Article
Medicine, General & Internal
Marcelo Farias-Jofre, Roberto Romero, Jose Galaz, Yi Xu, Derek Miller, Valeria Garcia-Flores, Marcia Arenas-Hernandez, Andrew D. Winters, Bruce A. Berkowitz, Robert H. Podolsky, Yimin Shen, Tomi Kanninen, Bogdan Panaitescu, Catherine R. Glazier, Roger Pique-Regi, Kevin R. Theis, Nardhy Gomez-Lopez
Summary: This study investigates the role of IL-6 and IL-1 alpha in sterile intra-amniotic inflammation (SIAI) and their impact on preterm birth and neonatal outcomes. The researchers found that IL-6 plays a critical role in the inflammatory response and that IL-1 alpha injection leads to preterm birth and neonatal mortality. Prenatal treatment with an IL-6R blockade shows promising results in preventing preterm birth and improving neonatal outcomes.
Article
Oncology
Yunmei Dong, Zhen Wang, Fei Mao, Luyao Cai, Hongxia Dan, Lu Jiang, Xin Zeng, Taiwen Li, Yu Zhou, Qianming Chen
Summary: T-cell exhaustion plays a crucial role in oral carcinogenesis, and PD-1 blockade can prevent the progression of oral cancer.
Article
Cell Biology
Faith H. Brennan, Benjamin T. Noble, Yan Wang, Zhen Guan, Hayes Davis, Xiaokui Mo, Clay Harris, Cagla Eroglu, Adam R. Ferguson, Phillip G. Popovich
Summary: After SCI, structural remodeling and plasticity within spinal autonomic circuitry lead to abnormal sympathetic reflexes. Early treatment with human-equivalent doses of GBP can prevent dysautonomia and protect against other complications, even after treatment is stopped. This suggests that GBP could be repurposed to prevent dysautonomia in individuals at high risk for SCI.
Article
Multidisciplinary Sciences
Naito Ishimoto, Jae-Hyun Park, Kouki Kawakami, Michiko Tajiri, Kenji Mizutani, Satoko Akashi, Jeremy R. H. Tame, Asuka Inoue, Sam-Yong Park
Summary: Neutrophil granulocytes play key roles in innate immunity and shaping adaptive immune responses. The chemokine CXCL8 and its receptors CXCR1 and CXCR2 are crucial in this process and the development of cancers. By solving the structure of CXCR1 complexed with CXCL8 and G-proteins using cryo-EM, the authors reveal the detailed interactions and ligand preferences of this receptor. This study provides valuable insights for structure-based drug design targeting specific CXC chemokine receptor subtypes.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Natalia Guillen Diaz-Maroto, Gemma Garcia-Vicien, Giovanna Polcaro, Maria Banuls, Nerea Albert, Alberto Villanueva, David G. Mollevi
Summary: This study demonstrates that IL1 beta secreted by cancer cells can alter the characteristics of surrounding normal fibroblasts, giving them protumorogenic features, particularly tolerance to cytotoxic drugs. This finding highlights the role of IL1 beta in promoting tumor cell development within the tumor microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Sharmony B. Kelly, Vanesa Stojanovska, Valerie A. Zahra, Alison Moxham, Suzanne L. Miller, Timothy J. M. Moss, Stuart B. Hooper, Marcel F. Nold, Claudia A. Nold-Petry, Justin M. Dean, Laura Bennet, Graeme R. Polglase, Alistair J. Gunn, Robert Galinsky
Summary: This study demonstrated that systemic IL-1 receptor antagonist administration can alleviate brain inflammation and injury in near-term fetal sheep exposed to lipopolysaccharide. IL-1Ra infusions reduced circulating cytokines, improved EEG activity and carotid artery perfusion, and decreased microglial reaction and oligodendrocyte loss. Further research is needed to explore the long-term effects on brain maturation.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Emanuel Della-Torre, Marco Lanzillotta, Corrado Campochiaro, Giulio Cavalli, Giacomo De Luca, Alessandro Tomelleri, Nicola Boffini, Rebecca De Lorenzo, Annalisa Ruggeri, Patrizia Rovere-Querini, Antonella Castagna, Giovanni Landoni, Moreno Tresoldi, Fabio Ciceri, Alberto Zangrillo, Lorenzo Dagna
Summary: This study shows that IL-1 and IL-6 blockade therapy is more likely to provide a survival advantage in hyper-inflamed COVID-19 patients, especially when initiated before the establishment of severe respiratory failure.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jingwei Shi, Xiao Shen, Qi Kang, Xing Yang, Maximilian Denzinger, Marko Kornmann, Benno Traub
Summary: In the search for new pancreatic cancer therapies, cytokine pathways have gained increasing interest. Inflammatory cytokines IL-4 and IL-13 are often found at increased levels in the microenvironment of pancreatic cancer. Loss of IL-13R alpha 1 induces apoptosis and epithelial-to-mesenchymal transition in pancreatic cancer cells. The differential expression of IL-4R alpha and IL-13R alpha 1 should be considered when targeting cytokine therapy in pancreatic cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Bhavesh Khatri, Ishika Pramanick, Sameer Kumar Malladi, Raju S. Rajmani, Sahil Kumar, Pritha Ghosh, Nayanika Sengupta, R. Rahisuddin, Narender Kumar, S. Kumaran, Rajesh P. Ringe, Raghavan Varadarajan, Somnath Dutta, Jayanta Chatterjee
Summary: This study demonstrates the design and development of a therapeutically effective peptide against SARS-CoV-2 by targeting dimerization, providing a promising approach for inhibiting viral infection.
