Article
Radiology, Nuclear Medicine & Medical Imaging
Julia C. Carmona-Bozo, Roido Manavaki, Jodi L. Miller, Cara Brodie, Corradina Caraco, Ramona Woitek, Gabrielle C. Baxter, Martin J. Graves, Tim D. Fryer, Elena Provenzano, Fiona J. Gilbert
Summary: This study explores the relationship between indices of hypoxia and vascular function in ER + breast cancer using [F-18]-FMISO PET/MRI and immunohistochemical markers. The results indicate that hypoxia is associated with increased CAIX expression, reduced microvessel density, and smaller vessel diameters in ER + breast cancer, further confirming the link between inadequate vascularity and hypoxia in this type of cancer.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Xiang Li, Zitao Li, Caijuan Li, Xuemei Wang, Bin Jiang, Jiannan Wang, Zhen Zhang
Summary: The study aimed to investigate the impact of CXCR7 on proliferation, migration, and angiogenesis in colon cancer cells by altering its expression levels. Contrast-enhanced ultrasound technology was used to quantify tumor perfusion parameters in vivo to detect angiogenesis after changes in CXCR7 expression in colon cancer xenografts.
Article
Biochemistry & Molecular Biology
Andreas Mamilos, Alexander Lein, Lina Winter, Markus Haas, Torsten E. Reichert, Tobias Ettl, Julian Kuenzel, Gerrit Spanier, Christoph Brochhausen
Summary: This study investigated the spatial heterogeneity of blood vessels in oral squamous cell carcinomas (OSCC) and evaluated its prognostic value. The results showed a significantly higher presence of blood vessels at the invasion front of OSCCs compared to the tumor center. High intratumoral blood vessel density was associated with better disease-free survival.
Article
Cell Biology
Yoichiro Okubo, Soji Toda, Shinya Sato, Emi Yoshioka, Kyoko Ono, Chie Hasegawa, Kota Washimi, Tomoyuki Yokose, Yohei Miyagi, Hiroyuki Iwasaki, Hiroyuki Hayashi
Summary: This study aimed to analyze the histological changes in patients who underwent thyroidectomy after lenvatinib therapy. Results showed that lenvatinib therapy may induce specific ischemic changes in thyroid cancer cells, and non-cancerous thyroid tissues may also show inflammatory cell infiltration and decreased microvessel density, possibly related to the side effect of hypothyroidism caused by lenvatinib.
Review
Biology
Fabio Grizzi, Mohamed A. A. A. Hegazi, Matteo Zanoni, Paolo Vota, Giovanni Toia, Maria Chiara Clementi, Cinzia Mazzieri, Maurizio Chiriva-Internati, Gianluigi Taverna
Summary: Angiogenesis plays a pivotal role in prostate cancer, but evaluating angiogenic activity remains challenging. This review discusses various angiogenic mechanisms in prostate cancer and their potential relevance for predictive and prognostic evaluations.
Article
Surgery
Lakhdar Khellaf, Francois Quenet, Marta Jarlier, Hugo Gil, Marie-Helene Pissas, Sebastien Carrere, Emmanuelle Samalin, Thibault Mazard, Marc Ychou, Olivia Sgarbura, Frederic Bibeau
Summary: The desmoplastic growth pattern may serve as a useful marker for early identification of patients who may benefit from two-stage hepatectomy completion.
Article
Oncology
Aymen Shatnawi, Nehad M. Ayoub, Amer E. Alkhalifa
Summary: ING4 plays a crucial role in breast cancer pathogenesis, with high ING4 gene expression associated with favorable prognostic parameters and positive clinical outcomes. It can serve as an indicator of treatment success and a potential therapeutic target in breast cancer-targeted therapy.
CLINICAL BREAST CANCER
(2021)
Article
Endocrinology & Metabolism
Dana M. Niedowicz, Jenna L. Gollihue, Erica M. Weekman, Panhavuth Phe, Donna M. Wilcock, Christopher M. Norris, Peter T. Nelson
Summary: Research on cerebrovasculature can provide useful insights into brain health and diseases. Immunohistochemical staining and digital pathology have the potential to revolutionize the measurement of blood vessel parameters. However, staining mouse brain tissue presents technical challenges, and proper protein markers are necessary for unbiased analysis using digital pathology.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Kun Li, Guangqing Tan, Xin Zhang, Weiyu Lu, Jingyi Ren, Yuewen Si, Enoch Appiah Adu-Gyamfi, Fangfang Li, Yingxiong Wang, Biao Xie, Meijiao Wang
Summary: EIF4G1 is identified as a potential prognostic biomarker and therapeutic target for breast cancer, as it may regulate the tumor microenvironment and affect metastasis and overall survival in breast cancer patients.
