Article
Biotechnology & Applied Microbiology
Mo Li, Yi Hu, Baihui Zhao, Luan Chen, Hailiang Huang, Cong Huai, Xiaoqing Zhang, Jinghong Zhang, Wei Zhou, Lu Shen, Qi Zhen, Bao Li, Wenjun Wang, Lin He, Shengying Qin
Summary: A two-stage study identified genetic markers associated with TB susceptibility in 616 TB patients and 709 healthy controls. The study confirmed 6 nominally significant SNPs and a HLA-II allele as predisposing factors for TB. The research provides insight into the genetic variants linked to TB susceptibility and sheds light on tuberculosis pathogenesis.
Article
Immunology
Miao Zhou, Chao Xue, Zhongdao Wu, Xiaoying Wu, Miaoxin Li
Summary: This study conducted a genome-wide association study on a Chinese population to investigate the genetic factors influencing schistosomiasis complications. Several novel significant single-nucleotide polymorphisms (SNPs) and genes were identified that were associated with liver damage indicators, serum levels, and clinical signs of schistosomiasis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Genetics & Heredity
Wenlong Carl Chen, Jean-Tristan Brandenburg, Ananyo Choudhury, Mahtaab Hayat, Dhriti Sengupta, Yaniv Swiel, Chantal Babb de Villiers, Lucien Ferndale, Colleen Aldous, Cassandra C. Soo, Sang Lee, Charles Curtis, Rob Newton, Tim Waterboer, Fredd Sitas, Debbie Bradshaw, Christian C. Abnet, Michele Ramsay, M. Iqbal Parker, Elvira Singh, Cathryn M. Lewis, Christopher G. Mathew
Summary: Esophageal squamous cell carcinoma (ESCC) has a high disease burden in sub-Saharan Africa and has a very poor prognosis. This study conducted a genome-wide association study (GWAS) in African individuals with ESCC and identified significant genetic risk loci, including FAM120A and MYO1B genes. A trans-ethnic meta-analysis also identified additional risk loci for ESCC, suggesting both shared and distinct genetic factors between African and Asian populations.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Review
Biochemistry & Molecular Biology
Yin Huang, Dan Li, Lu Qiao, Yu Liu, Qianqian Peng, Sijie Wu, Manfei Zhang, Yajun Yang, Jingze Tan, Shuhua Xu, Li Jin, Sijia Wang, Kun Tang, Stefan Grunewald
Summary: This study conducted a genome-wide association study on the genetic basis of facial morphology in the Han Chinese population, identifying significant associations between multiple facial features and different genomic regions. These findings contribute to a more comprehensive understanding of the genetic factors underlying variation in human facial morphology.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Article
Biochemistry & Molecular Biology
Pirro G. Hysi, Massimo Mangino, Paraskevi Christofidou, Mario Falchi, Edward D. Karoly, Robert P. Mohney, Ana M. Valdes, Tim D. Spector, Cristina Menni
Summary: This study conducted a genome-wide association study on the levels of circulating metabolites in European subjects, identifying 202 unique genomic regions associated with 478 different metabolites. The replication study confirmed the robustness of these associations and discovered 74 novel genomic regions not previously associated with any metabolites.
Article
Biotechnology & Applied Microbiology
Shan Lin, Cuncun Ke, Lin Liu, Yahui Gao, Lingna Xu, Bo Han, Yaofeng Zhao, Shengli Zhang, Dongxiao Sun
Summary: In this study, 14 candidate genes related to immunoglobulin concentrations in colostrum and serum in dairy cattle were identified through genome-wide association studies (GWASs). These findings provide a basis for further investigation into key genes and mutations affecting immunoglobulin concentrations, as well as important information for genetic improvement of immune traits in dairy cattle.
