Use of a predictive model derived from in vivo endophenotype measurements to demonstrate associations with a complex locus, CYP2A6

The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European–Americans

(2011) Joseph Bloom et al.   Pharmacogenetics and Genomics

The Importance of Synthetic Associations Will Only Be Resolved Empirically

(2011) David B. Goldstein   PLOS BIOLOGY

Associations of CYP2A6 genotype with smoking behaviors in southern China

(2010) Tao Liu et al.   ADDICTION

Sequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behavior

(2010) Thorgeir E Thorgeirsson et al.   NATURE GENETICS

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

(2010)   NATURE GENETICS

Rare Variants Create Synthetic Genome-Wide Associations

(2010) Samuel P. Dickson et al.   PLOS BIOLOGY

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes

(2009) Nancy L. Saccone et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

The CHRNA5-CHRNA3-CHRNB4 Nicotinic Receptor Subunit Gene Cluster Affects Risk for Nicotine Dependence in African-Americans and in European-Americans

(2009) N. L. Saccone et al.   CANCER RESEARCH

Hepatic CYP2A6 levels and nicotine metabolism: impact of genetic, physiological, environmental, and epigenetic factors

(2009) Nael Al Koudsi et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Epistasis in a quantitative trait captured by a molecular model of transcription factor interactions

(2009) Jason Gertz et al.   THEORETICAL POPULATION BIOLOGY

Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent

(2008) Jill C. Mwenifumbo et al.   HUMAN MUTATION

What is the expectation maximization algorithm?

(2008) Chuong B Do et al.   NATURE BIOTECHNOLOGY

A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent

(2008) Man Ki Ho et al.   Pharmacogenetics and Genomics