Article
Neurosciences
Kuan-Hua Chen, Alice Y. Hua, Sandy J. Lwi, Claudia M. Haase, Howard J. Rosen, Bruce L. Miller, Robert W. Levenson
Summary: This study examined the neuroanatomical correlates of subjective experience of non-target emotions in patients with neurodegenerative diseases. The findings indicated that smaller volume in left hemisphere regions was associated with greater experience of negative non-target emotions, with effects being left-lateralized. No correlates were found for positive non-target emotions.
Article
Clinical Neurology
Siddharth Ramanan, Ajay D. Halai, Lorna Garcia-Penton, Alistair G. Perry, Nikil Patel, Katie A. Peterson, Ruth U. Ingram, Ian Storey, Stefano F. Cappa, Eleonora Catricala, Karalyn Patterson, James B. Rowe, Peter Garrard, Matthew A. Lambon Ralph
Summary: The study investigated cognitive-linguistic heterogeneity in PPA using a data-driven approach. The findings revealed language and cognitive differences between different variants of PPA, which were associated with grey/white matter degeneration. By employing a transdiagnostic approach, the study revealed shared clinical and neural profiles across categorically defined variants of PPA.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Oncology
Xiao-Xia Hou, Hong-Xuan Feng, Bo Xu, Zhi-Sen Li, Yan-Li Lu, Hui -Min Zhao, Mei-Xia Wang, Qian-Ru Shi, Qian Gui, Guan-Hui Wu, Ming-Qiang Shen, Wei Zhu, Qin-Rong Xu, Xiao-Feng Dong, Qing-Zhang Cheng, Ji-Bin Zhang, Zhi-Liang Ding
Summary: This study used diffusion tensor imaging to investigate changes in the cerebral white matter of epilepsy patients. The results showed widespread alterations in white matter integrity in epileptic patients, potentially leading to affective disorders, impaired cognition, and motor abnormalities.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Clinical Neurology
Zhixia Cui, Liangliang Meng, Qing Zhang, Jing Lou, Yuan Lin, Yueji Sun
Summary: This study used diffusion-tensor imaging (DTI) and voxel-based morphometry (VBM) to investigate the neurobiological basis of dependent personality disorder (DPD). The results showed differences in neuronal fiber integrity, brain tissue integrity, and gray matter volume between DPD patients and healthy controls. These findings provide new insights into the brain structure alterations in DPD and suggest a potential link between brain structure and the pathophysiology of DPD.
Article
Neurosciences
Valerie Godefroy, Benedicte Batrancourt, Sylvain Charron, Arabella Bouzigues, Idil Sezer, David Bendetowicz, Guilhem Carle, Armelle Rametti-Lacroux, Stephanie Bombois, Emmanuel Cognat, Raffaella Migliaccio, Richard Levy
Summary: This study found distinct clinical subtypes of apathy in bvFTD patients, corresponding to different anatomical subtypes. These findings have important implications for clinicians in personalizing the treatment of apathy.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Alexandrine Morand, Shailendra Segobin, Gregory Lecouvey, Julie Gonneaud, Francis Eustache, Geraldine Rauchs, Beatrice Desgranges
Summary: This study found that older participants had lower gray matter volumes in several brain areas, but these did not correlate with TBPM performance. On the other hand, a decline in white matter integrity was correlated with TBPM performance, indicating a disconnection process that occurs in aging and contributes to cognitive decline.
Article
Neurosciences
Qian Chen, Han Lv, Zhaodi Wang, Xuan Wei, Pengfei Zhao, Zhenghan Yang, Shusheng Gong, Zhenchang Wang
Summary: This study explored brain structural and white matter microstructural reorganization in early tinnitus and identified specific brain alterations related to its improvement. Results indicated a connection between the right middle frontal gyrus/right precentral gyrus gray matter volume decrease and treatment effectiveness. The right MFG/PreCG and bilateral MCP could potentially serve as imaging indicators for evaluating prognosis and screening patients.