Article
Genetics & Heredity
Tianzi Liu, Mohetaboer Momin, Huiyue Zhou, Qiwen Zheng, Fangfang Fan, Jia Jia, Mengyuan Liu, Minghui Bao, Jianping Li, Yong Huo, Jialin Liu, Yaning Zhang, Xuemei Mao, Xiao Han, Zhiyuan Hu, Changqing Zeng, Fan Liu, Yan Zhang
Summary: This study identified genetic variants associated with tHCY in Chinese Han individuals, including a novel East Asian-specific missense variant in the MTHFR gene. These findings provide new insights into the presence of multiple causal mutations at the MTHFR locus.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Tarunveer S. Ahluwalia, Bram P. Prins, Mohammadreza Abdollahi, Nicola J. Armstrong, Stella Aslibekyan, Lisa Bain, Barbara Jefferis, Jens Baumert, Marian Beekman, Yoav Ben-Shlomo, Joshua C. Bis, Braxton D. Mitchell, Eco de Geus, Graciela E. Delgado, Diana Marek, Joel Eriksson, Eero Kajantie, Stavroula Kanoni, John P. Kemp, Chen Lu, Riccardo E. Marioni, Stela McLachlan, Yuri Milaneschi, Ilja M. Nolte, Alexandros M. Petrelis, Eleonora Porcu, Maria Sabater-Lleal, Elnaz Naderi, Ilkka Seppala, Tina Shah, Gaurav Singhal, Marie Standl, Alexander Teumer, Anbupalam Thalamuthu, Elisabeth Thiering, Stella Trompet, Christie M. Ballantyne, Emelia J. Benjamin, Juan P. Casas, Catherine Toben, George Dedoussis, Joris Deelen, Peter Durda, Jorgen Engmann, Mary F. Feitosa, Harald Grallert, Ann Hammarstedt, Sarah E. Harris, Georg Homuth, Jouke-Jan Hottenga, Sirpa Jalkanen, Yalda Jamshidi, Magdalene C. Jawahar, Tine Jess, Mika Kivimaki, Marcus E. Kleber, Jari Lahti, Yongmei Liu, Pedro Marques-Vidal, Dan Mellstrom, Simon P. Mooijaart, Martina Muller-Nurasyid, Brenda Penninx, Joana A. Revez, Peter Rossing, Katri Raikkonen, Naveed Sattar, Hubert Scharnagl, Bengt Sennblad, Angela Silveira, Beate St Pourcain, Nicholas J. Timpson, Julian Trollor, Jenny van Dongen, Diana Van Heemst, Sophie Visvikis-Siest, Peter Vollenweider, Uwe Volker, Melanie Waldenberger, Gonneke Willemsen, Delilah Zabaneh, Richard W. Morris, Donna K. Arnett, Bernhard T. Baune, Dorret Boomsma, Yen-Pei C. Chang, Ian J. Deary, Panos Deloukas, Johan G. Eriksson, David M. Evans, Manuel A. Ferreira, Tom Gaunt, Vilmundur Gudnason, Anders Hamsten, Joachim Heinrich, Aroon Hingorani, Steve E. Humphries, J. Wouter Jukema, Wolfgang Koenig, Meena Kumari, Zoltan Kutalik, Deborah A. Lawlor, Terho Lehtimaki, Winfried Marz, Karen A. Mather, Silvia Naitza, Matthias Nauck, Claes Ohlsson, Jackie F. Price, Olli Raitakari, Ken Rice, Perminder S. Sachdev, Eline Slagboom, Thorkild I. A. Sorensen, Tim Spector, David Stacey, Maria G. Stathopoulou, Toshiko Tanaka, S. Goya Wannamethee, Peter Whincup, Jerome Rotter, Abbas Dehghan, Eric Boerwinkle, Bruce M. Psaty, Harold Snieder, Behrooz Z. Alizadeh
Summary: This study identified novel genetic loci influencing circulating IL-6 levels, uncovering new immunological and inflammatory pathways that may impact the pathobiology of IL-6.
HUMAN MOLECULAR GENETICS
(2021)
Article
Multidisciplinary Sciences
Ruidong Xiang, Iona M. MacLeod, Hans D. Daetwyler, Gerben de Jong, Erin O'Connor, Chris Schrooten, Amanda J. Chamberlain, Michael E. Goddard
Summary: This study presents a method for fine-mapping potentially causal mutations by integrating functional, evolutionary, and pleiotropic information and developing a custom genotyping array. The custom array, containing variants with biological functions, outperformed the standard array in predicting genetic values for multiple traits in dairy cattle populations across different countries. This highlights the potential improvement in genomic prediction by utilizing mutations with functional, evolutionary, and pleiotropic consequences.