Article
Oncology
Jinxiao Liang, Yinjie Wang, Lei Cai, Jinshi Liu, Junrong Yan, Xin Chen, Xiaoying Wu, Qixun Chen
Summary: Esophageal squamous cell carcinoma (ESCC) is a common and deadly malignant tumor, with smoking, drinking, and poor eating habits being contributing factors. This study used whole-exome sequencing to analyze genetic variations in ESCC tumors and normal mucosa, finding significant differences in mutation frequencies and copy number variations. The study also revealed different evolution modes of primary tumors in bifocal ESCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Otorhinolaryngology
Tianxiao Wang, Yehao Zhang, Jia Wu, Hongjie Feng, Ruixia Wang, Hua Yuan
Summary: This study revealed the association between genetic variants in circCHST15 and the susceptibility to oral squamous cell carcinoma (OSCC). The expression of circCHST15 was found to be upregulated in OSCC. A genotyping analysis identified 61 loci in circCHST15 that were associated with the risk of OSCC, with rs28707473 (A > C) being selected as a potential genetic variation that could affect circCHST15 expression possibly by altering circular RNA structure and transcription factor binding.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Yi Shen, Yi Shao, Xiaoli Ruan, Lingyan Zhu, Zhaoping Zang, Tong Wei, Rena Nakyeyune, Wenqiang Wei, Fen Liu
Summary: This study found that the rs1804506 polymorphism located in miR-17-92 cluster binding sites is associated with the susceptibility of ESCC, especially in older individuals, females, or non-smokers. The rs1804506 T allele reduces the binding of miR-19a-3p and TGFBR3, suggesting its potential role in ESCC development.
Article
Biotechnology & Applied Microbiology
Yuanna Wu, Ming Liu, Ruoxin Zhang, Menghong Sun, Qingyi Wei, Kuaile Zhao, Mengyun Wang
Summary: This study found that two potential functional SNPs on the HDAC9 gene are significantly associated with survival rate in patients with esophageal squamous cell carcinoma (ESCC). Furthermore, these SNPs are also related to the expression levels of the HDAC9 gene. These findings suggest that these SNPs may serve as biomarkers for predicting survival in ESCC patients.
JOURNAL OF GENE MEDICINE
(2022)
Article
Oncology
Mo Chen, Wen-Mao Xu, Gui-Yang Wang, Ya-Xuan Hou, Ting-Ting Tian, Yu-Qing Li, Hong-Jiao Qi, Meng Zhou, Wei-Jia Kong, Mei-Xia Lu
Summary: Genetic alterations in the cell cycle pathway are common in HNSCC, and four novel susceptibility loci were identified through a matched case-control study. The interactions among these loci and their effects on gene expression and tumor progression were investigated, revealing a complex network of regulatory mechanisms involved in HNSCC development. E2F2 rs2075993 T>C was discovered to reduce stability and interfere with miR-940 binding, promoting tumor cell proliferation and migration, and suppressing senescence.
Article
Toxicology
Hanting Liu, Jingjing Gu, Yu Jin, Qi Yuan, Gaoxiang Ma, Mulong Du, Yuqiu Ge, Chao Qin, Qiang Lv, Guangbo Fu, Meilin Wang, Haiyan Chu, Lin Yuan, Zhengdong Zhang
Summary: The study investigated the association between genetic variants in m(6)A-switches and bladder cancer risk, identifying a significant effect of a specific SNP in the SOD2 gene on reducing bladder cancer risk. It was also found that SOD2 may regulate its expression through an m(6)A-hnRNP C dependent mechanism, playing a crucial role in suppressing bladder cancer cell growth and invasion.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Oncology
Dongqing Gao, Peipei Lu, Nan Zhang, Li Zhao, Jinhui Liu, Jia Yang, Jingmin Liu, Deli Zhao, Jialin Wang
Summary: This study examined the natural history of esophageal squamous cell carcinoma (ESCC) in rural Chinese and aimed to provide more support for ESCC screenings. The results showed that the higher the grade of precancerous lesions, the higher the incidence density of ESCC. Screening and follow-up management should be strengthened for males and the elderly population.
