Article
Oncology
Ji Hyeon You, Jaewang Lee, Jong-Lyel Roh
Summary: The study highlights that PGRMC1 promotes ferroptosis in paclitaxel-tolerant persister cancer cells (PCC) by affecting lipid metabolism and xCT inhibition. These findings reveal the mechanism of PGRMC1 in regulating ferroptosis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Cell Biology
John J. Peluso
Summary: This review discusses how PGRMC1 and PGRMC2 mediate signaling that influences ovarian follicle growth. The evidence shows that members of the PGRMC family promote follicle growth by regulating granulosa cell proliferation and viability.
Article
Medicine, General & Internal
Ying He, Xun-Hu Dong, Qiong Zhu, Ya-Li Xu, Ming-Liang Chen, Zheng Liu
Summary: This study found that UTMD can enhance the radiosensitivity of glioblastoma partially by disrupting PGRMC1-mediated autophagy.
MILITARY MEDICAL RESEARCH
(2022)
Article
Oncology
Joanna Kaminska, Olga Martyna Koper-Lenkiewicz, Donata Ponikwicka-Tyszko, Weronika Lebiedzinska, Ewelina Palak, Maria Sztachelska, Piotr Bernaczyk, Justyna Dorf, Katarzyna Guzinska-Ustymowicz, Konrad Zareba, Slawomir Wolczynski, Nafis Ahmed Rahman, Violetta Dymicka-Piekarska
Summary: PGRMC1/NENF complex may play a role in stimulating the proliferation and invasion of colorectal cancer cells. Targeting this complex could lead to potential therapeutic strategies for patients with advanced colorectal cancer.
Article
Endocrinology & Metabolism
Stefania Salsano, Roberto Gonzalez-Martin, Alicia Quinonero, Silvia Perez-Deben, Francisco Dominguez
Summary: This study found that PGRMC1 inhibition during decidualization in endometrial stromal cells does not interfere with cytoskeletal rearrangements and prolactin secretion, but does affect the expression of genes related to metabolism, transport, and hormonal biosynthesis. Additionally, activation of membrane progesterone receptor signaling alone is insufficient to induce proper decidualization.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Atsuya Tsuru, Mikihiro Yoshie, Ryota Negishi, Toko Mukoyama, Ryo Yonekawa, Junya Kojima, Mana Azumi, Kazuya Kusama, Hirotaka Nishi, Kazuhiro Tamura
Summary: The downregulation of PGRMC1 is associated with cellular senescence and the differentiation of endometrial cells. The study reveals the role of PGRMC1 in COX2 expression, further promoting cellular differentiation and maturation.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2023)
Review
Cell & Tissue Engineering
Yun-Xing Fu, Jing Ji, Fang Shan, Jialing Li, Rong Hu
Summary: Premature ovarian failure (POF) is a common disorder in women leading to female infertility. This study investigates the types of MSCs available for POF therapy, their biological characteristics, and mechanisms of action, providing a theoretical basis for further research and clinical treatment of POF.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Endocrinology & Metabolism
Jingyi Wen, Yanzhi Feng, Wei Yan, Suzhen Yuan, Jinjin Zhang, Aiyue Luo, Shixuan Wang
Summary: This study reveals the characteristics of vaginal microbiota in POI patients and their relationship with reduced ovarian reserve, endocrine disruption, and symptoms of perimenopausal syndrome. Differences in vaginal microbiota between POI and POF patients are also identified.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Reproductive Biology
Violetta Lozovyy, Lauren Richardson, George Saade, Ramkumar Menon
Summary: The study reveals that progesterone interacts with PGRMCs to maintain fetal membrane integrity, while oxidative stress decreases endogenous progesterone production and reduces PGRMC expression. These changes may lead to fetal membrane-specific functional progesterone withdrawal.
