Article
Thermodynamics
Joey Aarts, Bas van Ravensteijn, Hartmut Fischer, Olaf Adan, Henk Huinink
Summary: This study presents a one-pot synthesis method for creating salt hydrate composites with enhanced mechanical stability. The use of poly (dimethyl siloxane) as a binder allows for the production of mm-sized particles. The results demonstrate that these composites exhibit stable mechanical properties during cycling and achieve high energy densities and power outputs.
Review
Nutrition & Dietetics
Joseph J. Crivelli, Tanecia Mitchell, John Knight, Kyle D. Wood, Dean G. Assimos, Ross P. Holmes, Sonia Fargue
Summary: The prevalence of kidney stone disease is on the rise, with calcium oxalate being the most common stone composition. Dietary oxalate intake and endogenous production of oxalate play important roles in the pathophysiology of calcium oxalate stone disease, while oxalate-degrading bacteria in the gut microbiome may mitigate stone risk.
Article
Multidisciplinary Sciences
Tilman A. Grunewald, Stefano Checchia, Hamadou Dicko, Gilles Le Moullac, Manaarii Sham Koua, Jeremie Vidal-Dupiol, Julien Duboisset, Julius Nouet, Olivier Grauby, Marco Di Michiel, Virginie Chamard
Summary: This study utilizes nanobeam X-ray total scattering and reverse Monte Carlo modeling to spatially resolve the amorphous calcium carbonate compounds in mollusc shells. Three distinct amorphous compounds were discovered, and the presence of magnesium in the shell and its role in the amorphous-to-crystal transition were demonstrated. The findings contribute to the understanding of biomineralization and provide insights for bioinspired synthetic strategies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Physiology
Hao Li, Yingjian Zhou, Wenchao Xu, Jihong Liu, Shaogang Wang, Hongyang Jiang
Summary: This systematic review discusses the role of autophagy in the pathogenesis of kidney stone and suggests that upregulation of autophagy may be a future research direction for kidney stone treatment.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Materials Science, Ceramics
Masaya Shimabukuro, Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa
Summary: Increasing CO32- concentration in Na2HPO4 solution accelerates the fabrication rate of CO3Ap and results in changes in crystal shape and crystallite size. Higher CO32- concentration leads to more CO3 content in CO3Ap, larger pores, and altered pore distribution.
CERAMICS INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Jennifer Zehner, Anja Royne, Pawel Sikorski
Summary: Biocementation is a process based on either microbial-induced carbonate precipitation or enzyme-induced carbonate precipitation to create sustainable, consolidated porous material through the biomineralization of CaCO3 in a granular medium. A microscopy sample cell combined with confocal laser scanning microscopy allows real time monitoring of CaCO3 precipitation and pH, with the ability to characterize the precipitated crystals without sample disturbance. This approach offers a powerful tool for knowledge-based improvements in biocementation.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yinhui Li, Tao Ding, Haiyan Hu, Tingting Zhao, Chao Zhu, Jiarong Ding, Jihang Yuan, Zhiyong Guo
Summary: Through various experiments and analyses, this study revealed that lncRNA-ATB plays a crucial role in CaOx crystal-induced renal injury by influencing cell injury, apoptosis, proliferation inhibition, and EMT, ultimately contributing to the development of the disease.
MOLECULAR MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Felipe Diaz-Soler, Carlos Rodriguez-Navarro, Encarnacion Ruiz-Agudo, Andronico Neira-Carrillo
Summary: By stabilizing calcium oxalate precursors in vitro using PAA, the nucleation of ACO nanoparticles can be delayed, which may contribute to a better understanding of the pathological mineralization leading to urolithiasis in mammals.
Article
Microbiology
Alexander Sonke, Elizabeth Trembath-Reichert
Summary: Oxalate plays important roles in biological processes of plants, fungi, bacteria, and animals. It occurs naturally as calcium oxalates or oxalic acid. Oxalotrophic microbes are believed to limit oxalate accumulation by degrading oxalate minerals via the oxalate-carbonate pathway. The diversity and ecology of oxalotrophic bacteria are not fully understood.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Construction & Building Technology
Munique Fante, Francisco Roger Carneiro Ribeiro, David Brandao Nunes, Regina Celia Espinosa Modolo, Claudio de Souza Kazmierczak, Mauricio Mancio, Francisco Manoel Wohnrath Tognoli, Afonso Rangel Garcez de Azevedo, Marlova Piva Kulakowski
Summary: This study evaluated the physical and chemical effects of calcium carbonate limestone filler in mortar pastes subjected to accelerated carbonation. Results showed that a 25% filler substitution at a water/cement ratio of 0.42 achieved the best performance in terms of compression strength and water absorption. Carbonation primarily affected by the water/cement ratio rather than substitution level, consuming portlandite and forming calcite. Further studies identified additional calcium carbonate polymorphs after 28 days of accelerated carbonation.
