Article
Neurosciences
Julia F. Soares, Rodolfo Abreu, Ana Claudia Lima, Livia Sousa, Sonia Batista, Miguel Castelo-Branco, Joao Valente Duarte
Summary: Functional MRI (fMRI) is widely used in studying brain organization and connectivity abnormalities in neurological conditions. This study compared different methods for correcting motion effects in fMRI data and found that models with 6 motion parameters and volume interpolation were the most effective in preserving valuable information in both healthy controls and early multiple sclerosis patients. The results highlight the importance of motion correction strategies in task-based fMRI studies, particularly in clinical populations.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Bianca Wagner, Clara L. Haerig, Bertram Walter, Jens Sommer, Gebhard Sammer, Martin Berghoff
Summary: Cognitive impairments are common in multiple sclerosis (MS) patients, even those without significant cognitive deficits. This study found reduced activation in the hippocampus, pallidum, and anterior cingulate cortex (ACC) in MS patients during an attention network task. These functional brain changes might serve as a biological indicator of susceptibility to cognitive impairment in MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Adnan A. S. Alahmadi, Matteo Pardini, Rebecca S. Samson, Egidio D'Angelo, Karl J. Friston, Ahmed T. Toosy, Claudia A. M. Gandini Wheeler-Kingshott
Summary: This study demonstrates the selective impact of multiple sclerosis (MS) on regional BOLD responses to different levels of grip forces in the brain's motor areas BA 4a and BA 4p. MS patients show greater alterations in BA 4p compared to healthy volunteers, especially those with more severe disability. Polynomial analysis beyond the main effect of movement is crucial for uncovering these differences between MS patients and healthy individuals.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Yael Backner, Sol Zamir, Panayiota Petrou, Friedemann Paul, Dimitrios Karussis, Netta Levin
Summary: This study examined whether changes associated with optic neuritis can still be observed in the visual networks of progressive multiple sclerosis patients. The results showed that despite no significant difference in functional metrics between the two groups, the optic neuritis group had significantly lower anatomical global efficiency and density.
HUMAN BRAIN MAPPING
(2022)
Article
Neuroimaging
Maria A. Rocca, Menno M. Schoonheim, Paola Valsasina, Jeroen J. G. Geurts, Massimo Filippi
Summary: This article summarizes the main findings from studies using task-based and resting state fMRI in MS, and illustrates how these functional brain alterations are related to clinical disability and cognitive deficits. Longitudinal studies and the application of new technologies further reveal the disease progression and rehabilitation effects. In addition, preliminary results show the potential of two emerging topics. These functional studies are of great importance for understanding the mechanisms underlying progression in MS.
NEUROIMAGE-CLINICAL
(2022)
Article
Biology
Francisco Javier Ruiz-Sanchez, Maria do Rosario Martins, Salete Soares, Carlos Romero-Morales, Daniel Lopez-Lopez, Juan Gomez-Salgado, Ana Maria Jimenez-Cebrian
Summary: Fear of movement or kinesiophobia is an irrational fear of physical movement and fatigue that causes a limitation of functional capacity and decreased physical activity. This study aimed to assess the level of kinesiophobia in people with multiple sclerosis (pwMS) and compare it with a group of healthy people. The findings suggest that kinesiophobia is higher in pwMS than in the healthy control group.
Article
Clinical Neurology
Maria A. Rocca, Paola Valsasina, Bruno Colombo, Vittorio Martinelli, Massimo Filippi
Summary: Fatigue in multiple sclerosis patients improved regardless of treatment. Changes in resting state functional connectivity were located in sensorimotor, inferior frontal, and subcortical regions for fampridine- and amantadine-treated patients, while in associative sensory cortices for placebo-treated patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Isaiah Kletenik, Alexander L. Cohen, Bonnie I. Glanz, Michael A. Ferguson, Shahamat Tauhid, Jing Li, William Drew, Mariann Polgar-Turcsanyi, Miklos Palotai, Shan H. Siddiqi, Gad A. Marshall, Tanuja Chitnis, Charles R. G. Guttmann, Rohit Bakshi, Michael D. Fox
Summary: This study analyzed standard structural images and verbal memory scores of 431 patients with MS and found that memory dysfunction is associated with white matter damage, particularly damage to the brain circuit involving the hippocampus. This demonstrates the usefulness of a circuit-based approach using standard structural imaging for localization and prognosis of higher order deficits in MS.