HUMAN BRAIN MAPPING
(2021)
Article
Neuroimaging
Youling Bai, Li Zhang, Chengwei Liu, Xiaobing Cui, Dan Li, Huazhan Yin
Summary: The study investigated the association between white matter volume and sleep quality, finding a negative correlation between global PSQI score and white matter volume in specific brain regions. This suggests that exploring brain white structure in relation to sleep may help to explain the mechanisms underlying the association between sleep quality and brain function, behavior, and cognition, as well as the networks responsible for variations in sleep.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Geriatrics & Gerontology
Martina Amanzio, Sara Palermo, Mario Stanziano, Federico D'Agata, Antonello Galati, Salvatore Gentile, Giancarlo Castellano, Massimo Bartoli, Giuseppina Elena Cipriani, Elisa Rubino, Paolo Fonio, Innocenzo Rainero
Summary: Our study reveals a correlation between early frailty in bvFTD patients and a specific pattern of co-occurring GM atrophy and hypometabolism. These findings underscore the potentially critical and precocious role of the insula in the pathogenesis of frailty, combined with executive dysfunction and mood changes, which may lead to a higher risk of poor prognosis.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Qian Zhang, XiaoLi Yang, ZhongKui Sun
Summary: This study explores the importance of classification features and experimental algorithms in early detection and diagnosis of Alzheimer's disease. The results indicate that the combination of gray matter volume and lateralization index is an effective feature, and different classifier algorithms have varying performances in different subject groups. Combining the lateralization index with gray matter volume can significantly improve classification accuracy.
Article
Behavioral Sciences
Myrthe G. Rijpma, Maxime Montembeault, Suzanne Shdo, Joel H. Kramer, Bruce L. Miller, Katherine P. Rankin
Summary: Attaching semantic meaning to sensory information received from both inside and outside our bodies is a fundamental function of the human brain. The formation of semantic knowledge relies on connections between distributed modality-specific spoke-nodes and a modality-general hub in the anterior temporal lobes (ATLs). In addition to the ATL semantic hub, a social semantic task also requires input from hedonic evaluation structures.
Article
Geriatrics & Gerontology
Simon Rechberger, Yong Li, Sebastian J. Kopetzky, Markus Butz-Ostendorf, Alzheimer's Dis Neuroimaging Initiat
Summary: Longitudinal MRI studies are increasingly important in documenting the time course of neurodegenerative diseases and neuroprotective effects of drug candidates in clinical trials. This study proposes a comprehensive analysis pipeline that includes automated image processing, statistical assessment using a multiplicative model, and multiple testing correction. The pipeline was tested on a small cohort of Alzheimer's disease patients and showed significant study outcomes, demonstrating the reliability of precise image assessments, APC computation, and adequate multiple testing correction for small sample studies.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Francesca Trojsi, Federica Di Nardo, Mattia Siciliano, Giuseppina Caiazzo, Cinzia Femiano, Carla Passaniti, Dario Ricciardi, Antonio Russo, Alvino Bisecco, Sabrina Esposito, Maria Rosaria Monsurro, Mario Cirillo, Gabriella Santangelo, Fabrizio Esposito, Gioacchino Tedeschi
Summary: Advanced neuroimaging techniques may help monitor disease progression in amyotrophic lateral sclerosis (ALS), showing reduced functional connectivity in specific areas in ALS patients without longitudinal changes in cognitive functions. Impairment of extramotor networks may precede executive and language dysfunctions and could serve as radiological markers of disease progression.
