Article
Neurosciences
Dania Rishiq, Ashley Harkrider, Cary Springer, Mark Hedrick
Summary: The study compared speech-evoked auditory brainstem responses (ABR) with click-evoked ABR in multiple sclerosis (MS) patients and controls, finding that speech-evoked ABR was more sensitive to MS-related changes and could potentially be a more effective clinical tool. Group differences were observed in peak amplitudes, latency, and response correlations, indicating potential for speech-evoked ABR to highlight neural synchrony loss in MS.
NEUROSCIENCE LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Kenji Tanaka, Shuma Ohara, Tadaaki Matsuzaka, Aira Matsugaki, Takuya Ishimoto, Ryosuke Ozasa, Yukiko Kuroda, Koichi Matsuo, Takayoshi Nakano
Summary: The auditory brainstem response (ABR) is commonly used to assess auditory function, but determining the ABR threshold has been a challenge. Existing methods lack accuracy, efficiency, and convenience. We proposed an improved algorithm based on mutual covariance to objectively determine the ABR threshold. This method effectively reduced the burden on experimental animals and provided more efficient and accurate results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Sang-Ku Park, Hyun Seok Lee, Kyung Rae Cho, Kwan Park
Summary: BAEP testing is crucial during MVD surgery for detecting vestibulocochlear nerve damage, and real-time testing is the best way to minimize this damage. Recent studies on the relationship between vestibulocochlear nerve damage and BAEP waveforms provide valuable insights.
Review
Otorhinolaryngology
Meliha Basoz Behmen, Nilsu Guler, Elif Kuru, Nilufer Bal, Ozge Gedik Toker
Summary: Speech-ABR is an auditory brainstem response that evaluates the temporal and spectral coding of speech. It can objectively measure the auditory cues important for speech recognition and has many clinical applications.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Neurosciences
Ourania Manta, Michail Sarafidis, Nikolaos Vasileiou, Winfried Schlee, Christos Consoulas, Dimitris Kikidis, Evgenia Vassou, George K. Matsopoulos, Dimitrios D. Koutsouris
Summary: This study aimed to develop two automated annotation tools for auditory brainstem response (ABR) and auditory middle latency response (AMLR) tests. After processing 1046 raw waveforms, the tools successfully detected and annotated the waves of interest, achieving high match rates when compared to manual annotation by clinicians. The application of these tools is expected to facilitate easier interpretation of these signals.
Article
Biology
Hannah M. Oberle, Alexander N. Ford, Deepak Dileepkumar, Jordyn Czarny, Pierre F. Apostolides
Summary: Corticofugal projections from the neocortex to evolutionarily ancient subcortical structures are common in mammalian sensory systems, allowing the cortex to control ascending sensory representations predictively or in a feedback manner. This study focused on the projection from the mouse auditory cortex to the inferior colliculus (IC), revealing that although individual synapses were weak, IC neurons integrated inputs from multiple corticofugal axons to generate reliable depolarizations. Descending signals reached the IC within 30 ms of sound onset and were found to nonlinearly amplify IC neurons' acoustic responses.
Article
Otorhinolaryngology
Han-Yu Zhu, Li Chen, Xiao-Yan Hou, Zheng-Quan Tang, Jia-Qiang Sun, Jing-Wu Sun, Xiao-Tao Guo
Summary: This study investigated the auditory pathway functions in deaf patients with Mondini malformation using electrically evoked auditory brainstem response (EABR) during cochlear implantation. The results showed that patients with Mondini malformation had lower EABR extraction rates compared to those without inner ear malformations. However, for patients who showed EABRs, there were no significant differences in EABR thresholds or latency intervals between the two groups. Therefore, EABR can be used to objectively evaluate the auditory conduction function in patients with Mondini malformation.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Neurosciences
Johannes Wetekam, Julio Hechavarria, Luciana Lopez-Jury, Manfred Koessl
Summary: The present study investigates neural responses to unexpected acoustic inputs in bats and identifies differences in response strength related to deviance detection. The findings suggest the presence of deviance detection in auditory brainstem responses and reveal frequency-specific strategies used by bats to detect unexpected sounds.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Acoustics
See Ling Tan, Yu-Fu Chen, Chieh-Yu Liu, Kuo-Chung Chu, Pei-Chun Li
Summary: This study compared the auditory brainstem responses (ABRs) to chirps and clicks in normal-hearing young adults with tinnitus. The results showed no significant differences in hearing thresholds, click-evoked otoacoustic emissions, and speech perception in noise between the tinnitus group and the control group. While chirps elicited significantly larger wave I and V amplitudes than clicks, individuals with tinnitus did not show significantly smaller wave I amplitudes for either stimulus. However, individuals with tinnitus exhibited significantly smaller interpeak intervals (IPI) between waves I and V for chirps but not for clicks, and the IPI-chirp correlated significantly with speech perception in noise when the signal-to-noise ratio was low. These findings suggest that chirp-evoked ABR may be a valuable tool for objectively assessing speech perception in individuals with tinnitus. Further research is needed to investigate possible etiologies of tinnitus.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2023)
Article
Audiology & Speech-Language Pathology
Mario Cebulla, Ekkehard Stuerzebecher, Wafaa Shehata-Dieler, James M. Harte
Summary: This study reviewed the use of automated ASSR methods for children with ANSD and investigated possible causes for potential failures. The study found that narrow-band chirps can evoke ASSR in certain patients, and that CM residuals and enlarged wave I with absent neural responses may lead to misinterpretation of high stimulus levels. The study also introduced a CM detector to prevent misinterpretation of clinical ASSR results.
