A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset†

The Role of PGC-1α in the Pathogenesis of Neurodegenerative Disorders

(2012) Krisztina Rona-Voros et al.   CURRENT DRUG TARGETS

Sustained expression of PGC-1  in the rat nigrostriatal system selectively impairs dopaminergic function

(2012) C. Ciron et al.   HUMAN MOLECULAR GENETICS

NT-PGC-1α Protein Is Sufficient to Link β3-Adrenergic Receptor Activation to Transcriptional and Physiological Components of Adaptive Thermogenesis

(2012) Ji Suk Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of PGC-1alphapolymorphisms with age of onset and risk of Parkinson's disease

(2011) Joanne Clark et al.   BMC Medical Genetics

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

Characterization of Novel Peroxisome Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) Isoform in Human Liver

(2011) Thomas K. Felder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA polymerase III drives alternative splicing of the potassium channel–interacting protein contributing to brain complexity and neurodegeneration

(2011) Sara Massone et al.   JOURNAL OF CELL BIOLOGY

Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer’s disease

(2011) Baiyang Sheng et al.   JOURNAL OF NEUROCHEMISTRY

Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis

(2011) Wei Zhao et al.   Molecular Neurodegeneration

Localization of sequence variations in PGC-1α influence their modifying effect in Huntington disease

(2011) Hong Van B Che et al.   Molecular Neurodegeneration

PGC-1α protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model

(2011) Huiyun Liang et al.   MUSCLE & NERVE

Cholesterol metabolism in Huntington disease

(2011) Joanna M. Karasinska et al.   Nature Reviews Neurology

Truncated Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α Splice Variant Is Severely Altered in Huntington’s Disease

(2011) Ashu Johri et al.   Neurodegenerative Diseases

PGC-1α at the intersection of bioenergetics regulation and neuron function: From Huntington's disease to Parkinson's disease and beyond

(2011) Taiji Tsunemi et al.   PROGRESS IN NEUROBIOLOGY

Regulation of NT-PGC-1α Subcellular Localization and Function by Protein Kinase A-dependent Modulation of Nuclear Export by CRM1

(2010) Ji Suk Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Observing Huntington's disease: the European Huntington's Disease Network's REGISTRY

(2010) M. Orth et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Expansion of the eukaryotic proteome by alternative splicing

(2010) Timothy W. Nilsen et al.   NATURE

Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex

(2010) I. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PGC-1 , A Potential Therapeutic Target for Early Intervention in Parkinson's Disease

(2010) B. Zheng et al.   Science Translational Medicine

PGC-1α Expression Decreases in the Alzheimer Disease Brain as a Function of Dementia

(2009) Weiping Qin et al.   ARCHIVES OF NEUROLOGY

The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling

(2009) Stefanie K Tiefenböck et al.   EMBO JOURNAL

Sporadic ALS has compartment-specific aberrant exon splicing and altered cell–matrix adhesion biology

(2009) Stuart J. Rabin et al.   HUMAN MOLECULAR GENETICS

Alternative mRNA Splicing Produces a Novel Biologically Active Short Isoform of PGC-1α

(2009) Yubin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The gene coding for PGC-1α modifies age at onset in Huntington's Disease

(2009) Patrick Weydt et al.   Molecular Neurodegeneration

PGC-1alpha as modifier of onset age in Huntington disease

(2009) Elahe Taherzadeh-Fard et al.   Molecular Neurodegeneration

Isoform-Specific Increases in Murine Skeletal Muscle Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α (PGC-1α) mRNA in Response to β2-Adrenergic Receptor Activation and Exercise

(2008) Shinji Miura et al.   ENDOCRINOLOGY

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE