Article
Neurosciences
Lu Chen, Lin Zhu, Jing Xu, Puying Xu, Yanbing Han, Lvhua Chang, Qian Wu
Summary: DISC1 plays a role in regulating neurogenesis in the hilus after status epilepticus, and it may be involved in neuronal or neural development processes associated with astrocytes.
Article
Biochemistry & Molecular Biology
Yuka Takahashi, Chikara Abe, Masaya Hane, Di Wu, Ken Kitajima, Chihiro Sato
Summary: Schizophrenia is a severe psychiatric disorder influenced by genetic and environmental factors. Changes in polysialylation of neural cell adhesion molecules have been found in the brains of patients with psychiatric disorders. This study investigates the effects of genetic (G) and environmental (E) factors on polysialylated NCAM expression using a schizophrenia mouse model and acute stress conditions. The study discovers differences in polysialylation and NCAM responses to stress in different brain regions, suggesting the vulnerability of the schizophrenia mouse model to stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Yael Almog, Saja Fadila, Marina Brusel, Anat Mavashov, Karen Anderson, Moran Rubinstein
Summary: Dravet syndrome is a rare and severe childhood-onset epilepsy caused by mutations in the SCN1A gene. Studies on Dravet mice showed persistent reduced function in inhibitory neurons and changes in excitatory neurons during different disease stages. This suggests a complex pathophysiological mechanism with reciprocal functional changes in both excitatory and inhibitory neurons influencing the developmental trajectory of the disease.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Neurosciences
Lucinda J. Speers, Kirsten R. Cheyne, Elena Cavani, Tara Hayward, Robert Schmidt, David K. Bilkey
Summary: The study found that schizophrenia may lead to a greater variability in the starting phase of precession in animals entering new environments, resulting in a disorganization of the ordered representation of experience.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Ron Refaeli, Adi Doron, Aviya Benmelech-Chovav, Maya Groysman, Tirzah Kreisel, Yonatan Loewenstein, Inbal Goshen
Summary: The study utilized CLARITY technology to conduct large-scale detection of 3D astrocytic domains, revealing different distributions of neuronal content in CA1 and BLA astrocytic domains. SST neurons were found to be located in close proximity to neighboring astrocytes, relative to PV and VIP neurons.
Article
Biology
Lingjun Ding, Giuseppe Balsamo, Hongbiao Chen, Eduardo Blanco-Hernandez, Ioannis S. Zouridis, Robert Naumann, Patricia Preston-Ferrer, Andrea Burgalossi
Summary: Neural circuits are composed of diverse neuronal cell types, and this diversity plays a crucial role in brain function during natural behavior. In this study, the combination of juxtacellular recording, labeling, and optogenetics enabled the investigation of molecularly defined cell classes in freely moving mice, revealing the weaker spatial modulation and information transmission of Calbindin-positive CA1 pyramidal cells.
Article
Multidisciplinary Sciences
Thomas Chartrand, Rachel Dalley, Jennie Close, Natalia A. Goriounova, Brian R. Lee, Rusty Mann, Jeremy A. Miller, Gabor Molnar, Alice Mukora, Lauren Alfiler, Katherine Baker, Trygve E. Bakken, Jim Berg, Darren Bertagnolli, Thomas Braun, Krissy Brouner, Tamara Casper, Eva Adrienn Csajbok, Nick Dee, Tom Egdorf, Rachel Enstrom, Anna A. Galakhova, Amanda Gary, Emily Gelfand, Jeff Goldy, Kristen Hadley, Tim S. Heistek, Dijon Hill, Nik Jorstad, Lisa Kim, Agnes Katalin Kocsis, Lauren Kruse, Michael Kunst, Gabriela Leon, Brian Long, Matthew Mallory, Medea Mcgraw, Delissa Mcmillen, Erica J. Melief, Norbert Mihut, Lindsay Ng, Julie Nyhus, Gaspar Olah, Attila Ozsvar, Victoria Omstead, Zoltan Peterfi, Alice Pom, Lydia Potekhina, Ramkumar Rajanbabu, Marton Rozsa, Augustin Ruiz, Joanna Sandle, Susan M. Sunkin, Ildiko Szots, Michael Tieu, Martin Toth, Jessica Trinh, Sara Vargas, David Vumbaco, Grace Williams, Julia Wilson, Zizhen Yao, Pal Barzo, Charles Cobbs, Richard G. Ellenbogen, Luke Esposito, Manuel Ferreira, Nathan W. Gouwens, Benjamin Grannan, Ryder P. Gwinn, Jason S. Hauptman, Tim Jarsky, C. Dirk Keene, Andrew L. Ko, Christof Koch, Jeffrey G. Ojemann, Anoop Patel, Jacob Ruzevick, Daniel L. Silbergeld, Kimberly Smith, Staci A. Sorensen, Bosiljka Tasic, Jonathan T. Ting, Jack Waters, Christiaan P. J. de Kock, Huib D. Mansvelder, Gabor Tamas, Hongkui Zeng, Brian Kalmbach, Ed S. Lein
Summary: Neocortical layer 1 (L1) is a convergence site between pyramidal neurons and feedback axons, where local inhibitory signaling can have a significant impact on cortical processing. Through the study of human neurosurgical tissue, it is found that human L1 has greater transcriptomic differences compared to mouse L1, and is accompanied by greater layer thickness and other changes in cellular architecture.
