Mitochondrial redox signalling by p66Shc mediates ALS-like disease through Rac1 inactivation

The Shc locus regulates insulin signaling and adiposity in mammals

(2010) Alexey A. Tomilov et al.   AGING CELL

Guidelines for preclinical animal research in ALS/MND: A consensus meeting

(2010) Albert C. Ludolph et al.   Amyotrophic Lateral Sclerosis

The Lifespan-Regulator p66Shc in Mitochondria: Redox Enzyme or Redox Sensor?

(2010) Melanie Gertz et al.   ANTIOXIDANTS & REDOX SIGNALING

p66Shc, oxidative stress and aging: Importing a lifespan determinant into mitochondria

(2010) Paolo Pinton et al.   CELL CYCLE

Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity

(2010) Alberto Ferri et al.   HUMAN MOLECULAR GENETICS

ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2

(2010) Steve Pedrini et al.   HUMAN MOLECULAR GENETICS

Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis

(2010) Nichole A. Reyes et al.   JOURNAL OF CLINICAL INVESTIGATION

Misfolded Mutant SOD1 Directly Inhibits VDAC1 Conductance in a Mouse Model of Inherited ALS

(2010) Adrian Israelson et al.   NEURON

ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import

(2010) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice

(2009) Chiara Pizzasegola et al.   Amyotrophic Lateral Sclerosis

Oligomerization of Mutant SOD1 in Mitochondria of Motoneuronal Cells Drives Mitochondrial Damage and Cell Toxicity

(2009) Mauro Cozzolino et al.   ANTIOXIDANTS & REDOX SIGNALING

Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease

(2009) Manoj Jaiswal et al.   BMC NEUROSCIENCE

Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities

(2009) J. Magrane et al.   HUMAN MOLECULAR GENETICS

TDP-43 Depletion Induces Neuronal Cell Damage through Dysregulation of Rho Family GTPases

(2009) Yohei Iguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Activation of RhoA by Reactive Oxygen Species Requires a Redox-Sensitive Motif

(2009) Amir Aghajanian et al.   PLoS One

Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity

(2008) Gabriella Dobrowolny et al.   Cell Metabolism

Lysyl-tRNA Synthetase Is a Target for Mutant SOD1 Toxicity in Mitochondria

(2008) Hibiki Kawamata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p66Shc-generated Oxidative Signal Promotes Fat Accumulation

(2008) Ina Berniakovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Dysfunction in SOD1G93A-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants

(2008) P. Cassina et al.   JOURNAL OF NEUROSCIENCE

Dyslipidemia is a protective factor in amyotrophic lateral sclerosis

(2008) L. Dupuis et al.   NEUROLOGY

Activation of the lifespan regulator p66Shc through reversible disulfide bond formation

(2008) M. Gertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyotrophic Lateral Sclerosis: From Current Developments in the Laboratory to Clinical Implications

(2007) Mauro Cozzolino et al.   ANTIOXIDANTS & REDOX SIGNALING