期刊
HUMAN IMMUNOLOGY
卷 71, 期 10, 页码 988-991出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2010.06.020
关键词
VKH syndrome; Behcet's disease; Association; Polymorphism; IL-17
类别
资金
- Natural Science Foundation [30630064]
- National Supporting Project of P. R. China [2007BAI18B10]
- Natural Science Foundation Major International (Regional) Joint Research Project [30910103912]
- National Natural Science Foundation Project [30973242]
- Program for the Training of a Hundred Outstanding S&T Leaders of Chongqing Municipality
- Key Project of Health Bureau of Chongqing [2008-1-15]
- Project of Medical Science and Technology of Chongqing [2008/1/15]
- Key Project of Natural Science Foundation of Chongqing (CSTC) [2009BA5037]
- Chongqing Key Laboratory of Ophthalmology (CSTC) [2008CA5003]
Interleukin (IL)-17 has been shown to play an important role in certain autoimmune diseases. The present study was performed to investigate the association of IL-17A and IL-17F gene polymorphisms with two autoimmune uveitis entities, Vogt-Koyanagi-Harada (VKH) syndrome and Behcet's disease (BD), in a Chinese Han population. A total of 362 BD patients, 385 VKH syndrome patients, and 412 controls were genotyped for IL-17A/rs2275913 and IL-17F/rs763780 using polymerase chain reaction-restricted fragment length polymorphism. The result showed that the genotype and allele distribution of the two single nucleotide polymorphisms (SNPs) in all subjects were in Hardy-Weinberg equilibrium. A significantly decreased frequency of IL-17F/rs763780 C allele (p = 0.006, p(c) = 0.036) and an increased frequency of TT genotype (p = 0.005, p(c) = 0.030) were observed in VKH patients compared with normal controls. There was no association of the tested two SNPs with BD, even after adjusting gender ratio. Stratification analysis failed to find any association of extraocular manifestations of two uveitis entities and the tested two SNPs. The C allele and TT genotype of rs763780 in the IL-17F gene appear to be associated with protection and susceptibility to VKH syndrome. The tested two IL-17 SNPs are not found to be associated with Behcet's disease. Crown copyright (C) 2010 Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics. All rights reserved.
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