Article
Cell Biology
Hang Huang, Ping Li, Xueting Ye, Fangyi Zhang, Qi Lin, Keming Wu, Wei Chen
Summary: This study found that combination treatment of isoalantolactone (IATL) and cisplatin showed significantly enhanced growth inhibition and apoptosis in human prostate cancer cells, potentially through excessive accumulation of intracellular reactive oxygen species (ROS) and activation of endoplasmic reticulum (ER) stress and the JNK signaling pathway. In vivo, the combined treatment also exhibited the strongest anti-tumor effects compared to single agents, suggesting that IATL and cisplatin combination therapy may be more effective for treating prostate cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Yongshi Liu, Xiaohua Liang, Hongpei Zhang, Jiajia Dong, Yan Zhang, Juan Wang, Chunmei Li, Xiangbing Xin, Yan Li
Summary: This study found associations between polymorphisms of EIF2AK3, HSPA5, and DDIT3 genes and the risk of lung cancer. The A allele of rs6750998 was shown to be a protective allele, while the minor alleles of rs867529, rs391957, and rs697221 were all risk alleles. Different genotypes were associated with an increased or decreased risk of lung cancer.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Xiaofeng Jin, Shi Qing, Qian Li, Hui Zhuang, Liliang Shen, Jinhui Li, Honggang Qi, Ting Lin, Zihan Lin, Jian Wang, Xinyi Cao, Jianye Yang, Qi Ma, Linghua Cong, Yang Xi, Shuai Fang, Xiaodan Meng, Zhaohui Gong, Meng Ye, Shuyun Wang, Chenji Wang, Kun Gao
Summary: SPOP protein is phosphorylated by ATM kinase upon DNA damage, enhancing its binding to HIPK2 and facilitating DNA damage repair. This process is disrupted by SPOP mutations in prostate cancer, leading to genomic instability.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Oncology
Huang Chen, Ying Miao, Aiwu Bian, Jiangnan Ye, Jing Wang, Xiaonan Cong, Shuyi Jian, Zhengfang Yi, Lin Liang, Zhenliang Sun, Fan Yang, Tao Ding
Summary: This study identifies the unfolded protein response (UPR) as a potential target for the treatment of castration-resistant prostate cancer (CRPC). It also introduces a novel UPR activator, WJ-644A, which inhibits prostate cancer cell proliferation and causes tumor regression through induction of cell metaposis and autophagy.
Article
Environmental Sciences
Haohao Liu, Zhihui Tian, Yaxin Guo, Xiaohui Liu, Ya Ma, Xingde Du, Rui Wang, Shiyu Zhang, Linjia Shi, Hongxiang Guo, Huizhen Zhang
Summary: The study found that MC-LR can cause female reproductive toxicity by inducing apoptosis and follicular atresia in ovarian cells. The endoplasmic reticulum stress plays a crucial role in the apoptotic pathway induced by MC-LR, where Ddit3 regulates cell apoptosis and follicular atresia by modulating other genes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Cell Biology
Ruiyuan Xu, Jianlu Song, Rexiati Ruze, Yuan Chen, Xinpeng Yin, Chengcheng Wang, Yupei Zhao
Summary: This study reveals squalene epoxidase (SQLE) as a novel oncogene that promotes pancreatic cancer (PC) growth by mitigating endoplasmic reticulum stress and activating lipid raft-regulated Src/PI3K/Akt signaling pathway. SQLE facilitates cell proliferation, induces cell cycle progression, and inhibits apoptosis in vitro, while promoting tumor growth in vivo. SQLE inhibitors effectively suppress PC cell proliferation and xenograft tumor growth, highlighting the potential of SQLE as a therapeutic target for PC.
CELL DEATH & DISEASE
(2023)
Article
Gastroenterology & Hepatology
Qin Yang, Xi Chen, Yanfang Zhang, Sha Hu, Fengjiao Hu, Yongping Huang, Tengfei Ma, Heng Hu, Han Tian, Song Tian, Yan-Xiao Ji, Zhi-Gang She, Peng Zhang, Xiao-Jing Zhang, Yufeng Hu, Hailong Yang, Yufeng Yuan, Hongliang Li
Summary: The study demonstrated that RNF5 inhibits the progression of NASH by targeting HRD1 in the ubiquitin-mediated proteasomal pathway, providing new insights into the pathogenesis of NASH and potential strategies for prevention and treatment.
