Article
Biochemistry & Molecular Biology
Yue Liao, Susann Badmann, Fabian Kraus, Nicole Elisabeth Topalov, Doris Mayr, Thomas Kolben, Anna Hester, Susanne Beyer, Sven Mahner, Udo Jeschke, Fabian Trillsch, Bastian Czogalla, Alexander Burges
Summary: This study investigates the role of platelet-activating factor acetylhydrolase (PLA2G7/PAF-AH) in the Wnt signaling pathway in BRCA1 mutant breast cancer. The results show significantly higher nuclear expression levels of PAF-AH in BRCA1 mutant tissue specimens, which correlates with membranous beta-catenin. PLA2G7 silencing leads to translocation of beta-catenin from the membrane to the nucleus and activation of Wnt signaling downstream genes. These findings suggest a protective effect of high PAF-AH expression in BRCA1 mutant breast cancer through negative regulation of the Wnt pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yue Liao, Susann Badmann, Till Kaltofen, Doris Mayr, Elisa Schmoeckel, Eileen Deuster, Mareike Mannewitz, Sarah Landgrebe, Thomas Kolben, Anna Hester, Susanne Beyer, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch, Bastian Czogalla
Summary: The study investigated the role of platelet-activating factor acetylhydrolase in BRCA1 mutant ovarian cancer and its interaction with the Wnt signaling pathway. Results suggest that PAF-AH may have a protective role and negatively regulate the Wnt/beta-catenin pathway in ovarian cancer, particularly in BRCA1 mutant cases. Further research is needed to explore the potential use of PAF-AH as a biomarker for predicting disease risk and prognosis in ovarian cancer patients.
Article
Pharmacology & Pharmacy
Yasuhiro Nakamura, Momoko Yoshida, Kazunari Tanigawa, Ayako Harada, Fumiko Kihara-Negishi, Keiji Maruyama, Ken Karasawa
Summary: The deficiency of catalytic subunits of type I PAF-AH in mice leads to increased body weight, higher food intake, and significantly decreased testosterone levels in the serum and testis.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Medicine, General & Internal
Jordi Roca-Ferrer, Maria Perez-Gonzalez, Isam Alobid, Valeria Tubita, Mireya Fuentes, Marina Bantula, Rosa Munoz-Cano, Antonio Valero, Inaki Izquierdo, Joaquim Mullol, Jacopo Galli
Summary: This study aimed to assess the role of the Platelet-Activating Factor (PAF)/receptor (PAFR) system in chronic rhinosinusitis with nasal polyps (CRSwNP). The study found that PAFR protein was expressed in nasal mucosa and nasal polyps, and Lyso-PAF concentrations were higher in nasal polyps of asthmatic patients. These findings suggest that the PAF/PAFR system may play a role in CRSwNP pathogenesis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Shipeng Guo, Zhougeng Xu, Xiangjun Dong, Dongjie Hu, Yanshuang Jiang, Qunxian Wang, Jie Zhang, Qian Zhou, Shengchun Liu, Weihong Song
Summary: A comprehensive human perturbation database (GPSAdb) has been established by manually curating perturbed RNA-seq datasets from human cell lines. The database collects data associated with knocked out/down genes using various methods such as siRNA, shRNA, CRISPR/Cas9, or CRISPRi. An online tool (GPSA) has been developed to analyze the data and identify candidate causal perturbations.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Nutrition & Dietetics
Rajendran Harishkumar, Sakshi Hans, Janelle E. Stanton, Andreas M. Grabrucker, Ronan Lordan, Ioannis Zabetakis
Summary: This review discusses the role of platelet-activating factor (PAF) and its receptor in inflammatory diseases and atherosclerotic cardiovascular diseases, with a focus on how inhibiting PAF-R can reduce cardiovascular disease risk. Research suggests that dietary factors may modulate PAF metabolism and PAF-R function to regulate disease development.
