Review
Behavioral Sciences
Lucas R. Trambaiolli, Simon H. Kohl, David E. J. Linden, David M. A. Mehler
Summary: Neurofeedback training shows potential as an additional treatment option for MDD patients not reaching remission from standard care. Most studies indicate symptom improvement in MDD patients compared to control groups. Recommendations are provided for improving experimental designs and reporting standards in neurofeedback training.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Psychiatry
Victor De la Pena-Arteaga, Mercedes Berruga-Sanchez, Trevor Steward, Ignacio Martinez-Zalacain, Ximena Goldberg, Agustina Wainsztein, Carolina Abulafia, Narcis Cardoner, Mariana N. Castro, Mirta Villarreal, Jose M. Menchon, Salvador M. Guinjoan, Carles Soriano-Mas
Summary: This study identified a shared neurobiological contributor to emotion regulation deficits in MDD and BPD characterized by decreased vlPFC activity, while also observing disorder-specific alterations. In MDD, there is a primary deficit in prefrontal activations, while BPD is defined by connectivity disruptions between the vlPFC and temporal emotion processing regions. These findings substantiate the different profiles of emotion regulation alterations observed in these disorders in neurobiological terms.
EUROPEAN PSYCHIATRY
(2021)
Article
Clinical Neurology
Xitian Chen, Zhengjia Dai, Ying Lin
Summary: The study aims to parse heterogeneity in major depressive disorder (MDD) through neurophysiological subtypes (biotypes) using a multiview biotype discovery framework. Two stable biotypes characterized by increased and decreased functional connectivity (FC) were identified, which promoted the diagnosis of MDD and showed different symptom profiles.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Xuan Ouyang, Yicheng Long, Zhipeng Wu, Dayi Liu, Zhening Liu, Xiaojun Huang
Summary: Previous studies have shown that suicidality in patients with major depressive disorder (MDD) is related to abnormal brain functional connectivity (FC) patterns. This study investigated the relationship between suicidality and dynamic functional connectivity (dFC) in MDD patients and found that MDD patients had decreased temporal stability of dFC in the whole brain, as well as within the default mode network (DMN) and subcortical network. Additionally, the temporal correlation coefficients of the DMN were negatively correlated with the scores of suicidality item in the Hamilton Rating Scale for Depression (HAMD) in MDD patients.
Article
Clinical Neurology
Xiaoqin Wang, Yi Xia, Rui Yan, Hao Sun, Yinghong Huang, Haowen Zou, Yishan Du, Lingling Hua, Hao Tang, Hongliang Zhou, Zhijian Yao, Qing Lu
Summary: This study aimed to explore the sex differences in the regional brain neuroimaging features of anhedonia in the context of major depressive disorder (MDD). The results showed significant differences in brain activity between males and females in relation to anhedonia, which may have clinical implications for treating anhedonia symptoms in MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neuroimaging
Li-Ming Hsu, Timothy Joseph Lane, Changwei W. Wu, Chien-Yuan Lin, Chi-Bin Yeh, Hung-Wen Kao, Ching-Po Lin
Summary: This study found that Sertraline treatment can restore some brain network connections in MDD patients, but some connections remain impaired. Thalamo-prefrontal connectivity shows moderate predictive power for the effectiveness of Sertraline treatment.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qinghe Li, Fanghui Dong, Qun Gai, Kaili Che, Heng Ma, Feng Zhao, Tongpeng Chu, Ning Mao, Peiyuan Wang
Summary: Machine-learning models combined with multisequence MRI neuroimaging features significantly improve the diagnosis of major depressive disorder and accurately predict suicide risk in patients with MDD.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Neurosciences
Feng-Nan Jia, Xiao Chen, Xiang-Dong Du, Zhen Tang, Xiao-Yun Ma, Tian-Tian Ning, Si-Yun Zou, Shang-Fu Zuo, Hui-Xian Li, Shi-Xian Cui, Zhao-Yu Deng, Jia-Lin Fu, Xiao-Qian Fu, Yue-Xiang Huang, Xue-Ying Li, Tao Lian, Yi-Fan Liao, Li-Li Liu, Bin Lu, Yan Wang, Yu-Wei Wang, Zi-Han Wang, Gang Ye, Xin-Zhu Zhang, Hong-Liang Zhu, Chuan-Sheng Quan, Hong-Yan Sun, Chao-Gan Yan, Yan-Song Liu
Summary: Rumination is closely related to the onset and maintenance of major depressive disorder (MDD). This study found that the left superior frontal gyrus (SFG) plays an important role in the neural circuitry mechanism of rumination in MDD, and is associated with impaired executive control and functional connectivity to the frontoparietal and dorsal attention networks.