Article
Endocrinology & Metabolism
Shengren Cen, Dongmei Jiang, Daojun Lv, Ran Xu, Jiamao Hou, Zixiang Yang, Peng Wu, Xinhao Xiong, Xingcheng Gao
Summary: In this study, an ERS risk signature consisting of five genes (AFP, COL10A1, DNAJB1, EGF, and PTGS2) was constructed and found to effectively predict the biochemical recurrence time of prostate cancer patients. The high-risk score group might be involved in the apoptosis pathway, and differences were observed in immune cell infiltration and immune checkpoint expression levels between high- and low-risk scoring subgroups. Targeting ERS-related genes and pathways may provide potential guidance for the treatment of prostate cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xijie Yu, Xiaoxiao Xu, Wei Dong, Chang Yang, Yao Luo, Ying He, Chenxi Jiang, Yanru Wu, Jiawei Wang
Summary: The study reveals that DDIT3 partially regulates the inhibitory effect of ER stress on chondrocyte differentiation and matrix synthesis via the AMPK alpha-SIRT1 pathway, which may provide insights for developing therapeutic targets and preventing condyle cartilage destruction.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Oncology
Kumar Nikhil, Hanan S. Haymour, Mohini Kamra, Kavita Shah
Summary: This study identified that LIMK2 degrades SPOP by direct phosphorylation and creates a feedback loop to promote oncogenicity in prostate cancer. Understanding the relationship between LIMK2 and SPOP provides a powerful opportunity to inhibit LIMK2 and retain WT-SPOP, effectively halting disease progression.
BRITISH JOURNAL OF CANCER
(2021)
Article
Environmental Sciences
Ayse Tarbin Jannuzzi, Ayse Mine Yilmaz Goler, Buket Alpertunga
Summary: The widely used flame retardant Triphenyl phosphate (TPP) has been found to be cytotoxic to human skin keratinocytes, inhibiting cell proliferation and migration, and inducing apoptosis. TPP also induces the production of reactive oxygen species, increases protein oxidation and lipid peroxidation, and affects protein degradation and ubiquitination processes.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Neurosciences
Huirong Li, Bo Liu, Lili Lian, Jiajia Zhou, Shengjin Xiang, Yifan Zhai, Yu Chen, Xiaoyin Ma, Wencan Wu, Ling Hou
Summary: The study found that the expression levels of HMOX1 determine whether it is protective or deleterious in the retina. Low levels of HMOX1 before light exposure prevent photoreceptor degeneration, while high levels of HMOX1 directly induce photoreceptor degeneration even without light stress. The high level of HMOX1 is associated with DDIT3 induction and endoplasmic reticulum stress, which can lead to devastating effects, highlighting the importance of carefully considering expression levels in gene therapy approaches involving HMOX1.
MOLECULAR NEURODEGENERATION
(2021)
Article
Biochemistry & Molecular Biology
Xiaoxi Xu, Anoop Arunagiri, Leena Haataja, Maroof Alam, Shuhui Ji, Ling Qi, Billy Tsai, Ming Liu, Peter Arvan
Summary: Proteasome inhibitors can downregulate proinsulin synthesis in beta cells and lead to decreased insulin secretion and cell death. However, they can also rescue newly synthesized proinsulin from degradation. After 60 minutes of proteasomal inhibition, proinsulin levels start to decrease.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Environmental Sciences
Min-Hua Wu, Su-Chun Hui, Yong-Syuan Chen, Hui-Ling Chiou, Ching-Yi Lin, Chien-Hsing Lee, Yi-Hsien Hsieh
Summary: The combination therapy of NCTD and PTX effectively inhibits cell viability and proliferation, induces G2/M phase arrest, cell death, ER stress, and downregulates SIRT7 expression in PCa cells. This treatment strategy may become a potential therapeutic approach against human PCa.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Chemistry, Medicinal
Arielle Shkedi, Michael Adkisson, Andrew Schroeder, Walter L. Eckalbar, Szu-Yu Kuo, Leonard Neckers, Jason E. Gestwicki
Summary: By dosing 22Rv1 prostate cancer cells with inhibitors of four proteostasis targets, researchers found additive, synergistic, and antagonistic relationships between the inhibitors. These relationships were associated with activation of stress pathways.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Jie Ding, Liu Dong, Pengfei Jiang, Yue Tang, Songyi Lin
Summary: Enzymatic hydrolysis is an effective method to reduce the allergenicity of pea protein, and this study explored the relationship between reduced allergenicity and structural changes.