Article
Food Science & Technology
Mingming Li, Xin Zhang, Jiapeng Li, Linggao Liu, Qiujin Zhu, Chao Qu, Yunhan Zhang, Shouwei Wang
Summary: This study investigated the isolation, purification, and identification of potential cardioprotective bioactive peptides from dry-cured pork coppa. The results showed that M1F2 peptide had a higher inhibitory effect on cardiovascular inflammation compared to M2F2. Nano-liquid chromatography-tandem mass spectrometry identified a total of 30 peptides, among which LTDKPFL, VEAPPAKVP, KVPVPAPK, IPVPKK, and PIKRSP were found to be promising platelet-activating factor acetyl hydrolase inhibitory peptides. Overall, bioactive peptides produced during the processing of dry-cured pork coppa have positive effects on human health.
Article
Biochemistry & Molecular Biology
Carolyn J. English, Anna E. Lohning, Hannah L. Mayr, Mark Jones, Dianne P. Reidlinger
Summary: Traditionally, cardiovascular disease (CVD) risk has been assessed through blood lipids and the inflammatory marker C-reactive protein (hsCRP). However, recent research has shown that the pro-inflammatory markers platelet-activating factor (PAF) and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) can also indicate vascular damage in the absence of traditional risk factors. This study investigated the relationship between PAF, Lp-PLA(2), hsCRP, and traditional risk factors for CVD among 100 adults. The results showed that PAF, Lp-PLA(2), and hsCRP were independently correlated with various CVD risk factors, suggesting their involvement in different atherogenic pathways.
Article
Genetics & Heredity
Vaishali Chakravarty, Libi Anandi, K. A. Ashiq, K. Abhijith, Rintu Umesh, Mayurika Lahiri
Summary: Lipid species have diverse biological functions based on structural differences, some of which interact with proteins as second messengers. The accumulation of phospholipid mediator PAF in the tumor microenvironment disrupts cellular homeostasis and increases metastatic potential.
FRONTIERS IN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Palgan Krzysztof, Tretyn Andrzej
Summary: Anaphylaxis is a life-threatening hypersensitivity reaction, often caused by drugs and food. Factors such as physical exercise, acute infections, drugs, alcohol, and menstruation can exacerbate the severity of the reaction. This review highlights the role of platelet-activating factor in the development of severe anaphylactic reactions, including anaphylactic shock.
Article
Obstetrics & Gynecology
Preeti Gupta, Rachna Agarwal, Sruthi Bhaskaran, Seema Garg, Mohit Mehndiratta, Gita Radhakrishnan, Alpana Singh, Richa Agarwal, Divya Narang
Summary: The study found significantly higher plasma PAF-AH activity levels in preeclamptic patients compared to normotensive controls, while mRNA expression of the PAF-AH gene showed no significant difference between the two groups. This suggests that PAF-AH may play a role in the pathophysiology and severity of preeclampsia. Additionally, further research with larger sample sizes may be needed to confirm this association and explore the potential therapeutic use of PAF-AH inhibitors in the future.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Allergy
Julia E. M. Upton, Jennifer A. Hoang, Matilde Leon-Ponte, Yaron Finkelstein, Yue (Jennifer) Du, Khosrow Adeli, Thomas Eiwegger, Eyal Grunebaum, Peter Vadas
Summary: This study found that decreased serum PAF-AH activity is a biomarker of severe anaphylaxis and levels of this enzyme do not change during acute anaphylaxis. The results suggest that PAF-AH may modulate susceptibility to severe anaphylaxis.
Article
Immunology
Stefan Hug, Stefan Bernhard, Alexander Elias Paul Stratmann, Maike Erber, Lisa Wohlgemuth, Christiane Leonie Knapp, Jonas Martin Bauer, Laura Vidoni, Michael Fauler, Karl Josef Foehr, Peter Radermacher, Andrea Hoffmann, Markus Huber-Lang, David Alexander Christian Messerer
Summary: Platelet-activating factor (PAF) plays a crucial role in the systemic inflammatory response, particularly in sepsis. This study investigates the changes in neutrophil cellular responses induced by PAF during sepsis, focusing on membrane potential, intracellular pH, and cellular swelling. The study found that in a pathological environment, the response of neutrophils to PAF was altered, with exposure to lipopolysaccharide leading to diminished intracellular alkalization and neutrophil size changes. These findings suggest that an impaired physiological response of neutrophils to PAF stimulation may contribute to the development of neutrophil dysfunction in sepsis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
YingYing He, Zhicheng He, Xiaoyu Zhang, Shubai Liu
Summary: The study revealed abnormal overexpression of PAF-AH IB2 in ovarian cancer, and knocking down PAF-AH IB2 significantly inhibited cancer cell proliferation, migration, and tumorigenicity, and increased cell sensitivity to PAF.