Review
Psychiatry
Carolin Spindler, Louisa Mallien, Sebastian Trautmann, Nina Alexander, Markus Muehlhan
Summary: White matter (WM) alterations are significant in patients with alcohol use disorder (AUD), and these changes may contribute to motor, cognitive, affective, and perceptual impairments. However, further research is needed to understand the variations of WM alterations over the course of the disorder and their reversibility with prolonged abstinence.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychiatry
Guorui Zhao, Way K. W. Lau, Chanyu Wang, Haifeng Yan, Chichen Zhang, Kangguang Lin, Shijun Qiu, Ruiwang Huang, Ruibin Zhang
Summary: Schizophrenia and bipolar disorder share similarities in terms of brain white matter structure abnormalities, but also have disorder-specific abnormalities. Schizophrenia patients show more extensive white matter alterations compared to bipolar disorder cases, which may be the pathophysiological basis for the clinical continuity of both disorders.
SCHIZOPHRENIA BULLETIN
(2022)
Review
Clinical Neurology
Bonnie Yin Ka Lam, Yuan Cai, Rufus Akinyemi, Geert Jan Biessels, Hilde van den Brink, Christopher Chen, Chin Wai Cheung, King Ngai Chow, Henry Kwun Hang Chung, Marco Duering, Siu Ting Fu, Deborah Gustafson, Saima Hilal, Vincent Ming Ho Hui, Rajesh Kalaria, Sang Yun Kim, Maggie Li Man Lam, Frank Erik de Leeuw, Ami Sin Man Li, Hugh Stephen Markus, Anna Marseglia, Huijing Zheng, John O'Brien, Leonardo Pantoni, Perminder Singh Sachdev, Eric E. Smith, Joanna Wardlaw, Vincent Chung Tong Mok
Summary: This study systematically reviewed the prevalence of cerebral small vessel disease (cSVD) in low- and middle-income countries (LMICs). The results demonstrated a high prevalence of cSVD in LMICs. There is a need for more data from different regions to support the findings, as there is currently bias in the available studies.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Review
Psychology, Experimental
Muireann Irish
Summary: Autobiographical memory is a crucial aspect of human cognition that allows us to recall significant events from our personal past and envision future goals and behavior. Dementia syndromes provide valuable insights into the cognitive neuroarchitecture of autobiographical memory, and the disruption of this memory function varies across different types of dementia.
WILEY INTERDISCIPLINARY REVIEWS-COGNITIVE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Zac Chatterton, Praves Lamichhane, Diba Ahmadi Rastegar, Lauren Fitzpatrick, Helene Lebhar, Christopher Marquis, Glenda Halliday, John B. Kwok
Summary: This study presents a single-cell DNA methylation sequencing method that can accurately resolve the DNA methylation profiles of individual cells. The sciEM method improves sequencing alignment rates, reduces adapter contamination, and over-estimation of DNA methylation levels. The researchers successfully applied this method to resolve single-cell DNA methylation of major cell types in the human brain.
CELL AND BIOSCIENCE
(2023)
Article
Neuroimaging
Nga Yan Tse, Martina Bocchetta, Emily G. Todd, Emma M. Devenney, Sicong Tu, Jashelle Caga, John R. Hodges, Glenda M. Halliday, Muireann Irish, Matthew C. Kiernan, Olivier Piguet, Jonathan D. Rohrer, Rebekah M. Ahmed
Summary: Through studying a large sample of 211 participants, it was found that different subregions of the hypothalamus are correlated with cognitive and behavioral impairments. Patients with ALS, mixed ALS-FTD, and bvFTD all showed hypothalamic involvement. Cognitive and behavioral symptoms were correlated with bilateral involvement of the anterior inferior, anterior superior, and posterior hypothalamic subregions. The anterior superior and superior tuberal subregions displayed the greatest volume loss in bvFTD and ALS-FTD, and ALS, respectively, and were associated with specific neuropeptide expression abnormalities.