BIOLOGY OF REPRODUCTION
(2021)
Article
Immunology
Xiaoyan Li, Haifeng Ye, Tie Su, Chuan Hu, Yaoqi Huang, Xinxin Fu, Zhisheng Zhong, Xuelian Du, Yuehui Zheng
Summary: Premature ovarian failure (POF) is a leading cause of infertility in women, with no effective treatment currently available. Research suggests that immune disorders and Chitosan Oligosaccharides (COS) may play important roles in the development and treatment of POF.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Francesca Serena Abatematteo, Maria Majellaro, Bianca Montsch, Ruben Prieto-Diaz, Mauro Niso, Marialessandra Contino, Angela Stefanachi, Chiara Riganti, Giuseppe Felice Mangiatordi, Pietro Delre, Petra Heffeter, Eddy Sotelo, Carmen Abate
Summary: Sigma receptor subtypes, sigma 1 and sigma 2, are potential targets for cancer and Alzheimer's disease therapy. Novel specific fluorescent ligands have been developed, including compounds 19 (sigma pan affinity) and 29 (sigma 2 selective), which show specificity for sigma 2 receptors and can be used as powerful tools for studying these receptors.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Endocrinology & Metabolism
Congcong Guo, Yubo Ma, Yanqiu Situ, Li Liu, Guoqun Luo, Huan Li, Wenmin Ma, Li Sun, Wen Wang, Qiuying Weng, Linlin Wu, Dazhi Fan
Summary: This study conducted a systematic review and meta-analysis and found that the transplantation of mesenchymal stem cells (MSCs) may have therapeutic effects on animal models of premature ovarian failure (POF), potentially by improving sexual cycle disorder, modulating serum hormone expressions, and restoring ovarian function.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Integrative & Complementary Medicine
Li Jia, Chen Yu-Hang, Xu Jia-Yu, Liu Jiang-Ying, Fu Jia-Cheng, Cao Xiu-Ping, Huang Jian, Zheng Yue-Hui
Summary: The study shows that COS·Zn has a protective effect against POF and can improve ovarian and follicular development. By modulating signaling pathways such as SESN2/NRF2, it can reduce oxidative stress levels and enhance antioxidant capacity.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Reproductive Biology
Xiaodan Lv, Chunyi Guan, Ying Li, Xing Su, Lu Zhang, Xueqin Wang, Hong-Fei Xia, Xu Ma
Summary: This study investigated the efficacy of human umbilical cord blood mesenchymal stem cells (hUC-MSCs) in treating chemotherapy-induced premature ovarian failure (POF). The results demonstrated that multiple injections of hUC-MSCs were more effective in restoring ovarian function compared to single injections.
JOURNAL OF OVARIAN RESEARCH
(2021)
Review
Immunology
Yanjing Huang, Mengdi Zhu, Zhuo Liu, Runan Hu, Fan Li, Yufan Song, Yuli Geng, Wenwen Ma, Kunkun Song, Mingmin Zhang
Summary: Premature ovarian failure is a common female reproductive disorder characterized by early menopause, increased gonadotropin levels, and estrogen deficiency. The use of bone marrow mesenchymal stem cells may offer potential for restoring ovarian function and fertility in POF patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Loora Laan, Joakim Klar, Maria Sobol, Jan Hoeber, Mansoureh Shahsavani, Malin Kele, Ambrin Fatima, Muhammad Zakaria, Goran Anneren, Anna Falk, Jens Schuster, Niklas Dahl
CLINICAL EPIGENETICS
(2020)
Article
Immunology
Jitendra Badhai, Gaurav Kumar Pandey, Ji-Ying Song, Oscar Krijgsman, Rajith Bhaskaran, Gayathri Chandrasekaran, Min-chul Kwon, Lorenzo Bombardelli, Kim Monkhorst, Cristoforo Grasso, John Zevenhoven, Jan van der Vliet, Miranda Cozijnsen, Paul Krimpenfort, Daniel Peeper, Maarten van Lohuizen, Anton Berns
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Cell & Tissue Engineering
Ambrin Fatima, Jens Schuster, Talia Akram, Carolina Maya Gonzalez, Maria Sobol, Jan Hoeber, Niklas Dahl
STEM CELL RESEARCH
(2020)
Article
Cell & Tissue Engineering
Ambrin Fatima, Jens Schuster, Talia Akram, Maria Sobol, Jan Hoeber, Niklas Dahl
STEM CELL RESEARCH
(2020)
Article
Hematology
Talia Akram, Ambrin Fatima, Joakim Klar, Jan Hoeber, Muhammad Zakaria, Muhammad Tariq, Shahid M. Baig, Jens Schuster, Niklas Dahl
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2020)
Article
Cell & Tissue Engineering
Jens Schuster, Jan Hoeber, Maria Sobol, Ambrin Fatima, Goran Anneren, Niklas Dahl
STEM CELL RESEARCH
(2020)
Article
Cell & Tissue Engineering
Svitlana Vasylovska, Jens Schuster, Anja Brboric, Per-Ola Carlsson, Niklas Dahl, Joey Lau
Summary: Two high-quality human iPSC lines were generated from dermal fibroblasts of two healthy females using Sendai virus reprogramming, showing expression of pluripotency markers, trilineage differentiation capacity, and absence of exogenous expression of reprogramming factors. Both iPSC lines were genetically stable with a genotype that matched the fibroblast lines of donors, serving as a resource for disease modeling of polygenic and multifactorial diseases, evaluation of differentiation protocols, and toxicology screening.