CASE STUDIES IN CONSTRUCTION MATERIALS
(2022)
Article
Urology & Nephrology
Megan Prochaska, John Asplin, Arlene Chapman, Elaine Worcester
Summary: The study found that men had higher calcium oxalate supersaturation in urine before RYGB, while women had higher urine calcium oxalate supersaturation and calcium phosphate supersaturation, as well as lower urine volumes after RYGB.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Article
Cell Biology
Yu Lan, Wei Zhu, Xiaolu Duan, Tuo Deng, Shujue Li, Yang Liu, Zhou Yang, Yaoan Wen, Lianming Luo, Shankun Zhao, Jiamin Wang, Zhijian Zhao, Wenqi Wu, Guohua Zeng
Summary: The study identified a novel role of glycine in regulating kidney calcium oxalate crystal formation, showing that glycine can attenuate CaOx crystal deposition by decreasing urine oxalate and increasing urine citrate levels. The mechanism involves downregulating Slc26a6 expression to decrease urine oxalate and inhibiting Nadc1 expression to increase urine citrate, with additional regulation of protein expression by miRNA-411-3p. These findings provide a potential target for the treatment of kidney calcium oxalate stones.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Environmental Sciences
Xinwei Xiong, Yanfei Cao, Zhixin Li, Ronglian Huang, Yu Jiao, Liqiang Zhao, Xiaodong Du, Zhe Zheng
Summary: This study identified specific tyrosinases (NLSTyr) involved in nacre formation in pearl oysters, which inhibited calcium carbonate precipitation and affected crystal morphologies. These findings provide new insights into the evolution and function of tyrosinase in mollusks.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Crystallography
Niki Martini, Vaia Koukou, Christos Michail, George Fountos
Summary: Kidney and uteric stones are common sources of pain and may have links to atherosclerosis. Understanding the composition of stones can aid in providing optimal treatment for patients.
Article
Multidisciplinary Sciences
Zhongmin Geng, Xinyue Wang, Feng Wu, Zhenping Cao, Jinyao Liu
Summary: This study presents a cytocompatible approach of biointerface mineralization to generate an ultraresistant and self-removable coating on bacterial surface, addressing the challenges faced by bacteria during the manufacturing process. The mineral coating provides bacteria with resistance against oxygen exposure, ultraviolet irradiation, and ethanol. Upon oral ingestion, the coating actively neutralizes gastric acid and releases encapsulated bacteria through a rapid double-decomposition reaction. Furthermore, the generated calcium ions trigger bile acid micellar aggregation, enabling dual exemptions from gastric acid and bile acid insults for uncompromised bacterial viability. Supported by therapeutic efficacy in colitis mice, biointerface mineralization offers a versatile platform for developing next-generation living oral biotherapeutics.
Article
Oncology
Elizabeth M. Kander, Manisha H. Shah, Ye Zhou, Ashima Goyal, Joshua D. Palmer, Dwight H. Owen, Konstantin Shilo, Gopal Patel, Raju R. Raval, Javier Gonzalez, Michele Nguyen, Elizabeth Olek, Jennifer Kherani, S. Michael Rothenberg, Bhavana Konda
Summary: The study showed that atypical lung carcinoid can be detected through next-generation sequencing to identify potential driver mutations and provide clinical trial opportunities for patients.
CLINICAL LUNG CANCER
(2021)
Article
Pathology
Caroline Bissonnette, Konstantin Shilo, David Liebner, Alan Rogers, Raphael E. Pollock, O. Hans Iwenofu
Summary: The molecular findings in Ewing sarcoma have expanded in recent years, including new translocations in Ewing-like undifferentiated round cell sarcomas. This case report describes an extraskeletal undifferentiated round cell Ewing-like sarcoma in a 27-year-old female, with histomorphologic and molecular findings consistent with EWSR1-CREB3L1 fusion, adding to the understanding of tumors in the Ewing family.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Shelby L. Sloan, Kyle A. Renaldo, Mackenzie Long, Ji-Hyun Chung, Lindsay E. Courtney, Konstantin Shilo, Youssef Youssef, Sarah Schlotter, Fiona Brown, Brett G. Klamer, Xiaoli Zhang, Ayse S. Yilmaz, Hatice G. Ozer, Victor E. Valli, Kris Vaddi, Peggy Scherle, Lapo Alinari, William C. Kisseberth, Robert A. Baiocchi
Summary: The study characterized the expression pattern of PRMT5 in canine lymphoma and found that inhibition of PRMT5 can lead to growth suppression and induction of apoptosis. Analysis of changes in chromatin accessibility and whole-transcriptome changes in canine lymphoma cell lines upon PRMT5 inhibition was performed. This research validates PRMT5 as a promising therapeutic target for treating canine lymphoma.