NEUROIMAGE-CLINICAL
(2023)
Article
Clinical Neurology
Yannie Soo, Annaelle Zietz, Brian Yiu, Vincent C. T. Mok, Alexandros A. Polymeris, David Seiffge, Gareth Ambler, Duncan Wilson, Thomas Wai Hong Leung, Suk Fung Tsang, Winnie Chu, Jill Abrigo, Cyrus Cheng, Keon-Joo Lee, Jae-Sung Lim, Masayuki Shiozawa, Masatoshi Koga, Hugues Chabriat, Michael Hennerici, Yuen Kwun Wong, Henry Mak, Roger Collet, Shigeru Inamura, Kazuhisa Yoshifuji, Ethem Murat Arsava, Solveig Horstmann, Jan Purrucker, Bonnie Y. K. Lam, Adrian Wong, Young Dae Kim, Tae-Jin Song, Robin Lemmens, Sebastian Eppinger, Thomas Gattringer, Ender Uysal, Derya Selcuk Demirelli, Natan M. Bornstein, Einor Ben Assayag, Hen Hallevi, Jeremy Molad, Masashi Nishihara, Jun Tanaka, Shelagh B. Coutts, L. Jaap Kappelle, Rustam Al-Shahi Salman, Rolf Jager, Gregory Y. H. Lip, Martina B. Goeldlin, Leonidas D. Panos, Jean-Louis Mas, Laurence Legrand, Chris Karayiannis, Thanh Phan, Maximilian Bellut, Francesca Chappell, Stephen Makin, Derek Hayden, David Williams, Dianne H. K. van Dam-Nolen, Paul J. Nederkoorn, Carmen Barbato, Simone Browning, Kim Wiegertjes, Anil Man Tuladhar, Anne-Marie Mendyk, Sebastian Kohler, Robert van Oostenburgge, Ying Zhou, Chao Xu, Saima Hilal, Bibek Gyanwali, Christopher Chen, Min Lou, Julie Staals, Regis Bordet, Nagaendran Kandiah, Frank-Erik de Leeuw, Robert Simister, Jeroen Hendrikse, Joanna Wardlaw, Peter Kelly, Felix Fluri, Velandai Srikanth, David Calvet, Simon Jung, Vincent I. H. Kwa, Eric E. Smith, Hideo Hara, Yusuke Yakushiji, Dilek Necioglu Orken, Franz Fazekas, Vincent Thijs, Ji-Hoe Heo, Roland Veltkamp, Hakan Ay, Toshio Imaizumi, Kui Kai Lau, Eric Jouvent, Kazunori Toyoda, Sohei Yoshimura, Hee-Joon Bae, Joan Marti-Fabregas, Luis Prats-Sanchez, Philippe Lyrer, Jonathan Best, David Werring, Stefan T. Engelter, Nils Peters
Summary: This study aimed to evaluate the risks of intracranial hemorrhage and ischemic stroke associated with microbleeds in atrial fibrillation patients. The results showed that the presence of microbleeds increased the relative risk of hemorrhage and stroke. In patients taking a combination of anticoagulant and antiplatelet therapy, the risk of intracranial hemorrhage was higher than that of ischemic stroke.