Article
Biochemistry & Molecular Biology
Kristen A. McLaurin, Hailong Li, Charles F. Mactutus, Steven B. Harrod, Rosemarie M. Booze
Summary: Chronic cocaine use and HIV-1 viral protein exposure independently lead to neuroadaptations in the frontal-striatal circuit. However, the response of the frontal-striatal circuit to HIV-1 infection following chronic drug use has been unclear. A study using rats found that male rats preferred cocaine while female rats preferred sucrose. Regardless of biological sex, inoculation with chimeric HIV disrupted decision-making and resulted in structural alterations in the frontal-striatal circuit.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Mohammad Seidisarouei, Sandra Schable, Marijn van Wingerden, Svenja V. Trossbach, Carsten Korth, Tobias Kalenscher
Summary: This study found that disruptions in the DISC1 signaling pathway lead to selective deficits in social motivation, while non-social reward preferences remain unaffected, in a transgenic rat model.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Le Gao, Sang Liu, Yanzhi Wang, Qiwen Wu, Lingfeng Gou, Jun Yan
Summary: By studying the complete dendrite and axon morphology of nearly 2,000 neurons in the mouse prefrontal cortex, this study reveals the variations in somata, dendrites, and axons across different layers and subregions. The study also identifies distinct dendrite subtypes and unique axon projection patterns. Furthermore, coherent morphological changes associated with electrophysiological phenotypes are uncovered. The study provides a comprehensive structural repertoire for the reconstruction and analysis of the prefrontal cortex neural network.
NATURE NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Asako Noguchi, Roman Huszar, Shota Morikawa, Gyorgy Buzsaki, Yuji Ikegaya
Summary: The activation of inhibitory neurons prior to hippocampal sharp-wave ripples regulates the order of spikes, which is crucial for memory storage.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Tania Da Silva, Elisa Guma, Sina Hafizi, Alex Koppel, Pablo Rusjan, James L. Kennedy, Mallar M. Chakravarty, Romina Mizrahi
Summary: This study quantified genetically predicted brain C4A expression and its association with microglial marker (TSPO) and hippocampal morphology in living human brain for the first time. Individuals at clinical high risk showed significantly lower C4A expression compared to healthy control subjects, and both sex and cannabis use were found to have effects on brain TSPO.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Pharmacology & Pharmacy
Ying Zhang, Hai-Yan Yin, Patrizia Rubini, Peter Illes, Yong Tang
Summary: There is a dispute about whether CNS neurons possess ATP-sensitive P2X7 receptors. By genetically deleting P2X7 receptors in astrocytes and oligodendrocytes, it was found that these receptors indirectly modulate the neuronal input to neighboring neurons.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Neurosciences
Hugo Balleza-Tapia, Luis Enrique Arroyo-Garcia, Arturo G. Isla, Raul Loera-Valencia, Andre Fisahn
Summary: Gamma oscillations in the hippocampal area CA3 are crucial for memory function. Recent studies have found that pyramidal cells (PCs) in CA3 are organized into different functional subpopulations, which play important roles in cognition-related network dynamics.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jing Zhao, Dan Liang, Tao Xie, Jing Qiang, Qian Sun, Lan Yang, Weiping Wang
Summary: This study aimed to investigate the effectiveness of nicorandil in treating seizures. Seizure tests were used to evaluate the therapeutic effect of different doses of nicorandil, and it was found that nicorandil improved seizure symptoms. The results showed that nicorandil reduced the incidence of partial and generalized seizures and improved the seizure duration and convulsions. Nicorandil may function by reducing the excitability of pyramidal neurons in the hippocampal region, making it a potential candidate for the treatment of seizures.