NATURE CHEMICAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Kartik Sehgal, Andrew Portell, Elena Ivanova, Patrick H. Lizotte, Navin R. Mahadevan, Jonathan R. Greene, Amir Vajdi, Carino Gurjao, Tyler Teceno, Luke J. Taus, Tran C. Thai, Shunsuke Kitajima, Derek Liu, Tetsuo Tani, Moataz Noureddine, Christie J. Lau, Paul T. Kirschmeier, David Liu, Marios Giannakis, Russell W. Jenkins, Prafulla C. Gokhale, Silvia Goldoni, Maria Pinzon-Ortiz, William D. Hastings, Peter S. Hammerman, Juan J. Miret, Cloud P. Paweletz, David A. Barbie
Summary: The study identified a subpopulation of immunotherapy persister cells (IPCs) that resisted CD8(+) T cell-mediated killing under PD-1 blockade, exhibiting stem cell-like features, and could be targeted by specific therapeutic combinations.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Yufeng Deng, Weizhou Li, Yingying Zhang, Jingjing Li, Fangting He, Ke Dong, Zehui Hong, Ruocheng Luo, Xiaofang Pei
Summary: Inflammation is a risk factor for bone-destroying diseases. Zanthoxylum bungeanum seed oil (ZBSO) is rich in unsaturated fatty acids and has shown inhibitory effects on osteoclastogenesis. The key constituents in ZBSO and their mechanism in inflammation-related prevention of osteoclastogenesis are still unknown.
Article
Multidisciplinary Sciences
Zhaojuan Yang, Guiqin Xu, Boshi Wang, Yun Liu, Li Zhang, Tiantian Jing, Ming Tang, Xiaoli Xu, Kun Jiao, Lvzhu Xiang, Yujie Fu, Daoqiang Tang, Xiaoren Zhang, Weilin Jin, Guanglei Zhuang, Xiaojing Zhao, Yongzhong Liu
Summary: The study reveals that downregulation of deubiquitinase USP12 contributes to the development of an immune-suppressive tumor microenvironment in KRAS-driven lung cancers. This downregulation promotes lung tumor growth, increases macrophage recruitment, hypervascularization, and reduces T cell activation. Additionally, inhibition of USP12 makes mouse lung tumor cells less responsive to anti-PD-1 immunotherapy.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Jordana Kron, Thomas Crawford, Virginia Mihalick, Frank Bogun, Jennifer H. Jordan, Todd Koelling, Huzaefah Syed, Aamer Syed, Thomas Iden, Kelly Polly, Emily Federmann, Kirsta Bray, Sangeeta Lathkar-Pradhan, Shilpa Jasti, Lynda Rosenfeld, David Birnie, Melissa Smallfield, Le Kang, Alpha Berry Fowler, Amy Ladd, Kenneth Ellenbogen, Benjamin Van Tassell, W. Gregory Hundley, Antonio Abbate
Summary: Cardiac sarcoidosis is a rare disease that can lead to life-threatening complications, and this trial aims to investigate the effectiveness of IL-1 blockade with anakinra in combating systemic and cardiac inflammation in patients with this condition.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Teresa Ponce-Lopez, Jose Antonio Gonzalez Alvarez Tostado, Fernando Dias, Keren Happuck Montiel Maltez
Summary: N-nitrosodiethylamine (NDEA) is a potential carcinogen that causes liver tumors, chronic inflammation, diabetes, cognitive problems, and Alzheimer's disease-like symptoms in animals. Metformin may protect against memory issues and brain inflammation triggered by NDEA.
