Article
Immunology
Xianzhang Luo, Ji Zhang, Sijuan Zou, Xinqiang Wang, Gen Chen, Zhen Li, Kaiyan Li, Mengqing Wang, Zhishui Chen, Changshen Ming, Xiaohua Zhu, Nianqiao Gong
Summary: The combination of bone fragment co-transplantation and bone marrow aspirate infusion (BF-BM) in living kidney transplantation (LKT) was found to benefit recipients by improving kidney recovery and regulating the immune response. The study showed that BF-BM had positive effects on kidney function and immune regulation over a 5-year follow-up period.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Rainer Oberbauer, Matthias Edinger, Gabriela Berlakovich, Peter Kalhs, Nina Worel, Georg Heinze, Michael Wolzt, Thomas Lion, Thomas Wekerle
Summary: This study aims to investigate whether treatment with recipient Tregs and donor BM can lead to transient chimerism in kidney transplant recipients, potentially offering a new therapeutic option for immunomodulation in organ transplantation.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Elisabet Van Loon, Baptiste Lamarthee, Thomas Barba, Sandra Claes, Maarten Coemans, Henriette de Loor, Marie-Paule Emonds, Priyanka Koshy, Dirk Kuypers, Paul Proost, Aleksandar Senev, Ben Sprangers, Claire Tinel, Olivier Thaunat, Amaryllis H. Van Craenenbroeck, Dominique Schols, Maarten Naesens
Summary: Through multiplex assay, we found that kidney transplant patients with donor-specific anti-human leukocyte antigen antibodies and histological rejection have increased levels of pro-inflammatory cytokines in blood. Even in patients without histological rejection, elevated pro-inflammatory cytokine levels can be observed. These findings challenge the concept of histology as the gold standard for identifying ongoing allo-immune activation after transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Wensheng Zhang, Yong Wang, Fushun Zhong, Xinghuan Wang, Robert Sucher, Cheng-Hung Lin, Gerald Brandacher, Mario G. G. Solari, Vijay S. S. Gorantla, Xin Xiao Zheng
Summary: In this study, using rodent vascularized composite allotransplantation (VCA) models, it was demonstrated that the presence of donor-derived hematopoietic stem cell (HSC) niches in vascularized bone components facilitates long-term hematopoietic chimerism and promotes tolerance in recipients without harsh myeloablation. The transplanted donor HSC niches also contribute to the maintenance and homeostasis of stable mixed chimerism. Additionally, evidence was provided that chimeric thymus plays a role in the tolerance induced by mixed chimerism through thymic central deletion. This study suggests the potential use of vascularized donor bone with pre-engrafted HSC niches as a safe and effective strategy to induce robust and stable mixed chimerism-mediated tolerance in vascularized composite allotransplantation or solid organ transplantation recipients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biophysics
Gaurav Kharya, Atish Bakane, Shirali Agarwal, Archana Rauthan
Summary: The T-cell-replete haploidentical transplant with PTIS, augmented John Hopkins conditioning and plerixafor-based mobilization is a safe and effective way of treating patients suffering from SCD, with minimal or no risk of graft failure and acceptable GvHD rates.
BONE MARROW TRANSPLANTATION
(2021)
Article
Immunology
Olivier de Rougemont, Yun Deng, Lukas Frischknecht, Caroline Wehmeier, Jean Villard, Sylvie Ferrari-Lacraz, Dela Golshayan, Monique Gannage, Isabelle Binet, Urs Wirthmueller, Daniel Sidler, Thomas Schachtner, Stefan Schaub, Jakob Nilsson
Summary: The type of donation may affect how susceptible a donor kidney is to injury from pre-existing alloimmunity. However, there are no large studies comparing the impact of pre-transplant donor specific antibody (DSA) stratified on donation type in a cohort with long-term follow-up. This study compared the effect of pre-transplant DSA on rejection risk, graft loss, and eGFR decline in DBD, DCD, and LD transplants.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Cheng-Hung Lin, Madonna Rica Anggelia, Hui-Yun Cheng, Yun-Huan Hsieh, Wen-Yu Chuang, Huang-Yu Yang, Chih-Hung Lin
Summary: This study demonstrated that VBM transplantation is an efficient strategy to induce and maintain donor-specific tolerance for an osseous-free allograft.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell & Tissue Engineering
David Brett Erasmus, Nisha Durand, Francisco A. Alvarez, Tathagat Narula, David O. Hodge, Abba C. Zubair
Summary: This study demonstrates the therapeutic effects of intravenous infusion of low-dose bone marrow-derived MSCs in lung transplant patients. The results show that this treatment can slow the progression of chronic lung allograft syndrome in some patients and stabilize lung function decline.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Lukas Frischknecht, Yun Deng, Caroline Wehmeier, Olivier de Rougemont, Jean Villard, Sylvie Ferrari-Lacraz, Dela Golshayan, Monique Gannage, Isabelle Binet, Urs Wirthmueller, Daniel Sidler, Thomas Schachtner, Stefan Schaub, Jakob Nilsson
Summary: This study investigates the impact of pre-transplant donor specific antibodies (DSA) on kidney transplantation outcomes. The results show that DSA is associated with increased risk of antibody-mediated rejection, graft loss, and accelerated decline in eGFR. The target HLA antigen and mean fluorescence intensity (MFI) of DSA play significant roles in the outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Constantin Aschauer, Kira Jelencsics, Karin Hu, Mariella Gregorich, Roman Reindl-Schwaighofer, Sabine Wenda, Thomas Wekerle, Andreas Heinzel, Rainer Oberbauer
Summary: Longitudinal monitoring of kidney transplant recipients receiving different induction therapies showed increased donor-reactive T-cell repertoire in both ATLG and basiliximab groups, with no significant differences in overall TCR repertoire diversity and turnover.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Pallavi Mehta, Stalin Ramprakash, C. P. Raghuram, Deepa Trivedi, Rakesh Dhanya, Rajat Kumar Agarwal, Lawrence Faulkner
Summary: ABO incompatibility does not prevent allogeneic stem cell transplant, but may lead to acute hemolytic reactions. Administering donor-type red cell infusion can reduce the risk of hemolytic reactions and prevent adverse effects during major ABO-mismatched bone marrow transplants. This study showed that this method is safe and effective in preventing acute hemolysis in such transplants.