CANCER CELL INTERNATIONAL
(2021)
Article
Engineering, Biomedical
Meredith A. Jackson, Shrusti S. Patel, Fang Yu, Matthew A. Cottam, Evan B. Glass, Ella N. Hoogenboezem, R. Brock Fletcher, Bryan R. Dollinger, Prarthana Patil, Danielle D. Liu, Isom B. Kelly, Sean K. Bedingfield, Allyson R. King, Rachel E. Miles, Alyssa M. Hasty, Todd D. Giorgio, Craig L. Duvall
Summary: The study demonstrates that Kupffer cell release of plate activating factor (PAF) is a key determinant of siRNA nanocarrier toxicity, and inhibiting PAFR can increase the tolerated dose of siRNA nanocarriers.
Article
Multidisciplinary Sciences
Brian J. Andonian, Alec Koss, Timothy R. Koves, Elizabeth R. Hauser, Monica J. Hubal, David M. Pober, Janet M. Lord, Nancie J. MacIver, E. William St Clair, Deborah M. Muoio, William E. Kraus, David B. Bartlett, Kim M. Huffman
Summary: Rheumatoid arthritis (RA) T cells drive autoimmune features through metabolic reprogramming and reduced oxidative metabolism. High-intensity interval training (HIIT) improves cardiorespiratory fitness in RA patients, which may impact the oxidative metabolic function of RA T cells. This pilot study found that improvements in RA cardiorespiratory fitness following HIIT were associated with changes in CD4 + T cell metabolism and skeletal muscle oxidative metabolism.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Elizabeth J. Gifford, Stephen H. Boyle, Jacqueline Vahey, Kellie J. Sims, Jimmy T. Efird, Blair Chesnut, Crystal Stafford, Julie Upchurch, Christina D. Williams, Drew A. Helmer, Elizabeth R. Hauser
Summary: This study examines the impact of Gulf War illness (GWI) on health-related quality of life (HRQOL) and related indices. The results show that veterans with GWI, according to Kansas and CDC definitions, have poorer physical and mental health outcomes, higher rates of depression, PTSD, and severe pain compared to noncases.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Genetics & Heredity
Sridharan Raghavan, Jie Huang, Catherine Tcheandjieu, Jennifer E. Huffman, Elizabeth Litkowski, Chang Liu, Yuk-Lam A. Ho, Haley Hunter-Zinck, Hongyu Zhao, Eirini Marouli, Kari E. North, Ethan Lange, Leslie A. Lange, Benjamin F. Voight, J. Michael Gaziano, Saiju Pyarajan, Elizabeth R. Hauser, Philip S. Tsao, Peter W. F. Wilson, Kyong-Mi Chang, Kelly Cho, Christopher J. O'Donnell, Yan Sun, Themistocles L. Assimes
Summary: This study found that height may be an unrecognized non-modifiable risk factor for several common conditions in adults, suggesting a potential causal relationship rather than confounding factors.
