Article
Multidisciplinary Sciences
Nathan Gaddis, Ravi Mathur, Jesse Marks, Linran Zhou, Bryan Quach, Alex Waldrop, Orna Levran, Arpana Agrawal, Matthew Randesi, Miriam Adelson, Paul W. Jeffries, Nicholas G. Martin, Louisa Degenhardt, Grant W. Montgomery, Leah Wetherill, Dongbing Lai, Kathleen Bucholz, Tatiana Foroud, Bernice Porjesz, Valgerdur Runarsdottir, Thorarinn Tyrfingsson, Gudmundur Einarsson, Daniel F. Gudbjartsson, Bradley Todd Webb, Richard C. Crist, Henry R. Kranzler, Richard Sherva, Hang Zhou, Gary Hulse, Dieter Wildenauer, Erin Kelty, John Attia, Elizabeth G. Holliday, Mark McEvoy, Rodney J. Scott, Sibylle G. Schwab, Brion S. Maher, Richard Gruza, Mary Jeanne Kreek, Elliot C. Nelson, Thorgeir Thorgeirsson, Kari Stefansson, Wade H. Berrettini, Joel Gelernter, Howard J. Edenberg, Laura Bierut, Dana B. Hancock, Eric Otto Johnson
Summary: In this study, genomic structural equation modeling was used to conduct a genome-wide association study of opioid addiction (OA) phenotypes. Significant associations were found between OA and the genes OPRM1, PPP6C, and FURIN, suggesting pleiotropy in addiction and related traits.
SCIENTIFIC REPORTS
(2022)
Letter
Psychiatry
Alfonso Troisi
Summary: Research suggests that variation in the mu-opioid receptor gene is linked to attachment behavior in adults, with the A118G polymorphism and early maternal care interacting to influence levels of fearful attachment. Individuals carrying the minor 118G allele experience more pleasure in social situations and show lower levels of avoidant attachment compared to those with the A/A genotype.
WORLD JOURNAL OF PSYCHIATRY
(2022)
Review
Behavioral Sciences
Fawaz Alasmari, Deen B. Sari, Hasan Alhaddad, Salim S. Al-Rejaie, Youssef Sari
Summary: This review explores the interactive role of acid-sensing ion channels (ASICs) and ionotropic glutamate receptors (iGluRs) in opioid dependence. The dysregulation of ASICs and iGluRs may play a crucial role in drug abuse and addiction.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Pediatrics
Elizabeth Yen, Neel Madan, Tomo Tarui, Tomoko Kaneko-Tarui, Janis L. Breeze, Jonathan M. Davis, Jill L. Maron
Summary: This study investigates the effect of prenatal opioid exposure on inflammatory gene expression, reward signaling, and white matter injury in neonates. The findings suggest that opioids may induce inflammation and alter brain development, with sex-specific effects.
PEDIATRIC RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Catrina M. Loucks, Jennifer J. Lin, Jessica N. Trueman, Britt Drogemoller, Galen E. B. Wright, Wan-Chun Chang, Kathy H. Li, Eric M. Yoshida, Jo-Ann Ford, Samuel S. Lee, Pam Crotty, Richard B. Kim, Bandar Al-Judaibi, Ute Schwarz, Alnoor Ramji, Jeanette F. Farivar, Edward Tam, Lori Lee Walston, Colin J. D. Ross, Bruce C. Carleton
Summary: This study demonstrates that patient-specific genetic factors can be used as a tool to identify patients at higher risk of treatment failure, allowing for these patients to receive effective therapy sooner.
LIVER INTERNATIONAL
(2022)
Article
Neurosciences
Cesar Mateu, Marta Rodriguez-Arias, Isis Gil-Miravet, Ana Benito, Jose M. Tomas, Gonzalo Haro
Summary: A genetic association was found between a specific VNTR polymorphism in the MAOB gene and addiction to cocaine and opiates, highlighting new genetic marker associations in polyconsumer addictions. This research sheds light on the complex role of genetics in addictive disorders and its potential impact on prevention, diagnosis, and treatment.
