Review
Biology
Chio Oka, Razwa Saleh, Yasumasa Bessho, Hasan Mahmud Reza
Summary: This review provides a detailed overview of the role of high temperature requirement factor Al (HTRA1) in cellular processes and its association with various diseases, including preeclampsia, age-related macular degeneration (AMD), small vessel disease, and cancer. Additionally, possible therapeutic avenues utilizing HTRA1 are discussed.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Psychology, Developmental
Mattias Krantz, Emma Malm, Niklas Darin, Kalliopi Sofou, Antri Savvidou, Colin Reilly, Petra Bostrom
Summary: CLN3 disease has a significant impact on the family system, including parental feelings of loss, impact on family relationships, and lack of understanding in the healthcare and social insurance systems. The concept of family resilience may be helpful in understanding the experiences of families affected by pediatric neurodegenerative conditions.
CHILD CARE HEALTH AND DEVELOPMENT
(2022)
Review
Cell Biology
Marcel Klein, Guido Hermey
Summary: Evidence from genetics and cellular and animal models suggests a link between early and late neurodegenerative disorders. This review summarizes the connection between Alzheimer's disease and neuronal ceroid lipofuscinoses. Genetic studies have found overlapping mutations between clinically diagnosed Alzheimer's and neuronal ceroid lipofuscinoses. Dysfunctions in intracellular trafficking mechanisms and the autophagy-endolysosome system are believed to be shared cytopathological processes. Understanding these common mechanisms is important for finding therapeutic targets and tailored treatments.
NEURAL REGENERATION RESEARCH
(2023)
Review
Cell Biology
Abhinava K. Mishra, Vartika Sharma, Mousumi Mutsuddi, Ashim Mukherjee
Summary: Multicellular organisms rely on core signaling pathways to regulate cell fate choices, which integrate to form complex networks for distinct developmental outcomes. Notch pathway, a conserved mechanism, interacts with other pathways to produce context-dependent outputs, and understanding its crosstalk with JNK and NF-KB pathways is crucial for regulating various developmental events.
CELLULAR SIGNALLING
(2021)
Article
Biophysics
Weronika Ficerman, Marek Wisniewski, Katarzyna Roszek
Summary: This article summarizes the impact of nanomaterials on the functions of the purinergic signaling pathway in cells, including direct interactions with purinergic receptors, changes in receptor gene expression, activation of inflammatory processes, and induction of cell death. The article points out that although the mechanisms of action have not been fully elucidated, these nano-bio interactions are crucial for toxicity assessment and designing safer nanomaterials.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Medicine, Research & Experimental
Yan-Ting Chen, Ainun Nizar Masbuchin, Yi-Hsien Fang, Ling-Wei Hsu, Sheng-Nan Wu, Chia-Jui Yen, Yen-Wen Liu, Yu-Wei Hsiao, Ju-Ming Wang, Mohammad Saifur Rohman, Ping-Yen Liu
Summary: A study found that HCC patients may experience heart dysfunction after TKI treatment. Inhibition of PTX3 was found to improve this dysfunction. These findings suggest the therapeutic potential of PTX3 inhibition for TKI-associated cardiotoxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Agronomy
Beatriz Val-Torregrosa, Mireia Bundo, Blanca San Segundo
Summary: Rice production is affected by various stresses, including nutrient stress. Improper use of pesticides can have harmful effects on the environment and human health. Understanding the interaction between nutrient stress and disease resistance is essential for optimizing fertilizer and pesticide use in rice production.
Review
Plant Sciences
Elina Welchen, Maria Victoria Canal, Diana E. Gras, Daniel H. Gonzalez
Summary: Plant mitochondria play a crucial role in shaping various cellular processes through signal transduction, including metabolic, redox, ion fluxes, protein relocalization, and physical contacts with other organelles. In addition, changes in mitochondrial physiology also affect the activity of signaling pathways that regulate plant growth and stress responses. As a result, mitochondria have a significant impact on the responses to internal and external factors that modify the activity of these pathways and associated biological processes in plants.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Oncology
Garima Dixit, Jesus Gonzalez-Bosquet, Joseph Skurski, Eric J. J. Devor, Erin B. B. Dickerson, Warren B. B. Nothnick, Priya D. D. Issuree, Kimberly K. K. Leslie, Thorsten Maretzky
Summary: Mutations in the FGFR2 gene have been linked to advanced and recurrent endometrial cancer. This study reveals that FGFR2 mutations enhance the activation of ADAM17 and the subsequent transactivation of EGFR in response to FGF7. Furthermore, FGFR2 mutants also activate the Notch signaling pathway in an ADAM17-dependent manner. These findings highlight the importance of ADAM17 in the pathogenesis of endometrial cancer and provide a rationale for targeting ADAM17 protease activity in FGFR2-driven cancers.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Lisa M. Sevilla, Alba Jimenez-Panizo, Andrea Alegre-Marti, Eva Estebanez-Perpina, Carme Caelles, Paloma Perez
