Article
Medical Laboratory Technology
Qin Yuanyuan, Huang Yunhua, Chen Qingyun, Gan Min, Zhai Lujie, Wang Peng, Faquan Lin
Summary: This study evaluated the prevalence of hyperuricemia in a routine physical examination in Nanning, Guangxi Province and analyzed its influencing factors. The results showed a high prevalence of hyperuricemia in this region, with significant correlations with factors such as gender, waist circumference, BMI, alcohol consumption, hypertension, high education level, total cholesterol, triglycerides, LDL-C, BUN, and creatinine. Waist circumference, BMI, BUN, and creatinine were identified as independent risk factors for hyperuricemia.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Clinical Neurology
Shuqiong Zheng, Jia Guo, Qianqian Xin, Hanga Galfalvy, Youran Ye, Na Yan, Rongrong Qian, J. John Mann, Enze Li, Xiang Xue, Honglei Yin
Summary: This study investigated the association of EPHX2 and P2X2 polymorphisms and mRNA expression with depression and suicidal behavior, as well as the mediating role of cognition in these associations. The results showed that cognitive function played a significant mediator role in the genetic effect on depression. The rs202059124 C allele was associated with increased depression risk, and P2X2 mRNA expression was related to depression. Furthermore, a haploblock (rs9331942 and rs2279590) was associated with suicide attempts. These findings suggest that EPHX2 and P2X2 genes are implicated in depression and suicidal behavior.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Cell Biology
Jiro Miyamae, Masaharu Okano, Fumihiko Katakura, Jerzy K. Kulski, Tadaaki Moritomo, Takashi Shiina
Summary: Polymorphisms and genetic diversity of DLA-88, DLA-12/88L, and DLA-DRB1 loci were examined in 829 dogs of 59 breeds in Japan. Multiple alleles and various 88-12/88L-DRB1 haplotypes were detected. The findings suggest that high DLA homozygosity rate and low DLA diversity within a breed are beneficial for transplantation therapy but may affect biological fitness as homozygosity progresses.
Article
Multidisciplinary Sciences
Yan Zhu, Jinlan Rao, Jingsi Wei, Liu Liu, Shanshan Huang, Jingjing Lan, Chao Xue, Wei Li
Summary: This study examined the association of single-nucleotide polymorphisms (SNPs) in the ULK1 and PIK3CA genes with the risk of microscopic polyangiitis (MPA). Results showed that ULK1 and PIK3CA polymorphisms were significantly associated with MPA risk in the Guangxi population, with the association being influenced by age, sex, and ethnicity. Further research with larger sample sizes is needed to confirm these findings and explore underlying mechanisms.
Article
Medicine, General & Internal
Antonia Msafiri Makene, Jun-Lin Liu
Summary: This study identified multiple polymorphic loci in the CARD14 gene associated with susceptibility to psoriasis and confirmed the significant correlation of several loci with the development of psoriasis. Bioinformatic analysis further demonstrated the impact of these loci on gene function and identified two protective haplotypes for the disease.
Article
Nutrition & Dietetics
Yu Wang, Meizhi Du, Jillian Vallis, Matin Shariati, Patrick S. Parfrey, John R. Mclaughlin, Peizhong Peter Wang, Yun Zhu
Summary: Polymorphic variants in MTRR and MTHFR genes may be associated with survival in patients with CRC, and this gene-CRC outcome association seems to be modulated by alcohol drinking and fruit intake.
Article
Medicine, General & Internal
Rui-zhi Zeng, Xiao-dan Lv, Geng-feng Liu, Guang-li Gu, Shi-quan Li, Lan Chen, Jun-hua Fan, Zhao-liang Liang, Hui-qin Wang, Fei Ling, Ling-ling Zhan, Xiao-ping Lv
Summary: The study revealed a significant correlation between MYO9B gene site rs962917 and the incidence of Crohn's disease in the Guangxi Zhuang population, with differences in genotype frequency between the Zhuang and Han ethnic groups.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Ecology
Ping Fan, Jon Fjeldsa, Xuan Liu, Yafei Dong, Yongbin Chang, Yanhua Qu, Gang Song, Fumin Lei
Summary: Genetic diversity is crucial for biodiversity, and traditional methods for calculating genetic diversity rely on sequences of equal length, presenting challenges when dealing with sequences of unequal lengths. A new approach independent of sequence length has been developed to estimate haplotype diversity, showing robust performance in both simulation and real data sets.