JOURNAL OF NEUROLOGY
(2023)
Article
Neuroimaging
Christopher J. Cagna, Ahmet O. Ceceli, Joshua Sandry, Jamil P. Bhanji, Elizabeth Tricomi, Ekaterina Dobryakova
Summary: This study investigated feedback-based learning ability in multiple sclerosis (MS) patients, as well as associated cortico-striatal function and connectivity. The results showed that MS patients displayed preserved feedback-based learning ability despite reporting greater cognitive fatigue. Furthermore, the functional connectivity between the ventral striatum and task-relevant regions was stronger in MS patients compared to neurotypical individuals during feedback receipt.
NEUROIMAGE-CLINICAL
(2023)
Review
Chemistry, Analytical
Sagrario Perez-de la Cruz
Summary: This systematic review investigates the benefits of robot-assisted gait training in physiotherapy treatment for people with multiple sclerosis (MS). The findings suggest that robotic devices are not superior to other interventions in improving gait speed.
Article
Clinical Neurology
Daniela Pinter, Silvia Erika Kober, Viktoria Fruhwirth, Lisa Berger, Anna Damulina, Michael Khalil, Christa Neuper, Guilherme Wood, Christian Enzinger
Summary: This study found that cognitive improvement after neurofeedback training in patients with MS was associated with increased brain microstructure and functional connectivity. Successful neurofeedback training may help improve cognitive function.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Xiao Liang, Lei Wang, Yanyan Zhu, Yao Wang, Ting He, Lin Wu, Muhua Huang, Fuqing Zhou
Summary: The study explored the impact of cortical thickness on the identification accuracy of fALFF in patients with multiple sclerosis. Dividing fALFF by cortical thickness was found to potentially influence the identification accuracy. Additionally, 2d-fALFF per unit thickness showed promise as a potential diagnostic marker for distinguishing between acute and remitting MS patients, especially performing well in support vector machine analysis.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Andrea Tacchino, Ludovico Pedulla, Jessica Podda, Margherita Monti Bragadin, Mario Alberto Battaglia, Ambra Bisio, Marco Bove, Giampaolo Brichetto
Summary: This study investigates whether motor imagery (MI) can prime action execution in individuals with Multiple Sclerosis (MS). The results suggest that a few mental repetitions of an action might be sufficient to exert a priming effect on the actual execution of the same action in MS patients.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Review
Neurosciences
Eleonora Tavazzi, Marta Cazzoli, Alice Pirastru, Valeria Blasi, Marco Rovaris, Niels Bergsland, Francesca Baglio
Summary: The review summarized studies on the impact of motor rehabilitation on brain neuroplasticity in multiple sclerosis patients. It was found that motor rehabilitation can promote clinical improvement and induce positive adaptive brain changes, but the effects may vary depending on the type of rehabilitation approach.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Anna Maria Sobczak, Bartosz Bohaterewicz, Anna Ceglarek, Aleksandra Zyrkowska, Magdalena Fafrowicz, Agnieszka Slowik, Marcin Wnuk, Monika Marona, Klaudia Nowak, Kamila Zur-Wyrozumska, Tadeusz Marek
Summary: This study investigates the functional architecture of resting-state networks associated with fatigue in patients with multiple sclerosis (MS). It identifies differences in functional connectivity and brain activity between patients with high and low levels of fatigue.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Nancy D. Chiaravalloti, Erica Weber, Glenn Wylie, Trevor Dyson-Hudson, Jill M. Wecht
JOURNAL OF SPINAL CORD MEDICINE
(2020)
Article
Clinical Neurology
Nancy D. Chiaravalloti, Nancy B. Moore, John DeLuca
MULTIPLE SCLEROSIS JOURNAL
(2020)
Article
Psychology
Helen M. Genova, Katie Lancaster, Jean Lengenfelder, Christopher P. Bober, John DeLuca, Nancy D. Chiaravalloti
JOURNAL OF NEUROPSYCHOLOGY
(2020)
Article
Psychology, Biological
Olga Boukrina, Ekaterina Dobryakova, Veronica Schneider, John DeLuca, Nancy D. Chiaravalloti
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2020)
Article
Psychology
Marco Pitteri, Caterina Dapor, Anna Isabella Pisani, Marco Castellaro, John DeLuca, Nancy Chiaravalloti, Maddalena Guandalini, Stefano Ziccardi, Massimiliano Calabrese
JOURNAL OF NEUROPSYCHOLOGY
(2020)
Article
Clinical Neurology
Nancy D. Chiaravalloti, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Ulrik Dalgas, John DeLuca, Cecilia Meza, Nancy B. Moore, Peter Feys, Massimo Filippi, Jennifer Freeman, Matilde Inglese, Rob Motl, Maria Assunta Rocca, Brian M. Sandroff, Amber Salter, Gary Cutter, Anthony Feinstein
