Apoptotic cell death and altered calcium homeostasis caused by frataxin depletion in dorsal root ganglia neurons can be prevented by BH4 domain of Bcl-xL protein

Frataxin Deficiency Leads to Defects in Expression of Antioxidants and Nrf2 Expression in Dorsal Root Ganglia of the Friedreich's Ataxia YG8R Mouse Model

(2013) Yuxi Shan et al.   ANTIOXIDANTS & REDOX SIGNALING

Tat-Frataxin protects dopaminergic neuronal cells against MPTP-induced toxicity in a mouse model of Parkinson's disease

(2012) Mi Jin Kim et al.   BIOCHIMIE

Distinct roles of mitochondria- and ER-localized Bcl-xL in apoptosis resistance and Ca2+ homeostasis

(2012) Colins O. Eno et al.   MOLECULAR BIOLOGY OF THE CELL

Accumulation of cortical hyperphosphorylated neurofilaments as a marker of neurodegeneration in multiple sclerosis

(2012) E. Gray et al.   Multiple Sclerosis Journal

Calpastatin reduces calpain and caspase activation in methamphetamine-induced toxicity in human neuroblastoma SH-SY5Y cultured cells

(2012) Wilasinee Suwanjang et al.   NEUROSCIENCE LETTERS

Mitochondria, calcium-dependent neuronal death and neurodegenerative disease

(2012) Michael R. Duchen   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Mitochondria as a central sensor for axonal degenerative stimuli

(2012) Felipe A. Court et al.   TRENDS IN NEUROSCIENCES

Friedreich's ataxia: Past, present and future

(2011) Daniele Marmolino   BRAIN RESEARCH REVIEWS

A TAT–Frataxin fusion protein increases lifespan and cardiac function in a conditional Friedreich's ataxia mouse model

(2011) Piyush M. Vyas et al.   HUMAN MOLECULAR GENETICS

The BH4 domain of Bcl-XL rescues astrocyte degeneration in amyotrophic lateral sclerosis by modulating intracellular calcium signals

(2011) Francesca Martorana et al.   HUMAN MOLECULAR GENETICS

Silencing of frataxin gene expression triggers p53-dependent apoptosis in human neuron-like cells

(2011) G. M. Palomo et al.   HUMAN MOLECULAR GENETICS

The Canonical Nuclear Factor- B Pathway Regulates Cell Survival in a Developmental Model of Spinal Cord Motoneurons

(2011) S. Mincheva et al.   JOURNAL OF NEUROSCIENCE

A new model to study spinal muscular atrophy: Neurite degeneration and cell death is counteracted by BCL-XL Overexpression in motoneurons

(2011) Ana Garcera et al.   NEUROBIOLOGY OF DISEASE

Upregulation of neuronal nitric oxide synthase in the periphery promotes pain hypersensitivity after peripheral nerve injury

(2011) K.H. Kim et al.   NEUROSCIENCE

Calcium Dysregulation and Homeostasis of Neural Calcium in the Molecular Mechanisms of Neurodegenerative Diseases Provide Multiple Targets for Neuroprotection

(2010) Gregor Zündorf et al.   ANTIOXIDANTS & REDOX SIGNALING

Frataxin Depletion in Yeast Triggers Up-regulation of Iron Transport Systems before Affecting Iron-Sulfur Enzyme Activities

(2010) Armando Moreno-Cermeño et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The dorsal root ganglion in Friedreich’s ataxia

(2009) Arnulf H. Koeppen et al.   ACTA NEUROPATHOLOGICA

Structural and functional link between the mitochondrial network and the endoplasmic reticulum

(2009) Carlotta Giorgi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Multicellular models of Friedreich ataxia

(2009) Hélène Puccio   JOURNAL OF NEUROLOGY

Friedreich's ataxia: Oxidative stress and cytoskeletal abnormalities

(2009) Marco Sparaco et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor

(2009) Y.-P. Rong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BCL-XL regulates TNF-α-mediated cell death independently of NF-κB, FLIP and IAPs

(2008) Raffaella Gozzelino et al.   CELL RESEARCH

Regulation of neurofilament dynamics by phosphorylation

(2008) Thomas B. Shea et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

DNA triplexes and Friedreich ataxia

(2008) Robert D. Wells   FASEB JOURNAL

Nmnat Delays Axonal Degeneration Caused by Mitochondrial and Oxidative Stress

(2008) C. Press et al.   JOURNAL OF NEUROSCIENCE

FUSION OF THE TETANUS TOXIN C FRAGMENT BINDING DOMAIN AND BCL-XL FOR PROTECTION OF PERIPHERAL NERVE NEURONS

(2008) Erin Carlton et al.   NEUROSURGERY

Detrimental effects of antiapoptotic treatments in spinal cord injury

(2007) Diana M. Cittelly et al.   EXPERIMENTAL NEUROLOGY