STEM CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Elisa Mentegari, Federica Bertoletti, Miroslava Kissova, Elisa Zucca, Silvia Galli, Giulia Tagliavini, Anna Garbelli, Antonio Maffia, Silvia Bione, Elena Ferrari, Fabrizio d'Adda di Fagagna, Sofia Francia, Simone Sabbioneda, Liuh-Yow Chen, Joachim Lingner, Valerie Bergoglio, Jean-Sebastien Hoffmann, Ulrich Hubscher, Emmanuele Crespan, Giovanni Maga
Summary: This study reveals that silencing human DNA polymerase (Pol lambda) in ALT cells represses ALT activity and induces telomeric stress, while replication stress in the absence of Pol lambda strongly affects the survival of ALT cells. Additionally, Pol lambda can promote annealing of telomeric repeats and is regulated by TERRA and replication protein A, with the POT1/TPP1 heterodimer stimulating Pol lambda activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Anita Lombardi, Lavinia Arseni, Roberta Carriero, Emmanuel Compe, Elena Botta, Debora Ferri, Martina Ugge, Giuseppe Biamonti, Fiorenzo A. Peverali, Silvia Bione, Donata Orioli
Summary: PS-TTD and XP are rare monogenic disorders caused by mutations in the ERCC2/XPD or ERCC3/XPB genes, with XPD and XPB proteins playing key roles in the TFIIH complex. Mutations affecting TFIIH DNA repair activity are responsible for XP, while those impacting transcription result in TTD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Bruno Silva, Rajika Arora, Silvia Bione, Claus M. Azzalin
Summary: TERRA transcription actively destabilizes telomere integrity in ALT cells, thereby triggering BIR and promoting telomere elongation.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Johan Reimegard, Marcel Tarbier, Marcus Danielsson, Jens Schuster, Sathishkumar Baskaran, Styliani Panagiotou, Niklas Dahl, Marc R. Friedlander, Caroline J. Gallant
Summary: The SPARC method combines single-cell RNA sequencing with proximity extension assays to measure global mRNA and 89 intracellular proteins simultaneously in individual cells. Results show that mRNA expression does not accurately reflect protein abundance, with protein levels of transcription factors better predicting downstream effects. Overall, protein expression variation is lower than mRNA variation in single cells, but relative protein variation does not correlate with mRNA level.
COMMUNICATIONS BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Jens Schuster, Claudia de Guidi, Ambrin Fatima, Maria Sobol, Niklas Dahl
Summary: Heterozygous variants in the POLR2A gene can cause severe neurodevelopmental abnormalities in humans. The edited iPSC line KICRi002A-5 provides a valuable resource for studying developmental defects caused by RBP1 insufficiency.
STEM CELL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Volker Seiss, Uta Helbig, Ralf Loesel, Maik Eichelbaum
Summary: The study found that the interfacial charge transport parameters close to the open circuit potential (OCP) can indeed be used as descriptors for predicting and understanding the photocatalytic activity of TiO2 coatings. Experimental results showed that measuring the extracted photoelectrochemical parameters near OCP is the best way to correlate the respective photoactivities of amorphous and crystalline TiO2 nanolayers for prediction.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Jens Schuster, Joakim Klar, Ayda Khalfallah, Loora Laan, Jan Hoeber, Ambrin Fatima, Velin Marita Sequeira, Zhe Jin, Sergiy V. Korol, Mikael Huss, Ann Nordgren, Britt Marie Anderlid, Caroline Gallant, Bryndis Birnir, Niklas Dahl
Summary: This study investigates the dysregulated gene network and altered electrophysiological properties in ZEB2 haploinsufficient GABAergic development, providing insights into the neuropathogenesis and seizures in MWS.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Anna Di Matteo, Elisa Belloni, Davide Pradella, Anna Maria Chiaravalli, Giacomo Maria Pini, Mattia Bugatti, Roberta Alfieri, Chiara Barzan, Elena Franganillo Tena, Silvia Bione, Elisa Terenzani, Fausto Sessa, Christopher D. R. Wyatt, William Vermi, Claudia Ghigna
Summary: Angiogenesis is crucial for cancer progression, but current anti-angiogenic drugs have limited clinical benefits. This study provides a deeper understanding of the mechanisms regulating tumor vessel growth and identifies NOVA2 as a critical regulator of angiogenesis and vascular development. Moreover, the upregulation of NOVA2 in gastric cancer endothelial cells is associated with poor patient outcome, suggesting its potential as a biomarker and therapeutic target for anti-angiogenic treatment of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)