Article
Psychiatry
Rapson Gomez, Vasileios Stavropoulos, Taylor Brown, Mark D. Griffiths
Summary: This study aimed to examine the factor structure of ten potentially addictive behaviors, including psychoactive substance addictions and behavioral addictions, using exploratory factor analysis and confirmatory factor analysis. The results supported a two-factor solution, with better validation for behavioral addictions than psychoactive substance addictions. The implications of the findings were discussed in terms of taxonomy, theory, and clinical practice.
PSYCHIATRY RESEARCH
(2022)
Article
Economics
Alice M. Ellyson, Jevay Grooms, Alberto Ortega
Summary: The study found that Mandatory access Prescription Drug Monitoring Programs (MA-PDMPs) affect opioid prescribing behavior differently across provider specialties, with a decrease in prescribing for Primary Care and Internal Medicine providers. There is also suggestive evidence of an increase in opioid use disorder treatment drugs prescribed by these providers.
Article
Medicine, General & Internal
J. Deanna Wilson, Kaleab Z. Abebe, Kevin Kraemer, Jane Liebschutz, Jessica Merlin, Elizabeth Miller, David Kelley, Julie Donohue
Summary: This study identified two trajectories of opioid prescribing patterns in opioid-naive youths, with high-risk trajectory associated with older age and longer, more potent initial prescriptions. Even short and low-dose opioid prescriptions can be associated with risks of persistent opioid use for youths.
Editorial Material
Multidisciplinary Sciences
Alexander J. Gates, Deisy Morselli Gysi, Manolis Kellis, Albert-Laszlo Barabasi
Summary: The new analysis examines the impact of the draft genome on genomics since 2001, highlighting its effects on publications, drug approvals, and understanding of diseases.
Article
Behavioral Sciences
Luke A. Jelen, James M. Stone, Allan H. Young, Mitul A. Mehta
Summary: This article reviews the dysregulation of the opioid system in depression and the potential of pharmacological modulators of mu, delta, and kappa opioid receptors for the treatment of depression. The review presents evidence from animal and clinical studies supporting the dysregulation of the opioid system in depression, the modulation of behavioral processes and brain regions associated with depression by opioids, and the modulation of antidepressant responses by opioids. The review also evaluates clinical trials examining the safety and efficacy of opioidergic agents in depression and explores the involvement of the opioid system in the effects of other treatments, such as ketamine, that exert antidepressant effects through non-opioid actions. Furthermore, the review explores the neurochemical and molecular mechanisms underlying the therapeutic effects of opioid system engagement, providing a rationale for further investigation into this relevant target in depression treatment.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Kyle J. Rehrauer, Christopher W. Cunningham
Summary: This review highlights ongoing efforts in the development of bivalent and bifunctional analgesics that combine II agonism with efficacy at multiple target receptors, aiming to improve the side effect profile of opioid analgesics.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Dominik S. Skiba, Piotr Szczepaniak, Mateusz Siedlinski, Piotr Poznanski, Marzena Lazarczyk, Kinga Jaskula, Piotr Religa, Mariusz Sacharczuk, Zbigniew Gaciong
Summary: The study revealed that individuals with low endogenous opioid system activity have higher basal blood pressure, while naloxone only elevates blood pressure in individuals with high endogenous opioid system activity. In addition, low opioid system activity contributes to impaired vascular relaxation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Carlos Blanco, Melanie M. Wall, Mark Olfson
Summary: The quality and timeliness of US surveillance data often limits data-driven approaches, calling for investments in new infrastructure to prioritize improvements in data timeliness, representativeness, and flexibility while protecting the privacy of survey participants. The use of simulations, distributed research and data networks, alternative data sources, and blockchain technology could lead to an improved and more user-centered surveillance system.
MOLECULAR PSYCHIATRY
(2022)
News Item
Multidisciplinary Sciences
Diana Kwon
Summary: Drugs that silence faulty genes could potentially treat brain diseases, but a halted clinical trial has posed a setback in this field.