Article
Multidisciplinary Sciences
Jiaying Li, Hongjiao Wu, Hui Gao, Ruihuan Kou, Yuning Xie, Zhi Zhang, Xuemei Zhang
Summary: The study revealed an association between TLR4 genetic polymorphisms and esophageal cancer risk, with the rs1927914 GG genotype carriers having a lower risk. This variant affects promoter activity and is particularly relevant in elderly individuals and non-smokers.
Article
Genetics & Heredity
Wenlong Carl Chen, Jean-Tristan Brandenburg, Ananyo Choudhury, Mahtaab Hayat, Dhriti Sengupta, Yaniv Swiel, Chantal Babb de Villiers, Lucien Ferndale, Colleen Aldous, Cassandra C. Soo, Sang Lee, Charles Curtis, Rob Newton, Tim Waterboer, Fredd Sitas, Debbie Bradshaw, Christian C. Abnet, Michele Ramsay, M. Iqbal Parker, Elvira Singh, Cathryn M. Lewis, Christopher G. Mathew
Summary: Esophageal squamous cell carcinoma (ESCC) has a high disease burden in sub-Saharan Africa and has a very poor prognosis. This study conducted a genome-wide association study (GWAS) in African individuals with ESCC and identified significant genetic risk loci, including FAM120A and MYO1B genes. A trans-ethnic meta-analysis also identified additional risk loci for ESCC, suggesting both shared and distinct genetic factors between African and Asian populations.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Toxicology
Zhichao Han, Jingjing Gu, Junyi Xin, Hanting Liu, Yanling Wu, Mulong Du, Haiyan Chu, Yadong Liu, Zhengdong Zhang
Summary: This study investigated the association between genetic variants in the choline metabolism pathway and bladder cancer susceptibility. The results showed that the C allele of rs6810830 in ENPP6 was a significant protective allele for bladder cancer. Additionally, the study found that the expression of ENPP6 was decreased in bladder tumors and high expression was associated with worse overall survival in bladder cancer patients.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Oncology
Sheila Coelho Soares-Lima, Isabela Martins Gonzaga, Diego Camuzi, Pedro Nicolau-Neto, Raissa Vieira da Silva, Simone Guaraldi, Maria Aparecida Ferreira, Hector Hernandez-Vargas, Zdenko Herceg, Luis Felipe Ribeiro Pinto
Summary: The study suggests that overexpression of IL6 may play a key role in the carcinogenesis of ESCC, contributing to ESCC development through a homogeneous antiapoptotic signaling via BCL3 overexpression. The study also supports the potential of using BCL3 mRNA expression as a biomarker for ESCC detection.
FRONTIERS IN ONCOLOGY
(2021)
Article
Otorhinolaryngology
Yukinori Takenaka, Atsuhiko Uno, Hidenori Tanaka, Norihiko Takemoto, Hidenori Inohara
Summary: The study investigated the rates of distant metastasis (DM) and prognoses of different histological variants of head and neck squamous cell carcinoma (HNSCC). The lowest DM rate was found in verrucous carcinoma (0.2%) and the highest in basaloid squamous cell carcinoma (9.4%). Adenosquamous carcinoma had an odds ratio (OR) of 3.63 for DM, basaloid squamous cell carcinoma had an OR of 6.80, and spindle cell carcinoma had an OR of 3.91. Metastatic spindle cell carcinoma had a poor overall survival (HR, 1.61).
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Genetics & Heredity
Lujia Wang, Xiaoling Lin, Zijian Zhou, Yuanyuan Yang, Peng Gao, Zhong Wu
Summary: A replication study was conducted to investigate the association of 14 loci identified in a genome-wide association analysis study (GWAS) in the Japanese population with calcium nephrolithiasis in the Chinese Han population. Results showed that 10 loci associated with kidney or electrolyte-related traits, as well as 4 novel loci related to metabolic traits, were associated with calcium nephrolithiasis in the Chinese Han population.
Article
Immunology
Chao Shen, Zhijun Ge, Chen Dong, Chunhui Wang, Jianguo Shao, Weihua Cai, Peng Huang, Haozhi Fan, Jun Li, Yun Zhang, Ming Yue
Summary: The study revealed that KIR2DS4/KIR2DS1/KIR2DL1 rs35440472-A and HLA-C rs1130838-A variants are associated with increased susceptibility to HCV infection in a high-risk Chinese population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Shuang Zhao, Ni Sun, Xi Yuan, Zetian Shen, Xixu Zhu, Jing Li
Summary: This case report describes a 65-year-old male patient with ESCC who underwent CRT and immunotherapy but experienced rapid tumor progression, leading to death within just 3 months of symptom onset. Genetic analysis revealed the simultaneous presence of the TP53 gene and PIK3CA gene, which may be related to the rapid progression observed. Further studies are needed to validate these observations.
