Huntington's disease: progress toward effective disease-modifying treatments and a cure
出版年份 2010 全文链接
标题
Huntington's disease: progress toward effective disease-modifying treatments and a cure
作者
关键词
-
出版物
HUMAN MOLECULAR GENETICS
Volume 19, Issue R1, Pages R98-R102
出版商
Oxford University Press (OUP)
发表日期
2010-04-27
DOI
10.1093/hmg/ddq148
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Proteolysis of Mutant Huntingtin Produces an Exon 1 Fragment That Accumulates as an Aggregated Protein in Neuronal Nuclei in Huntington Disease
- (2010) Christian Landles et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Haplotype Background, Repeat Length Evolution, and Huntington's Disease
- (2009) Daniel Falush AMERICAN JOURNAL OF HUMAN GENETICS
- CAG Expansion in the Huntington Disease Gene Is Associated with a Specific and Targetable Predisposing Haplogroup
- (2009) Simon C. Warby et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Single-step detection of mutant huntingtin in animal and human tissues: A bioassay for Huntington’s disease
- (2009) Andreas Weiss et al. ANALYTICAL BIOCHEMISTRY
- Sustained effects of nonallele-specificHuntingtinsilencing
- (2009) Valérie Drouet et al. ANNALS OF NEUROLOGY
- Progress and Challenges in RNA Interference Therapy for Huntington Disease
- (2009) Scott Q. Harper ARCHIVES OF NEUROLOGY
- Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model
- (2009) S. Zhang et al. Disease Models & Mechanisms
- A majority of Huntington's disease patients may be treatable by individualized allele-specific RNA interference
- (2009) Maria Stella Lombardi et al. EXPERIMENTAL NEUROLOGY
- Huntington's disease: Silencing a brutal killer
- (2009) Edith L. Pfister et al. EXPERIMENTAL NEUROLOGY
- Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models
- (2009) Jack Phan et al. HUMAN MOLECULAR GENETICS
- Impaired PGC-1α function in muscle in Huntington's disease
- (2009) Rajnish K. Chaturvedi et al. HUMAN MOLECULAR GENETICS
- Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease
- (2009) Kirupa Sathasivam et al. HUMAN MOLECULAR GENETICS
- IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
- (2009) Leslie Michels Thompson et al. JOURNAL OF CELL BIOLOGY
- Intrabody Gene Therapy Ameliorates Motor, Cognitive, and Neuropathological Symptoms in Multiple Mouse Models of Huntington's Disease
- (2009) A. L. Southwell et al. JOURNAL OF NEUROSCIENCE
- Beyond the brain: widespread pathology in Huntington's disease
- (2009) Jorien MM van der Burg et al. LANCET NEUROLOGY
- Nonallele-specific Silencing of Mutant and Wild-type Huntingtin Demonstrates Therapeutic Efficacy in Huntington's Disease Mice
- (2009) Ryan L Boudreau et al. MOLECULAR THERAPY
- Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models
- (2009) Liliana Menalled et al. NEUROBIOLOGY OF DISEASE
- Huntington’s Disease – New Perspectives Based on Neuroendocrine Changes in Rodent Models
- (2009) Åsa Petersén et al. Neurodegenerative Diseases
- In vivo evidence for the selective subcortical degeneration in Huntington's disease
- (2009) Gwenaëlle Douaud et al. NEUROIMAGE
- Altered white matter microstructure in the corpus callosum in Huntington's disease: Implications for cortical “disconnection”
- (2009) H. Diana Rosas et al. NEUROIMAGE
- Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice
- (2009) Xiaofeng Gu et al. NEURON
- Distinct neuroinflammatory profile in post-mortem human Huntingtonʼs disease
- (2009) Aurelio Silvestroni et al. NEUROREPORT
- Formation of Polyglutamine Inclusions in a Wide Range of Non-CNS Tissues in the HdhQ150 Knock-In Mouse Model of Huntington's Disease
- (2009) Hilary Moffitt et al. PLoS One
- Full-Length Human Mutant Huntingtin with a Stable Polyglutamine Repeat Can Elicit Progressive and Selective Neuropathogenesis in BACHD Mice
- (2008) M. Gray et al. JOURNAL OF NEUROSCIENCE
- Huntington's disease phenocopies are clinically and genetically heterogeneous
- (2008) Edward J. Wild et al. MOVEMENT DISORDERS
- Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi
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