Article
Surgery
Adeseye Adekeye, Divyansh Agarwal, Anupma Nayak, Julia Tchou
Summary: The study found that the enzyme PTGES3 in the COX/prostaglandin pathway is upregulated in breast cancer and is associated with prognosis. Additionally, PTGES3 may have an immunomodulatory role in the tumor microenvironment.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Oncology
Jiale Sun, Wenchang Yue, Jiawei You, Xuedong Wei, Yuhua Huang, Zhixin Ling, Jianquan Hou
Summary: A novel prognostic signature of ferroptosis-related genes (FRGs) was identified, showing high predictive value for overall survival (OS) in bladder cancer (BLCA). The expression of these FRGs may be a potential target for BLCA treatment, and further experimental studies are needed to uncover the underlying mechanisms of their involvement in BLCA progression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Yizhou Huang, Lizhi Chen, Ziyi Tang, Yu Min, Wanli Yu, Gangyi Yang, Lili Zhang
Summary: By analyzing data from the TCGA database, the study identified ITK as a potential indicator for prognosis prediction in patients with breast cancer, and its expression was associated with immune activity in the tumor microenvironment.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Qing Kay Li, Tung-Shing Mamie Lih, Yuefan Wang, Yingwei Hu, Naseruddin Hoti, Daniel W. Chan, Hui Zhang
Summary: This study evaluated the diagnostic utility of 12 protein markers for assessing the aggressiveness of prostate cancer (PCa). Four proteins were found to be over-expressed in aggressive tumors, while three proteins showed stronger staining patterns in non-aggressive tumors. Combining different protein markers improved the accuracy of diagnosing the aggressiveness of PCa.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Zhenying Guo, Li Shen, Ningning Li, Xiaoxiao Wu, Canming Wang, Zheng Gu, Zhongjian Chen, Junping Liu, Weimin Mao, Yuchen Han
Summary: This study used bioinformatics to identify key genes in malignant mesothelioma, finding that Aurora-A could be an optimal diagnostic biomarker and a potential prognostic marker. Additionally, seven genes were identified as potential prognostic markers for MM.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yicheng Liang, Yangyang Lei, Mei Liang, Minjun Du, Zixu Liu, Xingkai Li, Xiangzhi Meng, Boxuan Zhou, Yushun Gao
Summary: The expression of GBE1 is associated with the prognosis and infiltration of tumor-associated macrophages in LUAD, suggesting it as a potential prognostic and immunological biomarker in LUAD.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Noorul Wahab, Michael Toss, Islam M. Miligy, Mostafa Jahanifar, Nehal M. Atallah, Wenqi Lu, Simon Graham, Mohsin Bilal, Abhir Bhalerao, Ayat G. Lashen, Shorouk Makhlouf, Asmaa Y. Ibrahim, David Snead, Fayyaz Minhas, Shan E. Ahmed Raza, Emad Rakha, Nasir Rajpoot
Summary: The study proposes an image-based prognostic marker for breast cancer that uses deep learning to objectively assess tumor heterogeneity. The marker demonstrates the ability to predict both patient survival and distant metastasis in early-stage breast cancer, with comparable accuracy to traditional manual assessment methods.
NPJ PRECISION ONCOLOGY
(2023)
Article
Oncology
Eva Welsch, Eva Schuster, Michael Krainer, Maximilian Marhold, Rupert Bartsch, Michael B. Fischer, Michael Hermann, Gabriele Hastermann, Heidemarie Uher, Gerhard Sliutz, Birgit Anker, Robert Zeillinger, Eva Obermayr
Summary: Liquid biopsy is a promising tool for monitoring cancer therapy, but further research is needed to improve sensitivity, specificity, standardization, and cost-effectiveness. In this study, two panels of transcripts related to circulating tumor cells (CTCs) were evaluated in breast cancer patients. The positivity rates of these panels were higher in metastatic patients compared to early-stage patients. Certain individual markers within these panels correlated with shorter overall survival in the metastatic patients. The findings highlight the additional value of non-epithelial phenotype markers in Panel 2.