ANNALS OF HEMATOLOGY
(2021)
Article
Immunology
Matthias Schaier, Christian Morath, Lei Wang, Christian Kleist, Gerhard Opelz, Thuong Hien Tran, Sabine Scherer, Lien Pham, Naruemol Ekpoom, Caner Suesal, Gerald Ponath, Florian Kaelble, Claudius Speer, Louise Benning, Christian Nusshag, Christoph F. Mahler, Luiza Pego da Silva, Claudia Sommerer, Angela Hueckelhoven-Krauss, David Czock, Arianeb Mehrabi, Constantin Schwab, Ruediger Waldherr, Paul Schnitzler, Uta Merle, Vedat Schwenger, Markus Krautter, Stephan Kemmner, Michael Fischereder, Manfred Stangl, Ingeborg A. Hauser, Anna-Isabelle Kaelsch, Bernhard K. Kraemer, Georg A. Boehmig, Carsten Mueller-Tidow, Jochen Reiser, Martin Zeier, Michael Schmitt, Peter Terness, Anita Schmitt, Volker Daniel
Summary: Administration of modified immune cells (MIC) before kidney transplantation led to improved clinical outcomes, including stable kidney graft function, absence of donor-specific human leukocyte antigen antibodies (DSA) or acute rejections, and reduced opportunistic infections compared to standard immunosuppressive therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Aleksandar Senev, Elisabet Van Loon, Evelyne Lerut, Jasper Callemeyn, Maarten Coemans, Vicky Van Sandt, Dirk Kuypers, Marie-Paule Emonds, Maarten Naesens
Summary: Transplant glomerulopathy can occur independently of HLA-DSA, with less inflammation and better graft survival compared to cases with HLA-DSA. The presence of HLA-DSA was identified as a risk factor for glomerulopathy development, and HLA-DSA negative cases had a lower risk of graft failure compared to HLA-DSA positive cases. Landmark analysis showed that HLA-DSA negative patients with glomerulopathy still had a significant increased risk of graft failure, indicating the importance of monitoring and managing transplant glomerulopathy even in the absence of HLA-DSA.
KIDNEY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Daniel E. Maidana, Lucia Gonzalez-Buendia, Joan W. Miller, Demetrios G. Vavvas
Summary: Recent evidence suggests that modulating the RIPK3 pathway can improve the survival of transplanted cells and aid in the repair of degenerated retinas. Simultaneous inhibition of RIPK3 in both the donor and host can maximize the survival of transplanted cells. Additionally, targeting RIPK3 in the immune system can protect both donor and host retinal cells. These findings highlight the potential of immunomodulatory and neuroprotective strategies targeting RIPK3 in the regenerative therapy of photoreceptor transplantation.
Article
Hematology
Hannah Kinoshita, Mamatha Mandava, Mariah Jensen-Wachspress, Haili Lang, Elisabeth Joy, Jay Tanna, Chase D. McCann, Samuel O'Brien, Sianna Burnett, Abeer Shibli, Fahmida Hoq, Monica Bhatia, Patrick J. Hanley, Blachy Davila Saldana, Kris M. Mahadeo, Catherine M. Bollard, Michael D. Keller, Allistair Abraham
Summary: Hematopoietic stem cell transplantation (HSCT) is increasingly used to treat sickle cell disease (SCD). However, this treatment increases the risk of viral infection. This study explores the use of virus-specific T-cell (VST) therapies after HSCT to prevent or treat viral infections in SCD patients.