METHODS IN ECOLOGY AND EVOLUTION
(2021)
Article
Genetics & Heredity
Fei Wang, Feng Song, Mengyuan Song, Haibo Luo, Yiping Hou
Summary: This study investigated the paternal genetic structure and affinities of the Zhuang population in China using genetic analyses. The results revealed a shared ancestry between the Zhuang and the Hainan Han, as well as genetic connections with other Chinese ethnic groups and Southeast Asians. The findings provide valuable insights into the genetic history of the Zhuang people.
FORENSIC SCIENCE INTERNATIONAL-GENETICS
(2022)
Article
Business, Finance
Xiaoqi Chen, Wouter Torsin, Dayong Zhang
Summary: This paper examines whether foreign CEOs from Anglo-Saxon countries receive higher compensation than other foreign CEOs. The findings reveal a positive association between Anglo-Saxon nationality and CEO compensation, limited to firms in non-culturally and non-ethnically diverse countries. This suggests that firms reward CEOs more for their fit within the company culture.
FINANCE RESEARCH LETTERS
(2022)
Article
Agronomy
B. M. Lokeshkumar, S. L. Krishnamurthy, Suman Rathor, Arvinder Singh Warriach, N. M. Vinaykumar, B. M. Dushyanthakumar, Parbodh Chander Sharma
Summary: This study evaluated the performance of 145 rice genotypes under saline stress conditions and identified three tolerant landraces and 14 moderately tolerant breeding lines. These findings have the potential to expand the genetic basis of salinity tolerance in rice and help identify key genomic regions responsible for this trait.
Article
Biochemistry & Molecular Biology
Concetta Cafiero, Cristina Grippaudo, Marco Dell'Aquila, Pasquale Cimmino, Antonio D'Addona, Paolo De Angelis, Maria Pia Ottaiano, Domenico Costagliola, Giulio Benincasa, Alessandra Micera, Luigi Santacroce, Raffaele Palmirotta
Summary: The study found that VDR gene polymorphisms, specifically BsmI and TaqI, are associated with periodontal disease susceptibility. Additionally, the FokI and BsmI polymorphisms may be involved in determining the quantity of periodontopathogenic oral bacteria.
Article
Agronomy
Vinay Bhatt, Vignesh Muthusamy, Rashmi Chhabra, Ashvinkumar Katral, Shridhar Ragi, Vinay Rojaria, Gulab Chand, Govinda Rai Sarma, Rajkumar Uttamrao Zunjare, Kusuma Kumari Panda, Ashok Kumar Singh, Firoz Hossain
Summary: Maize is an important crop that provides food, feed, fodder, and industrial uses, as well as valuable micronutrients. The Lpa1 gene in maize has been identified to have high variability, with 607 polymorphic sites detected. Functional motifs of Lpa1 involved in efficient utilization of key minerals were also discovered. This study provides important insights for enhancing nutritional value in maize kernels using the lpa1 mutant.
Article
Biochemistry & Molecular Biology
Fan Zhang, Chunchao Wang, Min Li, Yanru Cui, Yingyao Shi, Zhichao Wu, Zhiqiang Hu, Wensheng Wang, Jianlong Xu, Zhikang Li
Summary: This study characterized the gene-coding sequence-haplotype (gcHap) diversity of 45,963 rice genes in 3010 rice accessions, revealing three main categories of rice genes and a large number of potentially functional important gcHaps. The inferred proto-ancestors of local landrace populations correlated with wild rice accessions, supporting a multiorigin model of Oryza sativa. Breeding efforts have increased gcHap diversity in modern varieties and caused frequency shifts in predominant gcHaps, highlighting the potential for rice improvement through favorable gcHaps mining.
Article
Multidisciplinary Sciences
Yingli Fu, Xiaojun Ren, Wei Bai, Qiong Yu, Yaoyao Sun, Yaqin Yu, Na Zhou
Summary: This study identified a potential association between CMIP gene variant and schizophrenia risk in the female Han Chinese population, with rs287112 allele frequency showing significant difference in patients compared to healthy controls. The haplotype TTGT of rs12925980-rs2287112-rs3751859-rs77700579 was associated with lower risk of schizophrenia, although not surviving false discovery rate correction.