INTERNATIONAL JOURNAL OF AUDIOLOGY
(2022)
Article
Neurosciences
Jierong Chen, Zhen Wei, Chun Liang, Binguang Liu, Jimin Guo, Xuejun Kong, Minshi Huang, Ziwen Peng, Guobin Wan
Summary: Research suggests that language impairment in Autism Spectrum Disorder (ASD) may be linked to auditory-brainstem dysfunction, leading to potential subtypes of ASD. Through analysis of speech-evoked auditory brainstem response (speech-ABR), structural MRI, and language ability assessments in ASD participants, two subtypes were identified: ASD-typical (ASD-T) and ASD-atypical (ASD-A). These findings support the idea that cortical deficits may impact language abilities in children with ASD by affecting subcortical function, potentially indicating a distinct subtype of ASD.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biology
Tanya B. Lauridsen, Christian Brandt, Jakob Christensen-Dalsgaard
Summary: Hearing sensitivity has been extensively studied using various methods, with the masked ABR method showing the most sensitive results, followed by the tone burst ABR method, while the long-duration tone method is not suitable for studying hearing thresholds above 1000 Hz.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Jun Ma, Jae-Hyun Seo, Il Joon Moon, Moo Kyun Park, Jong Bin Lee, Hantai Kim, Joong Ho Ahn, Jeong Hun Jang, Jong Dae Lee, Seong Jun Choi, Min Hong
Summary: This article proposes an image preprocessing process for constructing an efficient image dataset for deep learning models using auditory brainstem response data. The ABR images are standardized and classified using the VGG16 model, and the accuracy of the proposed method is analyzed.
Article
Audiology & Speech-Language Pathology
Li Chen, Jun-Ge Zhang, Han-Yu Zhu, Xiao-Yan Hou, Zheng-Quan Tang, Jing-Wu Sun, Jia-Qiang Sun, Xiao-Tao Guo
Summary: This study investigates the effect of hearing aid use on the peripheral auditory pathways in children with sensorineural hearing loss prior to cochlear implantation. The study found that the onset age of hearing aid use was significantly correlated with the peak latencies of specific waves in the electrically evoked auditory brainstem response (EABR). Higher EABR thresholds were found in children with inner ear malformations compared to those without. The study provides evidence that earlier use of hearing aids may improve physiological functions of the peripheral auditory pathway in children.
Article
Neurosciences
Jianxin Bao, Segun Light Jegede, John W. Hawks, Bethany Dade, Qiang Guan, Samantha Middaugh, Ziyu Qiu, Anna Levina, Tsung-Heng Tsai
Summary: This study investigates the feasibility of using curvature quantification to detect cochlear synaptic loss. The results demonstrate that curvature measurement is more sensitive and consistent in identifying cochlear synaptic loss in mice compared to amplitude and latency measurements. Furthermore, different types of ear disorders show distinct changes in curvature profiles.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Physics, Applied
Rasmus Zetter, Antti J. Makinen, Joonas Iivanainen, Koos C. J. Zevenhoven, Risto J. Ilmoniemi, Lauri Parkkonen
JOURNAL OF APPLIED PHYSICS
(2020)
Correction
Multidisciplinary Sciences
Miiamaaria V. Kujala, Jukka-Pekka Kauppi, Heini Tornqvist, Liisa Helle, Outi Vainio, Jan Kujala, Lauri Parkkonen
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Liisa Helle, Jukka Nenonen, Eric Larson, Juha Simola, Lauri Parkkonen, Samu Taulu
Summary: The new extended signal-space separation (eSSS) method combines a physical model of magnetic fields with a statistical description of interference to suppress external interference more effectively than traditional methods. It also does not cause location or amplitude bias in dipole modeling.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Physics, Applied
Joonas Iivanainen, Antti J. Makinen, Rasmus Zetter, Koos C. J. Zevenhoven, Risto J. Ilmoniemi, Lauri Parkkonen
Summary: This paper presents a method to compute the spectral properties of thermal magnetic noise in conducting objects, by modeling divergence-free currents on the object's surface to calculate magnetically independent noise-current modes. The power spectral density, spatial correlations, and frequency dependence of thermal magnetic noise are obtained through this method, which is also implemented numerically and validated against analytic formulas. The implementation is provided as part of the open-source software package bfieldtools.