Article
Computer Science, Software Engineering
Xin Yang, Li Liu, Chen Zhu, Yingqing Guo, Dake Zhou
Summary: This paper proposes an improved SR algorithm based on low-rank constraint, which achieves better image reconstruction quality and speed by introducing locally weighted regularization and constraints on reconstruction blocks.
Article
Ecology
Chen Zhu, Wande Li, Tremaine Gregory, Duorun Wang, Peng Ren, Di Zeng, Yi Kang, Ping Ding, Xingfeng Si
Summary: The study developed a camera trap sampling method to monitor plant-frugivore interactions in trees, which proved to be reliable in a fragmented landscape. A sampling strategy covering the fruit maturation period was found to be effective in sampling plant-frugivore interactions.
REMOTE SENSING IN ECOLOGY AND CONSERVATION
(2022)
Article
Chemistry, Multidisciplinary
Lun Shu, Yuan Peng, Rui Yao, Hongling Song, Chenyu Zhu, Weishen Yang
Summary: A facile strategy has been developed to construct defect-free and flexible metal-organic framework (MOF)-based membranes with high selectivity. The fabricated soft-solid MOF composite membranes showed excellent separation performance for H-2/CO2 separation. This study demonstrates the potential of MOF-based membranes in practical separation applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Physics, Multidisciplinary
Long-Long Sun, Ya-Peng Hu, Chen-Ping Zhu, Yan-Jun Wang, Pei-Wen Yao
Summary: Investigation on passenger flight delays using statistical physics methods is lacking. This study treats flights as particles and employs quasi-thermodynamic variables to describe their behavior, proposing a new model for delay gases.
CHINESE JOURNAL OF PHYSICS
(2022)
Article
Geosciences, Multidisciplinary
Peng Lu, Guanru Zhang, John Apps, Chen Zhu
Summary: This article introduces the features and applications of the PHREEQC program, and evaluates and compares its thermodynamic data files. The results show that using different thermodynamic data files can lead to different modeling results, so it is important for users to specify the data file used when reporting modeling results.
EARTH-SCIENCE REVIEWS
(2022)
Article
Geochemistry & Geophysics
Jinting Kang, Jacquelyn N. Bracco, J. Donald Rimstidt, Gregory H. Zhu, Fang Huang, Chen Zhu
Summary: The study measured barium attachment and detachment fluxes from and to barite crystal surfaces. Experimental data accurately fit the AB crystal growth model, suggesting that barite recrystallization occurs through ion-by-ion addition and removal. Ba attachment and detachment fluxes at a fixed saturation state increase monotonically with [Ba]/[SO4] ratios, potentially impacting isotope and trace element cycling in natural environments.
GEOCHIMICA ET COSMOCHIMICA ACTA
(2022)
Article
Physics, Multidisciplinary
Chen-Lu Zhu, Bin Hu, Bo Li
Summary: We investigate the monogamy of multipartite quantum discord. The research shows that quantum discord is monogamous for multiqubit systems if it does not increase under the discard of subsystems. We analyze a family of multiqubit states and demonstrate that the above conditions hold. By examining the dynamics of quantum discord and geometric discord under the local decoherence channel based on previous studies, we find that even-partite systems exhibit frozen phenomenon while odd-partite systems do not. In terms of geometric discord, this family of states also shows the frozen phenomenon under local decoherence conditions. The results indicate that compound noises are not necessary for sudden changes in quantum correlation, and one qubit of quantum noise is sufficient. The investigation of these non-loss conditions is of great importance for understanding the evolution of quantum systems in the environment.