Article
Endocrinology & Metabolism
Jinquan Cai, Zhixian Wu, Xiumin Xu, Lianming Liao, Jin Chen, Lianghu Huang, Weizhen Wu, Fang Luo, Chenguang Wu, Alberto Pugliese, Antonello Pileggi, Camillo Ricordi, Jianming Tan
Article
Medicine, Research & Experimental
G. Zhou, J. Yu, A. Wang, S. -H. Liu, J. Sinnett-Smith, J. Wu, R. Sanchez, J. Nemunaitis, C. Ricordi, E. Rozengurt, F. C. Brunicardi
CURRENT MOLECULAR MEDICINE
(2016)
Article
Endocrinology & Metabolism
Dora M. Berman, Damaris Molano, Carmen Fotino, Ulisse Ulissi, Jennifer Gimeno, Armando J. Mendez, Norman M. Kenyon, Norma S. Kenyon, David M. Andrews, Camillo Ricordi, Antonello Pileggi
Article
Urology & Nephrology
Lorenzo Gallon, James M. Mathew, Sai Vineela Bontha, Catherine I. Dumur, Pranav Dalal, Lakshmi Nadimpalli, Daniel G. Maluf, Aneesha A. Shetty, Suzanne T. Ildstad, Joseph R. Leventhal, Valeria R. Mas
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2018)
Review
Immunology
James M. Mathew, Mohammed Javeed Ansari, Lorenzo Gallon, Joseph R. Leventhal
Article
Multidisciplinary Sciences
James M. Mathew, Jessica H-Voss, Ann LeFever, Iwona Konieczna, Cheryl Stratton, Jie He, Xuemei Huang, Lorenzo Gallon, Anton Skaro, Mohammed Javeed Ansari, Joseph R. Leventhal
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
James M. Mathew, Jessica H. Voss, Scott T. McEwen, Iwona Konieczna, Arjun Chakraborty, Xuemei Huang, Jie He, Lorenzo Gallon, Richard S. Kornbluth, Joseph R. Leventhal
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Opas Traitanon, James M. Mathew, Aneesha Shetty, Sai Vineela Bontha, Daniel G. Maluf, Yvonne El Kassis, Sook H. Park, Jing Han, M. Javeed Ansari, Joseph R. Leventhal, Valeria Mas, Lorenzo Gallon
Article
Multidisciplinary Sciences
Agnieszka I. Laskowski, Daniel S. Neems, Kyle Laster, Chelsee Strojny-Okyere, Ellen L. Rice, Iwona M. Konieczna, Jessica H. Voss, James M. Mathew, Joseph R. Leventhal, Rosalind Ramsey-Goldman, Erica D. Smith, Steven T. Kosak
SCIENTIFIC REPORTS
(2019)
Review
Surgery
Joseph R. Leventhal, James M. Mathew
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Correction
Multidisciplinary Sciences
Agnieszka I. Laskowski, Daniel S. Neems, Kyle Laster, Chelsee Strojny-Okyere, Ellen L. Rice, Iwona M. Konieczna, Jessica H. Voss, James M. Mathew, Joseph R. Leventhal, Rosalind Ramsey-Goldman, Erica D. Smith, Steven T. Kosak
SCIENTIFIC REPORTS
(2019)
Letter
Surgery
Piotr Witkowski, Rolf N. Barth, Anthony Japour, Gail Javitt, Jordan S. Pyda, Piotr J. Bachul, Eryk Nowicki, Camillo Ricordi
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Marta De Angelis, David Della-Morte, Gabriele Buttinelli, Angela Di Martino, Francesca Pacifici, Paola Checconi, Luigina Ambrosio, Paola Stefanelli, Anna Teresa Palamara, Enrico Garaci, Camillo Ricordi, Lucia Nencioni
Summary: Studies have shown that the A5+ mixture is more effective in inhibiting influenza virus and SARS-CoV-2 infections, reducing viral protein expression and viral release. Additionally, A5+ treatment significantly decreases IL-6 cytokine production in influenza virus-infected cells.
Article
Endocrinology & Metabolism
Marco Infante, Camillo Ricordi
Summary: Diabetes of the exocrine pancreas (DEP) refers to different types of diabetes resulting from disorders of the exocrine pancreas. Post-total pancreatectomy diabetes mellitus (PTPDM) is a unique form of DEP with distinct pathophysiological and clinical features.
EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM
(2023)
Article
Immunology
Marco Infante, Laura Vitiello, Andrea Fabbri, Camillo Ricordi, Nathalia Padilla, Francesca Pacifici, Pasquale Di Perna, Marina Passeri, David Della-Morte, Massimiliano Caprio, Luigi Uccioli
Summary: We describe a case of a 22-year-old Italian man with new-onset type 1 diabetes who experienced an unusually prolonged clinical remission phase (31 months). The patient was treated with calcifediol and low-dose insulin, resulting in the maintenance of residual beta-cell function and clinical remission. This may be attributed to the immunoregulatory properties of calcifediol.