Article
Chemistry, Multidisciplinary
Qian Gou, Huiqing Chen, Mingjun Chen, Juanjuan Shi, Jianhua Jin, Qian Liu, Yongzhong Hou
Summary: Immune cells play a role in protecting against tumor progression, while aberrant expression of PD-L1 in cancer cells leads to tumor immune escape. This study found that ING4 induces the autophagic degradation of PD-L1, inhibiting immune escape in NSCLC. However, high expression of CK2 was found to correlate with low ING4 protein levels in NSCLC. Further analysis revealed that CK2 induces the phosphorylation of ING4-S150, leading to its degradation by JFK ubiquitin ligase. In contrast, CK2 gene knockout increased ING4 protein stability and T cell activity, inhibiting NSCLC immune escape. Additionally, the combination of a CK2 inhibitor and PD-1 antibody effectively enhanced antitumor immunotherapy.
Article
Oncology
Elsebeth Lynge, Ilse Vejborg, Martin Lillholm, Mads Nielsen, George Napolitano, My von Euler-Chelpin
Summary: Early studies have shown that women with extremely dense and fatty breasts have a 4- to 6-fold increased risk of breast cancer. A population-based screening program in the Capital Region of Denmark was used to study the relationship between breast density and breast cancer incidence. The results indicate a smaller difference in breast cancer risk across levels of breast density than commonly stated.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Pathology
Fang Li, Guiqing Meng, Bibo Tan, Zihao Chen, Qiang Ji, Xiaoxiao Wang, Chang Liu, Shuyao Niu, Yong Li, Yueping Liu
Summary: HER2 overexpression is closely related to gastric cancer neovascularization and is an independent predictor of gastric cancer prognosis. In clinical treatment, anti-HER2 targeted therapy and antiangiogenesis drugs can be adopted for effective treatment.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Elis Angela Batistella, Andressa Fernanda Paza Miguel, Nicole Lonni Nascimento, Martinho Campolina Rebello Horta, Daniella Serafin Couto Vieira, Elena Correa Riet Rivero
Summary: The role of blood and lymphatic microvascular density in the progression of oral squamous cell carcinoma (OSCC) was investigated in this study. It was found that the expression of anti-alpha-smooth muscle actin (a-SMA) and anti-endoglin (CD105) was associated with microvessel density (MVD), while anti-podoplanin (D2-40) was associated with lymphatic vessel density (LVD). Furthermore, high tumour budding (TB) and tumour thickness were identified as risk factors for OSCC progression and worse patient outcomes.
Article
Biochemistry & Molecular Biology
Chongbiao Huang, Hui Li, Yang Xu, Chao Xu, Huizhi Sun, Zengxun Li, Yi Ge, Hongwei Wang, Tiansuo Zhao, Song Gao, Xiuchao Wang, Shengyu Yang, Peiqing Sun, Zhe Liu, Jing Liu, Antao Chang, Jihui Hao
Summary: VEGF inhibitors have been successful in treating solid tumors, but pancreatic adenocarcinoma (PAAD) cells can activate VEGF-independent pathways to reinstate tumor angiogenesis, leading to resistance to VEGF inhibitors. BICC1 is a top gene involved in PAAD-specific angiogenesis. Overexpression of BICC1 in human PAAD tissues is associated with increased microvessel density, tumor growth, and worse prognosis. BICC1 promotes angiogenesis in pancreatic cancer through a VEGF-independent mechanism. Its binding to LCN2 mRNA up-regulates LCN2 expression, leading to the activation of the JAK2/STAT3 signal pathway and increased production of the angiogenic factor CXCL1. Blocking the BICC1/LCN2 signaling reduces microvessel density and tumor volume, and enhances the suppressive effect of gemcitabine. BICC1/LCN2 signaling may be a promising therapeutic target for anti-angiogenesis in pancreatic cancer patients.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexey Surov, Andreas Wienke
Summary: This meta-analysis systematically reviewed the associations between SUVmax from FDG PET and the expression of VEGF and MVD. The results indicated a weak correlation between SUVmax and VEGF/MVD, suggesting that FDG PET may not be able to predict neoangiogenesis in malignant tumors.
ACADEMIC RADIOLOGY
(2021)