ANNALS OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Priscilla Youssef, Laura Hughes, Woojin S. Kim, Glenda M. Halliday, Simon J. G. Lewis, Antony Cooper, Nicolas Dzamko
Summary: Objective biomarkers for Parkinson's Disease (PD) could aid early and specific diagnosis, effective monitoring of disease progression, and improved design and interpretation of clinical trials. In this study, the potential of the SIMOA neurology 4-plex-A marker panel, along with plasma alpha-synuclein, as biomarkers for PD diagnosis and prognosis was assessed. The levels of NFL and GFAP in plasma positively correlated with alpha-synuclein levels, while as disease state biomarkers, NFL and GFAP showed correlation with motor severity and stage.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Hiu Chuen Lok, Jared S. Katzeff, John R. Hodges, Olivier Piguet, YuHong Fu, Glenda M. Halliday, Woojin Scott Kim
Summary: Neuroinflammation is a key feature of frontotemporal dementia (FTD), characterized by the degeneration of the frontal and temporal lobes. This study examined 48 cytokines in FTD serum and brain tissues to identify common dysregulation pathways. The results suggest the potential importance of the NLRP3 inflammasome in FTD.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Lyndal Henden, Liam G. Fearnley, Natalie Grima, Emily P. McCann, Carol Dobson-Stone, Lauren Fitzpatrick, Kathryn Friend, Lynne Hobson, Sandrine Chan Moi Fat, Dominic B. Rowe, Susan D'Silva, John B. Kwok, Glenda M. Halliday, Matthew C. Kiernan, Srestha Mazumder, Hannah C. Timmins, Margaret Zoing, Roger Pamphlett, Lorel Adams, Melanie Bahlo, Ian P. Blair, Kelly L. Williams
Summary: In this study, we analyzed whole-genome sequencing data from 608 patients with sporadic ALS, 68 patients with sporadic FTD, and 4703 matched controls using three tools. We found that 17.6% of clinically diagnosed ALS and FTD cases had expanded STR alleles reported to be pathogenic or intermediate for other neurodegenerative diseases, providing evidence for their contribution to the development of these diseases. We also identified multiple disease-relevant STR expansions associated with neurodegenerative diseases, highlighting the clinical and pathological pleiotropy of neurodegenerative disease genes and their importance in ALS and FTD.
Article
Neurosciences
Oana C. Marian, Jonathan D. Teo, Jun Yup Lee, Huitong Song, John B. Kwok, Ramon Landin-Romero, Glenda Halliday, Anthony S. Don
Summary: Heterozygous mutations in the GRN gene and hexanucleotide repeat expansions in C9orf72 are the most common genetic causes of Frontotemporal Dementia (FTD) with TDP-43 protein inclusions. Our comprehensive lipidomic analysis suggests that both C9orf72 and GRN mutations disrupt lysosomal homeostasis and result in white matter lipid loss, but GRN mutations cause more pronounced disruption to myelin lipid metabolism. The findings provide biochemical evidence supporting the use of MRI measures of white matter integrity in the diagnosis and management of FTD.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Review
Cell Biology
Jen-Hsiang T. Hsiao, Onur Tanglay, Anne A. Li, Aysha Y. G. Strobbe, Woojin Scott Kim, Glenda M. Halliday, YuHong Fu
Summary: Multiple system atrophy (MSA) is a debilitating movement disorder with unknown etiology. It presents with characteristic parkinsonism and/or cerebellar dysfunction due to deterioration in specific brain regions. The early pathological events and development mechanisms of MSA are reviewed, focusing on the involvement of oligodendrocyte lineage cells and alpha-synuclein. This understanding will guide future research in MSA.
Editorial Material
Clinical Neurology
Kristina Horne, Muireann Irish
BRAIN COMMUNICATIONS
(2023)
Article
Neurosciences
Adahir Labrador-Garrido, Siying Zhong, Laura Hughes, Shikara Keshiya, Woojin S. Kim, Glenda M. Halliday, Nicolas Dzamko
Summary: This study utilized a GCase substrate probe and live cell imaging to measure lysosomal enzyme activity. The results showed heterogeneity in GCase activity among PD patients, and a significant inverse correlation between GCase activity and α-synuclein protein levels. These findings suggest the importance of GCase in PD, and demonstrate the utility of this live cell imaging assay for further research on GCase in PD.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Letter
Clinical Neurology
Matthew C. Kiernan, Glenda M. Halliday, Dominic B. Rowe, Rachel H. Tan
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)
Article
Clinical Neurology
Kristina Horne, Rebekah M. Ahmed, Olivier Piguet, Muireann Irish
Summary: This study demonstrates the link between motivational changes and behavioral rigidity in frontotemporal dementia (FTD). The researchers found that FTD patients with severe behavioral rigidity also had a lack of motivation and decreased hedonic tone. By identifying candidate mechanisms of behavioral rigidity, these findings can inform targeted interventions to manage inflexible patterns of thought and behavior in daily life.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