Article
Health Care Sciences & Services
Corrine Voils, Cynthia J. Coffman, R. Ryanne Wu, Janet M. Grubber, Deborah A. Fisher, Elizabeth M. Strawbridge, Nina Sperber, Virginia Wang, Maren T. Scheuner, Dawn Provenzale, Richard E. Nelson, Elizabeth Hauser, Lori A. Orlando, Karen M. Goldstein
Summary: A patient-facing family health history (FHH) platform can accurately assess and document the clinical needs of patients at increased risk for colorectal cancer (CRC). However, there are barriers to acting on these recommendations.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Behavioral Sciences
Stephen K. Siecinski, Stephanie N. Giamberardino, Marina Spanos, Annalise C. Hauser, Jason R. Gibson, Tara Chandrasekhar, Maria del Pilar Trelles, Carol M. Rockhill, Michelle L. Palumbo, Allyson Witters Cundiff, Alicia Montgomery, Paige Siper, Mendy Minjarez, Lisa A. Nowinski, Sarah Marler, Lydia C. Kwee, Lauren C. Shuffrey, Cheryl Alderman, Jordana Weissman, Brooke Zappone, Jennifer E. Mullett, Hope Crosson, Natalie Hong, Sheng Luo, Lilin She, Manjushri Bhapkar, Russell Dean, Abby Scheer, Jacqueline L. Johnson, Bryan H. King, Christopher J. McDougle, Kevin B. Sanders, Soo-Jeong Kim, Alexander Kolevzon, Jeremy Veenstra-VanderWeele, Elizabeth R. Hauser, Linmarie Sikich, Simon G. Gregory
Summary: This study investigated the impact of genetic and epigenetic variations on oxytocin levels in the blood. By analyzing the integration of genome profiles, transcriptional activity, and genetic variation with blood oxytocin levels in 290 participants with autism enrolled in an oxytocin clinical trial, genetic variants associated with blood oxytocin levels were identified, some of which were located in known autism risk genes. The study also showed a statistically significant association between blood oxytocin levels and gene expression and epigenetic profiles across multiple gene pathways. These findings broaden our understanding of the influence of the peripheral oxytocin system and its interaction with the complex etiology of autism and oxytocin-based treatments in future studies.
Article
Oncology
Yu-Ru Su, Lori C. Sakoda, Jihyoun Jeon, Minta Thomas, Yi Lin, Jennifer L. Schneider, Natalia Udaltsova, Jeffrey K. Lee, Iris Lansdorp-Vogelaar, Elisabeth F. P. Peterse, Ann G. Zauber, Jiayin Zheng, Yingye Zheng, Elizabeth Hauser, John A. Baron, Elizabeth L. Barry, D. Timothy Bishop, Hermann Brenner, Daniel D. Buchanan, Andrea Burnett-Hartman, Peter T. Campbell, Graham Casey, Sergi Castellvi-Bel, Andrew T. Chan, Jenny Chang-Claude, Jane C. Figueiredo, Steven J. Gallinger, Graham G. Giles, Stephen B. Gruber, Andrea Gsur, Marc J. Gunter, Jochen Hampe, Heather Hampel, Tabitha A. Harrison, Michael Hoffmeister, Xinwei Hua, Jeroen R. Huyghe, Mark A. Jenkins, Temitope O. Keku, Loic Le Marchand, Li Li, Annika Lindblom, Victor Moreno, Polly A. Newcomb, Paul D. P. Pharoah, Elizabeth A. Platz, John D. Potter, Conghui Qu, Gad Rennert, Robert E. Schoen, Martha L. Slattery, Mingyang Song, Franzel J. B. van Duijnhoven, Bethany Van Guelpen, Pavel Vodicka, Alicja Wolk, Michael O. Woods, Anna H. Wu, Richard B. Hayes, Ulrike Peters, Douglas A. Corley, Li Hsu
Summary: This study externally validated a polygenic risk score (PRS)-enhanced colorectal cancer risk model comprising 140 known colorectal cancer loci. The results showed that the PRS improved the prediction and discrimination of colorectal cancer risk, suggesting its potential utility in risk-stratified colorectal cancer prevention.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Endocrinology & Metabolism
Katherine A. Collins, William E. Kraus, Renee J. Rogers, Elizabeth R. Hauser, Wei Lang, Rong Jiang, Erik B. Schelbert, Kim M. Huffman, John M. Jakicic
Summary: This study aimed to determine whether novel biomarkers of cardiometabolic health improve in response to a 12-month behavioral weight-loss intervention and to compare benefits of diet alone with diet plus physical activity for these biomarkers. The results showed that all intervention groups had significant improvements in biomarkers of insulin resistance and cardiometabolic health, but the addition of physical activity to a diet-only intervention did not provide any additional benefit.