Article
Environmental Sciences
Zong-Lin Wu, Quan Zhang, Zi-Yuan Xia, Min Gou, Zhao-Yong Sun, Yue-Qin Tang
Summary: This study investigated the effects of fluctuation disturbance of organic loading rate (OLR) on anaerobic digestion (AD) of municipal sludge. The performance of the AD reactors remained similar before and after disturbance, indicating their buffer capacity to OLR periodic fluctuation. Different microbial community at RNA level was observed in the two reactors, with greater changes in the thermophilic AD. The results showed that the thermophilic microbial community was more vulnerable, but the reactor performance could be maintained using the functional redundancy strategy under OLR fluctuation disturbance.
ENVIRONMENTAL RESEARCH
(2023)
Article
Computer Science, Hardware & Architecture
Yue Tang, Xu Jiang, Nan Guan, Dong Ji, Xiantong Luo, Wang Yi
Summary: This paper investigates the application of cause-effect chains in real-time systems and their impact on communication paradigms. It compares different communication paradigms in terms of the end-to-end latency of cause-effect chains and proposes priority assignment strategies to optimize the latency with specific communication paradigms. Experiments are conducted with synthesized data based on an automotive benchmark and randomly generated parameters to evaluate the results.
IEEE TRANSACTIONS ON COMPUTERS
(2023)
Article
Computer Science, Hardware & Architecture
Xu Jiang, Zewei Chen, Maolin Yang, Nan Guan, Yue Tang, Yi Wang
Summary: This paper studies the analysis of parallel real-time tasks using spin locks to protect shared resources and proposes a scalable blocking analysis technique based on linear programming. The method is evaluated through comprehensive experiments and compared with other state-of-the-art approaches for scheduling real-time parallel tasks using semaphores and spin locks.
IEEE TRANSACTIONS ON COMPUTERS
(2023)
Article
Computer Science, Theory & Methods
Xu Jiang, Haochun Liang, Nan Guan, Yue Tang, Lei Qiao, Yi Wang
Summary: This study investigates the scheduling of real-time parallel tasks on virtual multiprocessors. Through comprehensive performance evaluation, the proposed approach consistently outperforms existing methods under a wide range of parameter settings.
IEEE TRANSACTIONS ON PARALLEL AND DISTRIBUTED SYSTEMS
(2023)
Article
Agriculture, Multidisciplinary
Zhiyu Liu, Songyi Lin, Wenwen Liu, Yoshimasa Nakamura, Yue Tang
Summary: In this study, fish skin gelatin (FSG) and luteolin (LUT) were used as composite emulsifiers, and benzyl isothiocyanate (BITC) was used as a model nutrient for delivery. The FSG-LUT emulsion showed higher stability and embedding rate compared to the FSG emulsion. It also demonstrated resistance to oral and gastric digestion, resulting in higher retention and bioaccessibility of BITC. Furthermore, the ex vivo study in rat intestine showed that the FSG-LUT emulsion facilitated controlled release and absorption of BITC in a specific position.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Cell Biology
Yan Tang, Li-Jie Yang, Hao Liu, Yan-Jue Song, Qi-Qi Yang, Yang Liu, Shu-Wen Qian, Qi-Qun Tang
Summary: Obesity, especially increased visceral fat, is associated with metabolic challenges such as atherosclerosis, but the exact mechanism is not fully understood. This study aims to investigate the role of visceral-fat-derived exosomes in endothelial cells and atherosclerosis. The research shows that obesity alters the miRNA profile of adipose exosomes, and exosomal miR-27b-3p can enter endothelial cells and activate the NF-kB pathway by suppressing PPARa. In ApoE-deficient mice, administration of miR-27b-3p mimic increases inflammation and atherogenesis, while overexpression of PPARa protects against atherosclerosis. Therefore, obesity-induced exosomal miR-27b-3p promotes endothelial inflammation and facilitates atherogenesis through PPARa suppression.
Article
Microbiology
Gao Feng, Yan Zeng, Hui-Zhong Wang, Ya-Ting Chen, Yue-Qin Tang
Summary: Microorganisms in anaerobic digestion are affected by ammonia, especially methanogens. This study investigated the effect of ammonia on microbial community and metabolism in a mesophilic chemostat. Results showed that even at high ammonia concentrations, methanogenesis and acetate degradation remained normal. The dominant methanogen changed with increased ammonia, and Proteiniphilum showed a positive correlation with ammonia concentration. Proteiniphilum and M. harundinacea had strong ammonia tolerance and played critical roles in acetate degradation. These findings contribute to the regulation and management of anaerobic digestion processes.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Chi Li, Chaoying Huang, Ruimu Zhang, Hongmei Wang, Shufeng Tian, Yi-Wei Tang, Jikui Deng
Summary: In recent years, there have been outbreaks of pertussis in countries with high vaccination rates. Early diagnosis of pertussis is crucial and is usually done through laboratory measurements such as culture, serological tests, and PCR assays. This study compared the performance of different detection methods and found that BioFire Respiratory Panel 2 plus (RP2) had a higher sensitivity and specificity for detecting Bordetella pertussis compared to culture and quantitative real-time PCR (qPCR). RP2 also provided quick results, aiding in early diagnosis and treatment decisions.