Summary: Overall, there was little change in symptoms of depression or anxiety, as well as overall quality of life for individuals with Progressive Multiple Sclerosis during the COVID-19 pandemic.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Nancy D. Chiaravalloti, Silvana L. Costa, Nancy B. Moore, Kristen Costanza, John DeLuca
Summary: This study demonstrates the effectiveness of speed of processing training in improving processing speed deficits in individuals with multiple sclerosis. The training showed significant effects on the useful field of view and neuropsychological evaluation, with the number of completed training levels correlating with greater benefits.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Brian M. Sandroff, Robert W. Motl, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Nancy D. Chiaravalloti, Gary R. Cutter, Ulrik Dalgas, John DeLuca, Rachel Farrell, Peter Feys, Massimo Filippi, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Maria A. Rocca, Amber Salter, Anthony Feinstein
Summary: The study examined the associations among cardiorespiratory fitness, moderate-to-vigorous physical activity (MVPA), and cognitive performance in a large progressive MS sample, finding no significant correlation between them.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Nancy D. Chiaravalloti, John DeLuca, Amber Salter, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Ulrik Dalgas, Rachel Farrell, Peter Feys, Massimo Filippi, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Nancy B. Moore, Robert W. Motl, Maria Assunta Rocca, Brian M. Sandroff, Gary Cutter, Anthony Feinstein
Summary: This study examined the association between processing speed and learning ability in individuals with progressive multiple sclerosis. The results showed a significant correlation between processing speed and performance on the California Verbal Learning Test and the Brief Visuospatial Memory Test. However, the ability of processing speed to predict impaired performance on these tests was only 77% according to statistical analysis.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Medicine, Research & Experimental
Nancy D. Chiaravalloti, Erica Weber, Ekaterina Dobryakova, Amanda Botticello, Yael Goverover, Nancy B. Moore, John DeLuca
Summary: Learning and memory impairments in Multiple Sclerosis (MS) have a negative impact on everyday life. Few cognitive rehabilitation protocols have strong research evidence for MS patients. This study examines the efficacy of a cognitive rehabilitation protocol, KF-STEMTM, to treat impaired learning and memory in MS patients.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2022)
Article
Neurosciences
Amanda Gahlot, Nancy Chiaravalloti, Yael Goverover
Summary: The study examined the impact of four personal protective factors on positive adaptation in individuals with traumatic brain injury. The results showed that higher levels of self-efficacy and emotional functioning were related to better quality of life, while poorer cognitive functioning and lower self-awareness were also related to better quality of life. Cognitive and emotional functioning were significant predictors of quality of life.
Article
Neurosciences
Nancy D. Chiaravalloti, Silvana Costa, Caroline Armknecht, Kristen Costanza, Aubree Alexander, John DeLuca
Summary: This study investigated the influence of processing speed (PS) on the effectiveness of KF-mSMT treatment in traumatic brain injury (TBI) patients. The study found that PS significantly predicted post-treatment change following KF-mSMT treatment, but did not have a significant impact on learning and memory outcomes.
Editorial Material
Clinical Neurology
Yael Goverover, Nancy Chiaravalloti
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Health Care Sciences & Services
Michelle H. Chen, Alex Leow, Mindy K. Ross, John DeLuca, Nancy Chiaravalloti, Silvana L. Costa, Helen M. Genova, Erica Weber, Faraz Hussain, Alexander P. Demos
Summary: This study examined the associations between smartphone keystroke dynamics and cognitive functioning in persons with multiple sclerosis (MS). The results showed that typing speed was related to processing speed, attention, and executive functioning, as well as fatigue and anxiety symptoms. Individuals with better cognitive functioning and less severe symptoms were better at monitoring their typing errors.
Article
Clinical Neurology
Stefanos E. Prouskas, Nancy D. Chiaravalloti, Neeltje Kant, Karlene K. Ball, Vincent de Groot, Bernard M. J. Uitdehaag, Jeroen J. G. Geurts, Elizabeth A. Kooij, Hanneke E. Hulst
Summary: This study suggests that cognitive rehabilitation is feasible in patients with advanced multiple sclerosis, with high adherence and completion rates, as well as high satisfaction from patients. While energy levels decreased slightly during sessions, the training difficulty and duration were close to ideal levels.
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2021)