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Garan Jones, Katerina Trajanoska, Adam J. Santanasto, Najada Stringa, Chia-Ling Kuo, Janice L. Atkins, Joshua R. Lewis, ThuyVy Duong, Shengjun Hong, Mary L. Biggs, Jian'an Luan, Chloe Sarnowski, Kathryn L. Lunetta, Toshiko Tanaka, Mary K. Wojczynski, Ryan Cvejkus, Maria Nethander, Sahar Ghasemi, Jingyun Yang, M. Carola Zillikens, Stefan Walter, Kamil Sicinski, Erika Kague, Cheryl L. Ackert-Bicknell, Dan E. Arking, B. Gwen Windham, Eric Boerwinkle, Megan L. Grove, Misa Graff, Dominik Spira, Ilja Demuth, Nathalie van der Velde, Lisette C. P. G. M. de Groot, Bruce M. Psaty, Michelle C. Odden, Alison E. Fohner, Claudia Langenberg, Nicholas J. Wareham, Stefania Bandinelli, Natasja M. van Schoor, Martijn Huisman, Qihua Tan, Joseph Zmuda, Dan Mellstrom, Magnus Karlsson, David A. Bennett, Aron S. Buchman, Philip L. De Jager, Andre G. Uitterlinden, Uwe Voelker, Thomas Kocher, Alexander Teumer, Leocadio Rodriguez-Manas, Francisco J. Garcia, Jose A. Carnicero, Pamela Herd, Lars Bertram, Claes Ohlsson, Joanne M. Murabito, David Melzer, George A. Kuchel, Luigi Ferrucci, David Karasik, Fernando Rivadeneira, Douglas P. Kiel, Luke C. Pilling
Summary: Low muscle strength is a heritable indicator of poor health in older people, with genetic loci associated with muscle weakness identified through genome-wide meta-analysis. Possible causal relationships with diabetes susceptibility, hematological parameters, and the immune system were also discovered using Mendelian randomization. The distinct mechanisms of muscle weakness from continuous strength were highlighted, shedding light on potential pathways involved in ageing.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Maria K. Smatti, Yasser A. Al-Sarraj, Omar Albagha, Hadi M. Yassine
Summary: This study identifies genetic polymorphisms associated with anti-HEV antibody levels through GWAS, and highlights the correlation with anti-viral response-related pathways. Further validation and functional experiments are needed.
Article
Multidisciplinary Sciences
Wei-Yu Lin, Sarah E. Fordham, Nicola Sunter, Claire Elstob, Thahira Rahman, Elaine Willmore, Colin Shepherd, Gordon Strathdee, Tryfonia Mainou-Fowler, Rachel Piddock, Hannah Mearns, Timothy Barrow, Richard S. Houlston, Helen Marr, Jonathan Wallis, Geoffrey Summerfield, Scott Marshall, Andrew Pettitt, Christopher Pepper, Christopher Fegan, Francesco Forconi, Martin J. S. Dyer, Sandrine Jayne, April Sellors, Anna Schuh, Pauline Robbe, David Oscier, James Bailey, Syed Rais, Alison Bentley, Lynn Cawkwell, Paul Evans, Peter Hillmen, Guy Pratt, David J. Allsup, James M. Allan
Summary: Prognostication in CLL patients is challenging due to its heterogeneous clinical course. This study identifies two genomic locations associated with disease progression, highlighting the impact of constitutional genetic variation on CLL prognosis. Additionally, functional genes implicated in modulating key pathways in CLL pathogenesis are identified.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Yuanfeng Li, Yuehua Ke, Xinyi Xia, Yahui Wang, Fanjun Cheng, Xinyi Liu, Xin Jin, Boan Li, Chengyong Xie, Siyang Liu, Weijun Chen, Chenning Yang, Yuguang Niu, Ruizhong Jia, Yong Chen, Xiong Liu, Zhihua Wang, Fang Zheng, Yan Jin, Zhen Li, Ning Yang, Pengbo Cao, Hongxia Chen, Jie Ping, Fuchu He, Changjun Wang, Gangqiao Zhou
Summary: A genome-wide association study revealed two loci on chromosome 11q23.3 and 11q14.2 associated with the severity of COVID-19 in the Chinese population. These findings may offer new insights into the pathogenesis and clinical treatment of the disease.
Article
Obstetrics & Gynecology
Renee M. G. Verdiesen, Yvonne T. van der Schouw, Carla H. van Gils, W. M. Monique Verschuren, Frank J. M. Broekmans, Maria C. Borges, Ana L. Goncalves Soares, Deborah A. Lawlor, A. Heather Eliassen, Peter Kraft, Dale P. Sandler, Sioban D. Harlow, Jennifer A. Smith, Nanette Santoro, Minouk J. Schoemaker, Anthony J. Swerdlow, Anna Murray, Katherine S. Ruth, N. Charlotte Onland-Moret
Summary: This study identified four loci associated with circulating anti-Müllerian hormone levels in premenopausal women through a large-scale genome-wide association study meta-analysis. The findings contribute to the understanding of the biology of anti-Müllerian hormone and its role in ovarian aging.
