Alzheimer's disease in a dish: promises and challenges of human stem cell models

Developing Therapeutic Approaches to Tau, Selected Kinases, and Related Neuronal Protein Targets

(2013) V. M.-Y. Lee et al.   Cold Spring Harbor Perspectives in Medicine

Presenilin-1 L166P Mutant Human Pluripotent Stem Cell–Derived Neurons Exhibit Partial Loss of γ-Secretase Activity in Endogenous Amyloid-β Generation

(2012) Philipp Koch et al.   AMERICAN JOURNAL OF PATHOLOGY

Sortilin and SorLA Regulate Neuronal Sorting of Trophic and Dementia-Linked Proteins

(2012) Lone Tjener Pallesen et al.   MOLECULAR NEUROBIOLOGY

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses

(2012) Yichen Shi et al.   NATURE NEUROSCIENCE

Stem cell technology for neurodegenerative diseases

(2011) J. Simon Lunn et al.   ANNALS OF NEUROLOGY

Alzheimer's disease genetics: lessons to improve disease modelling: Table 1

(2011) Rita J. Guerreiro et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

RETRACTED: Directed Conversion of Alzheimer's Disease Patient Skin Fibroblasts into Functional Neurons

(2011) Liang Qiang et al.   CELL

Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

(2011) Frank Soldner et al.   CELL

LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress

(2011) Ha Nam Nguyen et al.   Cell Stem Cell

Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises

(2011) M. C. Marchetto et al.   HUMAN MOLECULAR GENETICS

Modeling familial Alzheimer's disease with induced pluripotent stem cells

(2011) Takuya Yagi et al.   HUMAN MOLECULAR GENETICS

Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients

(2011) Miguel Mitne-Neto et al.   HUMAN MOLECULAR GENETICS

Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells

(2011) P. Seibler et al.   JOURNAL OF NEUROSCIENCE

The projected effect of risk factor reduction on Alzheimer's disease prevalence

(2011) Deborah E Barnes et al.   LANCET NEUROLOGY

Modelling schizophrenia using human induced pluripotent stem cells

(2011) Kristen J. Brennand et al.   NATURE

Somatic coding mutations in human induced pluripotent stem cells

(2011) Athurva Gore et al.   NATURE

Copy number variation and selection during reprogramming to pluripotency

(2011) Samer M. Hussein et al.   NATURE

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

(2011) Ryan Lister et al.   NATURE

CSF biomarkers for Alzheimer's disease: current utility and potential future use

(2011) David M. Holtzman   NEUROBIOLOGY OF AGING

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

Pharmacotherapies for Alzheimer's disease: Beyond cholinesterase inhibitors

(2011) Haythum O. Tayeb et al.   PHARMACOLOGY & THERAPEUTICS

Cell-Surface Marker Signatures for the Isolation of Neural Stem Cells, Glia and Neurons Derived from Human Pluripotent Stem Cells

(2011) Shauna H. Yuan et al.   PLoS One

Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease

(2011) Naoki Yahata et al.   PLoS One

Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells

(2011) Silke Brunholz et al.   EXPERIMENTAL BRAIN RESEARCH

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

(2010) Maria C.N. Marchetto et al.   CELL

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors

(2009) Frank Soldner et al.   CELL

Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs

(2009) Gabsang Lee et al.   NATURE

Variation in the safety of induced pluripotent stem cell lines

(2009) Kyoko Miura et al.   NATURE BIOTECHNOLOGY

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration

(2009) P. Koch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetics of Alzheimer's disease: recent advances

(2009) Dimitrios Avramopoulos   Genome Medicine

Down Syndrome Fibroblast Model of Alzheimer-Related Endosome Pathology

(2008) Anne M. Cataldo et al.   AMERICAN JOURNAL OF PATHOLOGY

Disease-Specific Induced Pluripotent Stem Cells

(2008) In-Hyun Park et al.   CELL

Amyloid precursor protein-induced axonopathies are independent of amyloid-β peptides

(2008) Gorazd B. Stokin et al.   HUMAN MOLECULAR GENETICS

Zinc-finger Nucleases: The Next Generation Emerges

(2008) Toni Cathomen et al.   MOLECULAR THERAPY

Induced pluripotent stem cells from a spinal muscular atrophy patient

(2008) Allison D. Ebert et al.   NATURE

Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

(2008) J. T. Dimos et al.   SCIENCE

Evidence for CALM in Directing VAMP2 Trafficking

(2008) Asaff Harel et al.   TRAFFIC