloni, Francesca Grassi, Vittorio Miele, Antonio Barile, Andrea Giovagnoni, Nicoletta Gandolfo
Summary: Gender Medicine is a branch of medicine that studies the differences in diseases between men and women. It is important to value these differences in healthcare in order to provide personalized therapies and gender-specific prevention initiatives. This article assesses potential gender differences in clinical-radiological practice and their impact on health and healthcare.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Nursing
Anthony J. P. Trigueiro, Jeffery Ramirez, Erin Hennessey, Mirjeta Beqiri
Summary: The study, conducted in a community hospital's psychiatric unit, aimed to assess missed opportunities in identifying metabolic syndrome among patients treated with second-generation antipsychotic medication. Findings highlighted the significant impact of PCP involvement on the treatment of conditions related to metabolic syndrome.
JOURNAL OF PSYCHOSOCIAL NURSING AND MENTAL HEALTH SERVICES
(2022)
Article
Psychology, Developmental
Hua Chen, Ning Lyu, Wenyaw Chan, Austin De La Cruz, Chadi Calarge
Summary: This study examines the utilization and predictors of adjuvant metformin among pediatric recipients of second-generation antipsychotics. The findings suggest that the utilization of adjuvant metformin is uncommon among pediatric SGA recipients, and early introduction of the medication among nonobese children is rare.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Psychiatry
Emily Eyles, Ruta Margelyte, Hannah B. Edwards, Paul A. Moran, David S. Kessler, Simon J. C. Davies, Blanca Bolea-Alamanac, Maria Theresa Redaniel, Sarah A. Sullivan
Summary: This study investigated the association between combined use of two antipsychotic drugs and the risk of developing diabetes, hypertension, or hyperlipidemia in adults with schizophrenia. The results showed that compared to monotherapy, polypharmacy increased the risk of hypertension in patients.
SCHIZOPHRENIA BULLETIN
(2023)
Review
Psychiatry
Katherine R. H. Mortimer, Mohammed Zia Ul Haq Katshu, Lisa Chakrabarti
Summary: Psychosis and the use of second-generation antipsychotics (SGAs) are risk factors for developing metabolic syndrome (MetS). SGAs worsen metabolic abnormalities, leading to increased risks of severe weight gain, type 2 diabetes, and cardiovascular disease. Mitochondrial dysfunction is a hallmark of MetS, but the mechanisms through which SGAs induce MetS and how mitochondria are involved in this process are still unclear.
FRONTIERS IN PSYCHIATRY
(2023)
Letter
Endocrinology & Metabolism
N. Foussard, L. Baillet-Blanco, P. Poupon, M. Monlun, K. Mohammedi, A. Cougnard-Gregoire, C. Delcourt, C. Helmer, V. Rigalleau
Article
Ophthalmology
Cyril Dutheil, Melanie Le Goff, Audrey Cougnard-Gregoire, Sarra Gattoussi, Jean-Francois Korobelnik, Marie-Benedicte Rougier, Cedric Schweitzer, Cecile Delcourt, Marie-Noelle Delyfer
JAMA OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Ilhan E. Acar, Laura Lores-Motta, Johanna M. Colijn, Magda A. Meester-Smoor, Timo Verzijden, Audrey Cougnard-Gregoire, Soufiane Ajana, Benedicte M. J. Merle, Anita de Breuk, Thomas J. Heesterbeek, Erik van den Akker, Mohamed R. Daha, Birte Claes, Daniel Pauleikhoff, Hans-Werner Hense, Cornelia M. van Duijn, Sascha Fauser, Carel B. Hoyng, Cecile Delcourt, Caroline C. W. Klaver, Tessel E. Galesloot, Anneke den Hollander
Article
Ophthalmology
Soufiane Ajana, Audrey Cougnard-Gregoire, Johanna M. Colijn, Benedicte M. J. Merle, Timo Verzijden, Paulus T. V. M. de Jong, Albert Hofman, Johannes R. Vingerling, Boris P. Hejblum, Jean-Francois Korobelnik, Magda A. Meester-Smoor, Marius Ueffing, Helene Jacqmin-Gadda, Caroline C. W. Klaver, Cecile Delcourt
Summary: The study aimed to develop a comprehensive AMD prediction model using machine learning algorithm to automatically select the most predictive risk factors. The model showed high predictive performance in two cohort studies, paving the way towards precision medicine for AMD patients in the near future.
Article
Ophthalmology
Johanna M. Colijn, Magda Meester-Smoor, Timo Verzijden, Anita de Breuk, Rufino Silva, Benedicte M. J. Merle, Audrey Cougnard-Gregoire, Carel B. Hoyng, Sascha Fauser, Anthonius Coolen, Catherine Creuzot-Garcher, Hans-Werner Hense, Marius Ueffing, Cecile Delcourt, Anneke den Hollander, Caroline C. W. Klaver
Summary: The study investigated the genetic distribution of AMD-associated risk variants in a large European population and found ARMS2 and CHF as the most prominent risk genes. Genetic risk was associated with AMD severity, and lifestyle factors significantly influenced genetic outcomes.
Article
Nutrition & Dietetics
Benedicte M. J. Merle, Audrey Cougnard-Gregoire, Jean-Francois Korobelnik, Wolfgang Schalch, Stephane Etheve, Marie-Benedicte Rougier, Catherine Feart, Cecilia Samieri, Marie-Noelle Delyfer, Cecile Delcourt
Summary: The study found that higher plasma lutein concentrations were associated with a reduction in the risk of developing advanced AMD, suggesting a potential protective effect of lutein and zeaxanthin on AMD.
Article
Ophthalmology
Eric F. Thee, Johanna M. Colijn, Audrey Cougnard-Gregoire, Magda A. Meester-Smoor, Timo Verzijden, Carel B. Hoyng, Sascha Fauser, Hans -Werner Hense, Rufino Silva, Catherine Creuzot-Garcher, Marius Ueffing, Cecile Delcourt, Anneke I. den Hollander, Caroline C. W. Klaver
Summary: The study investigates the relationship between the ARMS2 and HTRA1 genes and the risk of age-related macular degeneration (AMD). The findings provide strong evidence for the association between these genes and AMD, contributing to the understanding of the disease.
Article
Nutrition & Dietetics
Benedicte M. J. Merle, Stephanie Barthes, Catherine Feart, Audrey Cougnard-Gregoire, Jean-Francois Korobelnik, Marie-Benedicte Rougier, Marie-Noelle Delyfer, Cecile Delcourt
Summary: B vitamins may protect against age-related macular degeneration (AMD), as suggested by a cohort study on older adults in Bordeaux, France. The study found a significant association between normal serum folate levels and a high dietary intake of B5 and B6 with a lower risk for developing advanced AMD. Adopting a healthy diet rich in B vitamins may help reduce vision loss due to AMD.
Article
Nutrition & Dietetics
Jeanne Bardinet, Virginie Chuy, Isabelle Carriere, Cedric Galera, Camille Pouchieu, Cecilia Samieri, Catherine Helmer, Audrey Cougnard-Gregoire, Catherine Feart
Summary: This study aimed to assess the association between adherence to the Mediterranean Diet (MeDi) and the risk of depressive symptoms among older French adults. The findings suggest a potential benefit of greater adherence to the MeDi in reducing the risk of depressive symptoms, although the results may depend on the definition of depressive symptoms.
Article
Ophthalmology
Joelle E. Vergroesen, Alexander K. Schuster, Kelsey V. Stuart, Nigus G. Asefa, Audrey Cougnard-Gregoire, Cecile Delcourt, Cedric Schweitzer, Patricia Barreto, Rita Coimbra, Paul J. Foster, Robert N. Luben, Norbert Pfeiffer, Julia V. Stingl, Toralf Kirsten, Franziska G. Rauscher, Kerstin Wirkner, Nomdo M. Jansonius, Louis Arnould, Catherine P. Creuzot-Garcher, Bruno H. Stricker, Christina Keskini, Fotis Topouzis, Geir Bertelsen, Anne E. Eggen, Mukharram M. Bikbov, Jost B. Jonas, Caroline C. W. Klaver, Wishal D. Ramdas, Anthony P. Khawaja
Summary: This study investigated the association between commonly used systemic medications and glaucoma and intraocular pressure (IOP) in the European population. The use of calcium channel blockers (CCBs) was found to be associated with a higher prevalence of glaucoma, while the use of β-blockers was associated with lower IOP.
Review
Ophthalmology
Audrey Cougnard-Gregoire, Benedicte M. J. Merle, Tariq Aslam, Johanna M. Seddon, Isabelle Aknin, Caroline C. W. Klaver, Gerhard Garhoefer, Alfredo Garcia Layana, Angelo Maria Minnella, Rufino Silva, Cecile Delcourt
Summary: Exposure to blue light from LED lights and digital devices raises concerns about its potential deleterious effects on eye health. This review discusses the ocular effects of blue light and the effectiveness of protection and prevention methods against potential blue light-induced ocular injury.
OPHTHALMOLOGY AND THERAPY
(2023)
Letter
Ophthalmology
Audrey Cougnard-Gregoire, Cecile Delcourt
OPHTHALMOLOGY AND THERAPY
(2023)
Meeting Abstract
Ophthalmology
Benedicte M. J. Merle, Stephanie Barthes, Audrey Cougnard-Gregoire, Catherine Feart, Marie-Noelle Delyfer, Jean-Francois Korobelnik, Cecile Delcourt
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Audrey Cougnard-Gregoire, Gobain Chan, Marie-Noelle Delyfer, Melanie Le Goff, Marie B. Rougier, Caroline Morillon, Cedric Schweitzer, Jean-Francois Korobelnik, Cecile Delcourt, Sarra Gattoussi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)
Meeting Abstract
Ophthalmology
Cedric Schweitzer, Gregoire Chevreau, Audrey Cougnard-Gregoire, Melanie L. E. Goff, Lauriane Salinas, Marie-Noelle Delyfer, Marie B. Rougier, Jean-Francois Korobelnik, Cecile Delcourt
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)