期刊
HUMAN MUTATION
卷 35, 期 6, 页码 654-662出版社
WILEY
DOI: 10.1002/humu.22559
关键词
TP53; p53; cancer; Li-Fraumeni syndrome; germline; screening; management; genetic counseling
资金
- NCI NIH HHS [T32 CA136432] Funding Source: Medline
Since its description by Li and Fraumeni over 40 years ago, Li-Fraumeni syndrome (LFS) remains one of the most striking familial cancer predisposition syndromes. Children and adults are affected by a wide array of cancers that occur predominantly at younger ages. This review discusses LFS, describes its association with TP53, and examines the classic and evolving definitions of the syndrome. The potential implications of multigene assessments of individuals at increased cancer risk, which have already begun to identify those with very little personal or family cancer history carrying germline TP53 mutations, are considered. Newer options in the management of individuals with LFS are also discussed, highlighting the importance of further clinical trials for cancer detection, prevention, and management. Finally, we observe how the clinical criteria for TP53 mutation screening appear to be evolving as our understanding of the impact of germline TP53 mutations continues to expand.
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