Article
Psychology, Multidisciplinary
WenWu Wang, Ping Yu, Yuejin Zhou, Tiejun Tong, Zhonghua Liu
Summary: In this paper, the authors focused on the mediation test based on the indirect effect in social and behavioral sciences. They examined the difference method and the product method in mediation models and demonstrated their equivalence in various scenarios. The authors also provided insights on the empirical distributions of indirect effect estimators and introduced popular R packages for mediation analysis.
CURRENT PSYCHOLOGY
(2023)
Article
Immunology
Xiaofang Lu, Yong Wang, Ying Ma, Dong Huang, Yuying Lu, Xiang Liu, Ruijia Zhou, Ping Yu, Lei Zhang, Jianlin Chen, Rong Lu, Fuyan Wang
Summary: This study reveals the involvement of MDSCs in the immune escape mechanism of C. trachomatis mediated by YAP1. The proportion of MDSCs increases, while the proportion of CD4+T and CD8+T cells decreases after C. trachomatis infection. The upregulation of Arg-1 and iNOS in MDSCs, as well as YAP1 in host cells, is observed. Inhibition of YAP1 leads to the inhibition of C. trachomatis growth.
IMMUNOLOGY LETTERS
(2022)
Article
Engineering, Multidisciplinary
Jie Cao, Jialin Ma, Dailin Huang, Ping Yu
Summary: In this paper, a neural architecture search network algorithm called NAS-PERIRB is proposed to simplify the design of deep learning network structures, with the use of Pareto efficiency reward and insert replay buffer. The algorithm improves training efficiency by employing early stopping and insert replay buffer techniques. Evaluation on two datasets demonstrates that the NAS-PERIRB achieves 99% accuracy in various situations, indicating its capability in independently designing network structures.
Article
Geriatrics & Gerontology
Jiaying Zheng, Ping Yu, Xueping Chen
Summary: Active game play can significantly improve the quality of life and alleviate depression in older people with dementia, but has no significant effect on cognitive status.
CLINICAL GERONTOLOGIST
(2022)
Article
Geriatrics & Gerontology
Yunshu Zhu, Ting Song, Zhenyu Zhang, Chao Deng, Mohammad Alkhalaf, Wanqing Li, Mengyang Yin, Hui Chen (Rita) Chang, Ping Yu
Summary: This study used artificial intelligence technologies to analyze the prevalence of agitated behaviors in people with dementia in residential aged care facilities in Australia. A total of 59 observable agitated behaviors were found. No significant differences were found in agitation prevalence between genders or facility types. Multiple coexisting agitated behaviors were found in a high percentage of dementia patients, indicating a heavy caregiver burden in these facilities. Improving caregiver training and care models are urgently needed for the sustainability of dementia care in residential aged care facilities.
JOURNAL OF GERONTOLOGICAL NURSING
(2022)
Article
Integrative & Complementary Medicine
Yuangeng Li, Ping Yu, Wenwen Fu, Shuo Wang, Wenjun Zhao, Yue Ma, Yi Wu, Heming Cui, Xiaofeng Yu, Li Fu, Huali Xu, Dayun Sui
Summary: Ginsenoside Rd protects against carbon tetrachloride-induced acute liver injury by inhibiting ferroptosis and activating the cGAS/STING pathway.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Management
Haiyan Yu, Ching-Chi Yang, Ping Yu
Summary: Diabetic patients require personalized treatments, and stratifying patients into sub-classes can help determine the optimal treatment for each group. However, challenges arise in conducting counterfactual inference and dealing with confounding effects of covariates. To address these challenges, a method called COSTAR is proposed, which uses constrained optimization to find the optimal treatment considering missing outcomes and covariate balance constraints. Experimental results with real-world data show that COSTAR outperforms related methods in reducing hospital readmission rates within 30 days and provides robust estimation of mean treatment response in each sub-class.