HUMAN REPRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Meng Zhu, Jingyi Fan, Chang Zhang, Jing Xu, Rong Yin, Erbao Zhang, Yuzhuo Wang, Mengmeng Ji, Qi Sun, Juncheng Dai, Guangfu Jin, Liang Chen, Lin Xu, Zhibin Hu, Hongxia Ma, Hongbing Shen
Summary: This study conducted a cross-tissue transcriptome-wide association study using UTMOST, identifying 6 known susceptibility genes and 12 novel ones for lung cancer susceptibility. Among these, 5 novel genes were significantly associated with lung cancer risk in both cross-tissue and lung tissue models. Further analysis indicated that specific genetic variants drove the GWAS association signals and influenced the expression of certain genes in lung tissue, supporting their role in lung carcinogenesis.
HUMAN MOLECULAR GENETICS
(2021)
Article
Genetics & Heredity
Rui-Meng Yang, Ming Zhan, Qin-Yi Zhou, Xiao-Ping Ye, Feng-Yao Wu, Mei Dong, Feng Sun, Ya Fang, Rui-Jia Zhang, Chang-Run Zhang, Liu Yang, Miao-Miao Guo, Jun-Xiu Zhang, Jun Liang, Feng Cheng, Wei Liu, Bing Han, Yi Zhou, Shuang-Xia Zhao, Huai-Dong Song
Summary: This study identified four pathogenic GBP1 variants that caused defective thyroid primordium morphogenesis and hypothyroidism in zebrafish embryos. Furthermore, it was found that GBP1 promoted beta-catenin translocation into the cytosol and suppressed the formation of cellular adhesion complexes, leading to defects in thyroid primordium growth.
GENETICS IN MEDICINE
(2021)
Article
Cell Biology
Meng Gu, Chong Liu, TianYe Yang, Ming Zhan, Zhikang Cai, Yanbo Chen, Qi Chen, Zhong Wang
Summary: The study investigated the impact of high-fat diet induced gut microbiota alteration and Ghrelin in benign prostatic hyperplasia (BPH). Results showed elevated levels of Ghrelin were associated with increased cell proliferation and decreased apoptosis of prostate cells. The findings indicated a potential correlation between gut microbiota, Ghrelin, and BPH development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Surgery
Xinsen Xu, Ming Zhan, Xinxing Li, Tao Chen, Linhua Yang
Summary: The study found that compared to polytetrafluoroethylene mesh and polypropylene mesh, biologic mesh showed better resistance against E. coli within the concentration range of 10(6) to 10(8) CFU/ml. Prophylactic antibiotic treatment did not decrease the colonization rate of E. coli at 10(6) CFU/ml or 10(8) CFU/ml concentrations.
FRONTIERS IN SURGERY
(2021)
Article
Cell Biology
Peizhang Li, Huan Xu, Liu Yang, Ming Zhan, Yuanping Shi, Caoxu Zhang, Dajun Gao, Meng Gu, Yanbo Chen, Zhong Wang
Summary: This study evaluated the expression and roles of lncRNA DLEU2 in prostate cancer and found that patients with high expression of DLEU2 had a poor prognosis. Overexpression of DLEU2 promoted the proliferation, migration, and invasion of prostate cancer. Mechanistically, DLEU2 acted as an miR-582-5p sponge to promote the expression of SGK1, and its transcription was activated by the dysregulation of E2F2 expression. Animal experiments confirmed that knockdown of DLEU2 attenuated prostate cancer tumorigenesis. These findings suggest that E2F2-activated DLEU2 may function as a competing endogenous RNA to facilitate prostate cancer progression.
CELL DEATH & DISEASE
(2022)
Article
Gastroenterology & Hepatology
Xinsen Xu, Min He, Hui Wang, Ming Zhan, Linhua Yang
Summary: The study aimed to develop a prognostic nomogram for predicting survival of gallbladder cancer patients after surgery. The nomogram showed good discrimination and calibration in both the primary and validation cohorts. It also had a higher concordance index compared to the Nevin staging system and the 8th TNM staging system. The proposed nomogram resulted in more accurate prognostic prediction for patients with gallbladder cancer after surgery.
BMC GASTROENTEROLOGY
(2022)
Correction
Biochemistry & Molecular Biology
Xince Huang, Min He, Shuai Huang, Ruirong Lin, Ming Zhan, Dong Yang, Hui Shen, Sunwang Xu, Wei Cheng, Jianxiu Yu, Zilong Qiu, Jian Wang
Article
Endocrinology & Metabolism
Huan Xu, Zhixiao Liu, Dajun Gao, Peizhang Li, Yanting Shen, Yi Sun, Lingfan Xu, Nan Song, Yue Wang, Ming Zhan, Xu Gao, Zhong Wang
Summary: This study investigates the effect of metabolic reprogramming on lineage differentiation in prostate cancer cells. The results show that metabolic reprogramming leads to antiandrogen drug resistance and tumor development, and this lineage differentiation can be reversed by the overexpression of certain genes.
