Review
Immunology
Xiaozhu Hu, Guoquan Yin, Yuan Zhang, Liangyu Zhu, Haoyu Huang, Kun Lv
Summary: This article reviews and summarizes studies on the functions of nuclear miRNAs, which are non-coding small RNAs that play a role in transcriptional regulation in the cell nucleus, expanding the functional range of miRNAs.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Thomas Jet, Guillaume Gines, Yannick Rondelez, Valerie Taly
Summary: MicroRNA detection is a crucial challenge in analytical chemistry, with the need for high sensitivity, specificity, robustness, and quantitative analysis. The ability to perform multiplexed detection of miRNA concentrations is important for recognizing disease signatures and new innovative detection methods have been developed to address this challenge.
CHEMICAL SOCIETY REVIEWS
(2021)
Review
Chemistry, Analytical
Chang Song, Wenhui Chen, Jingyu Kuang, Yao Yao, Sheng Tang, Ze Zhao, Xijie Guo, Wei Shen, Hian Kee Lee
Summary: MicroRNAs (miRNAs) are endogenous, noncoding, single-stranded RNA molecules with an average length of about 22 nucleotides, playing important roles in cell differentiation, biological development, and disease progression. Analytical tools focusing on multiple miRNAs detection have been developed to better meet the needs of miRNA research, as the collective roles of multiple miRNAs are more critical than that of a single miRNA.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Sarah Janati-Idrissi, Mariana Roza de Abreu, Cervin Guyomar, Fernanda de Mello, Thaovi Nguyen, Nazim Mechkouri, Stephanie Gay, Jerome Montfort, Anne Alicia Gonzalez, Marzieh Abbasi, Jerome Bugeon, Violette Thermes, Herve Seitz, Julien Bobe
Summary: This study provides a proof of concept for the successful identification of miRNA phenotypic targets from RNA-seq data. The researchers identified tead3b as a target of miR-202-5p, which is involved in ovarian function and egg production. This study highlights the importance of understanding miRNA functions and their targets in order to better understand biological processes.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Cell Biology
Mafalda Rizzuti, Luca Sali, Valentina Melzi, Simone Scarcella, Gianluca Costamagna, Linda Ottoboni, Lorenzo Quetti, Lorenzo Brambilla, Dimitra Papadimitriou, Federico Verde, Antonia Ratti, Nicola Ticozzi, Giacomo Pietro Comi, Stefania Corti, Delia Gagliardi
Summary: This article provides an overview of the research progress in investigating the molecular mechanisms of ALS using genomics, epigenomics, transcriptomics, and microRNAs. It reports the most relevant genes implicated in ALS pathogenesis and discusses the use of different high-throughput sequencing techniques and the role of epigenomic modifications. Furthermore, it presents the latest advances in transcriptomic studies and discusses the potential of microRNAs as biomarkers and molecular intervention tools.
AGEING RESEARCH REVIEWS
(2023)
Review
Biochemical Research Methods
Loukia Petrou, Sylvain Ladame
Summary: Circulating microRNAs are considered promising biomarkers for diagnosis and prediction, but the development of nucleic acid sensors for their detection faces challenges in robustness and sample processing. The transition of miRNA-based nucleic acid tests from the lab to the bedside relies on automated sample processing platforms.
Review
Biochemistry & Molecular Biology
Attila A. Seyhan
Summary: There is an urgent need for robust and reliable biomarkers for early diagnosis, prognosis, and prediction of response to specific treatments in aggressive and deadly cancers, such as pancreatic cancer. Liquid biopsy-based miRNA profiling shows potential for fulfilling this need. MiRNAs are non-coding RNAs that regulate gene expression and have emerged as potential diagnostic, prognostic, predictive, and therapeutic biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Genetics & Heredity
Zhipu Niu, Zitao Huo, Jichao Sha, Cuida Meng
Summary: miRNAs play important regulatory roles in biological events of cells, including the development of CRSwNP; RBPs and specific membrane proteins like caveolin-1 are crucial for the transport of miRNAs to exosomes; Exogenous miRNAs delivered via exosomes alter endogenous miRNA content, affecting inflammatory response and airway remodeling in CRSwNP.
FRONTIERS IN GENETICS
(2022)
Review
Oncology
Swapnil Parashram Bhavsar
Summary: Exosomal miRNAs (exo-miRs) are crucial in cell-cell communication and drive cancer progression. However, there is limited research on the role of exo-miRs in neuroblastoma, a children's cancer. This mini review provides a brief summary of the existing literature on this topic.
FRONTIERS IN ONCOLOGY
(2023)
Review
Genetics & Heredity
Bruna Maria de Sa Pereira, Rafaela Montalvao de Azevedo, Joao Victor da Silva Guerra, Paulo A. Faria, Sheila Coelho Soares-Lima, Beatriz De Camargo, Mariana Maschietto
Summary: Non-coding RNAs, particularly miRNAs, play important roles in tumorigenesis and resistance to chemotherapy, and are potentially related to the development of various cancers. Genes regulated by miRNAs may serve as potential targets for cancer therapies, including Wilms' tumors.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Review
Pharmacology & Pharmacy
Ning Ding, Sangsin Lee, Matan Lieber-Kotz, Jie Yang, Xue Gao
Summary: With over 466 million people worldwide affected by hearing loss, genetic factors contributing to 50% of congenital hearing loss, CRISPR-Cas9 systems offer new gene therapy strategies for treating genetic hearing impairment. This technology shows promise in targeted gene editing for deafness-associated genes and has the potential to revolutionize the treatment of genetic hearing diseases.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Chemistry, Analytical
Xin-Yuan Hu, Zhen Song, Zi-Wei Yang, Jia-Jing Li, Jing Liu, Huai-Song Wang
Summary: The study shows that miRNAs are related to cancer drug resistance and regulated by multiple mechanisms. Developing accurate miRNA detection methods is crucial for understanding drug resistance.
Review
Biochemistry & Molecular Biology
Mubashir Hassan, Aqsa Amir, Saba Shahzadi, Andrzej Kloczkowski
Summary: MicroRNAs play a significant role in depression, affecting associated proteins and signaling pathways. They have the potential to be used as biomarkers and therapy targets for treating depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Alexander G. Raufi, Michael S. May, Matthew J. Hadfield, Attila A. Seyhan, Wafik S. El-Deiry
Summary: Pancreatic cancer is a highly aggressive malignancy with late detection and high recurrence rate. Liquid biopsies represent an emerging group of technologies that can help with diagnosis, prognosis, treatment response prediction, and recurrence detection. Although not yet approved for routine use, the increasing sensitivity and specificity of contemporary liquid biopsy platforms will likely change clinical practice in the near future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Qidi Jiang, Yiran Li, Quanli Wu, Li Huang, Jiasheng Xu, Qingfu Zeng
Summary: Ischemic stroke resulting from atherosclerosis, particularly in the carotid artery, is a common subtype of stroke with a high mortality rate. The pathological processes involve lipid homeostasis, inflammation, plaque formation, and rupture. MicroRNAs play a crucial role in regulating these processes and have potential diagnostic and therapeutic implications for atherosclerotic ischemic stroke.