期刊
HUMAN GENETICS
卷 131, 期 9, 页码 1467-1480出版社
SPRINGER
DOI: 10.1007/s00439-012-1176-0
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资金
- Medical Research Council's Health of the Public grant
- Wellcome Trust [083478, 076467]
- National Institute for Health Research
- Ulverscroft Vision Research Group
- National Institutes of Health [N01AG12100]
- National Insitute on Aging
- National Eye Institute Intramural Research Programs [ZIAAG007380, ZI-AEY000401]
- Hjartavernd (the Icelandic Heart Association)
- Althingi (the Icelandic Parliament)
- UK Medical Research Council [4882]
- University of Bristol
- National Eye Research Centre, Bristol [SCIAD053]
- National Eye Institute/National Institutes of Health, Bethesda, MD
- Bausch & Lomb Inc, Rochester, NY
- National Eye Institute [R01 EY020483]
- Intramural Research Program of the National Human Genome Research Institute, National Institutes of Health, USA
- Australian National Health and Medical Research Council (NHMRC) Enabling Grant [20042009, 350415]
- Clifford Craig Medical Research Trust
- Ophthalmic Research Institute of Australia
- American Health Assistance Foundation
- Peggy and Leslie Cranbourne Foundation
- Foundation for Children
- Jack Brockhoff Foundation
- National Institutes of Health/National Eye Institute [RO1EY01824601]
- Pfizer
- Australian NHMRC Career Development Award
- NHMRC
- NIH Center for Inherited Disease Research a
- Netherlands Scientific Organization [NWO48005003]
- Australian National Health & Medical Research Council (NH& MRC), Canberra Australia [974159, 211069, 457349, 512423, 475604, 529912]
- Centre for Clinical Research Excellence in Translational Clinical Research in Eye Diseases
- NH& MRC research fellowships [358702, 632909, 1028444]
- Wellcome Trust, UK
- Victorian government
- Medical Research Council (UK)
- Republic of Croatia Ministry of Science, Education and Sports [10810803150302]
- European Union [LSHGCT2006018947]
- NEI [N01EY22112, N01EY92109]
- National Heart, Lung, and Blood Institute [N02HL64278]
- SHARe genotyping
- Boston University [N01HC25195]
- National Human Genome Research Institute, NIH, USA
- government of Rheinland-Pfalz (Stiftung Rheinland Pfalz fur Innovation [AZ961386261733]
- Johannes Gutenberg-University of Mainz
- Boehringer Ingelheim
- PHILIPS Medical Systems
- National Genome Network NGFNplus
- Federal Ministry of Education and Research, Germany [A301GS0833]
- Japan Society for the Promotion of Science, Tokyo [21249084, 22791653]
- Italian Ministry of Education, University and Research [5571DSPAR2002, 718Ric2005]
- Netherlands Organisation of Scientific Research (NWO) [Vidi 91796357]
- Erasmus Medical Center and Erasmus University, Rotterdam, The Netherlands
- Netherlands Organization for Health Research and Development (ZonMw)
- UitZicht
- Research Institute for Diseases in the Elderly
- Ministry of Education, Culture and Science
- Ministry for Health, Welfare and Sports
- European Commission (DG XII)
- Municipality of Rotterdam
- Netherlands Genomics Initiative/NWO
- Center for Medical Systems Biology of NGI
- Lijf en Leven
- M. D. Fonds
- Stichting Nederlands Oogheelkundig
- Swart van Essen
- Bevordering van Volkskracht
- Blindenhulp
- Landelijke Stichting voor Blinden en Slechtzienden
- Rotterdamse Vereniging voor Blindenbelangen
- OOG
- Algemene Nederlandse Vereniging ter Voorkoming van Blindheid
- Rotterdam Eye Hospital Research Foundation
- Topcon Europe
- National Medical Research Council, Singapore [NMRC 07962003, NMRC 11762008]
- Singapore Bio-Medical Research Council [0612119466, 0913519616]
- Interdisciplinary Centre for Clinical Research at the University of Leipzig
- German Diabetes Association
- DHFD, Diabetes Hilfsund Forschungsfonds Deutschland
- European Commission under a Marie Curie Intra-European Fellowship
- European Community's Seventh Framework Programme [FP720072013]
- ENGAGE project [HEALTHF42007201413]
- European Union MyEuropia Marie Curie Research Training Network
- Guide Dogs for the Blind Association
- European Community [HEALTHF22008201865GEFOS]
- ENGAGE [HEALTHF4200720 1413]
- US National Institutes of Health/National Eye Institute [1RO1EY018246]
- NIH Center for Inherited Disease Research
- National Institute for Health Research comprehensive Biomedical Research Centre
- St. Thomas' National Health Service Foundation Trust
- King's College London
- Academy of Finland [134309, 126925, 121584, 124282, 129378, 117787, 41071]
- Social Insurance Institution of Finland, Kuopio, Tampere
- Turku University Hospital Medical Funds [9M048]
- Juho Vainio Foundation
- Paavo Nurmi Foundation
- Finnish Foundation of Cardiovascular Research and Finnish Cultural Foundation
- Tampere Tuberculosis Foundation
- Emil Aaltonen Foundation
- Chief Scientist Office [CZB/4/710, CZB/4/438] Funding Source: researchfish
- Medical Research Council [MC_PC_U127561128, G0400546B, MC_U127561128, G0400546, G9815508] Funding Source: researchfish
- MRC [G0400546, MC_U127561128, MC_PC_U127561128] Funding Source: UKRI
- Grants-in-Aid for Scientific Research [22791653, 21249084] Funding Source: KAKEN
- National Health and Medical Research Council of Australia [632909] Funding Source: NHMRC
Myopia is a complex genetic disorder and a common cause of visual impairment among working age adults. Genome-wide association studies have identified susceptibility loci on chromosomes 15q14 and 15q25 in Caucasian populations of European ancestry. Here, we present a confirmation and meta-analysis study in which we assessed whether these two loci are also associated with myopia in other populations. The study population comprised 31 cohorts from the Consortium of Refractive Error and Myopia (CREAM) representing 4 different continents with 55,177 individuals; 42,845 Caucasians and 12,332 Asians. We performed a meta-analysis of 14 single nucleotide polymorphisms (SNPs) on 15q14 and 5 SNPs on 15q25 using linear regression analysis with spherical equivalent as a quantitative outcome, adjusted for age and sex. We calculated the odds ratio (OR) of myopia versus hyperopia for carriers of the top-SNP alleles using a fixed effects meta-analysis. At locus 15q14, all SNPs were significantly replicated, with the lowest P value 3.87 x 10(-12) for SNP rs634990 in Caucasians, and 9.65 x 10(-4) for rs8032019 in Asians. The overall meta-analysis provided P value 9.20 x 10(-23) for the top SNP rs634990. The risk of myopia versus hyperopia was OR 1.88 (95 % CI 1.64, 2.16, P < 0.001) for homozygous carriers of the risk allele at the top SNP rs634990, and OR 1.33 (95 % CI 1.19, 1.49, P < 0.001) for heterozygous carriers. SNPs at locus 15q25 did not replicate significantly (P value 5.81 x 10(-2) for top SNP rs939661). We conclude that common variants at chromosome 15q14 influence susceptibility for myopia in Caucasian and Asian populations world-wide.
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