MOLECULAR METABOLISM
(2022)
Article
Immunology
Guopeng Yu, Jiahao Bao, Ming Zhan, Jiangyi Wang, Xinjuan Li, Xin Gu, Shangqing Song, Qing Yang, Yushan Liu, Zhong Wang, Bin Xu
Summary: This study investigated the genetic, transcriptional alterations, and prognostic value of m5C regulatory genes in prostate cancer. The findings suggest that these genes may play a role in clinical features and the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Guopeng Yu, Bo Liang, Keneng Yin, Ming Zhan, Xin Gu, Jiangyi Wang, Shangqing Song, Yushan Liu, Qing Yang, Tianhai Ji, Bin Xu
Summary: The study identified a metabolism-related gene-based subgroup in prostate cancer, revealing the survival advantage of subgroup 2 and its associated metabolic and immunological mechanisms.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yu Lin, Haisong Tan, Guopeng Yu, Ming Zhan, Bin Xu
Summary: Although several therapeutic options have been shown to improve survival of most patients with prostate cancer, progression to castration-refractory state continues to present challenges in clinics and scientific research. Noncoding RNAs (ncRNAs) are closely related to almost all biological regulations, and their role in castration-resistant prostate cancer (CRPC) has been investigated. In clinical practice, ncRNAs, especially miRNAs and lncRNAs, may function as potential biomarkers for diagnosis and prognosis of CRPC. This review summarizes the recent findings of miRNAs and lncRNAs, discusses their potential mechanisms, and highlights their clinical application prospects in CRPC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Jiayida Nulali, Ming Zhan, Kaiwen Zhang, Pinghui Tu, Yu Liu, Huaidong Song
Summary: The extracellular matrix (ECM) is composed of noncellular components and has special properties for influencing cell behavior and tissue structure. Small leucine-rich proteoglycans (SLRPs) are nonfibrillar ECM components that serve as structural scaffolds and signaling molecules. Osteoglycin (OGN), a class III SLRP, is a ubiquitous ECM component that not only helps to organize the extracellular matrix but also regulates a number of important biological processes. In addition to its role in fiber assembly and fibrosis, OGN is also found in cancer tissues and is involved in cellular processes linked to tumorigenesis.
Article
Oncology
Yu Lin, Ming Zhan, Bin Xu
Summary: In this study, the expression pattern and prognostic significance of XPO7 in prostate cancer (PCa) were determined using immunohistochemistry and bioinformatics. It was found that XPO7 was overexpressed in PCa tissues and predicted a poorer prognosis. Further experiments revealed that ectopic expression of XPO7 promoted cell proliferation, migration, cell cycle progression, and EMT in PCa cells in vitro and tumor growth in vivo. Mechanistically, XPO7 was found to regulate cell cycle-related and PI3K-AKT pathways and showed a significantly positive correlation with TCF3 expression. Targeting XPO7 may have therapeutic benefits for patients with PCa.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Genetics & Heredity
Feng-Yao Wu, Rui-Meng Yang, Hai-Yang Zhang, Ming Zhan, Ping-Hui Tu, Ya Fang, Cao-Xu Zhang, Shi-Yang Song, Mei Dong, Ren-Jie Cui, Xiao-Yu Liu, Liu Yang, Chen-Yan Yan, Feng Sun, Rui-Jia Zhang, Zheng Wang, Jun Liang, Huai-Dong Song, Feng Cheng, Shuang-Xia Zhao
Summary: Through next-generation sequencing and in vitro and in vivo experiments, this study identified MAML2 and MAMLD1 gene variants that downregulated Notch signaling, leading to impaired thyroid hormone biosynthesis in patients with congenital hypothyroidism.
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Oncology
Linhua Yang, Hui Wang, Miaomiao Guo, Min He, Wei Zhang, Ming Zhan, Yingbin Liu
Summary: This study found a consistent positive correlation between ELF3 overexpression and gemcitabine resistance in gallbladder cancer cells. ELF3 upregulated the expression of PKMYT1 by interacting with the DNA binding region of PKMYT1, thereby promoting the phosphorylation of CDK1 and inducing gemcitabine resistance. Therefore, the ELF3/PKMYT1/CDK1 axis may represent a promising drug target for treating gallbladder cancer patients.
Article
Urology & Nephrology
Yanbo Chen, Huan Xu, Dajun Gao, Meng Gu, Chong Liu, Ming Zhan, Zhikang Cai, Qi Chen, Zhong Wang
Summary: This study examined the efficiency and safety of two different morcellator systems in HoLEP surgery. The Piranha morcellator showed higher efficiency for prostates larger than 60 mL.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)