Summary: Endogenous and synthetic glucocorticoids play critical roles in modulating tissue homeostasis and treating chronic inflammatory diseases, but imbalances in GC signaling can lead to disease or inadequate therapeutic outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Olivia J. J. Scully, Sukanya Shyamasundar, Ken Matsumoto, S. Thameem Dheen, George W. W. Yip, Boon Huat Bay
Summary: Breast carcinoma is the most prevalent cancer in women globally, and its development and progression involve complex genetic and molecular mechanisms. Challenges such as metastasis and drug resistance limit the prognosis of breast cancer, leading to the constant search for better treatment regimes and novel molecular therapeutic targets. C1QBP, a promising molecular target, has been implicated in breast carcinogenesis. This study demonstrates the role of C1QBP in breast cancer progression, specifically in cancer cell growth, and highlights its potential as a target for future breast cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hadeel Kheraldine, Ishita Gupta, Hashim Alhussain, Aayesha Jabeen, Farhan S. Cyprian, Saghir Akhtar, Ala-Eddin Al Moustafa, Ousama Rachid
Summary: The study revealed that cationic PAMAM dendrimers can significantly reduce cell viability, induce cell apoptosis, and inhibit colony formation in HER2-positive breast cancer cells. Furthermore, PAMAMs modulate the signaling pathways of JNK1/2/3, ERK1/2, and HER1/2, suggesting important therapeutic effects against HER2-positive breast cancer.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Dermatology
Weixue Jia, Yuanyuan Zhang, Xue Wang, Lingling Luo, Heng Sun, Yiqun Jiang, Jianbo Wang, Qiuxia Mao, Youming Guo, Lingzhuo Kong, Ran Mo, Chengrang Li
Summary: This study reveals that the downregulation of KRT5 in keratinocytes affects melanogenesis in melanocytes through the Notch signaling pathway. The findings provide insights into the molecular mechanism of KRT5-Notch signaling pathway in the regulation of melanocytes and shed light on the mechanism of DDD pigment abnormality caused by KRT5 mutation. These findings identify potential therapeutic targets of the Notch signaling pathway for the treatment of skin pigment disorders.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Cell Biology
Moein Ala, Razieh Mohammad Jafari, Mahan Ala, Sedigheh Marjaneh Hejazi, Seyed Mohammad Tavangar, Seied Rabi Mahdavi, Ahmad Reza Dehpour
Summary: This study found that sildenafil can improve radiation-induced oral mucositis by attenuating inflammation and oxidative stress, and reduce the apoptosis of mucosal cells.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Qiang Xu, Ping Zhan, Xiaofeng Li, Fengbo Mo, Huaen Xu, Yuan Liu, Qi Lai, Bin Zhang, Min Dai, Xuqiang Liu
Summary: The study demonstrated the inhibitory effects of a novel bone-targeting bisphosphonate derivative on osteoclast formation and bone resorption, as well as its ability to preserve bone mass in an OVX rat model without significant side effects, indicating its potential as a treatment for osteoporosis and other osteolytic diseases.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Kiterie M. E. Faller, Rodrigo Gutierrez-Quintana, Alamin Mohammed, Ahad A. Rahim, Richard I. Tuxworth, Kim Wager, Michael Bond
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2015)
Article
Developmental Biology
Marie-Sophie Cate, Sangeetha Gajendra, Samantha Alsbury, Thomas Raabe, Guy Tear, Kevin J. Mitchell
Review
Biochemistry & Molecular Biology
Elena Seranova, Kyle J. Connolly, Malgorzata Zatyka, Tatiana R. Rosenstock, Timothy Barrett, Richard I. Tuxworth, Sovan Sarkar
SIGNALLING MECHANISMS IN AUTOPHAGY
(2017)
Article
Neurosciences
Alamin Mohammed, Megan B. O'Hare, Alice Warley, Guy Tear, Richard I. Tuxworth
NEUROBIOLOGY OF DISEASE
(2017)
Article
Multidisciplinary Sciences
Olivia Bibollet-Bahena, Tatsuya Okafuji, Karsten Hokamp, Guy Tear, Kevin J. Mitchell
Article
Developmental Biology
Nick Lowe, Johanna S. Rees, John Roote, Ed Ryder, Irina M. Armean, Glynnis Johnson, Emma Drummond, Helen Spriggs, Jenny Drummond, Jose P. Magbanua, Huw Naylor, Benedicte Sanson, Rebecca Bastock, Sven Huelsmann, Vitor Trovisco, Matthias Landgraf, Seymour Knowles-Barley, J. Douglas Armstrong, Helen White-Cooper, Celia Hansen, Roger G. Phillips, Kathryn S. Lilley, Steven Russell, Daniel St Johnston
Article
Biology
Giulia Povellato, Richard I. Tuxworth, Diane P. Hanger, Guy Tear
Article
Genetics & Heredity
Matthew J. Taylor, Richard Tuxworth
JOURNAL OF NEUROGENETICS
(2019)
Article
Biochemistry & Molecular Biology
Robert J. Huber, Stephanie M. Hughes, Wenfei Liu, Alan Morgan, Richard Tuxworth, Claire Russell
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Multidisciplinary Sciences
Kyle J. Connolly, Megan B. O'Hare, Alamin Mohammed, Katelyn M. Aitchison, Niki C. Anthoney, Matthew J. Taylor, Bryan A. Stewart, Richard I. Tuxworth, Guy Tear
SCIENTIFIC REPORTS
(2019)
Article
Oncology
Zubair Ahmed, Richard I. Tuxworth
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Matthew J. Taylor, Adam M. Thompson, Sharif Alhajlah, Richard Tuxworth, Zubair Ahmed
Summary: DNA double-strand breaks play a crucial role in neurological conditions, and targeting the ATM-Chk2 pathway can slow down neural decline and promote neuroprotection by inhibiting nonhomologous end-joining.
Article
Clinical Neurology
Richard Tuxworth, Matthew J. Taylor, Ane Martin Anduaga, Alaa Hussien-Ali, Sotiroula Chatzimatthaiou, Joanne Longland, Adam M. Thompson, Sharif Almutiri, Pavlos Alifragis, Charalambos P. Kyriacou, Boris Kysela, Zubair Ahmed
BRAIN COMMUNICATIONS
(2019)