Article
Allergy
Aishath S. Naeem, Cristina Tommasi, Christian Cole, Stuart J. Brown, Yanan Zhu, Benjamin Way, Saffron A. G. Willis Owen, Miriam Moffatt, William O. Cookson, John I. Harper, Wei-Li Di, Sara J. Brown, Thomas Reinheckel, Ryan F. L. O'Shaughnessy
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2017)
Review
Dermatology
Clare Rogerson, Ryan F. L. O'Shaughnessy
EXPERIMENTAL DERMATOLOGY
(2018)
Article
Cell Biology
Danuta Gutowska-Owsiak, Jorge Bernardino de La Serna, Marco Fritzsche, Aishath Naeem, Ewa I. Podobas, Michael Leeming, Huw Colin-York, Ryan O'Shaughnessy, Christian Eggeling, Graham S. Ogg
CELL DEATH & DISEASE
(2018)
Review
Cell Biology
Clare Rogerson, Daniele Bergamaschi, Ryan F. L. O'Shaughnessy
Review
Cell Biology
Clare Rogerson, Daniele Bergamaschi, Ryan F. L. O'Shaughnessy
Article
Dermatology
I. I. Badshah, S. Brown, L. Weibel, A. Rose, B. Way, N. Sebire, G. Inman, J. Harper, R. F. L. O'Shaughnessy
BRITISH JOURNAL OF DERMATOLOGY
(2019)
Editorial Material
Dermatology
I. Garcia-Doval, P. Davila-Seijo
BRITISH JOURNAL OF DERMATOLOGY
(2019)
Article
Medicine, Research & Experimental
Eleftheria Papaioannou, Diana C. Yanez, Susan Ross, Ching-In Lau, Anisha Solanki, Mira Manilal Chawda, Alex Virasami, Ismael Ranz, Masahiro Ono, Ryan F. L. O'Shaughnessy, Tessa Crompton
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Editorial Material
Dermatology
Yutaka Shimomura, Ryan O'Shaughnessy, Neil Rajan
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Article
Dermatology
Cristina Tommasi, Clare Rogerson, Daniel P. Depledge, Meleri Jones, Aishath S. Naeem, Cristina Venturini, Dan Frampton, Helena J. Tutill, Benjamin Way, Judith Breuer, Ryan F. L. O'Shaughnessy
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)
Review
Dermatology
A. J. Hughes, S. S. Tawfik, K. P. Baruah, E. A. O'Toole, R. F. L. O'Shaughnessy
Summary: Tape strips are widely used in dermatology research as a minimally invasive sampling method to avoid the need for skin biopsies. Research has mainly focused on epidermal pathology, such as atopic eczema, but there is increasing interest in exploring the use of tape strips in other skin diseases.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Clare Rogerson, Duncan J. Wotherspoon, Cristina Tommasi, Robert W. Button, Ryan F. L. O'Shaughnessy
Summary: The study shows that the dispersal of phosphorylated Lamin A/C in differentiating keratinocytes is Akt1-dependent and involves the cytoskeletal proteins actin, Arp3, and Myh9. Disruption of actin filament polymerisation, nucleation, or myosin IIa activity prevents cytoplasmic Lamin A/C structure formation. Live imaging reveals a rapid nuclear volume reduction step before final destruction, dependent on Akt1 and cytoskeleton-associated proteins.
CELL DEATH AND DIFFERENTIATION
(2021)
Editorial Material
Dermatology
R. F. L. O'Shaughnessy
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Editorial Material
Dermatology
R. F. L. O'Shaughnessy
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Hephzi Tagoe, Sakinah Hassan, Emily Bliss, Gehad Youssef, Wendy Heywood, Kevin Mills, John Harper, Ryan F. L. O'Shaughnessy
Summary: By studying patients with autosomal recessive congenital ichthyosis (ARCI) and laboratory models, it was discovered that activation of Toll-like receptor 2 (TLR2) pathway is associated with ichthyosis. TLR2 activation leads to thickening of the scaly skin, while TLR2 inhibition reduces the expression of keratin 1 in the ichthyosis models. Therefore, the regulation of TLR2 activation may have potential therapeutic effects in treating diseases related to epidermal barrier dysfunction.
BRITISH JOURNAL OF DERMATOLOGY
(2023)