NEUROCHEMICAL RESEARCH
(2023)
Article
Neurosciences
Yuki Hirota, Ken-ichiro Kubo, Takahiro Fujino, Tokuo T. Yamamoto, Kazunori Nakajima
Article
Biochemistry & Molecular Biology
Koji Oishi, Kazunori Nakajima
NEUROCHEMICAL RESEARCH
(2018)
Article
Neurosciences
Minkyung Shin, Ayako Kitazawa, Satoshi Yoshinaga, Kanehiro Hayashi, Yukio Hirata, Colette Dehay, Ken-ichiro Kubo, Kazunori Nakajima
JOURNAL OF COMPARATIVE NEUROLOGY
(2019)
Article
Neurosciences
Seika Inoue, Kanehiro Hayashi, Kyota Fujita, Kazuhiko Tagawa, Hitoshi Okazawa, Ken-ichiro Kubo, Kazunori Nakajima
JOURNAL OF NEUROSCIENCE
(2019)
Review
Clinical Neurology
Ken-ichiro Kubo
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2020)
Article
Obstetrics & Gynecology
Ken-ichiro Kubo, Kimiko Deguchi
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2020)
Article
Environmental Sciences
Enock Mpofu, Amirah Alias, Keisuke Tomita, Chiho Suzuki-Minakuchi, Kenji Tomita, Joydeep Chakraborty, Michal Malon, Yusuke Ogura, Hirosato Takikawa, Kazunori Okada, Toshiaki Kimura, Hideaki Nojiri
Summary: This article reports the ability of Bacillus licheniformis strain TAB7 to degrade azoxystrobin through a novel degradation pathway, and identifies azoxystrobin amine as a less toxic metabolite compared to the parent compound. Additionally, the study reveals enzymatic isomerization of (E)-AZ to (Z)-AZ by TAB7.
Article
Multidisciplinary Sciences
Satoshi Yoshinaga, Minkyung Shin, Ayako Kitazawa, Kazuhiro Ishii, Masato Tanuma, Atsushi Kasai, Hitoshi Hashimoto, Ken-Ichiro Kubo, Kazunori Nakajima
Summary: The study revealed regional differences in neuronal migration profiles in different regions of the mammalian cerebral neocortex, depending on developmental stage. These differences, observed using FlashTag technology, were not well-replicated by thymidine analogs, suggesting a biological significance different from neurogenic gradient. The findings advance understanding of cortical development and demonstrate the utility of FlashTag in studying migration for future neurodevelopmental research.
Article
Neurosciences
Debabrata Hazra, Satoshi Yoshinaga, Keitaro Yoshida, Norio Takata, Kenji F. Tanaka, Ken-ichiro Kubo, Kazunori Nakajima
Summary: This study investigates the effects of activating excitatory neurons in the superficial layers of the prefrontal cortex in a rhythmic or nonrhythmic pattern on cognitive function in mice. The results showed that rhythmic activation enhanced spatial working memory and social recognition, while nonrhythmic activation had no significant effect. This suggests that the pattern of activation plays a crucial role in cognitive enhancement.
Article
Neurosciences
Satoshi Yoshinaga, Takao Honda, Ken-ichiro Kubo, Kazunori Nakajima
Summary: This study found that the absence of Dab1 leads to the migration of superficial layer neurons into the cortical plate and mispositioning of deep layer neurons. It was also observed that Dab1-deficient superficial layer neurons accumulate below the cortical plate, while deep layer neurons show higher cell density. These phenotypes were corrected by reducing the probability of gene knockout and expressing Dab1 in deep layer neurons.
NEUROSCIENCE RESEARCH
(2022)
Article
Neurosciences
Kota Oshima, Satoshi Yoshinaga, Ayako Kitazawa, Yuki Hirota, Kazunori Nakajima, Ken-Ichiro Kubo
Summary: This study investigated the development of the claustrum (CLA) in mice and revealed the migration profiles of CLA neurons. The findings showed that CLA neurons migrate radially outward and then change direction to migrate inward after reaching the brain surface. The study also demonstrated the essential role of Reelin signal in the distribution of CLA neurons.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Cell Biology
Mari Kawaguchi, Wen-Shan Chang, Hazuki Tsuchiya, Nana Kinoshita, Akira Miyaji, Ryouka Kawahara-Miki, Kenji Tomita, Atsushi Sogabe, Makiko Yorifuji, Tomohiro Kono, Toyoji Kaneko, Shigeki Yasumasu
Summary: The seahorse is a unique teleost fish with special morphology, including bony plates and spines, and males possessing a brooding organ called the brood pouch. The flame cone cells, found in the brood pouch and spines, express a gene called pgrich which is not present in related species. This pgrich gene may have originated from the elastin gene with the involvement of transposable elements and obtained its novel function in the flame cone cells during seahorse evolution.
CELL AND TISSUE RESEARCH
(2023)
Article
Multidisciplinary Sciences
Sho Watanabe, Yuri Sudo, Takumi Makino, Satoshi Kimura, Kenji Tomita, Makoto Noguchi, Hidetoshi Sakurai, Makoto Shimizu, Yu Takahashi, Ryuichiro Sato, Yoshio Yamauchi
Summary: Extracellular vesicles (EVs) released by skeletal muscle cells, known as SkM-EVs, have specific protein and miRNA profiles and mainly accumulate in the muscle interstitium. However, their contribution to plasma EVs is subtle, suggesting that SkM-EVs mainly play a role within the muscle microenvironment.