Article
Environmental Sciences
Linh M. Duong, Alice B. S. Nono Djotsa, Jacqueline Vahey, Lea Steele, Rachel Quaden, Kelly M. Harrington, Sarah T. Ahmed, Renato Polimanti, Elani Streja, John Michael Gaziano, John Concato, Hongyu Zhao, Krishnan Radhakrishnan, Elizabeth R. Hauser, Drew A. Helmer, Mihaela Aslan, Elizabeth J. Gifford
Summary: The study found that Gulf War Illness (GWI) is highly prevalent among veterans deployed to the 1990-1991 Gulf War, presenting as a chronic multisymptom illness with a complex and uncertain etiology and pathophysiology. The study also revealed that GWI phenotypes varied by demographic and military characteristics.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Psychiatry
Nathan A. Kimbrel, Allison E. Ashley-Koch, Xue J. Qin, Jennifer H. Lindquist, Melanie E. Garrett, Michelle F. Dennis, Lauren P. Hair, Jennifer E. Huffman, Daniel A. Jacobson, Ravi K. Madduri, Jodie A. Trafton, Hilary Coon, Anna R. Docherty, Niamh Mullins, Douglas M. Ruderfer, Philip D. Harvey, Benjamin H. McMahon, David W. Oslin, Jean C. Beckham, Elizabeth R. Hauser, Michael A. Hauser
Summary: This study aimed to identify the genetic basis of suicidal thoughts and behaviors. Through genome-wide association analysis, several risk loci for suicide were identified, and some of these loci were replicated in independent samples, providing evidence for their involvement in suicide.
Article
Genetics & Heredity
Sarah M. C. Colbert, Frank R. Wendt, Gita A. Pathak, Drew A. Helmer, Elizabeth R. Hauser, Matthew C. Keller, Renato Polimanti, Emma C. Johnson
Summary: Previous studies have suggested that autozygosity decreases over generational time. However, these studies had small samples and lacked diversity, limiting the generalizability of their findings. This study utilized large cohorts of diverse ancestries from the US and the UK to partially support the hypothesis. The results showed a decreasing trend of autozygosity over time, with differences observed between countries and the potential influence of socioeconomic factors.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Gastroenterology & Hepatology
D. Malhotra, S. H. Boyle, E. J. Gifford, B. A. Sullivan, T. H. Nguyen Wenker, Nono-Djotsa Abs, S. T. Ahmed, J. Upchurch, J. Vahey, C. Stafford, J. T. Efird, S. C. Hunt, A. Bradford, K. J. Sims, E. R. Hauser, D. A. Helmer, C. D. Williams
Summary: This study explores the relationship between post-traumatic stress disorder (PTSD), Gulf War Illness (GWI), and self-reported gastrointestinal (GI) disorders, and finds that Gulf War veterans with GWI and PTSD have higher odds of specific GI disorders.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Multidisciplinary Sciences
Minta Thomas, Yu-Ru Su, Elisabeth A. Rosenthal, Lori C. Sakoda, Stephanie L. Schmit, Maria N. Timofeeva, Zhishan Chen, Ceres Fernandez-Rozadilla, Philip J. Law, Neil Murphy, Robert Carreras-Torres, Virginia Diez-Obrero, Franzel J. B. van Duijnhoven, Shangqing Jiang, Aesun Shin, Alicja Wolk, Amanda I. Phipps, Andrea Burnett-Hartman, Andrea Gsur, Andrew T. Chan, Ann G. Zauber, Anna H. Wu, Annika Lindblom, Caroline Y. Um, Catherine M. Tangen, Chris Gignoux, Christina Newton, Christopher A. Haiman, Conghui Qu, D. Timothy Bishop, Daniel D. Buchanan, David R. Crosslin, David V. Conti, Dong-Hyun Kim, Elizabeth Hauser, Emily White, Erin Siegel, Fredrick R. Schumacher, Gad Rennert, Graham G. Giles, Heather Hampel, Hermann Brenner, Isao Oze, Jae Hwan Oh, Jeffrey K. Lee, Jennifer L. Schneider, Jenny Chang-Claude, Jeongseon Kim, Jeroen R. Huyghe, Jiayin Zheng, Jochen Hampe, Joel