Article
Oncology
Dinesh K. Ahirwar, Manish Charan, Sanjay Mishra, Ajeet K. Verma, Konstantin Shilo, Bhuvaneswari Ramaswamy, Ramesh K. Ganju
Summary: Slit2 inhibits metastasis in breast cancer by activating the phagocytic activity of M1-like TAMs against tumor cells and diminishing fibrosis. Slit2 expression along with CD163(+) TAMs could be used as an improved prognostic biomarker in patients with breast cancer.
Article
Cell Biology
Walter Z. Wang, Konstantin Shilo, Joseph M. Amann, Alyssa Shulman, Mohammad Hojjat-Farsangi, Hakan Mellstedt, Johan Schultz, Carlo M. Croce, David P. Carbone
Summary: The study demonstrates high expression of ROR1 and BCL2 in SCLC, and the small molecule ROR1 inhibitor shows antitumor activity in SCLC cell lines, especially when used in combination with the BCL2 inhibitor, indicating a synergistic effect between ROR1 and BCL2 inhibition in SCLC models.
CELL DEATH & DISEASE
(2021)
Review
Pathology
Vincent C. Daniel, Konstantin Shilo
Summary: This is a rare case of thymolipoma with two thymomas of different histological subtypes. The case highlights the potential malignancy of thymolipomas and emphasizes the importance of early surgical resection.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Pathology
Nada Shaker, Chiemezie C. Amadi, Meng Welliver, Gregory A. Otterson, David A. Liebner, Konstantin Shilo
Summary: In this article, we report a rare case of mediastinal carcinosarcoma with unique clinical manifestations and immunohistochemical and molecular profiles. The patient, a 44-year-old female, presented with an enlarging anterior mediastinal mass and a positive pregnancy test. The thoracoscopic biopsy revealed a carcinosarcoma with adenocarcinoma and chondrosarcoma components. The tumor showed focal expression of beta-HCG and had a KRAS G12A missense mutation. This case highlights the importance of recognizing the uncommon clinical and pathological manifestations of mediastinal carcinosarcoma in order to ensure accurate diagnosis and proper management.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Pathology
Nada Shaker, Chiemezie C. Amadi, Asvin M. Ganapathi, Swati Satturwar, Konstantin Shilo
Summary: In this report, a case of severe pulmonary histoplasmosis complicated by the involvement of the free wall of the right ventricle is described. The patient presented with cough, fevers, dyspnea, and unintentional weight loss. Imaging studies revealed an intracardiac mass accompanied by mediastinal lymphadenopathy and bilateral lung nodules. Diagnosis was further confirmed by the presence of yeast forms in lymph node aspiration and elevated serum antibodies against Histoplasma capsulatum. The report highlights an unusual presentation of pulmonary histoplasmosis and suggests a possible connection between cardiac infection site and the presence of a permanent intravascular pacer device.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2023)
Meeting Abstract
Oncology
W. Wang, K. Shilo, J. Amann, A. Shulman, M. Hojjat-Farsangi, H. Mellstedt, J. Schultz, C. Croce, D. Carbone
JOURNAL OF THORACIC ONCOLOGY
(2021)
Meeting Abstract
Medicine, Research & Experimental
Anil Parwani, Wendy Frankel, Martha Yearsley, Trina Shanks, Zaibo Li, David Kellough, Mark Lloyd, Xiaoyan Cui, Vidya Arole, Adrian Suarez, Konstantin Shilo, Lynn Schoenfield, Wei Chen, Gary Tozbikian, Ogechukwu Eze, Jae-Hoon Chung, Jose Otero, Abberly Lott Limbach, Peter Kobalka, Diana Thomas, Paul Wakely
LABORATORY INVESTIGATION
(2020)
Meeting Abstract
Pathology
Anil Parwani, Wendy Frankel, Martha Yearsley, Trina Shanks, Zaibo Li, David Kellough, Mark Lloyd, Xiaoyan Cui, Vidya Arole, Adrian Suarez, Konstantin Shilo, Lynn Schoenfield, Wei Chen, Gary Tozbikian, Ogechukwu Eze, Jae-Hoon Chung, Jose Otero, Abberly Lott Limbach, Peter Kobalka, Diana Thomas, Paul Wakely
Meeting Abstract
Medicine, Research & Experimental
Rongqin Ren, Konstantin Shilo, Weiqiang Zhao, Matthew Avenarius, Jason Garee, Sean Caruthers, Dan Jones
LABORATORY INVESTIGATION
(2020)
Meeting Abstract
Pathology
Rongqin Ren, Konstantin Shilo, Weiqiang Zhao, Matthew Avenarius, Jason Garee, Sean Caruthers, Dan Jones
Meeting Abstract
Medicine, Research & Experimental
Zaibo Li, Konstantin Shilo, Christina Hopkins, William Joy, Andrew Margerrison, Keith Wharton, Anil Parwani
LABORATORY INVESTIGATION
(2020)
Meeting Abstract
Pathology
Zaibo Li, Konstantin Shilo, Christina Hopkins, William Joy, Andrew Margerrison, Keith Wharton, Anil Parwani
