Article
Neurosciences
Yu-Ming Niu, Jie Zhang, Hong Tang, Lu-Hua Cao, Ting-Yun Jiang, Yuan-Yuan Hu
Summary: A meta-analysis was conducted to investigate the correlation between the DRD2/ANKK1 rs1800497 C > T polymorphism and the risk of post-traumatic stress disorder (PTSD). The results suggested that this polymorphism may contribute to susceptibility to PTSD.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Genetics & Heredity
Parham Habibzadeh, Azim Nemati, Hassan Dastsooz, Afsaneh Taghipour-Sheshdeh, Prisho Mariam Paul, Ali Sahraian, Mohammad Ali Faghihi
Summary: Genetic factors play a crucial role in the pathogenesis of schizophrenia, with the Taq1A polymorphism showing a protective effect against the development of schizophrenia. This variant may decrease ANKK1 protein stability and lead to gain of modification sites for ubiquitination and methylation.
JOURNAL OF GENETICS
(2021)
Article
Biotechnology & Applied Microbiology
Navina Suresh, Suvarna Jyothi Kantipudi, Deepika Ramu, Suresh Kumar Muniratnam, Vettriselvi Venkatesan
Summary: This study conducted a meta-analysis on four candidate gene polymorphisms associated with opioids and dopamine, aiming to clarify their association with alcohol dependence. The results indicate that the effects may vary based on ethnicity.
PHARMACOGENETICS AND GENOMICS
(2023)
Article
Neurosciences
Gianna Spitta, Lena E. Fliedner, Tobias Gleich, Tristan Zindler, Miriam Sebold, Ralph Buchert, Andreas Heinz, Juergen Gallinat, Eva Friedel
Summary: This study investigated the relationship between dopamine receptor availability and genetic factors in alcohol use disorder (AUD), but no significant association was found, possibly due to the small sample size. Further research is needed to clarify this relationship.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2022)
Article
Psychology, Multidisciplinary
Isik Bayraktar, Ladislav Cepicka, Magdalena Barasinska, Hasan Huseyin Kazan, Erdal Zorba, Mehmet Ali Ergun, Ozgur Eken, Halil Ibrahim Ceylan, Celal Bulgay, Tomasz Gabrys
Summary: The rs1800497 polymorphism was found to be significantly associated with sport experience but not with athletic performance.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychology, Clinical
Damian Czarnecki, Marcin Ziolkowski, Jan Chodkiewicz, Marta Gorzkiewicz, Napoleon Waszkiewicz, Anna Dlugosz, Jacek Budzynski, Anna Junkiert-Czarnecka, Agnieszka Kulak-Bejda
Summary: This study aimed to assess changes in the severity of alcohol craving according to allelic variants of the 5-HTTLPR gene polymorphism during hospitalisation and their association with selected clinical variables in alcohol-dependent patients. The results showed that there was a decrease in the severity of alcohol craving at the 6th week of the follow-up in subjects with the short/short allele and long/short allele of the 5-HTTLPR gene.
PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT
(2023)
Article
Management
Byung-Cheol Kim
Summary: The paper proposes a factor-driven dependence elicitation and modelling framework to address the high-dimensional dependence modelling problem in project risk assessment. The framework utilizes structured association technique and multi-factor association model to effectively utilize minimum information for scalability to large-scale project risks while maintaining computational efficiency.
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2022)
Article
Genetics & Heredity
Diana Z. Paderina, Anastasiia S. Boiko, Ivan Pozhidaev, Irina A. Mednova, Anastasia A. Goncharova, Anna Bocharova, Olga Yu Fedorenko, Elena G. Kornetova, Arkadiy Semke, Nikolay A. Bokhan, Anton J. M. Loonen, Svetlana A. Ivanova
Summary: The study found that the functional polymorphism rs1799732 of the DRD2 gene is associated with drug-induced metabolic syndrome in women with schizophrenia.
Review
Behavioral Sciences
Alexandre A. Guerin, Eric J. Nestler, Michael Berk, Andrew J. Lawrence, Susan L. Rossell, Jee Hyun Kim
Summary: This review systematically reviewed hypothesis-driven candidate gene association studies related to methamphetamine use disorder. Eleven gene markers were significantly associated with the disorder from adequately powered studies, but limitations include unclear rationale for candidate gene selection, low power and high risk of bias in some studies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Medicine, General & Internal
Noel Pabalan, Phanthip Chaweeborisuit, Phuntila Tharabenjasin, Adis Tasanarong, Hamdi Jarjanazi, Thanee Eiamsitrakoon, Pairath Tapanadechopone
Summary: A meta-analysis found that three CNR1 SNPs (rs1535255, rs2023239, and rs806379) were associated with the development of alcohol dependence, with rs1535255 showing stronger evidence of association than rs2023239. The rs806379 SNP was implicated in the Caucasian subgroup, while no significant effects were observed in African-Americans. Multiple statistical and meta-analytical features supported the strength of these outcomes, suggesting the potential clinical utility of CNR1 polymorphisms in alcohol dependence genetics.