MICROBIOLOGY SPECTRUM
(2023)
Article
Agricultural Engineering
Xiang-Yu Peng, Shi-Peng Wang, Xiu-Lin Chu, Zhao-Yong Sun, Zi-Yuan Xia, Cai-Yun Xie, Min Gou, Yue-Qin Tang
Summary: This study investigated the performance and bacterial community succession of a thermophilic semi-continuous composting (TSC) followed by static stacking (SS) for decentralized kitchen waste (KW) treatment. The TSC using an integrated automatic reactor achieved a stable performance with an organic matter degradation efficiency of 80.88% and a seed germination index (GI) of 78.51% by a daily feeding ratio of 10%. The subsequent SS for seven days further improved the compost quality with a GI of 91.58% by promoting the rapid proliferation of Proteobacteria and Bacteroidetes. The results offer new perspectives for practical applications of decentralized KW treatment using TSC.
BIORESOURCE TECHNOLOGY
(2023)
Article
Thermodynamics
Xinyu Zou, Shuqiang Guo, Li Ren, Xin Li, Ying Xu, Yuejin Tang
Summary: The HTS-SMES magnets inevitably produce AC loss during the charging and discharging process, causing temperature rise and potential damage. Detecting the temperature rise is delayed and measuring it is not feasible for monitoring and protecting the magnets. This paper proposes a safe operation strategy based on state prediction, establishing a state database and using intelligent algorithms to predict AC loss and temperature to determine the magnets' state.
Article
Geosciences, Multidisciplinary
Pei-yuan Hu, Qing-guo Zhai, Peter A. Cawood, Roberto F. Weinberg, Guo-chun Zhao, Yue Tang, Yi-ming Liu
Summary: Paleogeographic reconstruction of Precambrian terranes reworked by Phanerozoic orogens, such as the Tibetan Plateau, reveals complex lithotectonic relations due to intracrustal reworking. Global and regional detrital zircon rare earth element (REE) databases show trends in LREE/HREE and Eu/Eu* that record the crustal evolution of the source and provide a new approach for paleogeographic reconstructions. By analyzing sedimentary and igneous rocks in the Lhasa terrane and detrital zircon samples from the northern margin of Gondwana, it is demonstrated that the Lhasa terrane had an African affinity in the Rodinia-Gondwana supercontinent cycles (ca. 1.4-0.4 Ga).
GEOPHYSICAL RESEARCH LETTERS
(2023)
Article
Physics, Multidisciplinary
Haipeng Zhang, Jiajie Long, Li Ren, Ying Xu, Xianhao Li, Yuejin Tang
Summary: Developing a transient magneto-mechanical numerical model is crucial to accurately simulate the influence of deep-sea pressure on the magnetic field around underwater detectors. This study improved the Jiles-Atherton theory for complex stress and verified the hysteresis effect between magnetization and stress by calculating the variation in magnetic field with pressure. The effect of stress on magnetic field was determined by calculating the magnetic field distribution under different pressures.
Article
Automation & Control Systems
Yue Tang, Feng Chai, Ying Xie, William Cai
Summary: This article proposes a modular permanent magnet in-wheel motor design for electric vehicles, aiming to achieve high reliability and fault-tolerant capability. The design includes a slot-pole combination with high fault-tolerant performance. The electromagnetic characteristics and torque performance of the motor are investigated, and a prototype is produced and verified through experiments.
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2023)
Article
Agricultural Engineering
Jin-Ting He, Nan Yao, Zhao-Yong Sun, Feng Li, He-Qing Cai, Li-Feng Jin, Yue-Qin Tang
Summary: Tobacco processing waste can be used as feedstock for biogas production through anaerobic digestion. This study examined the thermophilic anaerobic digestion of flue-cured tobacco leaf waste and evaluated the effects of biochar on biogas production. The addition of biochar enhanced methane production by 1.12-1.20 fold at different organic loads. The presence of biochar shortened the lag period and increased the methane production rate. Specific bacterial and methanogenic genera played a crucial role in the digestion process. These findings provide valuable insights for the treatment of tobacco waste.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
