Altered spatio-temporal dynamics of RNase H2 complex assembly at replication and repair sites in Aicardi–Goutières syndrome

Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling

(2014) Gillian I Rice et al.   NATURE GENETICS

Aicardi-Goutières syndrome: a model disease for systemic autoimmunity

(2013) M. A. Lee-Kirsch et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Mouse models for Aicardi-Goutières syndrome provide clues to the molecular pathogenesis of systemic autoimmunity

(2013) R. Behrendt et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

New image colocalization coefficient for fluorescence microscopy to quantify (bio-)molecular interactions

(2013) H.D. HERCE et al.   JOURNAL OF MICROSCOPY

Dissection of cell cycle–dependent dynamics of Dnmt1 by FRAP and diffusion-coupled modeling

(2013) Katrin Schneider et al.   NUCLEIC ACIDS RESEARCH

RNase H2 roles in genome integrity revealed by unlinking its activities

(2013) Hyongi Chon et al.   NUCLEIC ACIDS RESEARCH

Structure-function analysis of ribonucleotide bypass by B family DNA replicases

(2013) A. R. Clausen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development

(2012) Martin A.M. Reijns et al.   CELL

Transcriptional responses to loss of RNase H2 in Saccharomyces cerevisiae

(2012) Mercedes E. Arana et al.   DNA REPAIR

Ribonucleotide incorporation, proofreading and bypass by human DNA polymerase δ

(2012) Anders R. Clausen et al.   DNA REPAIR

Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity

(2012) Bjoern Hiller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RNase H2-Initiated Ribonucleotide Excision Repair

(2012) Justin L. Sparks et al.   MOLECULAR CELL

RNase H and Postreplication Repair Protect Cells from Ribonucleotides Incorporated in DNA

(2012) Federico Lazzaro et al.   MOLECULAR CELL

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

Targeted manipulation of heterochromatin rescues MeCP2 Rett mutants and re-establishes higher order chromatin organization

(2012) Corella S. Casas-Delucchi et al.   NUCLEIC ACIDS RESEARCH

Functional Consequences of the RNase H2A Subunit Mutations That Cause Aicardi-Goutières Syndrome

(2011) Stephanie R. Coffin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms

(2011) Oliver Mortusewicz et al.   NUCLEIC ACIDS RESEARCH

PCNA directs type 2 RNase H activity on DNA replication and repair substrates

(2011) Doryen Bubeck et al.   NUCLEIC ACIDS RESEARCH

A New Twist for Topoisomerase

(2011) S. M. Cerritelli et al.   SCIENCE

Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I

(2011) N. Kim et al.   SCIENCE

Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutières syndrome

(2010) Georgia Ramantani et al.   ARTHRITIS AND RHEUMATISM

The Structural and Biochemical Characterization of Human RNase H2 Complex Reveals the Molecular Basis for Substrate Recognition and Aicardi-Goutières Syndrome Defects

(2010) Małgorzata Figiel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease

(2010) Martin A. M. Reijns et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of RNase H2 in Complex with Nucleic Acid Reveal the Mechanism of RNA-DNA Junction Recognition and Cleavage

(2010) Monika P. Rychlik et al.   MOLECULAR CELL

Genome instability due to ribonucleotide incorporation into DNA

(2010) Stephanie A Nick McElhinny et al.   Nature Chemical Biology

Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases

(2010) S. A. Nick McElhinny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribonuclease H: the enzymes in eukaryotes

(2009) Susana M. Cerritelli et al.   FEBS Journal

The Structure of the Mammalian RNase H2 Complex Provides Insight into RNA·DNA Hybrid Processing to Prevent Immune Dysfunction

(2009) Nadine M. Shaban et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

(2009) Gillian I Rice et al.   NATURE GENETICS

RNaseH2 mutants that cause Aicardi–Goutieres syndrome are active nucleases

(2008) Fred W. Perrino et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex

(2008) Hyongi Chon et al.   NUCLEIC ACIDS RESEARCH