Greenson, John L. Hopper, Julie R. Palmer, Kala Visvanathan, Keitaro Matsuo, Koichi Matsuda, Keum Ji Jung, Li Li, Loic Le Marchand, Ludmila Vodickova, Luis Bujanda, Marc J. Gunter, Marco Matejcic, Mark A. Jenkins, Martha L. Slattery, Mauro D'Amato, Meilin Wang, Michael Hoffmeister, Michael O. Woods, Michelle Kim, Mingyang Song, Motoki Iwasaki, Mulong Du, Natalia Udaltsova, Norie Sawada, Pavel Vodicka, Peter T. Campbell, Polly A. Newcomb, Qiuyin Cai, Rachel Pearlman, Rish K. Pai, Robert E. Schoen, Robert S. Steinfelder, Robert W. Haile, Rosita Vandenputtelaar, Ross L. Prentice, Sebastien Kuery, Sergi Castellvi-Bel, Shoichiro Tsugane, Sonja I. Berndt, Soo Chin Lee, Stefanie Brezina, Stephanie J. Weinstein, Stephen J. Chanock, Sun Ha Jee, Sun-Seog Kweon, Susan Vadaparampil, Tabitha A. Harrison, Taiki Yamaji, Temitope O. Keku, Veronika Vymetalkova, Volker Arndt, Wei-Hua Jia, Xiao-Ou Shu, Yi Lin, Yoon-Ok Ahn, Zsofia K. Stadler, Bethany Van Guelpen, Cornelia M. Ulrich, Elizabeth A. Platz, John D. Potter, Christopher I. Li, Reinier Meester, Victor Moreno, Jane C. Figueiredo, Graham Casey, Iris Lansdorp Vogelaar, Malcolm G. Dunlop, Stephen B. Gruber, Richard B. Hayes, Paul D. P. Pharoah, Richard S. Houlston, Gail P. Jarvik, Ian P. Tomlinson, Wei Zheng, Douglas A. Corley, Ulrike Peters, Li Hsu
Summary: Polygenic risk scores (PRS) have the potential to guide precision colorectal cancer (CRC) prevention, but current PRS using European ancestry data do not perform well in non-European ancestry populations. In this study, Asian ancestry data was incorporated to improve the performance of PRS, and it was found to be significantly better in different racial and ethnic groups.
NATURE COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Sarah T. Ahmed, Ruosha Li, Peter Richardson, Saurendro Ghosh, Lea Steele, Donna L. White, Alice Nono Djotsa, Kellie Sims, Elizabeth Gifford, Elizabeth R. Hauser, Salim S. Virani, Robert Morgan, George Delclos, Drew A. Helmer
Summary: Gulf War veterans with GWI had higher odds of hyperlipidemia, hypertension, diabetes, and ASCVD compared with Gulf War veterans without GWI.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Genetics & Heredity
Frank R. Wendt, Gita A. Pathak, Jacqueline Vahey, Xuejun Qin, Dora Koller, Brenda Cabrera-Mendoza, Angela Haeny, Kelly M. Harrington, Nallakkandi Rajeevan, Linh M. Duong, Daniel F. Levey, Flavio De Angelis, Antonella De Lillo, Tim B. Bigdeli, Saiju Pyarajan, John Michael Gaziano, Joel Gelernter, Mihaela Aslan, Dawn Provenzale, Drew A. Helmer, Elizabeth R. Hauser, Renato Polimanti
Summary: This study investigated the changes in population diversity among participants of the Million Veteran Program (MVP) over time and how to account for these changes in genome-wide association studies (GWAS). It found that there were significant changes in ancestry diversity among different birth cohorts. The study also demonstrated that using genetically defined ancestry groups can effectively control the confounding effects of population stratification in GWAS.
Article
Psychology, Clinical
Stephen H. Boyle, Julie Upchurch, Elizabeth J. Gifford, Thomas S. Redding IV, Elizabeth R. Hauser, Deeksha Malhotra, Ashlyn Press, Kellie J. Sims, Christina D. Williams
Summary: This study investigated the association between self-reported military exposures, Gulf War illness (GWI), and posttraumatic stress disorder (PTSD) in veterans deployed to the Persian Gulf during the Gulf War. The findings suggest that both PTSD and military exposures play a role in the etiology of GWI.
JOURNAL OF TRAUMATIC STRESS
(2023)