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2023)
Article
Psychology, Multidisciplinary
Yiqin Hu, Xinbo Lu, Wanjun Zheng, Luting Wang, Ping Yu
Summary: In daily decision-making, the human brain is modulated by the prefrontal cortex (PFC), particularly the dorsolateral prefrontal cortex (DLPFC), in risk and ambiguity decision-making. Through the use of transcranial direct current stimulation (tDCS), researchers revealed the causal relationship between the DLPFC and ambiguity decision-making. The study showed that the left DLPFC stimulation had a significant effect on ambiguity to loss, while its effect on ambiguity to gain was insignificant, and the right DLPFC stimulation had an insignificant effect on both ambiguity to gain and ambiguity to loss. Furthermore, participants who received anodal stimulation in the left DLPFC showed a lower degree of attitudes toward ambiguity loss, suggesting a strong aversion to ambiguity loss after the stimulation.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Psychology, Multidisciplinary
Yue Xie, Yue Ren, Changmin Niu, Ying Zheng, Ping Yu, Lin Li
Summary: Approximately 53.08% to 64% of female infertility patients worldwide are affected by the stigma of not giving birth to children. This stigma not only harms the mental health of these patients, but also affects their quality of life, leading to adverse social consequences such as domestic violence, marriage breakdown, and delay in receiving treatment. Therefore, it is crucial to understand the stigma experienced by these patients and develop effective interventions to alleviate it.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Engineering, Mechanical
Xianjun Du, Wenchao Jia, Ping Yu, Yaoke Shi, Bin Gong
Summary: In order to address the issues of insufficient feature extraction and loss of key features in the process of traditional convolutional neural network (CNN) based remaining life prediction of bearings, a CNN prediction model based on global attention mechanism (GAM) is proposed to accurately predict the remaining useful life (RUL) of bearings.
JOURNAL OF THE BRAZILIAN SOCIETY OF MECHANICAL SCIENCES AND ENGINEERING
(2023)
Article
Plant Sciences
Eme Eseme John, Thomas Astell-Burt, Ping Yu, Chris Brennan-Horley, Xiaoqi Feng
Summary: This study investigates the association between different types of green spaces and a person's healthy aging score (HAS) through two years of continuous exposure. The findings suggest that for women who did not relocate, their functional capacity is lower but resilience is higher compared to those who relocated. For participants who did not relocate, 30% grass cover is associated with decreased functional capacity and HAS, while 5-9% low-lying vegetation is associated with a decline in functional capacity and HAS but improved resilience. Green spaces with over 30% tree canopy appear to be most beneficial for functional capacity, resilience, and HAS.
URBAN FORESTRY & URBAN GREENING
(2023)
Article
Health Care Sciences & Services
Mohammad Alkhalaf, Zhenyu Zhang, Hui-Chen (Rita) Chang, Wenxi Wei, Mengyang Yin, Chao Deng, Ping Yu
Summary: This study explores the risk factors for malnutrition among older people in residential aged care facilities using natural language processing (NLP) techniques. The research demonstrates the importance of NLP technology in uncovering key information about health risks for older people. It identifies that 33% of older people suffer from malnutrition and suggests that NLP can be applied to predict other health risks in this setting.
TECHNOLOGY AND HEALTH CARE
(2023)
Article
Emergency Medicine
Belinda Munroe, Kate Curtis, Margaret Fry, Sharyn Balzer, Panchalee Perara, Tracey Couttie, Karlie Royston, Ping Yu, Natasha Tidswell, Julie Considine
Summary: This study aims to evaluate the impact of implementing the Emergency Department Clinical Emergency Response System (EDCERS) on inpatient deterioration events and identify causal factors. The results demonstrate that EDCERS implementation reduces the number of inpatient deterioration events within 72 hours of emergency admission. However, there is no overall change in the rate of inpatient deterioration events. Therefore, this study supports the wider implementation of rapid response systems in the emergency department to improve the management and outcomes of deteriorating patients.
AUSTRALASIAN EMERGENCY CARE
(2023)
Article
Health Policy & Services
Eme Eseme John, Thomas Astell-Burt, Ping Yu, Chris Brennan-Horley, Xiaoqi Feng
Summary: This paper examines the factors influencing healthy ageing and constructs a healthy ageing score. Eight of the 13 health domains, including physical functioning, cognitive function, mental health, etc., were found to be crucial for ageing well. The developed healthy ageing score ranges from 0 to 16, with higher scores indicating a healthier ageing profile.
HEALTH PROMOTION INTERNATIONAL
(2023)
Review
Health Care Sciences & Services
Ping Yu, Hua Xu, Xia Hu, Chao Deng
Summary: Generative artificial intelligence and large language models have the potential to revolutionize data and information management in healthcare. This study provides guidance on integrating these technologies into medical practices, highlighting their distinct mechanisms and the opportunities and challenges they present. Continued innovation and adherence to ethical and legal guidelines are crucial for realizing the full potential of these technologies.