期刊
HUMAN HEREDITY
卷 66, 期 3, 页码 157-169出版社
KARGER
DOI: 10.1159/000126050
关键词
linkage; linkage disequilibrium map; population differences; recombination hot spot
资金
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
Objective: A number of linkage disequilibrium (LD)-based methods have been developed to describe recombination and infer hotspots. We determine the correspondence between LDMAP and LDhat, and between LDMAP and LDhot by comparison with linkage maps and hotspots that have been verified by sperm typing. Methods: Regression and variance analyses were used to compare LDMAP and LDhat with linkage maps. The location and intensity of hotspots inferred by LDMAP and LDhot were compared with fifteen verified hotspots. Results: Despite different methodologies and assumptions, LDMAP, LDhat, and linkage maps are highly concordant. Closer inspection shows that LDMAP corresponds more closely with linkage maps across the genome and on sixteen chromosomes compared with LDhat. LDhot identified fourteen and ten of the verified hotspots using high and low density maps. In comparison, LDMAP identified all fifteen hotspots at high and low density. However, some significant discrepancies between sperm and LDbased recombination rates remain. Conclusions: Combining information from linkage and LDMAP to construct sex-specific high resolution linkage maps suggests that some of these discrepancies may be due to female recombination while others may relate to the age of hotspots. LDMAP based estimates between similar to 68,000 and similar to 112,000 hotspots in the genome with mean widths less than 4 kb. Copyright (C) 2008 S. Karger AG, Basel.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据