HUMAN BRAIN MAPPING
(2023)
Article
Psychiatry
Radfar Moloud, Yavari Saeed, Haghighi Mahmonir, Gharaaghaji Asl Rasool
Summary: This study aimed to determine the effect of cognitive-behavioral group therapy on self-esteem and optimism in patients with major depressive disorder. The results showed that there was a significant difference in the mean scores of self-esteem and optimism between the cognitive-behavioral group therapy group and the treatment-as-usual group immediately, three months, and six months after the intervention.
Article
Neurosciences
Emma Komulainen, Enrico Glerean, Roope Heikkila, Lauri Nummenmaa, Tuukka T. Raij, Erkki Isometsa, Jesper Ekelund
Summary: In a double-blind study, it was found that one-week treatment with escitalopram led to changes in brain activity in depressed patients when exposed to complex emotional narratives, particularly increasing synchronization with positive emotional parts. This may help improve emotional synchronization with others, indicating a potential contribution to the therapeutic effect of escitalopram that warrants further investigation.
Article
Clinical Neurology
Danielle A. Goldman, Anjali Sankar, Alexandra Rich, Jihoon A. Kim, Brian Pittman, R. Todd Constable, Dustin Scheinost, Hilary P. Blumberg
Summary: This study aimed to identify functional connectivity differences between depressions of bipolar disorder (BD-Dep) and depressions of major depressive disorder (MDD-Dep). The results showed that there were significant differences in functional connectivity patterns between these two groups, suggesting the potential for early diagnosis and treatment strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Clinical
Hannah Lemke, Lina Romankiewicz, Katharina Foerster, Susanne Meinert, Lena Waltemate, Stella M. Fingas, Dominik Grotegerd, Ronny Redlich, Katharina Dohm, Elisabeth J. Leehr, Katharina Thiel, Verena Enneking, Katharina Brosch, Tina Meller, Kai Ringwald, Simon Schmitt, Frederike Stein, Olaf Steinstraeter, Jochen Bauer, Walter Heindel, Andreas Jansen, Axel Krug, Igor Nenadic, Tilo Kircher, Udo Dannlowski
Summary: This study investigates the association between disease course in Major Depressive Disorder (MDD) and brain structural alterations. The results suggest that a more severe and chronic disease course in MDD is associated with reduced volume in brain regions relevant for executive and cognitive functions and emotion regulation.
DEPRESSION AND ANXIETY
(2022)
Article
Behavioral Sciences
P. M. Briley, L. Webster, C. Boutry, W. J. Cottam, D. P. Auer, P. F. Liddle, R. Morriss
Summary: This systematic review explores the differences in resting-state brain connectivity associated with comorbid anxiety in individuals with MDD. The findings suggest that dysconnectivity between the amygdala and other brain networks, as well as abnormalities in default mode network connectivity, may play a role in the co-occurrence of anxiety and MDD.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Clinical Neurology
Rubai Zhou, Jun Chen, Guoqing Zhao, Zuowei Wang, Daihui Peng, Weiping Xia, Ruizhi Mao, Jingjing Xu, Fan Wang, Chen Zhang, Yong Wang, Chengmei Yuan, Yousong Su, Jia Huang, Tao Yang, Chenglei Wang, Lvchun Cui, Jijun Wang, Lena Palaniyappan, Yiru Fang
Summary: The study identified a link between greater GM volume in the right parahippocampal gyrus and higher social function in patients with MDD. Even with improved overall social function over 12 weeks, there were continued differences in social function between high and low-functioning subgroups.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Psychiatry
Lan Hu, Hui He, Neil Roberts, Jiajia Chen, Guojian Yan, Li Pu, Xufeng Song, Cheng Luo
Summary: Interoception plays an important role in maintaining bodily homeostasis and promoting survival, and dysfunction of interoception is commonly observed in individuals with Major Depressive Disorder (MDD). Neuroimaging studies have revealed alterations in the structure and function of the insula, a major brain structure involved in interoception, in individuals with depression, but the precise relationship between these alterations and interoceptive dysfunction is still unclear. This review aims to examine the evidence of interoceptive dysfunction in people with MDD and the specific alterations in insular structure and function revealed by neuroimaging.
FRONTIERS IN PSYCHIATRY
(2023)