JOURNAL OF APPLIED PHYSICS
(2021)
Article
Neurosciences
Joonas Iivanainen, Antti J. Makinen, Rasmus Zetter, Matti Stenroos, Risto J. Ilmoniemi, Lauri Parkkonen
Summary: This paper analyzes the spatial sampling of EEG and MEG, proposing a new method to optimize sensor locations based on prior assumptions. Simulation results show that model-informed non-uniform sampling can be beneficial when the number of samples is small. Uniform sampling grids are as effective as model-informed grids when there are a large number of samples.
Article
Computer Science, Software Engineering
Ivan Zubarev, Gavriela Vranou, Lauri Parkkonen
Summary: MNEflow is a Python package that applies deep neural networks to EEG and MEG measurements. It includes Tensorflow implementations of popular CNN models for EEG-MEG data and introduces a flexible pipeline for preprocessing, validation, and model interpretation. The software aims to save time and computational resources in analyzing EEG and MEG data.
Article
Multidisciplinary Sciences
Hanna-Leena Halme, Lauri Parkkonen
Summary: This study measured neurophysiological changes in healthy subjects performing motor imagery-based BCI training using magnetoencephalography (MEG), comparing two different feedback modalities. The results showed that visual feedback enhanced gamma band activity in the visual cortex, while proprioceptive feedback increased power in the sensorimotor rhythms in the motor cortex.
Article
Chemistry, Analytical
Joonas Iivanainen, Amir Borna, Rasmus Zetter, Tony R. Carter, Julia M. Stephen, Jim McKay, Lauri Parkkonen, Samu Taulu, Peter D. D. Schwindt
Summary: This paper proposes a method for calibrating and localizing magnetic field sensors using electromagnetic coils. The method is applied to optically pumped magnetometers in magnetoencephalography. By measuring the coil fields, modeling them, and minimizing the errors, the sensor parameters can be obtained. Experimental results confirm the feasibility of this method.
Article
Physics, Applied
Michael C. D. Tayler, Kostas Mouloudakis, Rasmus Zetter, Dominic Hunter, Vito G. Lucivero, Sven Bodenstedt, Lauri Parkkonen, Morgan W. Mitchell
Summary: Atomic spin sensors, with their compact microfabricated packages, show great potential for precision measurements. This study focuses on enhancing the performance of these sensors through magnetic field control using miniature coils. The results demonstrate the effectiveness of the coils in laboratory-scale magnetometers and magnetoencephalography applications.
PHYSICAL REVIEW APPLIED
(2022)
Article
Neurosciences
Sam van Bijnen, Lauri Parkkonen, Tiina Parviainen
Summary: Sensory processing during development is crucial for the cognitive functions in children. This study found that auditory cortical activity in children predicts performance in inhibition tasks and is correlated with the variability of behavioral response time. The brain mechanisms for auditory-based cognitive tasks differ between children and adults.
Article
Neurosciences
Vahab Youssofzadeh, Sujit Roy, Anirban Chowdhury, Aqil Izadysadr, Lauri Parkkonen, Manoj Raghavan, Girijesh Prasad
Summary: This study analyzed magnetoencephalography (MEG) data to examine the cortical engagement during mental imagery tasks. They found that beta power decrements can be used as markers to map and decode cortical engagement and classify different task types with high accuracy.
HUMAN BRAIN MAPPING
(2023)
Article
Multidisciplinary Sciences
Amit Jaiswal, Jukka Nenonen, Lauri Parkkonen
Summary: In MEG and EEG studies, the accuracy of head digitization is crucial for the registration of functional and structural data. The Fastrak EMT system is commonly used for digitization, but it may face challenges due to electromagnetic interference. This study assessed the performance of the Fastrak system under different conditions and explored the usability of alternative EMT systems. The results showed that the Fastrak system is reliable if operating conditions are met, while the Aurora system has potential for digitization with some modifications.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Yongjie Zhu, Tiina Parviainen, Erkka Heinila, Lauri Parkkonen, Aapo Hyvarinen
Summary: This study developed a method based on nonlinear independent component analysis (ICA) to learn representations from resting-state MEG data and found complex but structured spatiotemporal patterns. The nonlinear ICA model achieved competitive performance in audio-visual classification tasks and outperformed baseline methods in attentional state decoding tasks with limited labels.
Article
Multidisciplinary Sciences
Dovile Kurmanaviciute, Hanna Kataja, Mainak Jas, Anne Valila, Lauri Parkkonen
Summary: Selective auditory attention allows for filtering relevant acoustic information. This study shows that attention modulates auditory evoked responses, and these modulations can be detected in unaveraged MEG responses. The most informative sources are located in the auditory cortices, and the discriminating information is available 200-400 ms after the stimulus onset.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Jukka Vanhanen, Lauri Parkkonen, Jyrki P. Makela, Alexandra Tolmacheva, Anastasia Shulga, Andrey Rodionov, Erika Kirveskari
Summary: This prospective interventional case series aimed to explore the changes in the modulation of cortical sensorimotor oscillations after long-term paired associative stimulation (PAS) in participants with spinal cord injury (SCI). The results showed that PAS treatment restored the modulation of sensorimotor oscillations in response to active hand movement, but had no effect on the modulation following tactile stimulation.
SPINAL CORD SERIES AND CASES
(2022)