Article
Biochemistry & Molecular Biology
Qiliang Zhai, Yan Hou, Yuedian Ye, Sujuan Dai, Guangxiu Guo, Qiao Yang, Guofu Pang, Qiang Wei
Summary: Alterations in m7G RNA methylation regulators may be implicated in the poor prognosis of patients with prostate adenocarcinoma. The expression patterns of 29 m7G RNA modification regulators were analyzed and 18 differentially expressed genes were identified in tumor and normal tissues. The risk model developed using The Cancer Genome Atlas (TCGA) data and validated using a Gene Expression Omnibus external dataset identified EIF4A1 and NCBP2 as prognostically significant genes associated with tumor progression.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Oncology
Long Wang, Xue Zhang, Mengxue Wang, Yunhai Li, Jiali Xu, Jiaying Wei, Hongzhong Li, Guosheng Ren, Xuedong Yin
Summary: By analyzing the ImmuneScore and StromalScore, differentially expressed genes, and performing immunohistochemical analyses, it was found that AMPD1 could serve as a novel biomarker for predicting the immune response and disease outcome in HER2+ BC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Yue-Yu Shi, Xing-Lei Chen, Qian-Xin Chen, Yuan-Zhong Yang, Meng Zhou, Yue-Xiang Ren, Lu-Ying Tang, Ze-Fang Ren
Summary: This study assessed the prognostic effect of ENO1 in breast cancer and considered potential confounders and modification effects. The results showed that ENO1 protein had a protective effect on OS in stage I/II patients but not in stage III patients. The study also found a positive correlation between ENO1 and several antitumor immune cells, which may explain its favorable prognosis in early-stage breast cancer.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Subbroto Kumar Saha, S. M. Riazul Islam, Tripti Saha, Afsana Nishat, Polash Kumar Biswas, Minchan Gil, Lewis Nkenyereye, Shaker El-Sappagh, Md Saiful Islam, Ssang-Goo Cho
Summary: A systematic multi-omics analysis revealed that EGR1 is often downregulated in breast cancer, with its low expression associated with poor survival. Additionally, EGR1 expression levels are linked to increased risk of ER+, PR+, and HER2- breast cancers. High positive correlations were observed among EGR1, DUSP1, FOS, FOSB, CYR61, and JUN mRNA expression in BC tissues.
Article
Oncology
Yan Yang, Xin He, Qian-Qian Tang, You-Cheng Shao, Wen-Jing Song, Peng-Ju Gong, Yi-Fan Zeng, Si-Rui Huang, Jiang-Yao Zhou, Hui-Fang Wan, Lei Wei, Jing-Wei Zhang
Summary: The research identified the immune gene GMFG as an important prognostic marker for breast cancer, with lower expression linked to poor prognosis. GMFG expression was also associated with tumor subtype, growth, and infiltration of CD8+ T cells, suggesting an anti-tumor role in breast cancer. GMFG has the potential to become a novel immune biomarker for the diagnosis and treatment of breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Shengnan Sha, Luyi Si, Xinrui Wu, Yuanbiao Chen, Hui Xiong, Ying Xu, Wangrui Liu, Haijun Mei, Tao Wang, Mei Li
Summary: This study investigates the potential role of cuproptosis-related genes (CRGs) in the tumor microenvironment (TME) of triple-negative breast cancer (TNBC). The results show that CRGs are closely associated with tumor immunity in TNBC and can be used to evaluate tumor immune cell infiltration, clinical features, and prognosis. This research provides new directions for the development of novel drugs in the future.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Chenming Guo, Zhiwen Luo, Dilimulati Ismtula, Xiaojuan Bi, Han Kong, Yiyang Wang, Zhen Yang, Xinmin Mao
Summary: This study assessed the levels and potential therapeutic and prognostic significance of TIGIT in invasive breast cancer. The results showed that TIGIT was elevated in invasive breast cancer and closely associated with prognosis. Further analyses revealed correlations between TIGIT levels and specific clinicopathological features as well as immune cell infiltrations.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2023)
