Current status of genome-wide association studies in cancer

Estimating Missing Heritability for Disease from Genome-wide Association Studies

(2011) Sang Hong Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Variations in Chromosomes 9 and 6p21.3 with Risk of Non-Hodgkin Lymphoma

(2011) S. S. Wang et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Mapping copy number variation by population-scale genome sequencing

(2011) Ryan E. Mills et al.   NATURE

A decade’s perspective on DNA sequencing technology

(2011) Elaine R. Mardis   NATURE

A twist on admixture mapping

(2011) Stephen J Chanock   NATURE GENETICS

Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia

(2011) Jun J Yang et al.   NATURE GENETICS

Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21

(2011) Christopher A Haiman et al.   NATURE GENETICS

A rare variant in MYH6 is associated with high risk of sick sinus syndrome

(2011) Hilma Holm et al.   NATURE GENETICS

Risk of Gastric Cancer and Peptic Ulcers in Relation to ABO Blood Type: A Cohort Study

(2010) G. Edgren et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Admixture Mapping Comes of Age

(2010) Cheryl A. Winkler et al.   Annual Review of Genomics and Human Genetics

GSTM1 null and NAT2 slow acetylation genotypes, smoking intensity and bladder cancer risk: results from the New England bladder cancer study and NAT2 meta-analysis

(2010) L. E. Moore et al.   CARCINOGENESIS

A systematic approach to understand the functional consequences of non-protein coding risk regions

(2010) Gerhard A. Coetzee et al.   CELL CYCLE

Genome-wide association studies in common cancers—what have we learnt?

(2010) Jajini Susan Varghese et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Adjusting for covariates in logistic regression models

(2010) Guan Xing et al.   GENETIC EPIDEMIOLOGY

MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes

(2010) Yun Li et al.   GENETIC EPIDEMIOLOGY

Assessment of copy number variation using the Illumina Infinium 1M SNP-array: a comparison of methodological approaches in the Spanish Bladder Cancer/EPICURO study

(2010) Gaëlle Marenne et al.   HUMAN MUTATION

Replication of Lung Cancer Susceptibility Loci at Chromosomes 15q25, 5p15, and 6p21: A Pooled Analysis From the International Lung Cancer Consortium

(2010) Therese Truong et al.   JNCI-Journal of the National Cancer Institute

Integrating common and rare genetic variation in diverse human populations

(2010)   NATURE

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk

(2010) Dalemari Crowther-Swanepoel et al.   NATURE GENETICS

Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer

(2010) Clare Turnbull et al.   NATURE GENETICS

Common variants at 19p13 are associated with susceptibility to ovarian cancer

(2010) Kelly L Bolton et al.   NATURE GENETICS

A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci

(2010) Jin-Xin Bei et al.   NATURE GENETICS

A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma

(2010) Christian C Abnet et al.   NATURE GENETICS

Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies a susceptibility locus at PLCE1

(2010) Li-Dong Wang et al.   NATURE GENETICS

Sequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behavior

(2010) Thorgeir E Thorgeirsson et al.   NATURE GENETICS

GWAS identifies a common breast cancer risk allele among BRCA1 carriers

(2010) Peter Kraft et al.   NATURE GENETICS

Estimation of effect size distribution from genome-wide association studies and implications for future discoveries

(2010) Ju-Hyun Park et al.   NATURE GENETICS

Genome-wide association study identifies five new breast cancer susceptibility loci

(2010) Clare Turnbull et al.   NATURE GENETICS

Performance of Common Genetic Variants in Breast-Cancer Risk Models

(2010) Sholom Wacholder et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inherited genetic variant predisposes to aggressive but not indolent prostate cancer

(2010) J. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inherited genetic markers discovered to date are able to identify a significant number of men at considerably elevated risk for prostate cancer

(2010) Jielin Sun et al.   PROSTATE

A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma

(2009) Maria Teresa Landi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-wide Association Study Reveals Multiple Nasopharyngeal Carcinoma-Associated Loci within the HLA Region at Chromosome 6p21.3

(2009) Ka-Po Tse et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Unified Approach to Genotype Imputation and Haplotype-Phase Inference for Large Data Sets of Trios and Unrelated Individuals

(2009) Brian L. Browning et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genotype Imputation

(2009) Yun Li et al.   Annual Review of Genomics and Human Genetics

Established Prostate Cancer Susceptibility Variants are not Associated with Disease Outcome

(2009) F. E. Wiklund et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Two Independent Prostate Cancer Risk-Associated Loci at 11q13

(2009) S. L. Zheng et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Deciphering the Impact of Common Genetic Variation on Lung Cancer Risk: A Genome-Wide Association Study

(2009) P. Broderick et al.   CANCER RESEARCH

Association of a Germ-Line Copy Number Variation at 2p24.3 and Risk for Aggressive Prostate Cancer

(2009) W. Liu et al.   CANCER RESEARCH

Genome-wide association studies in cancer--current and future directions

(2009) C. C. Chung et al.   CARCINOGENESIS

Fine mapping association study and functional analysis implicate a SNP in MSMB at 10q11 as a causal variant for prostate cancer risk

(2009) B.-L. Chang et al.   HUMAN MOLECULAR GENETICS

Value of Adding Single-Nucleotide Polymorphism Genotypes to a Breast Cancer Risk Model

(2009) Mitchell H. Gail   JNCI-Journal of the National Cancer Institute

ABO Blood Group and the Risk of Pancreatic Cancer

(2009) B. M. Wolpin et al.   JNCI-Journal of the National Cancer Institute

Risk of Estrogen Receptor–Positive and –Negative Breast Cancer and Single–Nucleotide Polymorphism 2q35-rs13387042

(2009) Roger L. Milne et al.   JNCI-Journal of the National Cancer Institute

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma

(2009) Christine F Skibola et al.   NATURE GENETICS

New common variants affecting susceptibility to basal cell carcinoma

(2009) Simon N Stacey et al.   NATURE GENETICS

Identification of a new prostate cancer susceptibility locus on chromosome 8q24

(2009) Meredith Yeager et al.   NATURE GENETICS

A genome-wide association study of testicular germ cell tumor

(2009) Elizabeth A Rapley et al.   NATURE GENETICS

Common variations in BARD1 influence susceptibility to high-risk neuroblastoma

(2009) Mario Capasso et al.   NATURE GENETICS

Multiple loci on 8q24 associated with prostate cancer susceptibility

(2009) Ali Amin Al Olama et al.   NATURE GENETICS

Germline genomic variants associated with childhood acute lymphoblastic leukemia

(2009) Lisa R Treviño et al.   NATURE GENETICS

The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer

(2009) Mark M Pomerantz et al.   NATURE GENETICS

Sequence variants at the TERT-CLPTM1L locus associate with many cancer types

(2009) Thorunn Rafnar et al.   NATURE GENETICS

Genome-wide association study identifies five susceptibility loci for glioma

(2009) Sanjay Shete et al.   NATURE GENETICS

Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer

(2009) Laufey Amundadottir et al.   NATURE GENETICS

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling

(2009) Sari Tuupanen et al.   NATURE GENETICS

Beyond odds ratios — communicating disease risk based on genetic profiles

(2009) Peter Kraft et al.   NATURE REVIEWS GENETICS

A Spectrum of Severe Familial Liver Disorders Associate with Telomerase Mutations

(2009) Rodrigo T. Calado et al.   PLoS One

Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia

(2009) R. T. Calado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common Regulatory Variation Impacts Gene Expression in a Cell Type-Dependent Manner

(2009) A. S. Dimas et al.   SCIENCE

Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers

(2008) Meredith Yeager et al.   HUMAN GENETICS

Familial Aggregation of Common Sequence Variants on 15q24-25.1 in Lung Cancer

(2008) Pengyuan Liu et al.   JNCI-Journal of the National Cancer Institute

When the smoke clears ...

(2008) Stephen J. Chanock et al.   NATURE

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

(2008) Thorgeir E. Thorgeirsson et al.   NATURE

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

(2008) Rayjean J. Hung et al.   NATURE

Progress and challenges in genome-wide association studies in humans

(2008) Peter Donnelly   NATURE

Multiple ADH genes are associated with upper aerodigestive cancers

(2008) Mia Hashibe et al.   NATURE GENETICS

Common 5p15.33 and 6p21.33 variants influence lung cancer risk

(2008) Yufei Wang et al.   NATURE GENETICS

Multiple loci identified in a genome-wide association study of prostate cancer

(2008) Gilles Thomas et al.   NATURE GENETICS

Evidence for two independent prostate cancer risk–associated loci in the HNF1B gene at 17q12

(2008) Jielin Sun et al.   NATURE GENETICS

Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

(2008) Lambertus A Kiemeney et al.   NATURE GENETICS

Variation in KLK genes, prostate-specific antigen and risk of prostate cancer

(2008) Jiyoung Ahn et al.   NATURE GENETICS

Multiple newly identified loci associated with prostate cancer susceptibility

(2008) Rosalind A Eeles et al.   NATURE GENETICS

Common and rare variants in multifactorial susceptibility to common diseases

(2008) Walter Bodmer et al.   NATURE GENETICS

Integrated detection and population-genetic analysis of SNPs and copy number variation

(2008) Steven A McCarroll et al.   NATURE GENETICS

Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs

(2008) Joshua M Korn et al.   NATURE GENETICS

Two newly identified genetic determinants of pigmentation in Europeans

(2008) Patrick Sulem et al.   NATURE GENETICS

Chromosome 6p22 Locus Associated with Clinically Aggressive Neuroblastoma

(2008) John M. Maris et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cumulative Association of Five Genetic Variants with Prostate Cancer

(2008) S. Lilly Zheng et al.   NEW ENGLAND JOURNAL OF MEDICINE

Polygenes, Risk Prediction, and Targeted Prevention of Breast Cancer

(2008) Paul D.P. Pharoah et al.   NEW ENGLAND JOURNAL OF MEDICINE