Article
Psychiatry
Jiayi Cox, Richard Sherva, Leah Wetherill, Tatiana Foroud, Howard J. Edenberg, Henry R. Kranzler, Joel Gelernter, Lindsay A. Farrer
Summary: The study found stimulant dependence to be heritable, with potential genetic factors and genes underlying the trait identified through a genome-wide association study. Four suggestive loci were identified, with genes related to other substance use disorders also being highlighted.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Rheumatology
Eunji Ha, Sang-Cheol Bae, Kwangwoo Kim
Summary: A large trans-ancestral meta-analysis identified 11 new susceptibility loci for RA, explaining a significant portion of the heritability in East Asians and Europeans, and confirmed 71 known non-HLA susceptibility loci. The study also highlighted the importance of CD4(+) T-cell activation and potential non-immune organs in RA pathogenesis, providing insights into genetic etiology and variant-driven RA pathogenesis.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Oncology
J. Lee Westmaas, Sara E. Strollo, Christina C. Newton, Brian D. Carter, W. Ryan Diver, W. Dana Flanders, Victoria L. Stevens, Alpa Patel, Kassandra Alcaraz, Johannes Thrul, Eric J. Jacobs
Summary: The study investigated the association between smoking cannabis and quitting cigarettes, finding that cannabis use did not inhibit smoking cessation among adults. Factors such as cannabis smoking status and frequency did not significantly impact quitting rates, suggesting a need for future research on the effects of intensity/frequency of cannabis use and motivation to quit on smoking cessation.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Psychiatry
Xie Zhang, Huankun Sun, Fan Wang, Michelle Niculescu, Guanghui Shen, Siyao Zhou, Fan Yang, Yu-Hsin Chen, Li Chen, Wei Wang, Yanlong Liu
Summary: This study found a significant interaction between ZNF804A rs1344706 and alcohol use in Chinese Han adult males diagnosed with AUD, indicating that carriers of the T allele of ZNF804A rs1344706 may be more susceptible to alcohol problem severity and impulsivity.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Narges Taheri, Rokhshid Pirboveiri, Mehdi Sayyah, Mahdi Bijanzadeh, Pegah Ghandil
Summary: This study aimed to investigate the association between four polymorphisms in DRD2, DRD4, and COMT genes and antipsychotic treatment response in patients with schizophrenia. The study found significant associations between certain gene polymorphisms and treatment resistance, as well as correlations with clinical and demographic factors. Discovering these polymorphisms can potentially enhance treatment response and reduce side effects and costs through genetic screening before initiating antipsychotic treatment.
Article
Critical Care Medicine
Tiffanie K. Jones, Rui Feng, V. Eric Kerchberger, John P. Reilly, Brian J. Anderson, Michael G. S. Shashaty, Fan Wang, Thomas G. Dunn, Thomas R. Riley, Jason Abbott, Caroline A. G. Ittner, David C. Christiani, Carmen Mikacenic, Mark M. Wurfel, Lorraine B. Ware, Carolyn S. Calfee, Michael A. Matthay, Jason D. Christie, Nuala J. Meyer
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Clinical Neurology
Yingli Fu, Na Zhou, Yaqin Yu, Huiping Zhang, Yaoyao Sun, Mingyuan Zhang, Xin Chen, Yueying Wang, Qiong Yu
JOURNAL OF NEURAL TRANSMISSION
(2020)
Review
Substance Abuse
Emily E. Hartwell, Richard Feinn, Paige E. Morris, Joel Gelernter, John Krystal, Albert J. Arias, Michaela Hoffman, Ismene Petrakis, Ralitza Gueorguieva, Joseph P. Schacht, David Oslin, Raymond F. Anton, Henry R. Kranzler
Article
Genetics & Heredity
Yulin Dai, Ruifeng Hu, Guangsheng Pei, Huiping Zhang, Zhongming Zhao, Peilin Jia
JOURNAL OF MEDICAL GENETICS
(2020)
Article
Cardiac & Cardiovascular Systems
Yabo Li, Hyosuk Cho, Fan Wang, Oriol Canela-Xandri, Chunyan Luo, Konrad Rawlik, Stephen Archacki, Chengqi Xu, Albert Tenesa, Qiuyun Chen, Qing Kenneth Wang
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Biochemistry & Molecular Biology
Hyosuk Cho, Yabo Li, Stephen Archacki, Fan Wang, Gang Yu, Susmita Chakrabarti, Yang Guo, Qiuyun Chen, Qing Kenneth Wang
Article
Genetics & Heredity
Honghuang Lin, Fan Wang, Andrew J. Rosato, Lindsay A. Farrer, David C. Henderson, Huiping Zhang
Article
Psychiatry
Muhammad Moazzam, Terrence Yim, Vidhya Kumaresan, David C. Henderson, Lindsay A. Farrer, Huiping Zhang
Summary: This study investigated the impact of ethanol on telomere length and Shelterin complex subunit gene expression in human embryonic stem cells. The findings suggest that TL variation and expression changes of certain Shelterin subunit genes are primarily influenced by the length of ethanol exposure, while others are affected by ethanol concentration, exposure time, and their interaction. After a 7-day ethanol exposure, TL and expression of five genes decreased, but recovered after a 14-day exposure, indicating adaptation of hESCs to ethanol-induced stress.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychiatry
Yolpanhchana Lim, Jennifer E. Beane-Ebel, Yoshiaki Tanaka, Boting Ning, Christopher R. Husted, David C. Henderson, Yangfei Xiang, In-Hyun Park, Lindsay A. Farrer, Huiping Zhang
Summary: Transcriptomic changes in specific brain regions may influence the risk of alcohol use disorder, and alcohol could induce concerted miRNA and mRNA expression changes in reward-related or alcohol-responsive brain regions. Altered brain miRNA-mRNA regulatory networks might contribute to the development of alcohol use disorder.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Genetics & Heredity
Ying Liu, Huiping Zhang
Summary: This study identified RNA methylomic changes in the NAc of individuals with alcohol use disorder (AUD), suggesting a potential link between chronic alcohol consumption and AUD through epitranscriptomic RNA modifications. Further validation of these findings in a larger sample is warranted.
Article
Biochemistry & Molecular Biology
Kristyn N. Borrelli, Elisha M. Wachman, Jacob A. Beierle, Elizabeth S. Taglauer, Mayuri Jain, Camron D. Bryant, Huiping Zhang
Summary: The study reveals that prenatal exposure to opioids can lead to epigenetic modifications in the placenta, resulting in placental dysfunction and abnormal fetal brain development, as well as symptoms of opioid withdrawal in neonates.
Article
Oncology
Fan Wang, Wonjong Moon, William Letsou, Yadav Sapkota, Zhaoming Wang, Cindy Im, Jessica L. Baedke, Leslie Robison, Yutaka Yasui
Summary: This study identified 13 rare high-risk loci for breast cancer, which exhibit significant risk increase when combined as haplotypes. The individual variants forming these rare haplotypes have smaller effects. Functional annotation revealed extensive cis-regulatory DNA elements in breast cancer-related cells underlying these replicated rare haplotypes.
Article
Biochemistry & Molecular Biology
Vidhya Kumaresan, Yolpanhchana Lim, Poorva Juneja, Allison E. Tipton, Giordano de Guglielmo, Lieselot L. G. Carrette, Marsida Kallupi, Lisa Maturin, Ying Liu, Olivier George, Huiping Zhang
Summary: Cocaine administration alters miRNA expression in the cortico-accumbal pathway, potentially impacting gene expression regulation during withdrawal. This study examined miRNA changes in this pathway during acute withdrawal and protracted abstinence from escalated cocaine intake. Results showed differential miRNA expression and pathways enriched in mRNA targets associated with addiction. The findings emphasize the importance of miRNA expression in addiction-related circuits and suggest the potential for developing biomarkers and therapies targeting abstinence-associated miRNAs.
Article
Biology
William Letsou, Fan Wang, Wonjong Moon, Cindy Im, Yadav Sapkota, Leslie L. Robison, Yutaka Yasui
Summary: This study found that common variants are associated with small but significant differences in breast cancer risk, supporting the polygenic model of inherited predisposition. Using a novel algorithm, the researchers showed that rare haplotypes may refine the association of breast cancer risk with common germline alleles. These findings provide insight into the genetic risk factors for breast cancer.
LIFE SCIENCE ALLIANCE
(2023)
Article
Substance Abuse
Ismene Petrakis, Elizabeth Ralevski, Albert J. Arias, Diana DeNegre, Jenelle Newcomb, Mayumi Gianoli, Elissa McCarthy, Sarah Meshberg-Cohen, Gihyun Yoon
AMERICAN JOURNAL ON ADDICTIONS
(2020)