Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Higher-Order Assemblies in a New Paradigm of Signal Transduction

(2013) Hao Wu   CELL

A novel mutation in the C2 domain of protein kinase C gamma associated with spinocerebellar ataxia type 14

(2013) Takehiro Ueda et al.   JOURNAL OF NEUROLOGY

A de novo SCA14 mutation in an isolated case of late-onset cerebellar ataxia

(2013) Judith van Gaalen et al.   MOVEMENT DISORDERS

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Exome sequencing in an SCA14 family demonstrates its utility in diagnosing heterogeneous diseases

(2012) A. Sailer et al.   NEUROLOGY

SCA14 in Norway, two families with autosomal dominant cerebellar ataxia and a novel mutation in the PRKCG gene

(2011) J. Koht et al.   ACTA NEUROLOGICA SCANDINAVICA

Crystal Structure and Allosteric Activation of Protein Kinase C βII

(2011) Thomas A. Leonard et al.   CELL

Mutant PKC  in Spinocerebellar Ataxia Type 14 Disrupts Synapse Elimination and Long-Term Depression in Purkinje Cells In Vivo

(2011) A. N. Shuvaev et al.   JOURNAL OF NEUROSCIENCE

Elucidation of the Molecular Mechanism and Exploration of Novel Therapeutics for Spinocerebellar Ataxia Caused by Mutant Protein Kinase Cγ

(2011) Takahiro Seki et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Congo Red, an Amyloid-Inhibiting Compound, Alleviates Various Types of Cellular Dysfunction Triggered by Mutant Protein Kinase Cγ That Causes Spinocerebellar Ataxia Type 14 (SCA14) by Inhibiting Oligomerization and Aggregation

(2010) Takahiro Seki et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Protein aggregation diseases: pathogenicity and therapeutic perspectives

(2010) Adriano Aguzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Protein kinase Cγ, a protein causative for dominant ataxia, negatively regulates nuclear import of recessive-ataxia-related aprataxin

(2009) Hirohide Asai et al.   HUMAN MOLECULAR GENETICS

Protein folding: Sticky N17 speeds huntingtin pile-up

(2009) Susan W Liebman et al.   Nature Chemical Biology

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

(2009) Stephen Tam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Enzymological Analysis of Mutant Protein Kinase Cγ Causing Spinocerebellar Ataxia Type 14 and Dysfunction in Ca2+Homeostasis

(2008) Naoko Adachi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKC  mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling

(2008) D. S. Verbeek et al.   JOURNAL OF CELL SCIENCE

Prediction of Aggregation-Prone Regions in Structured Proteins

(2008) Gian Gaetano Tartaglia et al.   JOURNAL OF MOLECULAR BIOLOGY

Mutant γPKC found in spinocerebellar ataxia type 14 induces aggregate-independent maldevelopment of dendrites in primary cultured Purkinje cells

(2008) Takahiro Seki et al.   NEUROBIOLOGY OF DISEASE