The 420K LEKTI variant alters LEKTI proteolytic activation and results in protease deregulation: implications for atopic dermatitis

Skin Barrier Disruption: A Requirement for Allergen Sensitization?

(2012) Anna De Benedetto et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Filaggrin Genotype in Ichthyosis Vulgaris Predicts Abnormalities in Epidermal Structure and Function

(2011) Robert Gruber et al.   AMERICAN JOURNAL OF PATHOLOGY

SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing

(2011) Takeshi Matsui et al.   EMBO Molecular Medicine

Proteolytic Activation Cascade of the Netherton Syndrome–Defective Protein, LEKTI, in the Epidermis: Implications for Skin Homeostasis

(2011) Paola Fortugno et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Filaggrin Mutations Associated with Skin and Allergic Diseases

(2011) Alan D. Irvine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing

(2010) Chrystelle Bonnart et al.   JOURNAL OF CLINICAL INVESTIGATION

Par2 Inactivation Inhibits Early Production of TSLP, but Not Cutaneous Inflammation, in Netherton Syndrome Adult Mouse Model

(2010) Anaïs Briot et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TLR2 Expression Is Increased in Rosacea and Stimulates Enhanced Serine Protease Production by Keratinocytes

(2010) Kenshi Yamasaki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A functional polymorphism in the SPINK5 gene is associated with asthma in a Chinese Han Population

(2009) Qiji Liu et al.   BMC Medical Genetics

A heterozygous null mutation combined with the G1258A polymorphism ofSPINK5causes impaired LEKTI function and abnormal expression of skin barrier proteins

(2009) W-L. Di et al.   BRITISH JOURNAL OF DERMATOLOGY

Increased stratum corneum serine protease activity in acute eczematous atopic skin

(2009) R. Voegeli et al.   BRITISH JOURNAL OF DERMATOLOGY

Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens

(2009) Tiffany C. Scharschmidt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Filaggrin in the frontline: role in skin barrier function and disease

(2009) A. Sandilands et al.   JOURNAL OF CELL SCIENCE

Kallikrein 5 induces atopic dermatitis–like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome

(2009) Anaïs Briot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epidermal Barrier Dysfunction in Atopic Dermatitis

(2009) Michael J. Cork et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The emerging roles of serine protease cascades in the epidermis

(2009) Petra Ovaere et al.   TRENDS IN BIOCHEMICAL SCIENCES

Basis for the barrier abnormality in atopic dermatitis: Outside-inside-outside pathogenic mechanisms

(2008) Peter M. Elias et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk

(2008) Stephan Weidinger et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Increased basal transepidermal water loss leads to elevation of some but not all stratum corneum serine proteases

(2008) R. Voegeli et al.   INTERNATIONAL JOURNAL OF COSMETIC SCIENCE

Acute Modulations in Permeability Barrier Function Regulate Epidermal Cornification

(2007) Marianne Demerjian et al.   AMERICAN JOURNAL OF PATHOLOGY

Correlation between SPINK5 Gene Mutations and Clinical Manifestations in Netherton Syndrome Patients

(2007) Nahoko Komatsu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY