期刊
HUMAN GENETICS
卷 131, 期 1, 页码 77-85出版社
SPRINGER
DOI: 10.1007/s00439-011-1048-z
关键词
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资金
- Huntsman Cancer Foundation
- NIH National Cancer Institute [R01 CA102422]
- Utah Cancer Registry
- National Cancer Institute [N01-PC-35141, P30 CA42014]
- Utah State Department of Health
- University of Utah
- Huntsman Cancer Institute
- Huntsman Cancer Institute's Cancer Center
- University of Utah General Clinical Research Center [UL1-RR025764]
Only two genome-wide association (GWA) screens have been published for melanoma (Nat Genet 47:920-925, 2009; Nat Genet 40:838-840, 2008). Using a unique approach, we performed a genome-wide association study in 156 related melanoma cases from 34 high-risk Utah pedigrees. Genome-wide association analysis was performed on nearly 500,000 markers; we compared cases to 2,150 genotypically matched samples from Illumina's iControls database. We performed genome-wide association with EMMAX software, which is designed to account for population structure, including relatedness between cases. Three SNPs exceeded a genome-wide significance threshold of p < 5 x 10(-8) on chromosome arm 10q25.1 (rs17119434, rs17119461, and rs17119490), where the most extreme p value was 7.21 x 10(-12). This study represents a new and unique approach to predisposition gene identification; and it is the first genome-wide association study performed in related cases in high-risk pedigrees. Our approach illustrates an example of using high-risk pedigrees for the identification of new melanoma predisposition variants.
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