INTERNATIONAL JOURNAL OF THEORETICAL PHYSICS
(2022)
Article
Geosciences, Multidisciplinary
Peng Lu, Pan Luo, Wei Wei, Chen Zhu
Summary: Varied concentrations of H2S have been discovered in the carbonate reservoir of the Puguang gas field in China, where thermochemical sulfate reduction (TSR) is considered the primary process for H2S generation. The study conducted reactive transport modeling to simulate TSR and H2S generation processes, indicating that mineralogical composition and gas saturation in the reservoir affect the efficiency and extent of TSR reactions. The modeling results were reliable, with predicted H2S and CO2 concentrations comparable to observed values after calibration.
MARINE AND PETROLEUM GEOLOGY
(2022)
Article
Energy & Fuels
Chenyang Zhu, Ziwen Zhang, Sa Xue, Kun Hou, Hui Liu, Xiangyang Liu, Maogang He
Summary: This study investigates the association effects on the density and viscosity of fatty acid ester + alcohol mixtures. Experimental results show that the mixtures exhibit positive excess volume and viscosity deviation. By employing the Cubic-Plus-Association equation of state (CPA EoS) and the friction theory model, the properties of the mixtures are successfully modeled and the relationships between their associations and density, viscosity, and excess properties are established.
Article
Geochemistry & Geophysics
Jonas Toupal, David R. Vann, Chen Zhu, Reto Giere
Summary: There are several Li-mica and spodumene deposits in Central Europe, with the Cinovec deposit being the largest known hard-rock Li deposit in Europe. The weathering and mining of these deposits may release Li and F into the environment, posing potential health risks. However, the aqueous geochemistry of streams and creeks around Li hard-rock deposits is not well understood.
JOURNAL OF GEOCHEMICAL EXPLORATION
(2022)
Article
Chemistry, Applied
Rui Yao, Wenhao Zhang, Yuan Peng, Hongling Song, Chenyu Zhu, Lun Shu, Weishen Yang
Summary: Pure UZM-5 zeolite with nanosheet or rosette-shaped morphology was successfully synthesized by adjusting the synthesis parameters and incorporating trace ethanol in the reagent solution. The pure UZM-5 zeolite showed Lewis acid sites, making it a promising catalyst for electrocatalytic reduction of nitrate to ammonia.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Editorial Material
Geosciences, Multidisciplinary
Chen Zhu, D. Kirk Nordstrom
Article
Green & Sustainable Science & Technology
Peng Lu, Guanru Zhang, Yi Huang, John Apps, Chen Zhu
Summary: This study investigates the potential use of dawsonite mineral trapping for carbon capture and storage (CCS) as a strategy. By utilizing a dawsonite-rich CO2 gas reservoir in northern China as a natural analogue, along with numerical modeling, the study demonstrates the possibility of generating a large amount of dawsonite in sandstone formations. The short-term trapping of CO2 in dawsonite helps lower CO2 pressure and mitigates the risk of leakage, while the re-dissolution of dawsonite facilitates the dissipation of CO2 over time. Considering aquifer geochemistry can significantly increase the number of potential CCS sites globally.
INTERNATIONAL JOURNAL OF GREENHOUSE GAS CONTROL
(2022)
Article
Geosciences, Multidisciplinary
Chen Zhu, Alan E. Fryar, John Apps
Summary: Research in hydrogeochemistry has made significant progress in the past two decades, including arsenic contamination in groundwater, the use of isotopic and chemical tracers, chemical reaction kinetics, and the transformation of geochemical modeling. In the future, advancements in technology such as machine learning, cyberinfrastructure, and isotope analytical tools will enable breakthrough research and enhance the role of hydrogeochemistry in addressing climate change and the transition to renewable energies.
Article
Chemistry, Multidisciplinary
Yiming Jiang, Jiawei Zhu, Li Li, Yahui Gao, Juncai Leng, Jiai Yan, Shuoming Liu, Feng Zhang, Han Liu, Chenlu Zhu, Lichun Guo, Haijiao Xie, Wei Zhao
Summary: Researchers have designed and fabricated a novel peroxidase mimic catalyst based on Pd@PtxRu4-x (1 <= x <= 3). The catalyst exhibits higher catalytic activity and kinetics compared to classical PtRu nanozyme and horseradish peroxidase. Density functional theory calculations suggest that the superior catalytic performance is due to the modulation of the adsorption behavior of key reaction intermediates on the surface. The catalyst also shows potential for sensing glucose and glutathione molecules in human serum.
